Amino acid dipepetide frequency for Candidatus Fukatsuia symbiotica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.701AlaAla: 7.701 ± 0.145
0.821AlaCys: 0.821 ± 0.039
4.265AlaAsp: 4.265 ± 0.093
4.828AlaGlu: 4.828 ± 0.096
2.899AlaPhe: 2.899 ± 0.066
5.444AlaGly: 5.444 ± 0.1
1.732AlaHis: 1.732 ± 0.051
5.699AlaIle: 5.699 ± 0.086
4.49AlaLys: 4.49 ± 0.097
9.683AlaLeu: 9.683 ± 0.154
2.236AlaMet: 2.236 ± 0.06
3.152AlaAsn: 3.152 ± 0.07
2.612AlaPro: 2.612 ± 0.066
3.845AlaGln: 3.845 ± 0.081
4.37AlaArg: 4.37 ± 0.086
4.958AlaSer: 4.958 ± 0.088
4.54AlaThr: 4.54 ± 0.09
5.266AlaVal: 5.266 ± 0.103
1.012AlaTrp: 1.012 ± 0.043
2.382AlaTyr: 2.382 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.871CysAla: 0.871 ± 0.039
0.226CysCys: 0.226 ± 0.019
0.623CysAsp: 0.623 ± 0.031
0.566CysGlu: 0.566 ± 0.028
0.485CysPhe: 0.485 ± 0.026
0.92CysGly: 0.92 ± 0.041
0.382CysHis: 0.382 ± 0.024
0.654CysIle: 0.654 ± 0.034
0.469CysLys: 0.469 ± 0.025
1.086CysLeu: 1.086 ± 0.039
0.23CysMet: 0.23 ± 0.019
0.37CysAsn: 0.37 ± 0.026
0.442CysPro: 0.442 ± 0.024
0.647CysGln: 0.647 ± 0.036
0.714CysArg: 0.714 ± 0.033
0.693CysSer: 0.693 ± 0.029
0.518CysThr: 0.518 ± 0.028
0.703CysVal: 0.703 ± 0.034
0.21CysTrp: 0.21 ± 0.02
0.469CysTyr: 0.469 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
4.062AspAla: 4.062 ± 0.102
0.579AspCys: 0.579 ± 0.029
2.798AspAsp: 2.798 ± 0.077
3.23AspGlu: 3.23 ± 0.071
2.085AspPhe: 2.085 ± 0.06
3.266AspGly: 3.266 ± 0.075
1.139AspHis: 1.139 ± 0.038
4.18AspIle: 4.18 ± 0.089
3.208AspLys: 3.208 ± 0.07
4.726AspLeu: 4.726 ± 0.085
1.247AspMet: 1.247 ± 0.042
2.66AspAsn: 2.66 ± 0.066
2.33AspPro: 2.33 ± 0.061
2.184AspGln: 2.184 ± 0.054
2.812AspArg: 2.812 ± 0.064
2.878AspSer: 2.878 ± 0.063
2.768AspThr: 2.768 ± 0.069
3.143AspVal: 3.143 ± 0.083
0.701AspTrp: 0.701 ± 0.03
1.909AspTyr: 1.909 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
4.284GluAla: 4.284 ± 0.083
0.504GluCys: 0.504 ± 0.024
2.219GluAsp: 2.219 ± 0.065
3.404GluGlu: 3.404 ± 0.09
1.904GluPhe: 1.904 ± 0.056
3.23GluGly: 3.23 ± 0.077
1.402GluHis: 1.402 ± 0.045
4.108GluIle: 4.108 ± 0.084
4.572GluLys: 4.572 ± 0.111
6.042GluLeu: 6.042 ± 0.098
1.473GluMet: 1.473 ± 0.049
2.92GluAsn: 2.92 ± 0.062
1.785GluPro: 1.785 ± 0.057
3.711GluGln: 3.711 ± 0.078
3.567GluArg: 3.567 ± 0.067
2.91GluSer: 2.91 ± 0.077
3.171GluThr: 3.171 ± 0.062
3.388GluVal: 3.388 ± 0.076
0.634GluTrp: 0.634 ± 0.028
