Amino acid dipepetide frequency for Bifiguratus adelaidae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.992AlaAla: 6.992 ± 0.071	1.045AlaCys: 1.045 ± 0.017	4.199AlaAsp: 4.199 ± 0.037	4.729AlaGlu: 4.729 ± 0.043	3.184AlaPhe: 3.184 ± 0.039	4.611AlaGly: 4.611 ± 0.049	1.89AlaHis: 1.89 ± 0.025	4.463AlaIle: 4.463 ± 0.038	4.588AlaLys: 4.588 ± 0.045	7.505AlaLeu: 7.505 ± 0.058	2.029AlaMet: 2.029 ± 0.024	3.371AlaAsn: 3.371 ± 0.037	3.756AlaPro: 3.756 ± 0.047	3.556AlaGln: 3.556 ± 0.034	4.125AlaArg: 4.125 ± 0.04	6.832AlaSer: 6.832 ± 0.054	4.904AlaThr: 4.904 ± 0.045	4.922AlaVal: 4.922 ± 0.041	0.961AlaTrp: 0.961 ± 0.018	2.4AlaTyr: 2.4 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	0.904CysAla: 0.904 ± 0.019	0.233CysCys: 0.233 ± 0.01	0.633CysAsp: 0.633 ± 0.014	0.586CysGlu: 0.586 ± 0.015	0.583CysPhe: 0.583 ± 0.013	0.903CysGly: 0.903 ± 0.02	0.323CysHis: 0.323 ± 0.011	0.778CysIle: 0.778 ± 0.014	0.575CysLys: 0.575 ± 0.014	1.303CysLeu: 1.303 ± 0.02	0.288CysMet: 0.288 ± 0.01	0.452CysAsn: 0.452 ± 0.014	0.601CysPro: 0.601 ± 0.016	0.463CysGln: 0.463 ± 0.012	0.691CysArg: 0.691 ± 0.017	0.835CysSer: 0.835 ± 0.016	0.685CysThr: 0.685 ± 0.015	0.817CysVal: 0.817 ± 0.017	0.173CysTrp: 0.173 ± 0.008	0.397CysTyr: 0.397 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	4.801AspAla: 4.801 ± 0.037	0.627AspCys: 0.627 ± 0.015	4.267AspAsp: 4.267 ± 0.05	4.386AspGlu: 4.386 ± 0.05	2.255AspPhe: 2.255 ± 0.026	3.644AspGly: 3.644 ± 0.035	1.36AspHis: 1.36 ± 0.022	3.611AspIle: 3.611 ± 0.034	2.87AspLys: 2.87 ± 0.036	5.335AspLeu: 5.335 ± 0.045	1.596AspMet: 1.596 ± 0.024	2.222AspAsn: 2.222 ± 0.026	3.067AspPro: 3.067 ± 0.034	2.102AspGln: 2.102 ± 0.029	2.97AspArg: 2.97 ± 0.034	3.756AspSer: 3.756 ± 0.042	3.396AspThr: 3.396 ± 0.035	4.004AspVal: 4.004 ± 0.038	0.805AspTrp: 0.805 ± 0.017	1.929AspTyr: 1.929 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	5.175GluAla: 5.175 ± 0.047	0.669GluCys: 0.669 ± 0.016	4.35GluAsp: 4.35 ± 0.047	5.56GluGlu: 5.56 ± 0.076	2.034GluPhe: 2.034 ± 0.029	3.45GluGly: 3.45 ± 0.033	1.59GluHis: 1.59 ± 0.024	3.095GluIle: 3.095 ± 0.035	3.625GluLys: 3.625 ± 0.041	5.36GluLeu: 5.36 ± 0.046	1.48GluMet: 1.48 ± 0.025	2.391GluAsn: 2.391 ± 0.025	2.502GluPro: 2.502 ± 0.031	2.902GluGln: 2.902 ± 0.035	3.884GluArg: 3.884 ± 0.038	4.118GluSer: 4.118 ± 0.039	3.507GluThr: 3.507 ± 0.035	3.552GluVal: 3.552 ± 0.039	0.742GluTrp: 0.742 ± 0.015	1.917GluTyr: 