Amino acid dipepetide frequency for Puteibacter caeruleilacunae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.09AlaAla: 4.09 ± 0.056	0.703AlaCys: 0.703 ± 0.018	3.58AlaAsp: 3.58 ± 0.049	4.03AlaGlu: 4.03 ± 0.045	2.848AlaPhe: 2.848 ± 0.035	4.398AlaGly: 4.398 ± 0.048	1.126AlaHis: 1.126 ± 0.024	4.643AlaIle: 4.643 ± 0.049	4.376AlaLys: 4.376 ± 0.047	5.634AlaLeu: 5.634 ± 0.056	1.552AlaMet: 1.552 ± 0.029	3.252AlaAsn: 3.252 ± 0.04	1.972AlaPro: 1.972 ± 0.032	2.178AlaGln: 2.178 ± 0.031	2.245AlaArg: 2.245 ± 0.032	3.963AlaSer: 3.963 ± 0.04	3.301AlaThr: 3.301 ± 0.044	3.852AlaVal: 3.852 ± 0.053	0.815AlaTrp: 0.815 ± 0.021	2.62AlaTyr: 2.62 ± 0.03	0.01AlaXaa: 0.01 ± 0.002
Cys	0.54CysAla: 0.54 ± 0.019	0.152CysCys: 0.152 ± 0.008	0.624CysAsp: 0.624 ± 0.018	0.563CysGlu: 0.563 ± 0.018	0.509CysPhe: 0.509 ± 0.015	0.72CysGly: 0.72 ± 0.022	0.211CysHis: 0.211 ± 0.011	0.681CysIle: 0.681 ± 0.017	0.624CysLys: 0.624 ± 0.017	0.814CysLeu: 0.814 ± 0.019	0.236CysMet: 0.236 ± 0.011	0.537CysAsn: 0.537 ± 0.017	0.397CysPro: 0.397 ± 0.017	0.296CysGln: 0.296 ± 0.011	0.367CysArg: 0.367 ± 0.013	0.705CysSer: 0.705 ± 0.021	0.5CysThr: 0.5 ± 0.017	0.569CysVal: 0.569 ± 0.016	0.136CysTrp: 0.136 ± 0.008	0.441CysTyr: 0.441 ± 0.014	0.003CysXaa: 0.003 ± 0.001
Asp	3.611AspAla: 3.611 ± 0.047	0.514AspCys: 0.514 ± 0.018	3.319AspAsp: 3.319 ± 0.052	4.202AspGlu: 4.202 ± 0.047	3.32AspPhe: 3.32 ± 0.043	4.455AspGly: 4.455 ± 0.064	1.205AspHis: 1.205 ± 0.026	4.384AspIle: 4.384 ± 0.047	4.18AspLys: 4.18 ± 0.045	5.181AspLeu: 5.181 ± 0.049	1.338AspMet: 1.338 ± 0.026	3.349AspAsn: 3.349 ± 0.05	2.178AspPro: 2.178 ± 0.034	2.169AspGln: 2.169 ± 0.027	2.39AspArg: 2.39 ± 0.037	3.033AspSer: 3.033 ± 0.041	2.304AspThr: 2.304 ± 0.037	3.891AspVal: 3.891 ± 0.05	0.953AspTrp: 0.953 ± 0.021	3.108AspTyr: 3.108 ± 0.042	0.019AspXaa: 0.019 ± 0.004
Glu	4.149GluAla: 4.149 ± 0.058	0.478GluCys: 0.478 ± 0.015	3.802GluAsp: 3.802 ± 0.041	5.135GluGlu: 5.135 ± 0.068	2.904GluPhe: 2.904 ± 0.032	4.185GluGly: 4.185 ± 0.041	1.188GluHis: 1.188 ± 0.025	5.053GluIle: 5.053 ± 0.056	5.436GluLys: 5.436 ± 0.056	6.507GluLeu: 6.507 ± 0.057	1.837GluMet: 1.837 ± 0.028	3.97GluAsn: 3.97 ± 0.044	1.588GluPro: 1.588 ± 0.026	2.594GluGln: 2.594 ± 0.037	2.775GluArg: 2.775 ± 0.038	3.587GluSer: 3.587 ± 0.034	3.093GluThr: 3.093 ± 0.036	4.571GluVal: 4.571 ± 0.055	0.863GluTrp: 0.863 ± 0.018	2.674GluTyr: 2.674 ± 0.034	0.016GluXaa: 0.016 ± 0.004
Phe	2.778PheAla: 2.778 ± 0.036	0.508PheCys: 0.508 ± 0.013	3.206PheAsp: 3.206 ± 0.03	3.051PheGlu: 3.051 ± 0.037	2.376PhePhe: 2.376 ± 0.036	3.215PheGly: 3.215 ± 0.038	0.89PheHis: 0.89 ± 0.019	3.475PheIle: 3.475 ± 0.044	3.401PheLys: 3.401 ± 0.04	3.819PheLeu: 3.819 ± 0.04	1.201PheMet: 1.201 ± 0.023	3.074PheAsn: 3.074 ± 0.04	1.696PhePro: 1.696 ± 0.026	1.416PheGln: 1.416 ± 0.022	1.817PheArg: 1.817 ± 0.031	3.698PheSer: 3.698 ± 0.045	2.704PheThr: 2.704 ± 0.032	2.936PheVal: 2.936 ± 0.037	0.659PheTrp: 0.659 ± 0.017	2.049PheTyr: 2.049 ± 0.034	0.009PheXaa: 0.009 ± 0.002
Gly	4.027GlyAla: 4.027 ± 0.054	0.762GlyCys: 0.762 ± 0.027	3.796GlyAsp: 3.796 ± 0.05	4.229GlyGlu: 4.229 ± 0.043	3.293GlyPhe: 3.293 ± 0.039	4.629GlyGly: 4.629 ± 0.053	1.27GlyHis: 1.27 ± 0.027	5.204GlyIle: 5.204 ± 0.055	5.531GlyLys: 5.531 ± 0.057	5.748GlyLeu: 5.748 ± 0.058	1.8GlyMet: 1.8 ± 0.032	3.954GlyAsn: 3.954 ± 0.047	1.476GlyPro: 1.476 ± 0.025	1.99GlyGln: 1.99 ± 0.03	2.625GlyArg: 2.625 ± 0.04	4.223GlySer: 4.223 ± 0.048	3.956GlyThr: 3.956 ± 0.05	4.808GlyVal: 4.808 ± 0.05	1.052GlyTrp: 1.052 ± 0.025	3.373GlyTyr: 3.373 ± 0.046	0.011GlyXaa: 0.011 ± 0.003
His	1.07HisAla: 1.07 ± 0.021	0.247HisCys: 0.247 ± 0.01	1.044HisAsp: 1.044 ± 0.024	1.145HisGlu: 1.145 ± 0.021	1.089HisPhe: 1.089 ± 0.021	1.336HisGly: 1.336 ± 0.026	0.562HisHis: 0.562 ± 0.017	1.359HisIle: 1.359 ± 0.025	1.18HisLys: 1.18 ± 0.026	1.852HisLeu: 1.852 ± 0.029	0.409HisMet: 0.409 ± 0.013	1.013HisAsn: 1.013 ± 0.019	0.973HisPro: 0.973 ± 0.023	0.772HisGln: 0.772 ± 0.017	0.835HisArg: 0.835 ± 0.019	1.126HisSer: 1.126 ± 0.021	0.989HisThr: 0.989 ± 0.021	1.12HisVal: 1.12 ± 0.022	0.315HisTrp: 0.315 ± 0.011	0.948HisTyr: 0.948 ± 0.019	0.009HisXaa: 0.009 ± 0.002
Ile	4.964IleAla: 4.964 ± 0.051	0.729IleCys: 0.729 ± 0.018	4.899IleAsp: 4.899 ± 0.055	4.954IleGlu: 4.954 ± 0.05	3.026IlePhe: 3.026 ± 0.037	4.735IleGly: 4.735 ± 0.054	1.392IleHis: 1.392 ± 0.026	5.092IleIle: 5.092 ± 0.06	5.243IleLys: 5.243 ± 0.049	6.152IleLeu: 6.152 ± 0.059	1.404IleMet: 1.404 ± 0.027	4.341IleAsn: 4.341 ± 0.044	3.074IlePro: 3.074 ± 0.041	2.285IleGln: 2.285 ± 0.036	3.039IleArg: 3.039 ± 0.036	5.191IleSer: 5.191 ± 0.049	4.18IleThr: 4.18 ± 0.046	4.508IleVal: 4.508 ± 0.055	0.833IleTrp: 0.833 ± 0.022	2.737IleTyr: 2.737 ± 0.031	0.017IleXaa: 0.017 ± 0.004
Lys	4.699LysAla: 4.699 ± 0.055	0.527LysCys: 0.527 ± 0.018	4.669LysAsp: 4.669 ± 0.048	5.942LysGlu: 5.942 ± 0.055	2.711LysPhe: 2.711 ± 0.039	4.969LysGly: 4.969 ± 0.05	1.564LysHis: 1.564 ± 0.027	5.071LysIle: 5.071 ± 0.053	5.873LysLys: 5.873 ± 0.064	6.418LysLeu: 6.418 ± 0.064	1.99LysMet: 1.99 ± 0.032	4.269LysAsn: 4.269 ± 0.044	2.38LysPro: 2.38 ± 0.034	2.892LysGln: 2.892 ± 0.038	3.234LysArg: 3.234 ± 0.043	4.432LysSer: 4.432 ± 0.045	3.872LysThr: 3.872 ± 0.039	4.998LysVal: 4.998 ± 0.051	1.017LysTrp: 1.017 ± 0.023	3.427LysTyr: 3.427 ± 0.039	0.014LysXaa: 0.014 ± 0.003
Leu	5.413LeuAla: 5.413 ± 0.052	0.842LeuCys: 0.842 ± 0.02	4.812LeuAsp: 4.812 ± 0.052	5.521LeuGlu: 5.521 ± 0.053	4.369LeuPhe: 4.369 ± 0.053	5.485LeuGly: 5.485 ± 0.061	1.54LeuHis: 1.54 ± 0.027	6.288LeuIle: 6.288 ± 0.057	7.536LeuLys: 7.536 ± 0.059	8.14LeuLeu: 8.14 ± 0.079	2.185LeuMet: 2.185 ± 0.033	5.411LeuAsn: 5.411 ± 0.054	3.589LeuPro: 3.589 ± 0.039	2.963LeuGln: 2.963 ± 0.046	3.511LeuArg: 3.511 ± 0.044	6.467LeuSer: 6.467 ± 0.057	4.904LeuThr: 4.904 ± 0.042	5.185LeuVal: 5.185 ± 0.055	1.076LeuTrp: 1.076 ± 0.025	3.3LeuTyr: 3.3 ± 0.042	0.022LeuXaa: 0.022 ± 0.004
Met	1.624MetAla: 1.624 ± 0.031	0.191MetCys: 0.191 ± 0.01	1.296MetAsp: 1.296 ± 0.024	1.446MetGlu: 1.446 ± 0.026	0.959MetPhe: 0.959 ± 0.021	1.595MetGly: 1.595 ± 0.027	0.444MetHis: 0.444 ± 0.014	1.71MetIle: 1.71 ± 0.028	2.411MetLys: 2.411 ± 0.031	2.069MetLeu: 2.069 ± 0.031	0.724MetMet: 0.724 ± 0.016	1.534MetAsn: 1.534 ± 0.028	0.981MetPro: 0.981 ± 0.019	0.848MetGln: 0.848 ± 0.019	1.111MetArg: 1.111 ± 0.023	1.437MetSer: 1.437 ± 0.024	1.307MetThr: 1.307 ± 0.022	1.56MetVal: 1.56 ± 0.027	0.256MetTrp: 0.256 ± 0.01	0.775MetTyr: 0.775 ± 0.017	0.009MetXaa: 0.009 ± 0.002
Asn	3.353AsnAla: 3.353 ± 0.036	0.511AsnCys: 0.511 ± 0.017	3.313AsnAsp: 3.313 ± 0.042	3.571AsnGlu: 3.571 ± 0.043	2.51AsnPhe: 2.51 ± 0.036	4.334AsnGly: 4.334 ± 0.052	1.177AsnHis: 1.177 ± 0.026	4.459AsnIle: 4.459 ± 0.052	4.206AsnLys: 4.206 ± 0.045	4.894AsnLeu: 4.894 ± 0.05	1.374AsnMet: 1.374 ± 0.024	3.538AsnAsn: 3.538 ± 0.048	2.675AsnPro: 2.675 ± 0.034	2.127AsnGln: 2.127 ± 0.031	2.378AsnArg: 2.378 ± 0.033	3.555AsnSer: 3.555 ± 0.046	3.044AsnThr: 3.044 ± 0.04	3.589AsnVal: 3.589 ± 0.045	0.852AsnTrp: 0.852 ± 0.019	2.817AsnTyr: 2.817 ± 0.04	0.012AsnXaa: 0.012 ± 0.003
Pro	2.151ProAla: 2.151 ± 0.035	0.279ProCys: 0.279 ± 0.012	2.275ProAsp: 2.275 ± 0.036	3.05ProGlu: 3.05 ± 0.037	1.838ProPhe: 1.838 ± 0.029	2.554ProGly: 2.554 ± 0.032	0.72ProHis: 0.72 ± 0.019	2.345ProIle: 2.345 ± 0.036	2.292ProLys: 2.292 ± 0.033	2.953ProLeu: 2.953 ± 0.039	0.8ProMet: 0.8 ± 0.018	2.027ProAsn: 2.027 ± 0.027	0.802ProPro: 0.802 ± 0.023	1.232ProGln: 1.232 ± 0.021	1.167ProArg: 1.167 ± 0.022	2.195ProSer: 2.195 ± 0.034	1.849ProThr: 1.849 ± 0.034	2.735ProVal: 2.735 ± 0.037	0.466ProTrp: 0.466 ± 0.016	1.507ProTyr: 1.507 ± 0.027	0.013ProXaa: 0.013 ± 0.003
Gln	2.041GlnAla: 2.041 ± 0.034	0.269GlnCys: 0.269 ± 0.01	1.73GlnAsp: 1.73 ± 0.026	2.322GlnGlu: 2.322 ± 0.033	1.613GlnPhe: 1.613 ± 0.024	2.132GlnGly: 2.132 ± 0.03	0.721GlnHis: 0.721 ± 0.017	2.426GlnIle: 2.426 ± 0.036	2.671GlnLys: 2.671 ± 0.034	3.567GlnLeu: 3.567 ± 0.044	0.866GlnMet: 0.866 ± 0.02	1.867GlnAsn: 1.867 ± 0.028	1.116GlnPro: 1.116 ± 0.023	1.625GlnGln: 1.625 ± 0.032	1.491GlnArg: 1.491 ± 0.024	2.056GlnSer: 2.056 ± 0.03	1.758GlnThr: 1.758 ± 0.028	2.191GlnVal: 2.191 ± 0.033	0.464GlnTrp: 0.464 ± 0.014	1.514GlnTyr: 1.514 ± 0.026	0.013GlnXaa: 0.013 ± 0.003
Arg	2.219ArgAla: 2.219 ± 0.034	0.339ArgCys: 0.339 ± 0.012	2.111ArgAsp: 2.111 ± 0.03	2.593ArgGlu: 2.593 ± 0.036	2.295ArgPhe: 2.295 ± 0.032	2.308ArgGly: 2.308 ± 0.034	0.76ArgHis: 0.76 ± 0.018	3.258ArgIle: 3.258 ± 0.035	3.296ArgLys: 3.296 ± 0.042	3.882ArgLeu: 3.882 ± 0.039	1.134ArgMet: 1.134 ± 0.021	2.355ArgAsn: 2.355 ± 0.032	1.236ArgPro: 1.236 ± 0.025	1.258ArgGln: 1.258 ± 0.021	1.724ArgArg: 1.724 ± 0.029	2.376ArgSer: 2.376 ± 0.036	2.043ArgThr: 2.043 ± 0.03	2.363ArgVal: 2.363 ± 0.038	0.663ArgTrp: 0.663 ± 0.019	2.126ArgTyr: 2.126 ± 0.035	0.013ArgXaa: 0.013 ± 0.003
Ser	3.648SerAla: 3.648 ± 0.039	0.771SerCys: 0.771 ± 0.02	3.68SerAsp: 3.68 ± 0.042	3.798SerGlu: 3.798 ± 0.043	3.662SerPhe: 3.662 ± 0.044	4.658SerGly: 4.658 ± 0.047	1.226SerHis: 1.226 ± 0.023	4.881SerIle: 4.881 ± 0.051	4.438SerLys: 4.438 ± 0.043	5.773SerLeu: 5.773 ± 0.059	1.475SerMet: 1.475 ± 0.024	3.541SerAsn: 3.541 ± 0.043	2.183SerPro: 2.183 ± 0.031	1.99SerGln: 1.99 ± 0.03	2.545SerArg: 2.545 ± 0.036	4.417SerSer: 4.417 ± 0.06	3.339SerThr: 3.339 ± 0.04	4.275SerVal: 4.275 ± 0.043	0.983SerTrp: 0.983 ± 0.02	3.024SerTyr: 3.024 ± 0.036	0.015SerXaa: 0.015 ± 0.004
Thr	3.223ThrAla: 3.223 ± 0.042	0.47ThrCys: 0.47 ± 0.016	3.268ThrAsp: 3.268 ± 0.047	2.998ThrGlu: 2.998 ± 0.038	2.525ThrPhe: 2.525 ± 0.039	3.948ThrGly: 3.948 ± 0.041	0.964ThrHis: 0.964 ± 0.022	4.244ThrIle: 4.244 ± 0.048	3.459ThrLys: 3.459 ± 0.036	4.574ThrLeu: 4.574 ± 0.046	1.094ThrMet: 1.094 ± 0.022	2.935ThrAsn: 2.935 ± 0.037	2.429ThrPro: 2.429 ± 0.037	1.67ThrGln: 1.67 ± 0.028	1.843ThrArg: 1.843 ± 0.031	3.456ThrSer: 3.456 ± 0.04	3.145ThrThr: 3.145 ± 0.043	3.611ThrVal: 3.611 ± 0.05	0.759ThrTrp: 0.759 ± 0.023	2.262ThrTyr: 2.262 ± 0.033	0.011ThrXaa: 0.011 ± 0.003
Val	4.197ValAla: 4.197 ± 0.041	0.702ValCys: 0.702 ± 0.016	4.111ValAsp: 4.111 ± 0.049	4.358ValGlu: 4.358 ± 0.047	3.175ValPhe: 3.175 ± 0.041	4.055ValGly: 4.055 ± 0.049	1.077ValHis: 1.077 ± 0.02	4.574ValIle: 4.574 ± 0.053	4.787ValLys: 4.787 ± 0.05	5.538ValLeu: 5.538 ± 0.053	1.518ValMet: 1.518 ± 0.028	3.685ValAsn: 3.685 ± 0.045	2.303ValPro: 2.303 ± 0.032	1.85ValGln: 1.85 ± 0.028	2.592ValArg: 2.592 ± 0.033	4.418ValSer: 4.418 ± 0.042	3.546ValThr: 3.546 ± 0.052	4.665ValVal: 4.665 ± 0.057	0.783ValTrp: 0.783 ± 0.022	2.468ValTyr: 2.468 ± 0.035	0.012ValXaa: 0.012 ± 0.003
Trp	0.721TrpAla: 0.721 ± 0.016	0.156TrpCys: 0.156 ± 0.008	0.87TrpAsp: 0.87 ± 0.021	0.962TrpGlu: 0.962 ± 0.019	0.594TrpPhe: 0.594 ± 0.018	1.007TrpGly: 1.007 ± 0.022	0.369TrpHis: 0.369 ± 0.012	1.024TrpIle: 1.024 ± 0.027	1.047TrpLys: 1.047 ± 0.019	1.132TrpLeu: 1.132 ± 0.022	0.406TrpMet: 0.406 ± 0.012	0.883TrpAsn: 0.883 ± 0.02	0.387TrpPro: 0.387 ± 0.015	0.542TrpGln: 0.542 ± 0.014	0.603TrpArg: 0.603 ± 0.018	0.862TrpSer: 0.862 ± 0.023	0.735TrpThr: 0.735 ± 0.021	0.705TrpVal: 0.705 ± 0.017	0.221TrpTrp: 0.221 ± 0.01	0.579TrpTyr: 0.579 ± 0.017	0.004TrpXaa: 0.004 ± 0.001
Tyr	2.655TyrAla: 2.655 ± 0.036	0.468TyrCys: 0.468 ± 0.014	2.683TyrAsp: 2.683 ± 0.037	2.518TyrGlu: 2.518 ± 0.032	2.35TyrPhe: 2.35 ± 0.033	3.021TyrGly: 3.021 ± 0.039	0.982TyrHis: 0.982 ± 0.02	2.609TyrIle: 2.609 ± 0.036	2.96TyrLys: 2.96 ± 0.038	3.897TyrLeu: 3.897 ± 0.051	0.936TyrMet: 0.936 ± 0.02	2.748TyrAsn: 2.748 ± 0.041	1.811TyrPro: 1.811 ± 0.03	1.743TyrGln: 1.743 ± 0.025	2.045TyrArg: 2.045 ± 0.032	3.113TyrSer: 3.113 ± 0.044	2.309TyrThr: 2.309 ± 0.032	2.262TyrVal: 2.262 ± 0.032	0.64TyrTrp: 0.64 ± 0.018	2.157TyrTyr: 2.157 ± 0.04	0.006TyrXaa: 0.006 ± 0.002
Xaa	0.016XaaAla: 0.016 ± 0.003	0.004XaaCys: 0.004 ± 0.001	0.017XaaAsp: 0.017 ± 0.004	0.015XaaGlu: 0.015 ± 0.004	0.013XaaPhe: 0.013 ± 0.003	0.015XaaGly: 0.015 ± 0.004	0.006XaaHis: 0.006 ± 0.002	0.013XaaIle: 0.013 ± 0.003	0.021XaaLys: 0.021 ± 0.004	0.016XaaLeu: 0.016 ± 0.003	0.006XaaMet: 0.006 ± 0.002	0.007XaaAsn: 0.007 ± 0.002	0.006XaaPro: 0.006 ± 0.002	0.014XaaGln: 0.014 ± 0.003	0.016XaaArg: 0.016 ± 0.005	0.014XaaSer: 0.014 ± 0.003	0.011XaaThr: 0.011 ± 0.002	0.018XaaVal: 0.018 ± 0.003	0.003XaaTrp: 0.003 ± 0.001	0.006XaaTyr: 0.006 ± 0.002	0.018XaaXaa: 0.018 ± 0.004

Statistics based on 5722 proteins (2334750 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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