Amino acid dipepetide frequency for Streptococcus phage phiARI0460-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.967AlaAla: 2.967 ± 0.721
0.247AlaCys: 0.247 ± 0.131
5.522AlaAsp: 5.522 ± 0.584
5.851AlaGlu: 5.851 ± 0.668
2.802AlaPhe: 2.802 ± 0.688
4.615AlaGly: 4.615 ± 1.004
0.577AlaHis: 0.577 ± 0.218
4.368AlaIle: 4.368 ± 0.902
5.934AlaLys: 5.934 ± 0.697
6.428AlaLeu: 6.428 ± 0.934
2.225AlaMet: 2.225 ± 0.428
4.285AlaAsn: 4.285 ± 0.701
2.143AlaPro: 2.143 ± 0.414
1.813AlaGln: 1.813 ± 0.356
2.472AlaArg: 2.472 ± 0.456
2.637AlaSer: 2.637 ± 0.624
4.203AlaThr: 4.203 ± 0.805
5.357AlaVal: 5.357 ± 0.87
1.483AlaTrp: 1.483 ± 0.443
1.236AlaTyr: 1.236 ± 0.281
0.0AlaXaa: 0.0 ± 0.0
Cys
0.165CysAla: 0.165 ± 0.097
0.082CysCys: 0.082 ± 0.083
0.33CysAsp: 0.33 ± 0.15
0.247CysGlu: 0.247 ± 0.115
0.412CysPhe: 0.412 ± 0.206
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.247CysIle: 0.247 ± 0.195
0.659CysLys: 0.659 ± 0.244
0.494CysLeu: 0.494 ± 0.189
0.0CysMet: 0.0 ± 0.0
0.165CysAsn: 0.165 ± 0.167
0.412CysPro: 0.412 ± 0.201
0.33CysGln: 0.33 ± 0.142
0.33CysArg: 0.33 ± 0.148
0.247CysSer: 0.247 ± 0.148
0.082CysThr: 0.082 ± 0.083
0.247CysVal: 0.247 ± 0.145
0.082CysTrp: 0.082 ± 0.083
0.494CysTyr: 0.494 ± 0.188
0.0CysXaa: 0.0 ± 0.0
Asp
3.791AspAla: 3.791 ± 0.77
0.577AspCys: 0.577 ± 0.232
3.461AspAsp: 3.461 ± 0.694
4.533AspGlu: 4.533 ± 0.997
3.214AspPhe: 3.214 ± 0.564
4.615AspGly: 4.615 ± 0.641
0.577AspHis: 0.577 ± 0.263
5.687AspIle: 5.687 ± 0.683
5.192AspLys: 5.192 ± 0.693
5.11AspLeu: 5.11 ± 0.763
1.648AspMet: 1.648 ± 0.342
2.472AspAsn: 2.472 ± 0.501
1.648AspPro: 1.648 ± 0.367
1.648AspGln: 1.648 ± 0.343
2.308AspArg: 2.308 ± 0.497
3.626AspSer: 3.626 ± 0.64
3.791AspThr: 3.791 ± 0.581
3.544AspVal: 3.544 ± 0.46
1.648AspTrp: 1.648 ± 0.371
3.132AspTyr: 3.132 ± 0.72
0.0AspXaa: 0.0 ± 0.0
Glu
5.769GluAla: 5.769 ± 0.857
0.165GluCys: 0.165 ± 0.107
4.368GluAsp: 4.368 ± 0.696
6.016GluGlu: 6.016 ± 0.952
3.544GluPhe: 3.544 ± 0.525
3.544GluGly: 3.544 ± 0.568
1.236GluHis: 1.236 ± 0.312
5.604GluIle: 5.604 ± 0.609
7.664GluLys: 7.664 ± 1.287
7.994GluLeu: 7.994 ± 1.111
1.896GluMet: 1.896 ± 0.424
4.121GluAsn: 4.121 ± 0.524
1.319GluPro: 1.319 ± 0.332
2.802GluGln: 2.802 ± 0.45
4.038GluArg: 4.038 ± 0.678
5.522GluSer: 5.522 ± 0.725
3.461GluThr: 3.461 ± 0.576
5.274GluVal: 5.274 ± 0.641
1.236GluTrp: 1.236 ± 0.26