1.917 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.094PheAla: 3.094 ± 0.035	0.577PheCys: 0.577 ± 0.015	2.43PheAsp: 2.43 ± 0.031	2.237PheGlu: 2.237 ± 0.029	1.562PhePhe: 1.562 ± 0.027	2.848PheGly: 2.848 ± 0.034	0.98PheHis: 0.98 ± 0.018	1.921PheIle: 1.921 ± 0.028	1.71PheLys: 1.71 ± 0.025	3.512PheLeu: 3.512 ± 0.041	0.858PheMet: 0.858 ± 0.016	1.535PheAsn: 1.535 ± 0.022	1.764PhePro: 1.764 ± 0.023	1.444PheGln: 1.444 ± 0.02	1.889PheArg: 1.889 ± 0.029	2.864PheSer: 2.864 ± 0.03	2.199PheThr: 2.199 ± 0.027	2.568PheVal: 2.568 ± 0.035	0.596PheTrp: 0.596 ± 0.014	1.297PheTyr: 1.297 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	4.392GlyAla: 4.392 ± 0.044	0.753GlyCys: 0.753 ± 0.016	3.366GlyAsp: 3.366 ± 0.035	3.302GlyGlu: 3.302 ± 0.035	2.494GlyPhe: 2.494 ± 0.031	4.482GlyGly: 4.482 ± 0.057	1.65GlyHis: 1.65 ± 0.026	3.458GlyIle: 3.458 ± 0.036	3.467GlyLys: 3.467 ± 0.038	5.301GlyLeu: 5.301 ± 0.054	1.525GlyMet: 1.525 ± 0.025	2.51GlyAsn: 2.51 ± 0.031	2.483GlyPro: 2.483 ± 0.032	2.49GlyGln: 2.49 ± 0.029	3.33GlyArg: 3.33 ± 0.037	4.88GlySer: 4.88 ± 0.048	3.623GlyThr: 3.623 ± 0.037	4.031GlyVal: 4.031 ± 0.043	0.889GlyTrp: 0.889 ± 0.018	2.216GlyTyr: 2.216 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	1.985HisAla: 1.985 ± 0.026	0.347HisCys: 0.347 ± 0.01	1.359HisAsp: 1.359 ± 0.019	1.367HisGlu: 1.367 ± 0.02	1.002HisPhe: 1.002 ± 0.019	1.624HisGly: 1.624 ± 0.023	0.96HisHis: 0.96 ± 0.023	1.42HisIle: 1.42 ± 0.024	1.136HisLys: 1.136 ± 0.02	2.518HisLeu: 2.518 ± 0.031	0.572HisMet: 0.572 ± 0.014	0.923HisAsn: 0.923 ± 0.017	1.726HisPro: 1.726 ± 0.024	1.097HisGln: 1.097 ± 0.02	1.601HisArg: 1.601 ± 0.026	1.829HisSer: 1.829 ± 0.028	1.393HisThr: 1.393 ± 0.022	1.724HisVal: 1.724 ± 0.022	0.314HisTrp: 0.314 ± 0.01	0.858HisTyr: 0.858 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.474IleAla: 4.474 ± 0.042	0.78IleCys: 0.78 ± 0.017	3.218IleAsp: 3.218 ± 0.034	3.081IleGlu: 3.081 ± 0.034	2.069IlePhe: 2.069 ± 0.029	3.172IleGly: 3.172 ± 0.036	1.359IleHis: 1.359 ± 0.022	2.827IleIle: 2.827 ± 0.036	2.696IleLys: 2.696 ± 0.031	4.921IleLeu: 4.921 ± 0.042	1.137IleMet: 1.137 ± 0.019	2.061IleAsn: 2.061 ± 0.026	3.259IlePro: 3.259 ± 0.033	2.213IleGln: 2.213 ± 0.025	2.851IleArg: 2.851 ± 0.034	3.949IleSer: 3.949 ± 0.039	3.074IleThr: 3.074 ± 0.034	3.571IleVal: 3.571 ± 0.039	0.692IleTrp: 0.692 ± 0.015	1.603IleTyr: 1.603 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	4.697LysAla: 4.697 ± 0.053	0.564LysCys: 0.564 ± 0.014	3.193LysAsp: 3.193 ± 0.031	3.766LysGlu: 3.766 ± 0.044	1.607LysPhe: 1.607 ± 0.022	2.919LysGly: 2.919 ± 0.035	1.346LysHis: 1.346 ± 0.02	2.5LysIle: 2.5 ± 0.032	3.319LysLys: 3.319 ± 0.054	4.493LysLeu: 4.493 ± 0.042	1.134LysMet: 1.134 ± 0.019	1.853LysAsn: 1.853 ± 0.023	2.697LysPro: 2.697 ± 0.038	2.382LysGln: 2.382 ± 0.032	3.661LysArg: 3.661 ± 0.037	3.758LysSer: 3.758 ± 0.037	3.097LysThr: 3.097 ± 0.03	3.391LysVal: 3.391 ± 0.035	0.592LysTrp: 0.592 ± 0.014	1.662LysTyr: 1.662 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	7.426LeuAla: 7.426 ± 0.062	1.286LeuCys: 1.286 ± 0.019	5.487LeuAsp: 5.487 ± 0.046	5.707LeuGlu: 5.707 ± 0.055	3.421LeuPhe: 3.421 ± 0.035	5.455LeuGly: 5.455 ± 0.046	2.341LeuHis: 2.341 ± 0.025	4.296LeuIle: 4.296 ± 0.047	4.737LeuLys: 4.737 ± 0.039	8.703LeuLeu: 8.703 ± 0.062	1.977LeuMet: 1.977 ± 0.025	3.683LeuAsn: 3.683 ± 0.04	5.125LeuPro: 5.125 ± 0.044	4.295LeuGln: 4.295 ± 0.047	5.374LeuArg: 5.374 ± 0.047	7.372LeuSer: 7.372 ± 0.052	5.196LeuThr: 5.196 ± 0.048	5.588LeuVal: 5.588 ± 0.045	1.107LeuTrp: 1.107 ± 0.02	2.776LeuTyr: 2.776 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.135MetAla: 2.135 ± 0.028	0.262MetCys: 0.262 ± 0.01	1.555MetAsp: 1.555 ± 0.021	1.571MetGlu: 1.571 ± 0.021	0.802MetPhe: 0.802 ± 0.015	1.353MetGly: 1.353 ± 0.026	0.538MetHis: 0.538 ± 0.013	1.129MetIle: 1.129 ± 0.018	1.135MetLys: 1.135 ± 0.021	2.067MetLeu: 2.067 ± 0.026	0.668MetMet: 0.668 ± 0.013	0.936MetAsn: 0.936 ± 0.02	1.255MetPro: 1.255 ± 0.021	1.082MetGln: 1.082 ± 0.021	1.242MetArg: 1.242 ± 0.018	2.024MetSer: 2.024 ± 0.026	1.49MetThr: 1.49 ± 0.02	1.423MetVal: 1.423 ± 0.021	0.265MetTrp: 0.265 ± 0.009	0.637MetTyr: 0.637 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.651AsnAla: 3.651 ± 0.037	0.477AsnCys: 0.477 ± 0.013	2.389AsnAsp: 2.389 ± 0.03	2.301AsnGlu: 2.301 ± 0.027	1.465AsnPhe: 1.465 ± 0.024	2.928AsnGly: 2.928 ± 0.04	0.948AsnHis: 0.948 ± 0.015	2.355AsnIle: 2.355 ± 0.035	1.789AsnLys: 1.789 ± 0.027	3.679AsnLeu: 3.679 ± 0.034	1.015AsnMet: 1.015 ± 0.021	1.671AsnAsn: 1.671 ± 0.029	2.345AsnPro: 2.345 ± 0.03	1.503AsnGln: 1.503 ± 0.026	1.976AsnArg: 1.976 ± 0.027	2.708AsnSer: 2.708 ± 0.031	2.472AsnThr: 2.472 ± 0.03	2.938AsnVal: 2.938 ± 0.031	0.488AsnTrp: 0.488 ± 0.015	1.292AsnTyr: 1.292 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	3.953ProAla: 3.953 ± 0.045	0.444ProCys: 0.444 ± 0.012	2.845ProAsp: 2.845 ± 0.033	3.263ProGlu: 3.263 ± 0.03	2.053ProPhe: 2.053 ± 0.025	2.831ProGly: 2.831 ± 0.035	1.376ProHis: 1.376 ± 0.023	2.732ProIle: 2.732 ± 0.035	2.722ProLys: 2.722 ± 0.038	4.486ProLeu: 4.486 ± 0.039	1.164ProMet: 1.164 ± 0.021	2.401ProAsn: 2.401 ± 0.029	4.055ProPro: 4.055 ± 0.069	2.428ProGln: 2.428 ± 0.034	2.698ProArg: 2.698 ± 0.037	5.49ProSer: 5.49 ± 0.062	3.912ProThr: 3.912 ± 0.04	3.249ProVal: 3.249 ± 0.039	0.594ProTrp: 0.594 ± 0.013	1.669ProTyr: 1.669 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.618GlnAla: 3.618 ± 0.042	0.505GlnCys: 0.505 ± 0.014	2.415GlnAsp: 2.415 ± 0.027	2.811GlnGlu: 2.811 ± 0.038	1.504GlnPhe: 1.504 ± 0.022	2.461GlnGly: 2.461 ± 0.03	1.261GlnHis: 1.261 ± 0.023	1.996GlnIle: 1.996 ± 0.024	2.225GlnLys: 2.225 ± 0.03	4.033GlnLeu: 4.033 ± 0.044	1.004GlnMet: 1.004 ± 0.018	1.69GlnAsn: 1.69 ± 0.024	2.346GlnPro: 2.346 ± 0.036	2.609GlnGln: 2.609 ± 0.048	2.756GlnArg: 2.756 ± 0.038	3.34GlnSer: 3.34 ± 0.035	2.452GlnThr: 2.452 ± 0.031	2.652GlnVal: 2.652 ± 0.031	0.586GlnTrp: 0.586 ± 0.015	1.429GlnTyr: 1.429 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	3.818ArgAla: 3.818 ± 0.038	0.634ArgCys: 0.634 ± 0.017	3.135ArgAsp: 3.135 ± 0.031	3.462ArgGlu: 3.462 ± 0.038	2.119ArgPhe: 2.119 ± 0.028	2.909ArgGly: 2.909 ± 0.036	1.651ArgHis: 1.651 ± 0.025	2.981ArgIle: 2.981 ± 0.037	3.564ArgLys: 3.564 ± 0.038	5.342ArgLeu: 5.342 ± 0.046	1.329ArgMet: 1.329 ± 0.02	2.287ArgAsn: 2.287 ± 0.029	2.799ArgPro: 2.799 ± 0.038	2.853ArgGln: 2.853 ± 0.033	4.355ArgArg: 4.355 ± 0.053	4.37ArgSer: 4.37 ± 0.05	3.037ArgThr: 3.037 ± 0.04	3.102ArgVal: 3.102 ± 0.033	0.766ArgTrp: 0.766 ± 0.015	1.863ArgTyr: 1.863 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.089SerAla: 6.089 ± 0.051	0.736SerCys: 0.736 ± 0.018	4.432SerAsp: 4.432 ± 0.043	4.29SerGlu: 4.29 ± 0.042	2.892SerPhe: 2.892 ± 0.034	4.768SerGly: 4.768 ± 0.044	1.974SerHis: 1.974 ± 0.028	4.192SerIle: 4.192 ± 0.037	4.046SerLys: 4.046 ± 0.044	7.067SerLeu: 7.067 ± 0.047	1.849SerMet: 1.849 ± 0.025	3.388SerAsn: 3.388 ± 0.034	4.899SerPro: 4.899 ± 0.057	3.382SerGln: 3.382 ± 0.033	4.214SerArg: 4.214 ± 0.047	8.071SerSer: 8.071 ± 0.091	5.54SerThr: 5.54 ± 0.051	4.673SerVal: 4.673 ± 0.039	0.896SerTrp: 0.896 ± 0.017	2.067SerTyr: 2.067 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	4.729ThrAla: 4.729 ± 0.04	0.745ThrCys: 0.745 ± 0.016	3.032ThrAsp: 3.032 ± 0.032	3.221ThrGlu: 3.221 ± 0.031	2.48ThrPhe: 2.48 ± 0.031	3.659ThrGly: 3.659 ± 0.04	1.424ThrHis: 1.424 ± 0.021	3.32ThrIle: 3.32 ± 0.037	2.891ThrLys: 2.891 ± 0.031	5.702ThrLeu: 5.702 ± 0.049	1.324ThrMet: 1.324 ± 0.021	2.343ThrAsn: 2.343 ± 0.03	4.176ThrPro: 4.176 ± 0.049	2.328ThrGln: 2.328 ± 0.03	2.958ThrArg: 2.958 ± 0.035	5.71ThrSer: 5.71 ± 0.054	4.324ThrThr: 4.324 ± 0.052	3.755ThrVal: 3.755 ± 0.034	0.787ThrTrp: 0.787 ± 0.016	1.783ThrTyr: 1.783 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	4.93ValAla: 4.93 ± 0.043	0.869ValCys: 0.869 ± 0.018	4.088ValAsp: 4.088 ± 0.037	3.826ValGlu: 3.826 ± 0.041	2.476ValPhe: 2.476 ± 0.031	3.756ValGly: 3.756 ± 0.04	1.578ValHis: 1.578 ± 0.023	3.485ValIle: 3.485 ± 0.037	3.345ValLys: 3.345 ± 0.034	5.816ValLeu: 5.816 ± 0.045	1.483ValMet: 1.483 ± 0.022	2.623ValAsn: 2.623 ± 0.032	3.365ValPro: 3.365 ± 0.041	2.701ValGln: 2.701 ± 0.03	3.256ValArg: 3.256 ± 0.033	4.497ValSer: 4.497 ± 0.04	3.7ValThr: 3.7 ± 0.033	4.274ValVal: 4.274 ± 0.043	0.807ValTrp: 0.807 ± 0.019	2.013ValTyr: 2.013 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	0.844TrpAla: 0.844 ± 0.015	0.197TrpCys: 0.197 ± 0.008	0.793TrpAsp: 0.793 ± 0.016	0.672TrpGlu: 0.672 ± 0.014	0.531TrpPhe: 0.531 ± 0.013	0.694TrpGly: 0.694 ± 0.015	0.332TrpHis: 0.332 ± 0.01	0.753TrpIle: 0.753 ± 0.017	0.712TrpLys: 0.712 ± 0.016	1.215TrpLeu: 1.215 ± 0.021	0.372TrpMet: 0.372 ± 0.012	0.631TrpAsn: 0.631 ± 0.014	0.484TrpPro: 0.484 ± 0.012	0.581TrpGln: 0.581 ± 0.014	0.774TrpArg: 0.774 ± 0.016	0.98TrpSer: 0.98 ± 0.017	0.815TrpThr: 0.815 ± 0.018	0.709TrpVal: 0.709 ± 0.015	0.228TrpTrp: 0.228 ± 0.009	0.399TrpTyr: 0.399 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.356TyrAla: 2.356 ± 0.028	0.47TyrCys: 0.47 ± 0.011	1.819TyrAsp: 1.819 ± 0.023	1.767TyrGlu: 1.767 ± 0.022	1.35TyrPhe: 1.35 ± 0.02	2.177TyrGly: 2.177 ± 0.031	0.873TyrHis: 0.873 ± 0.016	1.695TyrIle: 1.695 ± 0.026	1.48TyrLys: 1.48 ± 0.023	2.993TyrLeu: 2.993 ± 0.032	0.763TyrMet: 0.763 ± 0.018	1.419TyrAsn: 1.419 ± 0.021	1.662TyrPro: 1.662 ± 0.024	1.282TyrGln: 1.282 ± 0.021	1.773TyrArg: 1.773 ± 0.023	2.08TyrSer: 2.08 ± 0.029	1.875TyrThr: 1.875 ± 0.027	1.946TyrVal: 1.946 ± 0.026	0.425TyrTrp: 0.425 ± 0.012	1.177TyrTyr: 1.177 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5718 proteins (3128832 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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