Amino acid dipepetide frequency for Alistipes sp. AF17-16

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.742AlaAla: 8.742 ± 0.121	1.046AlaCys: 1.046 ± 0.038	5.313AlaAsp: 5.313 ± 0.083	5.723AlaGlu: 5.723 ± 0.086	3.565AlaPhe: 3.565 ± 0.07	6.949AlaGly: 6.949 ± 0.101	1.25AlaHis: 1.25 ± 0.039	4.632AlaIle: 4.632 ± 0.086	3.817AlaLys: 3.817 ± 0.076	7.621AlaLeu: 7.621 ± 0.092	2.016AlaMet: 2.016 ± 0.047	2.637AlaAsn: 2.637 ± 0.058	3.125AlaPro: 3.125 ± 0.064	2.758AlaGln: 2.758 ± 0.061	4.568AlaArg: 4.568 ± 0.074	4.575AlaSer: 4.575 ± 0.076	4.279AlaThr: 4.279 ± 0.082	6.639AlaVal: 6.639 ± 0.099	0.948AlaTrp: 0.948 ± 0.031	2.974AlaTyr: 2.974 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.965CysAla: 0.965 ± 0.033	0.264CysCys: 0.264 ± 0.019	0.746CysAsp: 0.746 ± 0.03	0.684CysGlu: 0.684 ± 0.028	0.528CysPhe: 0.528 ± 0.026	1.213CysGly: 1.213 ± 0.04	0.246CysHis: 0.246 ± 0.015	0.749CysIle: 0.749 ± 0.03	0.59CysLys: 0.59 ± 0.025	0.944CysLeu: 0.944 ± 0.03	0.277CysMet: 0.277 ± 0.016	0.498CysAsn: 0.498 ± 0.023	0.614CysPro: 0.614 ± 0.031	0.244CysGln: 0.244 ± 0.016	0.876CysArg: 0.876 ± 0.036	0.819CysSer: 0.819 ± 0.031	0.662CysThr: 0.662 ± 0.026	0.79CysVal: 0.79 ± 0.031	0.138CysTrp: 0.138 ± 0.013	0.502CysTyr: 0.502 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.541AspAla: 4.541 ± 0.076	0.679AspCys: 0.679 ± 0.027	3.095AspAsp: 3.095 ± 0.057	3.538AspGlu: 3.538 ± 0.066	2.943AspPhe: 2.943 ± 0.063	5.003AspGly: 5.003 ± 0.087	0.867AspHis: 0.867 ± 0.029	3.766AspIle: 3.766 ± 0.069	3.22AspLys: 3.22 ± 0.062	4.791AspLeu: 4.791 ± 0.079	1.477AspMet: 1.477 ± 0.044	2.389AspAsn: 2.389 ± 0.054	2.836AspPro: 2.836 ± 0.054	1.291AspGln: 1.291 ± 0.041	4.109AspArg: 4.109 ± 0.072	3.387AspSer: 3.387 ± 0.083	2.992AspThr: 2.992 ± 0.062	3.591AspVal: 3.591 ± 0.069	0.781AspTrp: 0.781 ± 0.028	2.712AspTyr: 2.712 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.157GluAla: 5.157 ± 0.075	0.563GluCys: 0.563 ± 0.024	2.671GluAsp: 2.671 ± 0.049	3.767GluGlu: 3.767 ± 0.075	2.429GluPhe: 2.429 ± 0.054	3.816GluGly: 3.816 ± 0.067	1.093GluHis: 1.093 ± 0.036	4.517GluIle: 4.517 ± 0.078	4.375GluLys: 4.375 ± 0.078	5.854GluLeu: 5.854 ± 0.08	1.835GluMet: 1.835 ± 0.046	3.171GluAsn: 3.171 ± 0.057	2.184GluPro: 2.184 ± 0.05	2.578GluGln: 2.578 ± 0.055	4.137GluArg: 4.137 ± 0.077	3.299GluSer: 3.299 ± 0.055	3.653GluThr: 3.653 ± 0.076	3.858GluVal: 3.858 ± 0.067	0.767GluTrp: 0.767 ± 0.029	2.486GluTyr: 2.486 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.604PheAla: 3.604 ± 0.064	0.637PheCys: 0.637 ± 0.029	3.136PheAsp: 3.136 ± 0.066	2.585PheGlu: 2.585 ± 0.055	2.245PhePhe: 2.245 ± 0.06	3.711PheGly: 3.711 ± 0.067	0.729PheHis: 0.729 ± 0.027	2.619PheIle: 2.619 ± 0.057	1.965PheLys: 1.965 ± 0.055	3.708PheLeu: 3.708 ± 0.073	1.057PheMet: 1.057 ± 0.035	1.895PheAsn: 1.895 ± 0.049	1.862PhePro: 1.862 ± 0.045	0.97PheGln: 0.97 ± 0.037	2.859PheArg: 2.859 ± 0.061	3.107PheSer: 3.107 ± 0.059	2.551PheThr: 2.551 ± 0.051	3.272PheVal: 3.272 ± 0.069	0.555PheTrp: 0.555 ± 0.024	1.804PheTyr: 1.804 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	5.655GlyAla: 5.655 ± 0.09	1.099GlyCys: 1.099 ± 0.037	4.272GlyAsp: 4.272 ± 0.083	4.487GlyGlu: 4.487 ± 0.071	3.37GlyPhe: 3.37 ± 0.062	5.653GlyGly: 5.653 ± 0.106	1.298GlyHis: 1.298 ± 0.039	5.468GlyIle: 5.468 ± 0.089	4.748GlyLys: 4.748 ± 0.078	6.243GlyLeu: 6.243 ± 0.084	2.073GlyMet: 2.073 ± 0.048	3.306GlyAsn: 3.306 ± 0.06	1.734GlyPro: 1.734 ± 0.048	2.212GlyGln: 2.212 ± 0.057	4.55GlyArg: 4.55 ± 0.08	4.479GlySer: 4.479 ± 0.082	4.416GlyThr: 4.416 ± 0.07	5.351GlyVal: 5.351 ± 0.094	1.134GlyTrp: 1.134 ± 0.045	3.526GlyTyr: 3.526 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.239HisAla: 1.239 ± 0.042	0.306HisCys: 0.306 ± 0.017	0.896HisAsp: 0.896 ± 0.032	0.915HisGlu: 0.915 ± 0.032	0.898HisPhe: 0.898 ± 0.034	1.307HisGly: 1.307 ± 0.04	0.368HisHis: 0.368 ± 0.021	1.175HisIle: 1.175 ± 0.038	0.798HisLys: 0.798 ± 0.032	1.526HisLeu: 1.526 ± 0.043	0.34HisMet: 0.34 ± 0.019	0.724HisAsn: 0.724 ± 0.029	1.099HisPro: 1.099 ± 0.036	0.411HisGln: 0.411 ± 0.02	1.138HisArg: 1.138 ± 0.038	0.991HisSer: 0.991 ± 0.029	1.101HisThr: 1.101 ± 0.036	1.051HisVal: 1.051 ± 0.036	0.229HisTrp: 0.229 ± 0.017	0.802HisTyr: 0.802 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.988IleAla: 5.988 ± 0.086	0.824IleCys: 0.824 ± 0.031	4.328IleAsp: 4.328 ± 0.072	4.206IleGlu: 4.206 ± 0.075	2.49IlePhe: 2.49 ± 0.06	4.986IleGly: 4.986 ± 0.082	1.113IleHis: 1.113 ± 0.035	3.247IleIle: 3.247 ± 0.08	2.872IleLys: 2.872 ± 0.068	5.312IleLeu: 5.312 ± 0.098	1.204IleMet: 1.204 ± 0.037	2.48IleAsn: 2.48 ± 0.057	3.19IlePro: 3.19 ± 0.062	1.614IleGln: 1.614 ± 0.039	4.521IleArg: 4.521 ± 0.073	3.756IleSer: 3.756 ± 0.061	3.396IleThr: 3.396 ± 0.058	5.033IleVal: 5.033 ± 0.089	0.577IleTrp: 0.577 ± 0.023	2.306IleTyr: 2.306 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.292LysAla: 4.292 ± 0.074	0.448LysCys: 0.448 ± 0.022	2.757LysAsp: 2.757 ± 0.056	3.851LysGlu: 3.851 ± 0.083	1.899LysPhe: 1.899 ± 0.047	3.745LysGly: 3.745 ± 0.073	0.888LysHis: 0.888 ± 0.029	3.924LysIle: 3.924 ± 0.072	3.792LysLys: 3.792 ± 0.083	4.483LysLeu: 4.483 ± 0.069	1.843LysMet: 1.843 ± 0.046	2.681LysAsn: 2.681 ± 0.063	2.187LysPro: 2.187 ± 0.05	1.954LysGln: 1.954 ± 0.045	3.179LysArg: 3.179 ± 0.071	2.829LysSer: 2.829 ± 0.057	3.32LysThr: 3.32 ± 0.061	3.395LysVal: 3.395 ± 0.062	0.623LysTrp: 0.623 ± 0.027	2.225LysTyr: 2.225 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	7.16LeuAla: 7.16 ± 0.094	1.35LeuCys: 1.35 ± 0.038	4.744LeuAsp: 4.744 ± 0.076	4.803LeuGlu: 4.803 ± 0.089	4.561LeuPhe: 4.561 ± 0.085	5.887LeuGly: 5.887 ± 0.076	1.747LeuHis: 1.747 ± 0.044	5.535LeuIle: 5.535 ± 0.094	5.117LeuLys: 5.117 ± 0.088	9.032LeuLeu: 9.032 ± 0.128	2.206LeuMet: 2.206 ± 0.055	3.788LeuAsn: 3.788 ± 0.076	4.131LeuPro: 4.131 ± 0.07	3.069LeuGln: 3.069 ± 0.066	5.416LeuArg: 5.416 ± 0.082	6.497LeuSer: 6.497 ± 0.101	5.172LeuThr: 5.172 ± 0.077	5.158LeuVal: 5.158 ± 0.08	1.078LeuTrp: 1.078 ± 0.04	3.451LeuTyr: 3.451 ± 0.065	0.001LeuXaa: 0.001 ± 0.001
Met	2.068MetAla: 2.068 ± 0.054	0.22MetCys: 0.22 ± 0.017	1.33MetAsp: 1.33 ± 0.037	1.626MetGlu: 1.626 ± 0.041	0.887MetPhe: 0.887 ± 0.036	1.706MetGly: 1.706 ± 0.057	0.443MetHis: 0.443 ± 0.023	1.556MetIle: 1.556 ± 0.05	2.058MetLys: 2.058 ± 0.042	2.467MetLeu: 2.467 ± 0.055	0.709MetMet: 0.709 ± 0.028	1.219MetAsn: 1.219 ± 0.039	1.222MetPro: 1.222 ± 0.032	0.937MetGln: 0.937 ± 0.035	1.564MetArg: 1.564 ± 0.041	1.459MetSer: 1.459 ± 0.039	1.491MetThr: 1.491 ± 0.042	1.473MetVal: 1.473 ± 0.04	0.247MetTrp: 0.247 ± 0.016	0.674MetTyr: 0.674 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.156AsnAla: 3.156 ± 0.059	0.457AsnCys: 0.457 ± 0.024	2.338AsnAsp: 2.338 ± 0.052	2.336AsnGlu: 2.336 ± 0.057	1.824AsnPhe: 1.824 ± 0.044	3.611AsnGly: 3.611 ± 0.067	0.731AsnHis: 0.731 ± 0.029	2.856AsnIle: 2.856 ± 0.061	2.07AsnLys: 2.07 ± 0.051	3.752AsnLeu: 3.752 ± 0.08	1.042AsnMet: 1.042 ± 0.033	1.804AsnAsn: 1.804 ± 0.047	2.389AsnPro: 2.389 ± 0.047	1.127AsnGln: 1.127 ± 0.037	2.875AsnArg: 2.875 ± 0.068	2.119AsnSer: 2.119 ± 0.054	2.268AsnThr: 2.268 ± 0.052	2.804AsnVal: 2.804 ± 0.057	0.515AsnTrp: 0.515 ± 0.026	1.783AsnTyr: 1.783 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	3.88ProAla: 3.88 ± 0.075	0.383ProCys: 0.383 ± 0.019	3.276ProAsp: 3.276 ± 0.059	3.664ProGlu: 3.664 ± 0.063	1.91ProPhe: 1.91 ± 0.049	3.078ProGly: 3.078 ± 0.059	0.786ProHis: 0.786 ± 0.033	2.2ProIle: 2.2 ± 0.044	1.923ProLys: 1.923 ± 0.046	3.63ProLeu: 3.63 ± 0.059	0.969ProMet: 0.969 ± 0.038	1.521ProAsn: 1.521 ± 0.042	1.208ProPro: 1.208 ± 0.039	1.8ProGln: 1.8 ± 0.051	1.81ProArg: 1.81 ± 0.046	2.393ProSer: 2.393 ± 0.051	1.99ProThr: 1.99 ± 0.054	3.727ProVal: 3.727 ± 0.065	0.485ProTrp: 0.485 ± 0.023	1.739ProTyr: 1.739 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.641GlnAla: 2.641 ± 0.057	0.336GlnCys: 0.336 ± 0.018	1.397GlnAsp: 1.397 ± 0.034	1.816GlnGlu: 1.816 ± 0.047	1.25GlnPhe: 1.25 ± 0.039	2.046GlnGly: 2.046 ± 0.047	0.571GlnHis: 0.571 ± 0.027	2.195GlnIle: 2.195 ± 0.048	1.939GlnLys: 1.939 ± 0.05	2.802GlnLeu: 2.802 ± 0.057	0.967GlnMet: 0.967 ± 0.035	1.488GlnAsn: 1.488 ± 0.048	1.321GlnPro: 1.321 ± 0.039	1.639GlnGln: 1.639 ± 0.05	2.01GlnArg: 2.01 ± 0.049	1.695GlnSer: 1.695 ± 0.043	1.932GlnThr: 1.932 ± 0.047	2.03GlnVal: 2.03 ± 0.053	0.446GlnTrp: 0.446 ± 0.024	1.262GlnTyr: 1.262 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	3.982ArgAla: 3.982 ± 0.071	0.705ArgCys: 0.705 ± 0.029	3.184ArgAsp: 3.184 ± 0.065	4.204ArgGlu: 4.204 ± 0.083	3.13ArgPhe: 3.13 ± 0.066	3.476ArgGly: 3.476 ± 0.069	1.222ArgHis: 1.222 ± 0.044	4.994ArgIle: 4.994 ± 0.084	3.701ArgLys: 3.701 ± 0.064	5.688ArgLeu: 5.688 ± 0.099	1.832ArgMet: 1.832 ± 0.043	2.83ArgAsn: 2.83 ± 0.061	2.357ArgPro: 2.357 ± 0.059	2.322ArgGln: 2.322 ± 0.051	4.033ArgArg: 4.033 ± 0.083	3.253ArgSer: 3.253 ± 0.064	3.343ArgThr: 3.343 ± 0.061	3.654ArgVal: 3.654 ± 0.065	0.858ArgTrp: 0.858 ± 0.031	2.858ArgTyr: 2.858 ± 0.064	0.0ArgXaa: 0.0 ± 0.0
Ser	4.873SerAla: 4.873 ± 0.076	0.792SerCys: 0.792 ± 0.03	3.544SerAsp: 3.544 ± 0.066	3.432SerGlu: 3.432 ± 0.063	2.832SerPhe: 2.832 ± 0.064	5.234SerGly: 5.234 ± 0.083	1.004SerHis: 1.004 ± 0.034	3.453SerIle: 3.453 ± 0.058	2.702SerLys: 2.702 ± 0.058	5.58SerLeu: 5.58 ± 0.079	1.386SerMet: 1.386 ± 0.045	2.076SerAsn: 2.076 ± 0.046	2.517SerPro: 2.517 ± 0.049	1.73SerGln: 1.73 ± 0.041	3.376SerArg: 3.376 ± 0.067	3.338SerSer: 3.338 ± 0.073	2.808SerThr: 2.808 ± 0.059	4.692SerVal: 4.692 ± 0.079	0.739SerTrp: 0.739 ± 0.031	2.324SerTyr: 2.324 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	5.132ThrAla: 5.132 ± 0.077	0.52ThrCys: 0.52 ± 0.025	3.632ThrAsp: 3.632 ± 0.072	3.368ThrGlu: 3.368 ± 0.055	2.433ThrPhe: 2.433 ± 0.05	4.875ThrGly: 4.875 ± 0.063	0.905ThrHis: 0.905 ± 0.031	3.41ThrIle: 3.41 ± 0.065	2.258ThrLys: 2.258 ± 0.054	5.455ThrLeu: 5.455 ± 0.09	1.122ThrMet: 1.122 ± 0.036	1.899ThrAsn: 1.899 ± 0.054	3.103ThrPro: 3.103 ± 0.056	1.575ThrGln: 1.575 ± 0.043	2.521ThrArg: 2.521 ± 0.052	2.767ThrSer: 2.767 ± 0.061	2.949ThrThr: 2.949 ± 0.068	4.837ThrVal: 4.837 ± 0.084	0.593ThrTrp: 0.593 ± 0.029	1.955ThrTyr: 1.955 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	6.103ValAla: 6.103 ± 0.085	1.05ValCys: 1.05 ± 0.036	3.904ValAsp: 3.904 ± 0.07	4.222ValGlu: 4.222 ± 0.065	3.139ValPhe: 3.139 ± 0.067	4.821ValGly: 4.821 ± 0.075	1.082ValHis: 1.082 ± 0.038	4.11ValIle: 4.11 ± 0.08	3.681ValLys: 3.681 ± 0.068	6.095ValLeu: 6.095 ± 0.1	1.635ValMet: 1.635 ± 0.045	2.865ValAsn: 2.865 ± 0.056	3.138ValPro: 3.138 ± 0.056	1.91ValGln: 1.91 ± 0.039	4.47ValArg: 4.47 ± 0.08	4.771ValSer: 4.771 ± 0.073	4.118ValThr: 4.118 ± 0.079	5.483ValVal: 5.483 ± 0.075	0.833ValTrp: 0.833 ± 0.03	2.643ValTyr: 2.643 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.832TrpAla: 0.832 ± 0.034	0.162TrpCys: 0.162 ± 0.012	0.728TrpAsp: 0.728 ± 0.03	0.713TrpGlu: 0.713 ± 0.034	0.573TrpPhe: 0.573 ± 0.027	0.947TrpGly: 0.947 ± 0.032	0.241TrpHis: 0.241 ± 0.016	0.868TrpIle: 0.868 ± 0.033	0.702TrpLys: 0.702 ± 0.028	1.136TrpLeu: 1.136 ± 0.038	0.413TrpMet: 0.413 ± 0.022	0.761TrpAsn: 0.761 ± 0.035	0.309TrpPro: 0.309 ± 0.021	0.485TrpGln: 0.485 ± 0.022	0.658TrpArg: 0.658 ± 0.025	0.707TrpSer: 0.707 ± 0.027	0.659TrpThr: 0.659 ± 0.03	0.711TrpVal: 0.711 ± 0.032	0.174TrpTrp: 0.174 ± 0.016	0.45TrpTyr: 0.45 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.167TyrAla: 3.167 ± 0.063	0.506TyrCys: 0.506 ± 0.026	2.716TyrAsp: 2.716 ± 0.059	2.268TyrGlu: 2.268 ± 0.041	1.967TyrPhe: 1.967 ± 0.047	3.009TyrGly: 3.009 ± 0.066	0.731TyrHis: 0.731 ± 0.028	2.171TyrIle: 2.171 ± 0.045	1.987TyrLys: 1.987 ± 0.049	3.783TyrLeu: 3.783 ± 0.068	0.951TyrMet: 0.951 ± 0.031	1.826TyrAsn: 1.826 ± 0.05	1.845TyrPro: 1.845 ± 0.042	1.158TyrGln: 1.158 ± 0.039	2.957TyrArg: 2.957 ± 0.062	2.191TyrSer: 2.191 ± 0.05	2.209TyrThr: 2.209 ± 0.055	2.527TyrVal: 2.527 ± 0.053	0.509TyrTrp: 0.509 ± 0.024	1.825TyrTyr: 1.825 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 2605 proteins (907528 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---