1.546GluTyr: 1.546 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
2.948PheAla: 2.948 ± 0.063
0.573PheCys: 0.573 ± 0.029
2.284PheAsp: 2.284 ± 0.061
1.869PheGlu: 1.869 ± 0.052
1.937PhePhe: 1.937 ± 0.068
2.419PheGly: 2.419 ± 0.059
0.92PheHis: 0.92 ± 0.037
2.886PheIle: 2.886 ± 0.075
1.751PheLys: 1.751 ± 0.049
3.197PheLeu: 3.197 ± 0.079
0.9PheMet: 0.9 ± 0.035
1.932PheAsn: 1.932 ± 0.05
1.391PhePro: 1.391 ± 0.049
1.197PheGln: 1.197 ± 0.04
1.839PheArg: 1.839 ± 0.058
3.415PheSer: 3.415 ± 0.083
2.361PheThr: 2.361 ± 0.053
2.076PheVal: 2.076 ± 0.057
0.412PheTrp: 0.412 ± 0.028
1.375PheTyr: 1.375 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
4.435GlyAla: 4.435 ± 0.095
0.852GlyCys: 0.852 ± 0.041
3.267GlyAsp: 3.267 ± 0.081
3.673GlyGlu: 3.673 ± 0.079
2.487GlyPhe: 2.487 ± 0.061
4.108GlyGly: 4.108 ± 0.105
1.617GlyHis: 1.617 ± 0.051
4.678GlyIle: 4.678 ± 0.085
4.206GlyLys: 4.206 ± 0.1
6.268GlyLeu: 6.268 ± 0.113
1.866GlyMet: 1.866 ± 0.055
2.819GlyAsn: 2.819 ± 0.067
1.117GlyPro: 1.117 ± 0.046
2.688GlyGln: 2.688 ± 0.059
3.526GlyArg: 3.526 ± 0.086
4.012GlySer: 4.012 ± 0.094
3.163GlyThr: 3.163 ± 0.073
4.457GlyVal: 4.457 ± 0.097
1.106GlyTrp: 1.106 ± 0.043
2.281GlyTyr: 2.281 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
1.872HisAla: 1.872 ± 0.052
0.465HisCys: 0.465 ± 0.027
1.276HisAsp: 1.276 ± 0.044
1.112HisGlu: 1.112 ± 0.038
1.126HisPhe: 1.126 ± 0.034
1.618HisGly: 1.618 ± 0.053
0.877HisHis: 0.877 ± 0.039
1.64HisIle: 1.64 ± 0.051
1.169HisLys: 1.169 ± 0.046
2.638HisLeu: 2.638 ± 0.06
0.494HisMet: 0.494 ± 0.03
0.965HisAsn: 0.965 ± 0.039
1.222HisPro: 1.222 ± 0.042
1.423HisGln: 1.423 ± 0.044
1.415HisArg: 1.415 ± 0.048
1.529HisSer: 1.529 ± 0.043
1.09HisThr: 1.09 ± 0.042
1.33HisVal: 1.33 ± 0.045
0.462HisTrp: 0.462 ± 0.027
1.194HisTyr: 1.194 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.177IleAla: 6.177 ± 0.099
0.743IleCys: 0.743 ± 0.035
4.294IleAsp: 4.294 ± 0.087
4.605IleGlu: 4.605 ± 0.082
2.425IlePhe: 2.425 ± 0.075
4.31IleGly: 4.31 ± 0.089
1.446IleHis: 1.446 ± 0.047
4.254IleIle: 4.254 ± 0.101
4.183IleLys: 4.183 ± 0.097
6.019IleLeu: 6.019 ± 0.105
1.387IleMet: 1.387 ± 0.043
3.621IleAsn: 3.621 ± 0.079
2.868IlePro: 2.868 ± 0.067
2.573IleGln: 2.573 ± 0.059
3.544IleArg: 3.544 ± 0.071
4.539IleSer: 4.539 ± 0.083
4.412IleThr: 4.412 ± 0.098
3.727IleVal: 3.727 ± 0.077
0.678IleTrp: 0.678 ± 0.034
1.918IleTyr: 1.918 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.086LysAla: 4.086 ± 0.089
0.443LysCys: 0.443 ± 0.03
2.537LysAsp: 2.537 ± 0.071
3.58LysGlu: 3.58 ± 0.089
1.728LysPhe: 1.728 ± 0.044
3.166LysGly: 3.166 ± 0.076
1.153LysHis: 1.153 ± 0.047
4.506LysIle: 4.506 ± 0.099
4.589LysLys: 4.589 ± 0.108
5.65LysLeu: 5.65 ± 0.091
1.582LysMet: 1.582 ± 0.052
3.454LysAsn: 3.454 ± 0.086
2.163LysPro: 2.163 ± 0.067
2.962LysGln: 2.962 ± 0.08
3.269LysArg: 3.269 ± 0.071
3.083LysSer: 3.083 ± 0.07
3.705LysThr: 3.705 ± 0.08
3.313LysVal: 3.313 ± 0.076
0.657LysTrp: 0.657 ± 0.031
1.502LysTyr: 1.502 ± 0.055
0.0LysXaa: 0.0 ± 0.0
Leu
9.826LeuAla: 9.826 ± 0.145
1.319LeuCys: 1.319 ± 0.044
5.368LeuAsp: 5.368 ± 0.091
5.423LeuGlu: 5.423 ± 0.097
4.35LeuPhe: 4.35 ± 0.095
6.084LeuGly: 6.084 ± 0.115
2.537LeuHis: 2.537 ± 0.065
6.606LeuIle: 6.606 ± 0.114
5.632LeuLys: 5.632 ± 0.087
11.977LeuLeu: 11.977 ± 0.193
2.588LeuMet: 2.588 ± 0.073
4.991LeuAsn: 4.991 ± 0.095
5.426LeuPro: 5.426 ± 0.091
5.001LeuGln: 5.001 ± 0.087
5.835LeuArg: 5.835 ± 0.111
7.796LeuSer: 7.796 ± 0.108
6.569LeuThr: 6.569 ± 0.108
6.377LeuVal: 6.377 ± 0.109
1.117LeuTrp: 1.117 ± 0.047
3.009LeuTyr: 3.009 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.344MetAla: 2.344 ± 0.057
0.187MetCys: 0.187 ± 0.016
1.104MetAsp: 1.104 ± 0.044
1.185MetGlu: 1.185 ± 0.05
0.636MetPhe: 0.636 ± 0.03
1.555MetGly: 1.555 ± 0.047
0.464MetHis: 0.464 ± 0.024
1.555MetIle: 1.555 ± 0.049
1.617MetLys: 1.617 ± 0.049
2.753MetLeu: 2.753 ± 0.071
0.724MetMet: 0.724 ± 0.037
1.08MetAsn: 1.08 ± 0.038
1.054MetPro: 1.054 ± 0.036
1.178MetGln: 1.178 ± 0.04
1.224MetArg: 1.224 ± 0.043
1.582MetSer: 1.582 ± 0.045
1.557MetThr: 1.557 ± 0.048
1.646MetVal: 1.646 ± 0.058
0.193MetTrp: 0.193 ± 0.017
0.485MetTyr: 0.485 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.21AsnAla: 3.21 ± 0.076
0.396AsnCys: 0.396 ± 0.026
2.536AsnAsp: 2.536 ± 0.077
2.52AsnGlu: 2.52 ± 0.052
1.656AsnPhe: 1.656 ± 0.05
2.841AsnGly: 2.841 ± 0.077
1.136AsnHis: 1.136 ± 0.039
3.349AsnIle: 3.349 ± 0.076
2.874AsnLys: 2.874 ± 0.079
4.025AsnLeu: 4.025 ± 0.082
0.937AsnMet: 0.937 ± 0.039
2.492AsnAsn: 2.492 ± 0.075
2.304AsnPro: 2.304 ± 0.065
2.055AsnGln: 2.055 ± 0.057
2.507AsnArg: 2.507 ± 0.054
2.792AsnSer: 2.792 ± 0.084
2.618AsnThr: 2.618 ± 0.065
2.469AsnVal: 2.469 ± 0.052
0.572AsnTrp: 0.572 ± 0.03
1.382AsnTyr: 1.382 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
3.199ProAla: 3.199 ± 0.068
0.415ProCys: 0.415 ± 0.025
2.275ProAsp: 2.275 ± 0.066
2.624ProGlu: 2.624 ± 0.063
1.6ProPhe: 1.6 ± 0.05
2.324ProGly: 2.324 ± 0.052
1.119ProHis: 1.119 ± 0.044
2.55ProIle: 2.55 ± 0.06
1.83ProLys: 1.83 ± 0.052
4.863ProLeu: 4.863 ± 0.096
0.979ProMet: 0.979 ± 0.039
1.443ProAsn: 1.443 ± 0.046
1.791ProPro: 1.791 ± 0.051
2.004ProGln: 2.004 ± 0.053
1.796ProArg: 1.796 ± 0.052
2.531ProSer: 2.531 ± 0.07
2.37ProThr: 2.37 ± 0.053
2.835ProVal: 2.835 ± 0.068
0.54ProTrp: 0.54 ± 0.029
1.277ProTyr: 1.277 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
4.526GlnAla: 4.526 ± 0.091
0.482GlnCys: 0.482 ± 0.028
2.275GlnAsp: 2.275 ± 0.066
2.552GlnGlu: 2.552 ± 0.071
1.649GlnPhe: 1.649 ± 0.057
3.112GlnGly: 3.112 ± 0.075
1.549GlnHis: 1.549 ± 0.056
2.904GlnIle: 2.904 ± 0.065
2.613GlnLys: 2.613 ± 0.065
5.669GlnLeu: 5.669 ± 0.099
1.055GlnMet: 1.055 ± 0.035
1.768GlnAsn: 1.768 ± 0.065
2.161GlnPro: 2.161 ± 0.062
4.205GlnGln: 4.205 ± 0.086
3.215GlnArg: 3.215 ± 0.072
2.719GlnSer: 2.719 ± 0.072
2.559GlnThr: 2.559 ± 0.074
2.932GlnVal: 2.932 ± 0.062
0.593GlnTrp: 0.593 ± 0.026
1.401GlnTyr: 1.401 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.955ArgAla: 3.955 ± 0.083
0.681ArgCys: 0.681 ± 0.033
2.818ArgAsp: 2.818 ± 0.066
3.532ArgGlu: 3.532 ± 0.091
2.331ArgPhe: 2.331 ± 0.063
3.027ArgGly: 3.027 ± 0.079
1.562ArgHis: 1.562 ± 0.047
3.719ArgIle: 3.719 ± 0.072
3.123ArgLys: 3.123 ± 0.072
6.654ArgLeu: 6.654 ± 0.108
1.28ArgMet: 1.28 ± 0.043
2.088ArgAsn: 2.088 ± 0.061
1.932ArgPro: 1.932 ± 0.054
3.089ArgGln: 3.089 ± 0.086
3.335ArgArg: 3.335 ± 0.084
3.011ArgSer: 3.011 ± 0.063
2.652ArgThr: 2.652 ± 0.061
3.57ArgVal: 3.57 ± 0.077
0.87ArgTrp: 0.87 ± 0.037
2.161ArgTyr: 2.161 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
5.08SerAla: 5.08 ± 0.077
0.652SerCys: 0.652 ± 0.033
3.346SerAsp: 3.346 ± 0.077
3.529SerGlu: 3.529 ± 0.079
2.236SerPhe: 2.236 ± 0.06
4.837SerGly: 4.837 ± 0.097
1.6SerHis: 1.6 ± 0.049
4.068SerIle: 4.068 ± 0.091
3.047SerLys: 3.047 ± 0.08
6.997SerLeu: 6.997 ± 0.107
1.454SerMet: 1.454 ± 0.045
2.387SerAsn: 2.387 ± 0.066
2.562SerPro: 2.562 ± 0.05
2.988SerGln: 2.988 ± 0.069
3.509SerArg: 3.509 ± 0.076
4.287SerSer: 4.287 ± 0.103
3.561SerThr: 3.561 ± 0.081
4.271SerVal: 4.271 ± 0.088
0.808SerTrp: 0.808 ± 0.038
1.977SerTyr: 1.977 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
4.881ThrAla: 4.881 ± 0.103
0.527ThrCys: 0.527 ± 0.028
3.084ThrAsp: 3.084 ± 0.069
3.247ThrGlu: 3.247 ± 0.072
2.066ThrPhe: 2.066 ± 0.053
3.899ThrGly: 3.899 ± 0.077
1.45ThrHis: 1.45 ± 0.044
3.296ThrIle: 3.296 ± 0.078
2.436ThrLys: 2.436 ± 0.062
7.524ThrLeu: 7.524 ± 0.112
1.038ThrMet: 1.038 ± 0.039
1.945ThrAsn: 1.945 ± 0.059
2.922ThrPro: 2.922 ± 0.073
2.775ThrGln: 2.775 ± 0.071
2.893ThrArg: 2.893 ± 0.066
3.181ThrSer: 3.181 ± 0.08
3.519ThrThr: 3.519 ± 0.088
4.058ThrVal: 4.058 ± 0.087
0.647ThrTrp: 0.647 ± 0.034
1.437ThrTyr: 1.437 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
5.505ValAla: 5.505 ± 0.114
0.746ValCys: 0.746 ± 0.034
3.467ValAsp: 3.467 ± 0.065
3.616ValGlu: 3.616 ± 0.07
2.266ValPhe: 2.266 ± 0.056
3.811ValGly: 3.811 ± 0.084
1.266ValHis: 1.266 ± 0.041
4.478ValIle: 4.478 ± 0.095
3.426ValLys: 3.426 ± 0.079
6.471ValLeu: 6.471 ± 0.106
1.745ValMet: 1.745 ± 0.048
2.89ValAsn: 2.89 ± 0.066
2.383ValPro: 2.383 ± 0.059
2.3ValGln: 2.3 ± 0.054
3.132ValArg: 3.132 ± 0.071
4.459ValSer: 4.459 ± 0.073
3.754ValThr: 3.754 ± 0.076
4.518ValVal: 4.518 ± 0.1
0.619ValTrp: 0.619 ± 0.03
1.565ValTyr: 1.565 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.812TrpAla: 0.812 ± 0.038
0.181TrpCys: 0.181 ± 0.015
0.491TrpAsp: 0.491 ± 0.028
0.487TrpGlu: 0.487 ± 0.026
0.487TrpPhe: 0.487 ± 0.03
0.655TrpGly: 0.655 ± 0.033
0.374TrpHis: 0.374 ± 0.024
0.858TrpIle: 0.858 ± 0.043
0.553TrpLys: 0.553 ± 0.029
1.862TrpLeu: 1.862 ± 0.061
0.31TrpMet: 0.31 ± 0.02
0.443TrpAsn: 0.443 ± 0.028
0.459TrpPro: 0.459 ± 0.024
1.053TrpGln: 1.053 ± 0.044
0.844TrpArg: 0.844 ± 0.043
0.678TrpSer: 0.678 ± 0.03
0.497TrpThr: 0.497 ± 0.031
0.757TrpVal: 0.757 ± 0.037
0.171TrpTrp: 0.171 ± 0.017
0.426TrpTyr: 0.426 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.16TyrAla: 2.16 ± 0.057
0.485TyrCys: 0.485 ± 0.028
1.577TyrAsp: 1.577 ± 0.041
1.194TyrGlu: 1.194 ± 0.042
1.329TyrPhe: 1.329 ± 0.047
2.001TyrGly: 2.001 ± 0.056
1.192TyrHis: 1.192 ± 0.042
1.732TyrIle: 1.732 ± 0.056
1.341TyrLys: 1.341 ± 0.045
3.728TyrLeu: 3.728 ± 0.079
0.596TyrMet: 0.596 ± 0.027
1.248TyrAsn: 1.248 ± 0.051
1.44TyrPro: 1.44 ± 0.046
2.065TyrGln: 2.065 ± 0.057
2.046TyrArg: 2.046 ± 0.063
2.144TyrSer: 2.144 ± 0.061
1.441TyrThr: 1.441 ± 0.047
1.581TyrVal: 1.581 ± 0.049
0.397TyrTrp: 0.397 ± 0.025
1.178TyrTyr: 1.178 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2350 proteins (694485 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski