Amino acid dipepetide frequency for Paraburkholderia lacunae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.609AlaAla: 17.609 ± 0.133	1.316AlaCys: 1.316 ± 0.022	6.571AlaAsp: 6.571 ± 0.054	6.112AlaGlu: 6.112 ± 0.06	4.248AlaPhe: 4.248 ± 0.04	10.382AlaGly: 10.382 ± 0.08	2.847AlaHis: 2.847 ± 0.039	5.704AlaIle: 5.704 ± 0.05	3.653AlaLys: 3.653 ± 0.05	14.082AlaLeu: 14.082 ± 0.093	3.178AlaMet: 3.178 ± 0.041	3.366AlaAsn: 3.366 ± 0.047	5.834AlaPro: 5.834 ± 0.055	5.371AlaGln: 5.371 ± 0.06	8.802AlaArg: 8.802 ± 0.071	7.6AlaSer: 7.6 ± 0.068	6.354AlaThr: 6.354 ± 0.065	8.844AlaVal: 8.844 ± 0.07	1.633AlaTrp: 1.633 ± 0.029	2.673AlaTyr: 2.673 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.251CysAla: 1.251 ± 0.025	0.125CysCys: 0.125 ± 0.007	0.577CysAsp: 0.577 ± 0.016	0.52CysGlu: 0.52 ± 0.014	0.349CysPhe: 0.349 ± 0.015	1.009CysGly: 1.009 ± 0.021	0.257CysHis: 0.257 ± 0.012	0.429CysIle: 0.429 ± 0.012	0.231CysLys: 0.231 ± 0.011	0.829CysLeu: 0.829 ± 0.019	0.2CysMet: 0.2 ± 0.009	0.249CysAsn: 0.249 ± 0.011	0.437CysPro: 0.437 ± 0.012	0.231CysGln: 0.231 ± 0.012	0.657CysArg: 0.657 ± 0.017	0.545CysSer: 0.545 ± 0.016	0.502CysThr: 0.502 ± 0.016	0.828CysVal: 0.828 ± 0.018	0.126CysTrp: 0.126 ± 0.008	0.234CysTyr: 0.234 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.287AspAla: 7.287 ± 0.073	0.471AspCys: 0.471 ± 0.017	2.999AspAsp: 2.999 ± 0.041	3.358AspGlu: 3.358 ± 0.039	1.957AspPhe: 1.957 ± 0.029	4.541AspGly: 4.541 ± 0.05	1.168AspHis: 1.168 ± 0.023	2.574AspIle: 2.574 ± 0.036	1.55AspLys: 1.55 ± 0.028	5.114AspLeu: 5.114 ± 0.051	1.144AspMet: 1.144 ± 0.021	1.345AspAsn: 1.345 ± 0.023	2.91AspPro: 2.91 ± 0.037	1.637AspGln: 1.637 ± 0.028	3.327AspArg: 3.327 ± 0.037	2.585AspSer: 2.585 ± 0.035	2.867AspThr: 2.867 ± 0.038	4.307AspVal: 4.307 ± 0.044	0.888AspTrp: 0.888 ± 0.02	1.481AspTyr: 1.481 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.468GluAla: 6.468 ± 0.064	0.412GluCys: 0.412 ± 0.015	2.073GluAsp: 2.073 ± 0.037	2.426GluGlu: 2.426 ± 0.038	1.824GluPhe: 1.824 ± 0.029	3.396GluGly: 3.396 ± 0.045	1.479GluHis: 1.479 ± 0.03	2.835GluIle: 2.835 ± 0.039	1.741GluLys: 1.741 ± 0.032	5.494GluLeu: 5.494 ± 0.055	1.197GluMet: 1.197 ± 0.026	1.407GluAsn: 1.407 ± 0.026	2.51GluPro: 2.51 ± 0.033	2.416GluGln: 2.416 ± 0.033	4.777GluArg: 4.777 ± 0.052	2.602GluSer: 2.602 ± 0.031	2.854GluThr: 2.854 ± 0.036	3.63GluVal: 3.63 ± 0.044	0.728GluTrp: 0.728 ± 0.019	1.152GluTyr: 1.152 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.731PheAla: 4.731 ± 0.052	0.433PheCys: 0.433 ± 0.014	2.716PheAsp: 2.716 ± 0.032	2.036PheGlu: 2.036 ± 0.029	1.435PhePhe: 1.435 ± 0.028	3.745PheGly: 3.745 ± 0.049	0.761PheHis: 0.761 ± 0.017	1.642PheIle: 1.642 ± 0.031	1.029PheLys: 1.029 ± 0.022	3.005PheLeu: 3.005 ± 0.038	0.814PheMet: 0.814 ± 0.022	1.189PheAsn: 1.189 ± 0.023	1.615PhePro: 1.615 ± 0.029	1.023PheGln: 1.023 ± 0.02	2.075PheArg: 2.075 ± 0.034	2.362PheSer: 2.362 ± 0.033	1.952PheThr: 1.952 ± 0.03	3.153PheVal: 3.153 ± 0.042	0.5PheTrp: 0.5 ± 0.016	0.993PheTyr: 0.993 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	9.406GlyAla: 9.406 ± 0.085	0.864GlyCys: 0.864 ± 0.022	3.844GlyAsp: 3.844 ± 0.047	4.331GlyGlu: 4.331 ± 0.047	3.454GlyPhe: 3.454 ± 0.046	6.841GlyGly: 6.841 ± 0.078	1.904GlyHis: 1.904 ± 0.032	4.278GlyIle: 4.278 ± 0.045	3.28GlyLys: 3.28 ± 0.044	7.962GlyLeu: 7.962 ± 0.077	2.202GlyMet: 2.202 ± 0.031	2.442GlyAsn: 2.442 ± 0.039	2.936GlyPro: 2.936 ± 0.03	2.766GlyGln: 2.766 ± 0.038	5.108GlyArg: 5.108 ± 0.049	4.739GlySer: 4.739 ± 0.057	4.717GlyThr: 4.717 ± 0.074	6.752GlyVal: 6.752 ± 0.062	1.329GlyTrp: 1.329 ± 0.024	2.445GlyTyr: 2.445 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	3.028HisAla: 3.028 ± 0.038	0.258HisCys: 0.258 ± 0.01	1.356HisAsp: 1.356 ± 0.028	1.236HisGlu: 1.236 ± 0.026	0.971HisPhe: 0.971 ± 0.021	2.171HisGly: 2.171 ± 0.034	0.649HisHis: 0.649 ± 0.019	0.963HisIle: 0.963 ± 0.019	0.565HisLys: 0.565 ± 0.016	2.226HisLeu: 2.226 ± 0.029	0.516HisMet: 0.516 ± 0.015	0.543HisAsn: 0.543 ± 0.014	1.4HisPro: 1.4 ± 0.024	0.675HisGln: 0.675 ± 0.018	1.576HisArg: 1.576 ± 0.025	1.15HisSer: 1.15 ± 0.022	1.129HisThr: 1.129 ± 0.024	1.775HisVal: 1.775 ± 0.031	0.385HisTrp: 0.385 ± 0.013	0.682HisTyr: 0.682 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.973IleAla: 6.973 ± 0.062	0.476IleCys: 0.476 ± 0.014	3.489IleAsp: 3.489 ± 0.042	3.274IleGlu: 3.274 ± 0.04	1.486IlePhe: 1.486 ± 0.029	4.799IleGly: 4.799 ± 0.052	0.922IleHis: 0.922 ± 0.022	1.642IleIle: 1.642 ± 0.027	1.42IleLys: 1.42 ± 0.029	3.476IleLeu: 3.476 ± 0.047	0.758IleMet: 0.758 ± 0.019	1.411IleAsn: 1.411 ± 0.027	2.169IlePro: 2.169 ± 0.033	1.261IleGln: 1.261 ± 0.024	2.871IleArg: 2.871 ± 0.038	2.584IleSer: 2.584 ± 0.032	2.408IleThr: 2.408 ± 0.033	4.473IleVal: 4.473 ± 0.048	0.513IleTrp: 0.513 ± 0.015	1.077IleTyr: 1.077 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.555LysAla: 3.555 ± 0.052	0.188LysCys: 0.188 ± 0.009	1.455LysAsp: 1.455 ± 0.024	1.423LysGlu: 1.423 ± 0.027	0.916LysPhe: 0.916 ± 0.02	2.173LysGly: 2.173 ± 0.04	0.686LysHis: 0.686 ± 0.017	1.613LysIle: 1.613 ± 0.027	1.237LysLys: 1.237 ± 0.034	3.461LysLeu: 3.461 ± 0.038	0.793LysMet: 0.793 ± 0.017	0.88LysAsn: 0.88 ± 0.021	1.959LysPro: 1.959 ± 0.033	1.323LysGln: 1.323 ± 0.026	2.334LysArg: 2.334 ± 0.029	1.776LysSer: 1.776 ± 0.026	1.904LysThr: 1.904 ± 0.03	2.325LysVal: 2.325 ± 0.034	0.387LysTrp: 0.387 ± 0.013	0.688LysTyr: 0.688 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.774LeuAla: 13.774 ± 0.099	1.062LeuCys: 1.062 ± 0.02	5.902LeuAsp: 5.902 ± 0.044	5.03LeuGlu: 5.03 ± 0.053	3.664LeuPhe: 3.664 ± 0.04	8.045LeuGly: 8.045 ± 0.061	2.271LeuHis: 2.271 ± 0.035	4.849LeuIle: 4.849 ± 0.054	3.455LeuLys: 3.455 ± 0.045	10.029LeuLeu: 10.029 ± 0.097	2.281LeuMet: 2.281 ± 0.037	2.881LeuAsn: 2.881 ± 0.035	5.732LeuPro: 5.732 ± 0.056	3.489LeuGln: 3.489 ± 0.036	7.035LeuArg: 7.035 ± 0.061	6.441LeuSer: 6.441 ± 0.053	5.759LeuThr: 5.759 ± 0.051	7.324LeuVal: 7.324 ± 0.067	1.131LeuTrp: 1.131 ± 0.026	2.178LeuTyr: 2.178 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.433MetAla: 2.433 ± 0.031	0.186MetCys: 0.186 ± 0.009	0.932MetAsp: 0.932 ± 0.019	0.909MetGlu: 0.909 ± 0.02	0.799MetPhe: 0.799 ± 0.018	1.521MetGly: 1.521 ± 0.032	0.575MetHis: 0.575 ± 0.014	1.118MetIle: 1.118 ± 0.023	1.066MetLys: 1.066 ± 0.021	2.617MetLeu: 2.617 ± 0.039	0.591MetMet: 0.591 ± 0.015	0.929MetAsn: 0.929 ± 0.02	1.439MetPro: 1.439 ± 0.027	1.014MetGln: 1.014 ± 0.02	1.796MetArg: 1.796 ± 0.029	1.746MetSer: 1.746 ± 0.028	1.642MetThr: 1.642 ± 0.024	1.541MetVal: 1.541 ± 0.028	0.227MetTrp: 0.227 ± 0.01	0.4MetTyr: 0.4 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.603AsnAla: 3.603 ± 0.05	0.291AsnCys: 0.291 ± 0.01	1.515AsnAsp: 1.515 ± 0.025	1.356AsnGlu: 1.356 ± 0.027	1.007AsnPhe: 1.007 ± 0.023	2.728AsnGly: 2.728 ± 0.045	0.564AsnHis: 0.564 ± 0.015	1.258AsnIle: 1.258 ± 0.023	0.659AsnLys: 0.659 ± 0.019	2.837AsnLeu: 2.837 ± 0.037	0.583AsnMet: 0.583 ± 0.016	0.844AsnAsn: 0.844 ± 0.021	1.893AsnPro: 1.893 ± 0.03	0.973AsnGln: 0.973 ± 0.021	1.869AsnArg: 1.869 ± 0.033	1.422AsnSer: 1.422 ± 0.027	1.536AsnThr: 1.536 ± 0.031	2.316AsnVal: 2.316 ± 0.035	0.464AsnTrp: 0.464 ± 0.015	0.768AsnTyr: 0.768 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	6.617ProAla: 6.617 ± 0.061	0.353ProCys: 0.353 ± 0.012	3.164ProAsp: 3.164 ± 0.04	2.902ProGlu: 2.902 ± 0.033	1.932ProPhe: 1.932 ± 0.031	4.132ProGly: 4.132 ± 0.05	1.307ProHis: 1.307 ± 0.023	2.037ProIle: 2.037 ± 0.03	1.414ProLys: 1.414 ± 0.025	5.2ProLeu: 5.2 ± 0.05	1.092ProMet: 1.092 ± 0.021	1.516ProAsn: 1.516 ± 0.026	2.457ProPro: 2.457 ± 0.038	1.899ProGln: 1.899 ± 0.034	2.892ProArg: 2.892 ± 0.037	2.89ProSer: 2.89 ± 0.033	2.606ProThr: 2.606 ± 0.042	4.331ProVal: 4.331 ± 0.044	0.687ProTrp: 0.687 ± 0.018	1.235ProTyr: 1.235 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.571GlnAla: 4.571 ± 0.057	0.283GlnCys: 0.283 ± 0.012	1.359GlnAsp: 1.359 ± 0.023	1.352GlnGlu: 1.352 ± 0.024	1.379GlnPhe: 1.379 ± 0.027	2.484GlnGly: 2.484 ± 0.031	0.959GlnHis: 0.959 ± 0.021	2.039GlnIle: 2.039 ± 0.031	1.15GlnLys: 1.15 ± 0.025	3.929GlnLeu: 3.929 ± 0.049	1.045GlnMet: 1.045 ± 0.019	1.003GlnAsn: 1.003 ± 0.022	2.053GlnPro: 2.053 ± 0.04	2.001GlnGln: 2.001 ± 0.044	2.933GlnArg: 2.933 ± 0.037	2.059GlnSer: 2.059 ± 0.035	2.072GlnThr: 2.072 ± 0.031	2.579GlnVal: 2.579 ± 0.034	0.57GlnTrp: 0.57 ± 0.017	0.942GlnTyr: 0.942 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.054ArgAla: 8.054 ± 0.069	0.625ArgCys: 0.625 ± 0.016	3.747ArgAsp: 3.747 ± 0.04	4.135ArgGlu: 4.135 ± 0.044	2.975ArgPhe: 2.975 ± 0.037	4.538ArgGly: 4.538 ± 0.043	1.876ArgHis: 1.876 ± 0.028	3.673ArgIle: 3.673 ± 0.043	2.089ArgLys: 2.089 ± 0.029	7.192ArgLeu: 7.192 ± 0.063	1.779ArgMet: 1.779 ± 0.023	1.938ArgAsn: 1.938 ± 0.029	3.0ArgPro: 3.0 ± 0.04	2.594ArgGln: 2.594 ± 0.035	5.242ArgArg: 5.242 ± 0.057	3.716ArgSer: 3.716 ± 0.044	3.504ArgThr: 3.504 ± 0.04	5.165ArgVal: 5.165 ± 0.048	1.046ArgTrp: 1.046 ± 0.02	2.021ArgTyr: 2.021 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	7.231SerAla: 7.231 ± 0.065	0.476SerCys: 0.476 ± 0.014	2.842SerAsp: 2.842 ± 0.038	2.661SerGlu: 2.661 ± 0.041	2.274SerPhe: 2.274 ± 0.035	5.572SerGly: 5.572 ± 0.064	1.257SerHis: 1.257 ± 0.023	2.81SerIle: 2.81 ± 0.036	1.702SerLys: 1.702 ± 0.03	5.869SerLeu: 5.869 ± 0.051	1.435SerMet: 1.435 ± 0.024	1.751SerAsn: 1.751 ± 0.035	2.868SerPro: 2.868 ± 0.036	1.89SerGln: 1.89 ± 0.029	3.77SerArg: 3.77 ± 0.039	3.643SerSer: 3.643 ± 0.054	3.246SerThr: 3.246 ± 0.048	4.538SerVal: 4.538 ± 0.05	0.722SerTrp: 0.722 ± 0.019	1.388SerTyr: 1.388 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	6.136ThrAla: 6.136 ± 0.061	0.479ThrCys: 0.479 ± 0.016	2.682ThrAsp: 2.682 ± 0.034	2.373ThrGlu: 2.373 ± 0.038	2.027ThrPhe: 2.027 ± 0.035	4.847ThrGly: 4.847 ± 0.063	1.288ThrHis: 1.288 ± 0.022	2.632ThrIle: 2.632 ± 0.034	1.261ThrLys: 1.261 ± 0.027	6.56ThrLeu: 6.56 ± 0.062	1.183ThrMet: 1.183 ± 0.021	1.392ThrAsn: 1.392 ± 0.028	3.556ThrPro: 3.556 ± 0.038	2.019ThrGln: 2.019 ± 0.03	3.621ThrArg: 3.621 ± 0.038	3.08ThrSer: 3.08 ± 0.039	2.951ThrThr: 2.951 ± 0.047	4.449ThrVal: 4.449 ± 0.05	0.707ThrTrp: 0.707 ± 0.019	1.295ThrTyr: 1.295 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	9.463ValAla: 9.463 ± 0.073	0.869ValCys: 0.869 ± 0.017	4.269ValAsp: 4.269 ± 0.05	4.231ValGlu: 4.231 ± 0.045	2.94ValPhe: 2.94 ± 0.033	5.656ValGly: 5.656 ± 0.057	1.564ValHis: 1.564 ± 0.027	3.811ValIle: 3.811 ± 0.039	2.507ValLys: 2.507 ± 0.037	7.963ValLeu: 7.963 ± 0.074	1.882ValMet: 1.882 ± 0.036	2.272ValAsn: 2.272 ± 0.036	3.971ValPro: 3.971 ± 0.039	2.572ValGln: 2.572 ± 0.038	5.145ValArg: 5.145 ± 0.046	4.845ValSer: 4.845 ± 0.048	4.562ValThr: 4.562 ± 0.05	6.381ValVal: 6.381 ± 0.061	0.97ValTrp: 0.97 ± 0.023	1.692ValTyr: 1.692 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.169TrpAla: 1.169 ± 0.026	0.15TrpCys: 0.15 ± 0.009	0.62TrpAsp: 0.62 ± 0.018	0.502TrpGlu: 0.502 ± 0.017	0.566TrpPhe: 0.566 ± 0.015	0.854TrpGly: 0.854 ± 0.018	0.394TrpHis: 0.394 ± 0.014	0.707TrpIle: 0.707 ± 0.019	0.432TrpLys: 0.432 ± 0.013	1.945TrpLeu: 1.945 ± 0.037	0.36TrpMet: 0.36 ± 0.014	0.472TrpAsn: 0.472 ± 0.016	0.672TrpPro: 0.672 ± 0.016	0.675TrpGln: 0.675 ± 0.02	1.15TrpArg: 1.15 ± 0.025	0.812TrpSer: 0.812 ± 0.02	0.707TrpThr: 0.707 ± 0.018	0.908TrpVal: 0.908 ± 0.022	0.237TrpTrp: 0.237 ± 0.01	0.307TrpTyr: 0.307 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.819TyrAla: 2.819 ± 0.034	0.269TyrCys: 0.269 ± 0.01	1.396TyrAsp: 1.396 ± 0.024	1.254TyrGlu: 1.254 ± 0.024	1.004TyrPhe: 1.004 ± 0.022	2.165TyrGly: 2.165 ± 0.031	0.526TyrHis: 0.526 ± 0.015	0.867TyrIle: 0.867 ± 0.02	0.636TyrLys: 0.636 ± 0.018	2.544TyrLeu: 2.544 ± 0.035	0.447TyrMet: 0.447 ± 0.015	0.656TyrAsn: 0.656 ± 0.016	1.251TyrPro: 1.251 ± 0.022	0.934TyrGln: 0.934 ± 0.021	1.93TyrArg: 1.93 ± 0.029	1.346TyrSer: 1.346 ± 0.029	1.268TyrThr: 1.268 ± 0.024	1.949TyrVal: 1.949 ± 0.029	0.387TyrTrp: 0.387 ± 0.014	0.71TyrTyr: 0.71 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7264 proteins (2306885 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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