2.884GluTyr: 2.884 ± 0.482
0.0GluXaa: 0.0 ± 0.0
Phe
2.39PheAla: 2.39 ± 0.555
0.247PheCys: 0.247 ± 0.141
3.956PheAsp: 3.956 ± 0.53
3.461PheGlu: 3.461 ± 0.474
1.813PhePhe: 1.813 ± 0.368
2.472PheGly: 2.472 ± 0.618
0.33PheHis: 0.33 ± 0.147
1.731PheIle: 1.731 ± 0.397
3.461PheLys: 3.461 ± 0.515
2.967PheLeu: 2.967 ± 0.383
1.071PheMet: 1.071 ± 0.291
2.967PheAsn: 2.967 ± 0.585
0.577PhePro: 0.577 ± 0.229
1.566PheGln: 1.566 ± 0.402
1.566PheArg: 1.566 ± 0.25
3.049PheSer: 3.049 ± 0.811
2.72PheThr: 2.72 ± 0.416
1.813PheVal: 1.813 ± 0.377
0.742PheTrp: 0.742 ± 0.28
1.978PheTyr: 1.978 ± 0.409
0.0PheXaa: 0.0 ± 0.0
Gly
3.049GlyAla: 3.049 ± 0.545
0.165GlyCys: 0.165 ± 0.121
2.884GlyAsp: 2.884 ± 0.615
5.027GlyGlu: 5.027 ± 0.712
2.472GlyPhe: 2.472 ± 0.706
4.45GlyGly: 4.45 ± 1.32
0.907GlyHis: 0.907 ± 0.274
3.956GlyIle: 3.956 ± 0.685
5.439GlyLys: 5.439 ± 0.569
6.263GlyLeu: 6.263 ± 1.114
1.566GlyMet: 1.566 ± 0.279
3.873GlyAsn: 3.873 ± 0.517
1.071GlyPro: 1.071 ± 0.297
3.544GlyGln: 3.544 ± 0.499
3.626GlyArg: 3.626 ± 0.589
3.956GlySer: 3.956 ± 0.885
2.802GlyThr: 2.802 ± 0.528
4.78GlyVal: 4.78 ± 0.684
1.319GlyTrp: 1.319 ± 0.424
2.884GlyTyr: 2.884 ± 0.436
0.0GlyXaa: 0.0 ± 0.0
His
0.659HisAla: 0.659 ± 0.244
0.0HisCys: 0.0 ± 0.0
0.659HisAsp: 0.659 ± 0.23
1.154HisGlu: 1.154 ± 0.259
0.494HisPhe: 0.494 ± 0.194
0.989HisGly: 0.989 ± 0.312
0.165HisHis: 0.165 ± 0.114
0.742HisIle: 0.742 ± 0.31
0.824HisLys: 0.824 ± 0.342
1.319HisLeu: 1.319 ± 0.386
0.165HisMet: 0.165 ± 0.107
0.989HisAsn: 0.989 ± 0.243
0.824HisPro: 0.824 ± 0.217
0.494HisGln: 0.494 ± 0.175
0.412HisArg: 0.412 ± 0.164
1.483HisSer: 1.483 ± 0.453
0.907HisThr: 0.907 ± 0.286
0.824HisVal: 0.824 ± 0.247
0.165HisTrp: 0.165 ± 0.122
0.494HisTyr: 0.494 ± 0.211
0.0HisXaa: 0.0 ± 0.0
Ile
5.357IleAla: 5.357 ± 0.766
0.494IleCys: 0.494 ± 0.16
3.379IleAsp: 3.379 ± 0.587
6.675IleGlu: 6.675 ± 0.733
2.637IlePhe: 2.637 ± 0.604
4.45IleGly: 4.45 ± 0.868
0.494IleHis: 0.494 ± 0.203
3.297IleIle: 3.297 ± 0.486
6.675IleLys: 6.675 ± 0.642
3.297IleLeu: 3.297 ± 0.541
1.236IleMet: 1.236 ± 0.329
3.626IleAsn: 3.626 ± 0.618
2.06IlePro: 2.06 ± 0.464
2.555IleGln: 2.555 ± 0.347
2.72IleArg: 2.72 ± 0.459
4.945IleSer: 4.945 ± 0.772
4.698IleThr: 4.698 ± 0.637
3.544IleVal: 3.544 ± 0.577
0.742IleTrp: 0.742 ± 0.288
2.225IleTyr: 2.225 ± 0.575
0.0IleXaa: 0.0 ± 0.0
Lys
5.274LysAla: 5.274 ± 0.733
0.33LysCys: 0.33 ± 0.167
5.851LysAsp: 5.851 ± 0.569
7.17LysGlu: 7.17 ± 0.974
3.132LysPhe: 3.132 ± 0.45
5.027LysGly: 5.027 ± 0.698
1.813LysHis: 1.813 ± 0.403
6.016LysIle: 6.016 ± 0.816
8.736LysLys: 8.736 ± 1.126
7.5LysLeu: 7.5 ± 0.613
3.049LysMet: 3.049 ± 0.426
4.533LysAsn: 4.533 ± 0.533
2.884LysPro: 2.884 ± 0.645
3.709LysGln: 3.709 ± 0.699
2.967LysArg: 2.967 ± 0.525
4.533LysSer: 4.533 ± 0.494
5.851LysThr: 5.851 ± 0.588
6.428LysVal: 6.428 ± 0.8
1.236LysTrp: 1.236 ± 0.344
4.121LysTyr: 4.121 ± 0.526
0.0LysXaa: 0.0 ± 0.0
Leu
6.593LeuAla: 6.593 ± 0.805
0.412LeuCys: 0.412 ± 0.256
6.016LeuAsp: 6.016 ± 0.835
6.758LeuGlu: 6.758 ± 0.86
3.461LeuPhe: 3.461 ± 0.395
6.099LeuGly: 6.099 ± 1.413
1.236LeuHis: 1.236 ± 0.34
4.121LeuIle: 4.121 ± 0.667
7.417LeuLys: 7.417 ± 0.772
6.593LeuLeu: 6.593 ± 0.896
1.896LeuMet: 1.896 ± 0.393
3.709LeuAsn: 3.709 ± 0.617
3.297LeuPro: 3.297 ± 0.555
2.555LeuGln: 2.555 ± 0.528
3.626LeuArg: 3.626 ± 0.548
5.11LeuSer: 5.11 ± 0.89
5.274LeuThr: 5.274 ± 0.813
4.285LeuVal: 4.285 ± 0.572
0.494LeuTrp: 0.494 ± 0.201
2.39LeuTyr: 2.39 ± 0.411
0.0LeuXaa: 0.0 ± 0.0
Met
1.731MetAla: 1.731 ± 0.346
0.0MetCys: 0.0 ± 0.0
1.483MetAsp: 1.483 ± 0.317
2.143MetGlu: 2.143 ± 0.445
0.824MetPhe: 0.824 ± 0.274
1.154MetGly: 1.154 ± 0.413
0.165MetHis: 0.165 ± 0.116
2.06MetIle: 2.06 ± 0.534
2.555MetLys: 2.555 ± 0.538
1.566MetLeu: 1.566 ± 0.321
0.412MetMet: 0.412 ± 0.199
1.566MetAsn: 1.566 ± 0.349
0.824MetPro: 0.824 ± 0.271
0.989MetGln: 0.989 ± 0.301
1.154MetArg: 1.154 ± 0.292
1.154MetSer: 1.154 ± 0.312
1.483MetThr: 1.483 ± 0.348
1.071MetVal: 1.071 ± 0.229
0.247MetTrp: 0.247 ± 0.143
0.742MetTyr: 0.742 ± 0.2
0.0MetXaa: 0.0 ± 0.0
Asn
4.78AsnAla: 4.78 ± 0.975
0.33AsnCys: 0.33 ± 0.136
2.967AsnAsp: 2.967 ± 0.498
3.049AsnGlu: 3.049 ± 0.505
2.225AsnPhe: 2.225 ± 0.422
4.368AsnGly: 4.368 ± 0.533
0.824AsnHis: 0.824 ± 0.238
2.967AsnIle: 2.967 ± 0.45
4.368AsnLys: 4.368 ± 0.59
4.698AsnLeu: 4.698 ± 0.499
1.071AsnMet: 1.071 ± 0.281
2.637AsnAsn: 2.637 ± 0.542
2.06AsnPro: 2.06 ± 0.411
3.214AsnGln: 3.214 ± 0.587
2.637AsnArg: 2.637 ± 0.453
3.791AsnSer: 3.791 ± 0.623
2.967AsnThr: 2.967 ± 0.533
3.461AsnVal: 3.461 ± 0.433
0.907AsnTrp: 0.907 ± 0.248
1.978AsnTyr: 1.978 ± 0.353
0.0AsnXaa: 0.0 ± 0.0
Pro
1.731ProAla: 1.731 ± 0.431
0.165ProCys: 0.165 ± 0.116
2.225ProAsp: 2.225 ± 0.662
3.132ProGlu: 3.132 ± 0.374
0.742ProPhe: 0.742 ± 0.257
1.401ProGly: 1.401 ± 0.329
0.412ProHis: 0.412 ± 0.161
2.39ProIle: 2.39 ± 0.55
3.214ProLys: 3.214 ± 0.631
1.319ProLeu: 1.319 ± 0.343
0.412ProMet: 0.412 ± 0.179
1.813ProAsn: 1.813 ± 0.52
0.494ProPro: 0.494 ± 0.225
0.824ProGln: 0.824 ± 0.285
0.989ProArg: 0.989 ± 0.256
2.225ProSer: 2.225 ± 0.681
0.659ProThr: 0.659 ± 0.229
1.978ProVal: 1.978 ± 0.338
0.412ProTrp: 0.412 ± 0.213
1.483ProTyr: 1.483 ± 0.407
0.082ProXaa: 0.082 ± 0.07
Gln
3.544GlnAla: 3.544 ± 0.507
0.247GlnCys: 0.247 ± 0.138
1.401GlnAsp: 1.401 ± 0.406
3.379GlnGlu: 3.379 ± 0.639
1.566GlnPhe: 1.566 ± 0.323
1.896GlnGly: 1.896 ± 0.425
0.412GlnHis: 0.412 ± 0.204
3.626GlnIle: 3.626 ± 0.467
3.709GlnLys: 3.709 ± 0.587
2.967GlnLeu: 2.967 ± 0.476
0.824GlnMet: 0.824 ± 0.228
1.731GlnAsn: 1.731 ± 0.312
0.989GlnPro: 0.989 ± 0.292
1.566GlnGln: 1.566 ± 0.372
1.978GlnArg: 1.978 ± 0.416
2.225GlnSer: 2.225 ± 0.367
2.802GlnThr: 2.802 ± 0.534
3.544GlnVal: 3.544 ± 0.505
0.494GlnTrp: 0.494 ± 0.188
0.907GlnTyr: 0.907 ± 0.326
0.0GlnXaa: 0.0 ± 0.0
Arg
3.049ArgAla: 3.049 ± 0.447
0.33ArgCys: 0.33 ± 0.139
2.308ArgAsp: 2.308 ± 0.503
2.637ArgGlu: 2.637 ± 0.424
1.813ArgPhe: 1.813 ± 0.457
1.483ArgGly: 1.483 ± 0.329
0.494ArgHis: 0.494 ± 0.245
2.802ArgIle: 2.802 ± 0.487
3.956ArgLys: 3.956 ± 0.684
4.862ArgLeu: 4.862 ± 0.678
1.896ArgMet: 1.896 ± 0.419
2.637ArgAsn: 2.637 ± 0.425
0.824ArgPro: 0.824 ± 0.204
2.39ArgGln: 2.39 ± 0.401
2.637ArgArg: 2.637 ± 0.651
2.472ArgSer: 2.472 ± 0.451
2.472ArgThr: 2.472 ± 0.457
2.06ArgVal: 2.06 ± 0.371
0.494ArgTrp: 0.494 ± 0.186
1.483ArgTyr: 1.483 ± 0.441
0.0ArgXaa: 0.0 ± 0.0
Ser
4.533SerAla: 4.533 ± 0.943
0.165SerCys: 0.165 ± 0.102
3.709SerAsp: 3.709 ± 0.508
4.533SerGlu: 4.533 ± 0.747
2.06SerPhe: 2.06 ± 0.446
5.274SerGly: 5.274 ± 0.796
1.319SerHis: 1.319 ± 0.406
4.038SerIle: 4.038 ± 0.651
4.78SerLys: 4.78 ± 0.572
5.192SerLeu: 5.192 ± 0.621
1.319SerMet: 1.319 ± 0.364
3.626SerAsn: 3.626 ± 0.594
1.236SerPro: 1.236 ± 0.254
2.143SerGln: 2.143 ± 0.335
2.637SerArg: 2.637 ± 0.492
3.214SerSer: 3.214 ± 0.666
4.698SerThr: 4.698 ± 0.696
3.709SerVal: 3.709 ± 0.689
0.824SerTrp: 0.824 ± 0.369
2.884SerTyr: 2.884 ± 0.479
0.0SerXaa: 0.0 ± 0.0
Thr
4.698ThrAla: 4.698 ± 0.857
0.247ThrCys: 0.247 ± 0.157
4.368ThrAsp: 4.368 ± 0.525
4.038ThrGlu: 4.038 ± 0.521
3.214ThrPhe: 3.214 ± 0.522
4.615ThrGly: 4.615 ± 0.67
0.824ThrHis: 0.824 ± 0.317
4.203ThrIle: 4.203 ± 0.629
4.698ThrLys: 4.698 ± 0.709
3.709ThrLeu: 3.709 ± 0.615
0.742ThrMet: 0.742 ± 0.254
3.709ThrAsn: 3.709 ± 0.474
1.566ThrPro: 1.566 ± 0.453
2.555ThrGln: 2.555 ± 0.534
1.731ThrArg: 1.731 ± 0.368
4.203ThrSer: 4.203 ± 0.59
5.027ThrThr: 5.027 ± 0.833
4.285ThrVal: 4.285 ± 0.684
0.659ThrTrp: 0.659 ± 0.27
2.802ThrTyr: 2.802 ± 0.637
0.082ThrXaa: 0.082 ± 0.072
Val
4.45ValAla: 4.45 ± 0.615
0.247ValCys: 0.247 ± 0.15
4.121ValAsp: 4.121 ± 0.568
5.11ValGlu: 5.11 ± 0.616
1.896ValPhe: 1.896 ± 0.423
4.945ValGly: 4.945 ± 0.681
0.824ValHis: 0.824 ± 0.293
4.203ValIle: 4.203 ± 0.687
5.439ValLys: 5.439 ± 0.612
4.862ValLeu: 4.862 ± 0.604
0.659ValMet: 0.659 ± 0.243
4.368ValAsn: 4.368 ± 0.706
2.06ValPro: 2.06 ± 0.336
2.06ValGln: 2.06 ± 0.485
2.39ValArg: 2.39 ± 0.325
4.615ValSer: 4.615 ± 0.712
4.862ValThr: 4.862 ± 0.639
4.945ValVal: 4.945 ± 0.785
0.577ValTrp: 0.577 ± 0.179
2.308ValTyr: 2.308 ± 0.577
0.0ValXaa: 0.0 ± 0.0
Trp
1.154TrpAla: 1.154 ± 0.379
0.165TrpCys: 0.165 ± 0.115
0.907TrpAsp: 0.907 ± 0.338
0.989TrpGlu: 0.989 ± 0.299
1.071TrpPhe: 1.071 ± 0.41
0.659TrpGly: 0.659 ± 0.23
0.082TrpHis: 0.082 ± 0.076
0.659TrpIle: 0.659 ± 0.284
1.483TrpLys: 1.483 ± 0.37
1.071TrpLeu: 1.071 ± 0.384
0.412TrpMet: 0.412 ± 0.193
0.907TrpAsn: 0.907 ± 0.335
0.0TrpPro: 0.0 ± 0.0
0.907TrpGln: 0.907 ± 0.354
0.33TrpArg: 0.33 ± 0.162
0.247TrpSer: 0.247 ± 0.103
1.071TrpThr: 1.071 ± 0.363
1.319TrpVal: 1.319 ± 0.287
0.082TrpTrp: 0.082 ± 0.07
0.742TrpTyr: 0.742 ± 0.498
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.483TyrAla: 1.483 ± 0.28
0.412TyrCys: 0.412 ± 0.179
2.308TyrAsp: 2.308 ± 0.426
2.472TyrGlu: 2.472 ± 0.462
1.566TyrPhe: 1.566 ± 0.479
1.978TyrGly: 1.978 ± 0.38
1.071TyrHis: 1.071 ± 0.266
2.39TyrIle: 2.39 ± 0.445
3.956TyrLys: 3.956 ± 0.731
3.132TyrLeu: 3.132 ± 0.471
0.659TyrMet: 0.659 ± 0.32
1.566TyrAsn: 1.566 ± 0.355
1.813TyrPro: 1.813 ± 0.433
2.143TyrGln: 2.143 ± 0.379
2.555TyrArg: 2.555 ± 0.607
2.637TyrSer: 2.637 ± 0.56
2.143TyrThr: 2.143 ± 0.361
2.472TyrVal: 2.472 ± 0.525
0.412TyrTrp: 0.412 ± 0.203
1.813TyrTyr: 1.813 ± 0.552
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.082XaaGlu: 0.082 ± 0.07
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.082XaaMet: 0.082 ± 0.072
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (12135 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski