Amino acid dipepetide frequency for Hydrogenobaculum sp. (strain Y04AAS1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.126AlaAla: 3.126 ± 0.111
0.743AlaCys: 0.743 ± 0.044
2.395AlaAsp: 2.395 ± 0.075
2.588AlaGlu: 2.588 ± 0.083
3.973AlaPhe: 3.973 ± 0.098
3.774AlaGly: 3.774 ± 0.112
1.054AlaHis: 1.054 ± 0.048
6.677AlaIle: 6.677 ± 0.131
6.114AlaLys: 6.114 ± 0.132
6.897AlaLeu: 6.897 ± 0.115
1.763AlaMet: 1.763 ± 0.068
2.618AlaAsn: 2.618 ± 0.072
1.767AlaPro: 1.767 ± 0.067
1.822AlaGln: 1.822 ± 0.074
2.029AlaArg: 2.029 ± 0.075
4.201AlaSer: 4.201 ± 0.111
2.69AlaThr: 2.69 ± 0.071
3.784AlaVal: 3.784 ± 0.111
0.431AlaTrp: 0.431 ± 0.028
3.078AlaTyr: 3.078 ± 0.087
0.0AlaXaa: 0.0 ± 0.0
Cys
0.52CysAla: 0.52 ± 0.034
0.12CysCys: 0.12 ± 0.018
0.429CysAsp: 0.429 ± 0.03
0.538CysGlu: 0.538 ± 0.035
0.384CysPhe: 0.384 ± 0.03
0.758CysGly: 0.758 ± 0.045
0.211CysHis: 0.211 ± 0.021
0.695CysIle: 0.695 ± 0.044
0.721CysLys: 0.721 ± 0.047
0.593CysLeu: 0.593 ± 0.038
0.252CysMet: 0.252 ± 0.024
0.414CysAsn: 0.414 ± 0.029
0.524CysPro: 0.524 ± 0.034
0.232CysGln: 0.232 ± 0.023
0.217CysArg: 0.217 ± 0.022
0.628CysSer: 0.628 ± 0.037
0.374CysThr: 0.374 ± 0.029
0.567CysVal: 0.567 ± 0.037
0.057CysTrp: 0.057 ± 0.012
0.378CysTyr: 0.378 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
2.943AspAla: 2.943 ± 0.081
0.404AspCys: 0.404 ± 0.032
2.06AspAsp: 2.06 ± 0.079
3.482AspGlu: 3.482 ± 0.097
3.6AspPhe: 3.6 ± 0.104
2.657AspGly: 2.657 ± 0.076
0.662AspHis: 0.662 ± 0.036
7.847AspIle: 7.847 ± 0.131
5.176AspLys: 5.176 ± 0.111
4.737AspLeu: 4.737 ± 0.102
1.461AspMet: 1.461 ± 0.052
2.265AspAsn: 2.265 ± 0.079
1.751AspPro: 1.751 ± 0.061
0.965AspGln: 0.965 ± 0.049
1.723AspArg: 1.723 ± 0.055
2.293AspSer: 2.293 ± 0.073
2.558AspThr: 2.558 ± 0.076
4.093AspVal: 4.093 ± 0.106
0.473AspTrp: 0.473 ± 0.033
2.734AspTyr: 2.734 ± 0.081
0.0AspXaa: 0.0 ± 0.0
Glu
4.837GluAla: 4.837 ± 0.112
0.443GluCys: 0.443 ± 0.029
4.666GluAsp: 4.666 ± 0.117
6.49GluGlu: 6.49 ± 0.176
3.153GluPhe: 3.153 ± 0.088
3.963GluGly: 3.963 ± 0.112
1.408GluHis: 1.408 ± 0.052
5.58GluIle: 5.58 ± 0.124
6.957GluLys: 6.957 ± 0.184
7.362GluLeu: 7.362 ± 0.169
1.249GluMet: 1.249 ± 0.045
4.347GluAsn: 4.347 ± 0.095
1.889GluPro: 1.889 ± 0.058
1.97GluGln: 1.97 ± 0.079
2.541GluArg: 2.541 ± 0.079
3.177GluSer: 3.177 ± 0.084
2.592GluThr: 2.592 ± 0.085
4.099GluVal: 4.099 ± 0.107
0.5GluTrp: 0.5 ± 0.031
2.685GluTyr: 2.685 ± 0.073
0.0GluXaa: 0.0 ± 0.0
Phe
2.616PheAla: 2.616 ± 0.08
0.546PheCys: 0.546 ± 0.034
3.21PheAsp: 3.21 ± 0.089
3.413PheGlu: 3.413 ± 0.1
2.822PhePhe: 2.822 ± 0.107
3.825PheGly: 3.825 ± 0.101
0.715PheHis: 0.715 ± 0.04
4.711PheIle: 4.711 ± 0.119
4.079PheLys: 4.079 ± 0.088
5.832PheLeu: 5.832 ± 0.153
1.296PheMet: 1.296 ± 0.053
2.18PheAsn: 2.18 ± 0.073
1.422PhePro: 1.422 ± 0.053
1.036PheGln: 1.036 ± 0.052
1.546PheArg: 1.546 ± 0.064
3.636PheSer: 3.636 ± 0.103
2.04PheThr: 2.04 ± 0.066
3.732PheVal: 3.732 ± 0.095
0.433PheTrp: 0.433 ± 0.033
2.868PheTyr: 2.868 ± 0.08
0.0PheXaa: 0.0 ± 0.0
Gly
4.355GlyAla: 4.355 ± 0.115
0.609GlyCys: 0.609 ± 0.045
2.927GlyAsp: 2.927 ± 0.084
3.09GlyGlu: 3.09 ± 0.09
4.036GlyPhe: 4.036 ± 0.099
3.933GlyGly: 3.933 ± 0.138
1.077GlyHis: 1.077 ± 0.048
6.515GlyIle: 6.515 ± 0.134
4.957GlyLys: 4.957 ± 0.109
5.733GlyLeu: 5.733 ± 0.109
1.517GlyMet: 1.517 ± 0.055
2.521GlyAsn: 2.521 ± 0.084
1.479GlyPro: 1.479 ± 0.06
1.457GlyGln: 1.457 ± 0.068
1.944GlyArg: 1.944 ± 0.072
3.356GlySer: 3.356 ± 0.109
2.85GlyThr: 2.85 ± 0.076
4.528GlyVal: 4.528 ± 0.101
0.522GlyTrp: 0.522 ± 0.037
3.076GlyTyr: 3.076 ± 0.088
0.0GlyXaa: 0.0 ± 0.0
His
0.92HisAla: 0.92 ± 0.044
0.205HisCys: 0.205 ± 0.022
0.725HisAsp: 0.725 ± 0.045
0.851HisGlu: 0.851 ± 0.044
0.985HisPhe: 0.985 ± 0.044
1.038HisGly: 1.038 ± 0.05
0.477HisHis: 0.477 ± 0.032
2.029HisIle: 2.029 ± 0.069
1.377HisLys: 1.377 ± 0.05
1.587HisLeu: 1.587 ± 0.049
0.475HisMet: 0.475 ± 0.028
0.678HisAsn: 0.678 ± 0.04
0.888HisPro: 0.888 ± 0.043
0.526HisGln: 0.526 ± 0.035
0.634HisArg: 0.634 ± 0.034
0.815HisSer: 0.815 ± 0.049
0.859HisThr: 0.859 ± 0.046
1.004HisVal: 1.004 ± 0.047
0.14HisTrp: 0.14 ± 0.017
0.804HisTyr: 0.804 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.905IleAla: 5.905 ± 0.122
0.681IleCys: 0.681 ± 0.041
5.442IleAsp: 5.442 ± 0.114
7.187IleGlu: 7.187 ± 0.143
4.311IlePhe: 4.311 ± 0.125
5.844IleGly: 5.844 ± 0.125
1.422IleHis: 1.422 ± 0.055
6.819IleIle: 6.819 ± 0.132
9.159IleLys: 9.159 ± 0.132
8.656IleLeu: 8.656 ± 0.167
1.84IleMet: 1.84 ± 0.066
4.906IleAsn: 4.906 ± 0.14
3.939IlePro: 3.939 ± 0.108
1.93IleGln: 1.93 ± 0.059
3.122IleArg: 3.122 ± 0.081
6.647IleSer: 6.647 ± 0.139
4.707IleThr: 4.707 ± 0.107
6.173IleVal: 6.173 ± 0.102
0.595IleTrp: 0.595 ± 0.032
3.894IleTyr: 3.894 ± 0.095
0.0IleXaa: 0.0 ± 0.0
Lys
6.838LysAla: 6.838 ± 0.15
0.445LysCys: 0.445 ± 0.031
7.699LysAsp: 7.699 ± 0.127
9.81LysGlu: 9.81 ± 0.2
2.836LysPhe: 2.836 ± 0.082
4.581LysGly: 4.581 ± 0.093
1.844LysHis: 1.844 ± 0.067
6.866LysIle: 6.866 ± 0.128
7.61LysLys: 7.61 ± 0.157
7.92LysLeu: 7.92 ± 0.133
1.631LysMet: 1.631 ± 0.064
5.743LysAsn: 5.743 ± 0.114
3.659LysPro: 3.659 ± 0.095
2.184LysGln: 2.184 ± 0.075
3.232LysArg: 3.232 ± 0.093
5.623LysSer: 5.623 ± 0.112
4.514LysThr: 4.514 ± 0.105
4.916LysVal: 4.916 ± 0.117
0.581LysTrp: 0.581 ± 0.039
3.579LysTyr: 3.579 ± 0.092
0.0LysXaa: 0.0 ± 0.0
Leu
5.613LeuAla: 5.613 ± 0.106
0.743LeuCys: 0.743 ± 0.042
5.115LeuAsp: 5.115 ± 0.105
8.119LeuGlu: 8.119 ± 0.181
4.76LeuPhe: 4.76 ± 0.141
6.003LeuGly: 6.003 ± 0.123
1.394LeuHis: 1.394 ± 0.05
7.354LeuIle: 7.354 ± 0.138
10.368LeuLys: 10.368 ± 0.156
8.778LeuLeu: 8.778 ± 0.171
2.291LeuMet: 2.291 ± 0.067
5.093LeuAsn: 5.093 ± 0.114
3.459LeuPro: 3.459 ± 0.096
2.417LeuGln: 2.417 ± 0.079
3.49LeuArg: 3.49 ± 0.094
7.417LeuSer: 7.417 ± 0.131
3.996LeuThr: 3.996 ± 0.083
5.56LeuVal: 5.56 ± 0.114
0.815LeuTrp: 0.815 ± 0.04
4.0LeuTyr: 4.0 ± 0.1
0.0LeuXaa: 0.0 ± 0.0
Met
1.818MetAla: 1.818 ± 0.069
0.211MetCys: 0.211 ± 0.02
1.221MetAsp: 1.221 ± 0.047
1.566MetGlu: 1.566 ± 0.056
1.203MetPhe: 1.203 ± 0.052
1.692MetGly: 1.692 ± 0.063
0.394MetHis: 0.394 ± 0.026
1.763MetIle: 1.763 ± 0.057
2.019MetLys: 2.019 ± 0.061
2.639MetLeu: 2.639 ± 0.077
0.53MetMet: 0.53 ± 0.034
0.983MetAsn: 0.983 ± 0.047
1.113MetPro: 1.113 ± 0.052
0.512MetGln: 0.512 ± 0.031
0.916MetArg: 0.916 ± 0.046
1.511MetSer: 1.511 ± 0.053
0.829MetThr: 0.829 ± 0.044
1.483MetVal: 1.483 ± 0.061
0.181MetTrp: 0.181 ± 0.02
0.76MetTyr: 0.76 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
3.153AsnAla: 3.153 ± 0.087
0.412AsnCys: 0.412 ± 0.032
1.932AsnAsp: 1.932 ± 0.067
2.541AsnGlu: 2.541 ± 0.077
2.208AsnPhe: 2.208 ± 0.079
2.714AsnGly: 2.714 ± 0.088
0.829AsnHis: 0.829 ± 0.044
6.374AsnIle: 6.374 ± 0.112
4.15AsnLys: 4.15 ± 0.099
5.182AsnLeu: 5.182 ± 0.109
1.245AsnMet: 1.245 ± 0.05
2.153AsnAsn: 2.153 ± 0.075
2.659AsnPro: 2.659 ± 0.077
1.66AsnGln: 1.66 ± 0.07
1.54AsnArg: 1.54 ± 0.054
2.7AsnSer: 2.7 ± 0.097
2.95AsnThr: 2.95 ± 0.097
3.466AsnVal: 3.466 ± 0.092
0.388AsnTrp: 0.388 ± 0.03
2.149AsnTyr: 2.149 ± 0.078
0.0AsnXaa: 0.0 ± 0.0
Pro
1.765ProAla: 1.765 ± 0.073
0.345ProCys: 0.345 ± 0.029
1.729ProAsp: 1.729 ± 0.065
2.279ProGlu: 2.279 ± 0.07
2.011ProPhe: 2.011 ± 0.071
1.952ProGly: 1.952 ± 0.066
0.723ProHis: 0.723 ± 0.044
3.752ProIle: 3.752 ± 0.101
3.317ProLys: 3.317 ± 0.086
2.98ProLeu: 2.98 ± 0.078
0.867ProMet: 0.867 ± 0.041
1.991ProAsn: 1.991 ± 0.07
1.548ProPro: 1.548 ± 0.091
1.125ProGln: 1.125 ± 0.054
1.134ProArg: 1.134 ± 0.053
2.488ProSer: 2.488 ± 0.077
1.889ProThr: 1.889 ± 0.059
2.393ProVal: 2.393 ± 0.083
0.337ProTrp: 0.337 ± 0.03
1.849ProTyr: 1.849 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
1.792GlnAla: 1.792 ± 0.067
0.199GlnCys: 0.199 ± 0.02
1.721GlnAsp: 1.721 ± 0.061
2.377GlnGlu: 2.377 ± 0.084
0.811GlnPhe: 0.811 ± 0.043
1.361GlnGly: 1.361 ± 0.049
0.364GlnHis: 0.364 ± 0.025
2.135GlnIle: 2.135 ± 0.078
2.732GlnLys: 2.732 ± 0.082
1.639GlnLeu: 1.639 ± 0.065
0.563GlnMet: 0.563 ± 0.033
2.066GlnAsn: 2.066 ± 0.084
0.67GlnPro: 0.67 ± 0.038
0.681GlnGln: 0.681 ± 0.047
1.123GlnArg: 1.123 ± 0.05
1.497GlnSer: 1.497 ± 0.06
1.475GlnThr: 1.475 ± 0.071
1.298GlnVal: 1.298 ± 0.054
0.163GlnTrp: 0.163 ± 0.019
0.9GlnTyr: 0.9 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.23ArgAla: 2.23 ± 0.073
0.278ArgCys: 0.278 ± 0.022
1.645ArgAsp: 1.645 ± 0.058
2.444ArgGlu: 2.444 ± 0.086
2.092ArgPhe: 2.092 ± 0.063
1.905ArgGly: 1.905 ± 0.071
0.63ArgHis: 0.63 ± 0.033
3.041ArgIle: 3.041 ± 0.081
2.781ArgLys: 2.781 ± 0.088
3.435ArgLeu: 3.435 ± 0.077
0.798ArgMet: 0.798 ± 0.034
1.519ArgAsn: 1.519 ± 0.056
1.266ArgPro: 1.266 ± 0.047
0.878ArgGln: 0.878 ± 0.043
1.416ArgArg: 1.416 ± 0.051
1.53ArgSer: 1.53 ± 0.051
1.416ArgThr: 1.416 ± 0.051
2.275ArgVal: 2.275 ± 0.072
0.313ArgTrp: 0.313 ± 0.025
1.747ArgTyr: 1.747 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
3.311SerAla: 3.311 ± 0.085
0.638SerCys: 0.638 ± 0.039
2.387SerAsp: 2.387 ± 0.072
2.854SerGlu: 2.854 ± 0.089
3.979SerPhe: 3.979 ± 0.119
3.717SerGly: 3.717 ± 0.102
1.06SerHis: 1.06 ± 0.041
6.092SerIle: 6.092 ± 0.113
6.049SerLys: 6.049 ± 0.11
6.921SerLeu: 6.921 ± 0.137
1.641SerMet: 1.641 ± 0.059
3.163SerAsn: 3.163 ± 0.102
1.989SerPro: 1.989 ± 0.072
1.802SerGln: 1.802 ± 0.066
1.82SerArg: 1.82 ± 0.062
4.76SerSer: 4.76 ± 0.144
2.7SerThr: 2.7 ± 0.065
4.006SerVal: 4.006 ± 0.1
0.463SerTrp: 0.463 ± 0.032
3.11SerTyr: 3.11 ± 0.088
0.0SerXaa: 0.0 ± 0.0
Thr
2.598ThrAla: 2.598 ± 0.068
0.408ThrCys: 0.408 ± 0.031
2.178ThrAsp: 2.178 ± 0.071
2.259ThrGlu: 2.259 ± 0.072
2.336ThrPhe: 2.336 ± 0.076
3.049ThrGly: 3.049 ± 0.095
0.943ThrHis: 0.943 ± 0.045
4.242ThrIle: 4.242 ± 0.099
4.091ThrLys: 4.091 ± 0.092
4.603ThrLeu: 4.603 ± 0.106
1.119ThrMet: 1.119 ± 0.049
2.196ThrAsn: 2.196 ± 0.083
2.318ThrPro: 2.318 ± 0.078
1.233ThrGln: 1.233 ± 0.054
1.322ThrArg: 1.322 ± 0.045
2.765ThrSer: 2.765 ± 0.073
2.462ThrThr: 2.462 ± 0.076
2.643ThrVal: 2.643 ± 0.081
0.307ThrTrp: 0.307 ± 0.029
2.239ThrTyr: 2.239 ± 0.086
0.0ThrXaa: 0.0 ± 0.0
Val
3.982ValAla: 3.982 ± 0.092
0.764ValCys: 0.764 ± 0.042
3.571ValAsp: 3.571 ± 0.078
4.367ValGlu: 4.367 ± 0.11
3.724ValPhe: 3.724 ± 0.098
4.449ValGly: 4.449 ± 0.113
0.831ValHis: 0.831 ± 0.041
5.379ValIle: 5.379 ± 0.109
5.395ValLys: 5.395 ± 0.112
6.622ValLeu: 6.622 ± 0.11
1.461ValMet: 1.461 ± 0.059
2.907ValAsn: 2.907 ± 0.075
2.287ValPro: 2.287 ± 0.07
1.331ValGln: 1.331 ± 0.057
2.159ValArg: 2.159 ± 0.075
4.585ValSer: 4.585 ± 0.106
1.81ValThr: 1.81 ± 0.071
4.865ValVal: 4.865 ± 0.113
0.471ValTrp: 0.471 ± 0.034
3.163ValTyr: 3.163 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.483TrpAla: 0.483 ± 0.031
0.093TrpCys: 0.093 ± 0.015
0.469TrpAsp: 0.469 ± 0.03
0.589TrpGlu: 0.589 ± 0.038
0.461TrpPhe: 0.461 ± 0.034
0.494TrpGly: 0.494 ± 0.033
0.209TrpHis: 0.209 ± 0.021
0.656TrpIle: 0.656 ± 0.04
0.524TrpLys: 0.524 ± 0.035
0.792TrpLeu: 0.792 ± 0.043
0.205TrpMet: 0.205 ± 0.025
0.388TrpAsn: 0.388 ± 0.03
0.201TrpPro: 0.201 ± 0.02
0.301TrpGln: 0.301 ± 0.024
0.303TrpArg: 0.303 ± 0.024
0.372TrpSer: 0.372 ± 0.031
0.282TrpThr: 0.282 ± 0.023
0.435TrpVal: 0.435 ± 0.033
0.083TrpTrp: 0.083 ± 0.014
0.319TrpTyr: 0.319 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.72TyrAla: 2.72 ± 0.084
0.321TyrCys: 0.321 ± 0.024
2.365TyrAsp: 2.365 ± 0.063
3.065TyrGlu: 3.065 ± 0.08
2.273TyrPhe: 2.273 ± 0.078
2.771TyrGly: 2.771 ± 0.086
0.772TyrHis: 0.772 ± 0.044
4.652TyrIle: 4.652 ± 0.101
4.532TyrLys: 4.532 ± 0.101
3.876TyrLeu: 3.876 ± 0.103
1.136TyrMet: 1.136 ± 0.052
2.273TyrAsn: 2.273 ± 0.072
1.647TyrPro: 1.647 ± 0.054
1.505TyrGln: 1.505 ± 0.064
1.428TyrArg: 1.428 ± 0.056
2.464TyrSer: 2.464 ± 0.07
2.32TyrThr: 2.32 ± 0.082
2.803TyrVal: 2.803 ± 0.079
0.408TyrTrp: 0.408 ± 0.032
2.224TyrTyr: 2.224 ± 0.078
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1626 proteins (492277 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski