Amino acid dipepetide frequency for Aurantimonas phage AmM-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.296AlaAla: 22.296 ± 1.607
1.284AlaCys: 1.284 ± 0.202
9.324AlaAsp: 9.324 ± 0.885
9.121AlaGlu: 9.121 ± 0.78
4.662AlaPhe: 4.662 ± 0.517
13.31AlaGly: 13.31 ± 0.912
2.567AlaHis: 2.567 ± 0.457
6.148AlaIle: 6.148 ± 0.697
3.919AlaLys: 3.919 ± 0.553
12.026AlaLeu: 12.026 ± 0.744
4.527AlaMet: 4.527 ± 0.473
2.432AlaAsn: 2.432 ± 0.385
7.027AlaPro: 7.027 ± 0.726
5.067AlaGln: 5.067 ± 0.575
10.878AlaArg: 10.878 ± 0.981
7.567AlaSer: 7.567 ± 0.621
7.837AlaThr: 7.837 ± 0.773
8.581AlaVal: 8.581 ± 0.855
2.567AlaTrp: 2.567 ± 0.402
2.838AlaTyr: 2.838 ± 0.383
0.0AlaXaa: 0.0 ± 0.0
Cys
0.946CysAla: 0.946 ± 0.257
0.27CysCys: 0.27 ± 0.119
0.473CysAsp: 0.473 ± 0.167
0.743CysGlu: 0.743 ± 0.239
0.405CysPhe: 0.405 ± 0.163
0.946CysGly: 0.946 ± 0.272
0.473CysHis: 0.473 ± 0.173
0.203CysIle: 0.203 ± 0.105
0.135CysLys: 0.135 ± 0.101
0.473CysLeu: 0.473 ± 0.196
0.203CysMet: 0.203 ± 0.116
0.27CysAsn: 0.27 ± 0.124
0.541CysPro: 0.541 ± 0.222
0.203CysGln: 0.203 ± 0.122
0.878CysArg: 0.878 ± 0.262
0.473CysSer: 0.473 ± 0.159
0.608CysThr: 0.608 ± 0.182
0.338CysVal: 0.338 ± 0.16
0.135CysTrp: 0.135 ± 0.103
0.135CysTyr: 0.135 ± 0.085
0.0CysXaa: 0.0 ± 0.0
Asp
8.243AspAla: 8.243 ± 0.664
0.473AspCys: 0.473 ± 0.173
3.919AspAsp: 3.919 ± 0.553
4.256AspGlu: 4.256 ± 0.503
2.297AspPhe: 2.297 ± 0.379
7.229AspGly: 7.229 ± 0.721
1.149AspHis: 1.149 ± 0.25
2.635AspIle: 2.635 ± 0.39
2.027AspLys: 2.027 ± 0.376
6.891AspLeu: 6.891 ± 0.681
0.946AspMet: 0.946 ± 0.252
1.486AspAsn: 1.486 ± 0.315
4.324AspPro: 4.324 ± 0.494
2.027AspGln: 2.027 ± 0.412
5.405AspArg: 5.405 ± 0.632
1.959AspSer: 1.959 ± 0.281
2.027AspThr: 2.027 ± 0.346
4.527AspVal: 4.527 ± 0.482
1.689AspTrp: 1.689 ± 0.283
1.419AspTyr: 1.419 ± 0.296
0.0AspXaa: 0.0 ± 0.0
Glu
9.053GluAla: 9.053 ± 0.816
0.743GluCys: 0.743 ± 0.199
2.432GluAsp: 2.432 ± 0.342
2.905GluGlu: 2.905 ± 0.639
2.365GluPhe: 2.365 ± 0.338
5.135GluGly: 5.135 ± 0.47
1.081GluHis: 1.081 ± 0.269
4.459GluIle: 4.459 ± 0.527
1.824GluLys: 1.824 ± 0.411
5.54GluLeu: 5.54 ± 0.778
2.027GluMet: 2.027 ± 0.287
1.216GluAsn: 1.216 ± 0.299
4.189GluPro: 4.189 ± 0.639
1.486GluGln: 1.486 ± 0.311
5.946GluArg: 5.946 ± 0.704
2.094GluSer: 2.094 ± 0.367
3.919GluThr: 3.919 ± 0.619
4.054GluVal: 4.054 ± 0.511
0.946GluTrp: 0.946 ± 0.287
1.216GluTyr: 1.216 ± 0.254
0.0GluXaa: 0.0 ± 0.0
Phe
4.865PheAla: 4.865 ± 0.598
0.473PheCys: 0.473 ± 0.213
2.5PheAsp: 2.5 ± 0.344
2.905PheGlu: 2.905 ± 0.362
0.878PhePhe: 0.878 ± 0.232
3.446PheGly: 3.446 ± 0.465
0.541PheHis: 0.541 ± 0.207
1.892PheIle: 1.892 ± 0.403
1.216PheLys: 1.216 ± 0.302
2.094PheLeu: 2.094 ± 0.339
0.473PheMet: 0.473 ± 0.211
0.743PheAsn: 0.743 ± 0.196
1.081PhePro: 1.081 ± 0.314
0.743PheGln: 0.743 ± 0.166
1.757PheArg: 1.757 ± 0.395
1.689PheSer: 1.689 ± 0.272
2.162PheThr: 2.162 ± 0.382
2.027PheVal: 2.027 ± 0.388
0.405PheTrp: 0.405 ± 0.156
0.946PheTyr: 0.946 ± 0.271
0.0PheXaa: 0.0 ± 0.0
Gly
12.296GlyAla: 12.296 ± 0.87
0.878GlyCys: 0.878 ± 0.229
6.554GlyAsp: 6.554 ± 0.642
6.554GlyGlu: 6.554 ± 0.666
2.635GlyPhe: 2.635 ± 0.609
7.094GlyGly: 7.094 ± 0.74
1.486GlyHis: 1.486 ± 0.346
3.513GlyIle: 3.513 ± 0.421
2.838GlyLys: 2.838 ± 0.387
6.554GlyLeu: 6.554 ± 0.698
2.5GlyMet: 2.5 ± 0.414
1.757GlyAsn: 1.757 ± 0.328
2.703GlyPro: 2.703 ± 0.44
3.243GlyGln: 3.243 ± 0.531
8.108GlyArg: 8.108 ± 0.755
5.135GlySer: 5.135 ± 0.549
3.446GlyThr: 3.446 ± 0.396
5.81GlyVal: 5.81 ± 0.582
1.554GlyTrp: 1.554 ± 0.33
2.094GlyTyr: 2.094 ± 0.394
0.0GlyXaa: 0.0 ± 0.0
His
2.5HisAla: 2.5 ± 0.428
0.338HisCys: 0.338 ± 0.134
1.554HisAsp: 1.554 ± 0.318
1.149HisGlu: 1.149 ± 0.234
0.676HisPhe: 0.676 ± 0.233
1.486HisGly: 1.486 ± 0.348
0.338HisHis: 0.338 ± 0.13
0.203HisIle: 0.203 ± 0.104
0.405HisLys: 0.405 ± 0.19
1.149HisLeu: 1.149 ± 0.346
0.338HisMet: 0.338 ± 0.135
0.338HisAsn: 0.338 ± 0.173
1.351HisPro: 1.351 ± 0.3
0.27HisGln: 0.27 ± 0.125
1.959HisArg: 1.959 ± 0.364
0.743HisSer: 0.743 ± 0.203
0.743HisThr: 0.743 ± 0.279
1.554HisVal: 1.554 ± 0.336
0.608HisTrp: 0.608 ± 0.228
0.405HisTyr: 0.405 ± 0.177
0.0HisXaa: 0.0 ± 0.0
Ile
8.243IleAla: 8.243 ± 0.86
0.405IleCys: 0.405 ± 0.142
4.527IleAsp: 4.527 ± 0.531
3.243IleGlu: 3.243 ± 0.358
1.081IlePhe: 1.081 ± 0.27
3.986IleGly: 3.986 ± 0.446
1.081IleHis: 1.081 ± 0.323
1.284IleIle: 1.284 ± 0.236
1.149IleLys: 1.149 ± 0.295
2.297IleLeu: 2.297 ± 0.329
0.608IleMet: 0.608 ± 0.2
1.216IleAsn: 1.216 ± 0.266
2.23IlePro: 2.23 ± 0.375
1.351IleGln: 1.351 ± 0.36
3.243IleArg: 3.243 ± 0.479
1.892IleSer: 1.892 ± 0.369
2.162IleThr: 2.162 ± 0.392
3.243IleVal: 3.243 ± 0.467
0.473IleTrp: 0.473 ± 0.144
0.608IleTyr: 0.608 ± 0.22
0.0IleXaa: 0.0 ± 0.0
Lys
4.865LysAla: 4.865 ± 0.611
0.135LysCys: 0.135 ± 0.088
0.811LysAsp: 0.811 ± 0.176
1.216LysGlu: 1.216 ± 0.219
0.743LysPhe: 0.743 ± 0.207
2.77LysGly: 2.77 ± 0.452
0.27LysHis: 0.27 ± 0.131
1.013LysIle: 1.013 ± 0.284
0.878LysLys: 0.878 ± 0.259
3.108LysLeu: 3.108 ± 0.566
1.351LysMet: 1.351 ± 0.324
0.473LysAsn: 0.473 ± 0.147
2.23LysPro: 2.23 ± 0.399
0.878LysGln: 0.878 ± 0.182
2.635LysArg: 2.635 ± 0.487
2.162LysSer: 2.162 ± 0.425
1.892LysThr: 1.892 ± 0.444
2.094LysVal: 2.094 ± 0.383
0.473LysTrp: 0.473 ± 0.165
0.608LysTyr: 0.608 ± 0.242
0.0LysXaa: 0.0 ± 0.0
Leu
12.229LeuAla: 12.229 ± 0.792
0.541LeuCys: 0.541 ± 0.188
6.216LeuAsp: 6.216 ± 0.615
5.202LeuGlu: 5.202 ± 0.561
2.5LeuPhe: 2.5 ± 0.392
7.094LeuGly: 7.094 ± 0.775
1.284LeuHis: 1.284 ± 0.273
1.959LeuIle: 1.959 ± 0.372
2.838LeuLys: 2.838 ± 0.481
6.418LeuLeu: 6.418 ± 0.741
1.486LeuMet: 1.486 ± 0.317
2.297LeuAsn: 2.297 ± 0.343
4.189LeuPro: 4.189 ± 0.493
2.77LeuGln: 2.77 ± 0.413
5.0LeuArg: 5.0 ± 0.545
5.337LeuSer: 5.337 ± 0.554
5.337LeuThr: 5.337 ± 0.606
5.337LeuVal: 5.337 ± 0.616
0.878LeuTrp: 0.878 ± 0.223
1.892LeuTyr: 1.892 ± 0.303
0.0LeuXaa: 0.0 ± 0.0
Met
4.729MetAla: 4.729 ± 0.55
0.135MetCys: 0.135 ± 0.105
0.743MetAsp: 0.743 ± 0.268
1.216MetGlu: 1.216 ± 0.313
0.608MetPhe: 0.608 ± 0.202
1.554MetGly: 1.554 ± 0.32
0.338MetHis: 0.338 ± 0.142
1.419MetIle: 1.419 ± 0.304
0.946MetLys: 0.946 ± 0.224
1.689MetLeu: 1.689 ± 0.267
0.405MetMet: 0.405 ± 0.135
0.27MetAsn: 0.27 ± 0.138
1.554MetPro: 1.554 ± 0.333
0.541MetGln: 0.541 ± 0.189
2.365MetArg: 2.365 ± 0.313
2.162MetSer: 2.162 ± 0.305
2.094MetThr: 2.094 ± 0.37
1.622MetVal: 1.622 ± 0.295
0.068MetTrp: 0.068 ± 0.069
0.27MetTyr: 0.27 ± 0.127
0.0MetXaa: 0.0 ± 0.0
Asn
2.905AsnAla: 2.905 ± 0.405
0.27AsnCys: 0.27 ± 0.124
0.743AsnAsp: 0.743 ± 0.266
0.676AsnGlu: 0.676 ± 0.233
0.473AsnPhe: 0.473 ± 0.162
2.838AsnGly: 2.838 ± 0.461
0.676AsnHis: 0.676 ± 0.171
1.284AsnIle: 1.284 ± 0.371
0.338AsnLys: 0.338 ± 0.162
1.689AsnLeu: 1.689 ± 0.341
0.608AsnMet: 0.608 ± 0.201
0.405AsnAsn: 0.405 ± 0.179
1.216AsnPro: 1.216 ± 0.279
0.405AsnGln: 0.405 ± 0.144
1.622AsnArg: 1.622 ± 0.282
1.351AsnSer: 1.351 ± 0.319
0.405AsnThr: 0.405 ± 0.183
1.824AsnVal: 1.824 ± 0.382
0.541AsnTrp: 0.541 ± 0.22
0.405AsnTyr: 0.405 ± 0.169
0.0AsnXaa: 0.0 ± 0.0
Pro
8.378ProAla: 8.378 ± 0.957
0.405ProCys: 0.405 ± 0.183
4.121ProAsp: 4.121 ± 0.705
3.243ProGlu: 3.243 ± 0.501
1.959ProPhe: 1.959 ± 0.41
4.256ProGly: 4.256 ± 0.404
1.013ProHis: 1.013 ± 0.237
3.108ProIle: 3.108 ± 0.524
1.824ProLys: 1.824 ± 0.303
3.513ProLeu: 3.513 ± 0.609
1.554ProMet: 1.554 ± 0.307
0.946ProAsn: 0.946 ± 0.246
2.432ProPro: 2.432 ± 0.498
1.622ProGln: 1.622 ± 0.338
4.797ProArg: 4.797 ± 0.657
2.905ProSer: 2.905 ± 0.373
2.567ProThr: 2.567 ± 0.433
5.27ProVal: 5.27 ± 0.753
0.811ProTrp: 0.811 ± 0.241
1.351ProTyr: 1.351 ± 0.323
0.0ProXaa: 0.0 ± 0.0
Gln
4.662GlnAla: 4.662 ± 0.628
0.27GlnCys: 0.27 ± 0.13
1.757GlnAsp: 1.757 ± 0.333
1.486GlnGlu: 1.486 ± 0.25
0.811GlnPhe: 0.811 ± 0.225
1.892GlnGly: 1.892 ± 0.317
0.743GlnHis: 0.743 ± 0.225
2.027GlnIle: 2.027 ± 0.388
0.743GlnLys: 0.743 ± 0.23
2.635GlnLeu: 2.635 ± 0.448
0.878GlnMet: 0.878 ± 0.311
0.743GlnAsn: 0.743 ± 0.199
1.486GlnPro: 1.486 ± 0.324
0.27GlnGln: 0.27 ± 0.139
2.838GlnArg: 2.838 ± 0.348
1.959GlnSer: 1.959 ± 0.334
1.689GlnThr: 1.689 ± 0.266
2.23GlnVal: 2.23 ± 0.319
0.743GlnTrp: 0.743 ± 0.232
0.338GlnTyr: 0.338 ± 0.165
0.0GlnXaa: 0.0 ± 0.0
Arg
9.864ArgAla: 9.864 ± 0.966
0.608ArgCys: 0.608 ± 0.217
4.797ArgAsp: 4.797 ± 0.701
5.202ArgGlu: 5.202 ± 0.58
3.581ArgPhe: 3.581 ± 0.509
5.946ArgGly: 5.946 ± 0.652
1.689ArgHis: 1.689 ± 0.396
3.919ArgIle: 3.919 ± 0.547
2.838ArgLys: 2.838 ± 0.424
8.108ArgLeu: 8.108 ± 0.572
2.432ArgMet: 2.432 ± 0.347
1.486ArgAsn: 1.486 ± 0.295
5.27ArgPro: 5.27 ± 0.523
2.838ArgGln: 2.838 ± 0.439
8.445ArgArg: 8.445 ± 0.967
3.919ArgSer: 3.919 ± 0.451
3.851ArgThr: 3.851 ± 0.576
6.148ArgVal: 6.148 ± 0.665
1.824ArgTrp: 1.824 ± 0.336
1.824ArgTyr: 1.824 ± 0.34
0.0ArgXaa: 0.0 ± 0.0
Ser
7.499SerAla: 7.499 ± 0.766
0.203SerCys: 0.203 ± 0.111
3.648SerAsp: 3.648 ± 0.498
3.513SerGlu: 3.513 ± 0.469
1.554SerPhe: 1.554 ± 0.324
5.135SerGly: 5.135 ± 0.543
0.338SerHis: 0.338 ± 0.152
1.892SerIle: 1.892 ± 0.338
2.027SerLys: 2.027 ± 0.331
3.986SerLeu: 3.986 ± 0.606
1.013SerMet: 1.013 ± 0.267
0.676SerAsn: 0.676 ± 0.229
3.108SerPro: 3.108 ± 0.428
1.689SerGln: 1.689 ± 0.329
4.662SerArg: 4.662 ± 0.532
2.162SerSer: 2.162 ± 0.44
3.378SerThr: 3.378 ± 0.624
3.446SerVal: 3.446 ± 0.466
0.946SerTrp: 0.946 ± 0.246
0.946SerTyr: 0.946 ± 0.287
0.0SerXaa: 0.0 ± 0.0
Thr
6.621ThrAla: 6.621 ± 0.576
0.203ThrCys: 0.203 ± 0.102
3.446ThrAsp: 3.446 ± 0.435
2.973ThrGlu: 2.973 ± 0.677
1.757ThrPhe: 1.757 ± 0.274
5.473ThrGly: 5.473 ± 0.605
0.676ThrHis: 0.676 ± 0.219
2.703ThrIle: 2.703 ± 0.527
1.689ThrLys: 1.689 ± 0.362
4.865ThrLeu: 4.865 ± 0.599
1.216ThrMet: 1.216 ± 0.349
1.149ThrAsn: 1.149 ± 0.242
3.919ThrPro: 3.919 ± 0.38
1.419ThrGln: 1.419 ± 0.268
3.446ThrArg: 3.446 ± 0.467
2.432ThrSer: 2.432 ± 0.343
3.446ThrThr: 3.446 ± 0.514
3.851ThrVal: 3.851 ± 0.633
0.878ThrTrp: 0.878 ± 0.215
0.811ThrTyr: 0.811 ± 0.265
0.0ThrXaa: 0.0 ± 0.0
Val
8.851ValAla: 8.851 ± 0.868
0.541ValCys: 0.541 ± 0.176
5.202ValAsp: 5.202 ± 0.627
5.405ValGlu: 5.405 ± 0.589
2.297ValPhe: 2.297 ± 0.396
4.662ValGly: 4.662 ± 0.452
1.081ValHis: 1.081 ± 0.25
3.311ValIle: 3.311 ± 0.493
1.824ValLys: 1.824 ± 0.45
4.527ValLeu: 4.527 ± 0.58
1.622ValMet: 1.622 ± 0.304
1.824ValAsn: 1.824 ± 0.445
4.662ValPro: 4.662 ± 0.599
1.622ValGln: 1.622 ± 0.369
6.756ValArg: 6.756 ± 0.652
3.986ValSer: 3.986 ± 0.51
3.851ValThr: 3.851 ± 0.509
5.067ValVal: 5.067 ± 0.722
0.676ValTrp: 0.676 ± 0.249
1.013ValTyr: 1.013 ± 0.292
0.0ValXaa: 0.0 ± 0.0
Trp
1.757TrpAla: 1.757 ± 0.335
0.338TrpCys: 0.338 ± 0.165
0.878TrpAsp: 0.878 ± 0.268
0.946TrpGlu: 0.946 ± 0.226
0.676TrpPhe: 0.676 ± 0.202
0.946TrpGly: 0.946 ± 0.208
0.676TrpHis: 0.676 ± 0.212
0.743TrpIle: 0.743 ± 0.239
0.676TrpLys: 0.676 ± 0.228
1.216TrpLeu: 1.216 ± 0.259
0.135TrpMet: 0.135 ± 0.092
0.676TrpAsn: 0.676 ± 0.179
1.486TrpPro: 1.486 ± 0.326
0.878TrpGln: 0.878 ± 0.202
1.824TrpArg: 1.824 ± 0.288
0.676TrpSer: 0.676 ± 0.196
1.081TrpThr: 1.081 ± 0.311
0.608TrpVal: 0.608 ± 0.203
0.203TrpTrp: 0.203 ± 0.098
0.203TrpTyr: 0.203 ± 0.104
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.175TyrAla: 3.175 ± 0.49
0.338TyrCys: 0.338 ± 0.14
1.284TyrAsp: 1.284 ± 0.284
0.743TyrGlu: 0.743 ± 0.198
0.878TyrPhe: 0.878 ± 0.228
1.554TyrGly: 1.554 ± 0.316
0.608TyrHis: 0.608 ± 0.175
0.608TyrIle: 0.608 ± 0.258
0.473TyrLys: 0.473 ± 0.166
2.027TyrLeu: 2.027 ± 0.471
0.338TyrMet: 0.338 ± 0.14
0.27TyrAsn: 0.27 ± 0.12
1.081TyrPro: 1.081 ± 0.229
0.878TyrGln: 0.878 ± 0.224
2.027TyrArg: 2.027 ± 0.331
1.216TyrSer: 1.216 ± 0.288
0.473TyrThr: 0.473 ± 0.172
1.149TyrVal: 1.149 ± 0.366
0.203TyrTrp: 0.203 ± 0.114
0.405TyrTyr: 0.405 ± 0.21
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 67 proteins (14802 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski