Amino acid dipepetide frequency for Leclercia phage 10164-302

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.999AlaAla: 10.999 ± 1.298
0.767AlaCys: 0.767 ± 0.32
5.542AlaAsp: 5.542 ± 0.694
6.224AlaGlu: 6.224 ± 0.915
3.155AlaPhe: 3.155 ± 0.625
7.759AlaGly: 7.759 ± 0.871
1.62AlaHis: 1.62 ± 0.273
5.286AlaIle: 5.286 ± 0.695
6.565AlaLys: 6.565 ± 0.771
8.271AlaLeu: 8.271 ± 0.761
2.814AlaMet: 2.814 ± 0.576
4.519AlaAsn: 4.519 ± 0.55
2.558AlaPro: 2.558 ± 0.457
4.349AlaGln: 4.349 ± 0.723
5.286AlaArg: 5.286 ± 0.856
5.713AlaSer: 5.713 ± 0.892
4.093AlaThr: 4.093 ± 0.838
5.713AlaVal: 5.713 ± 0.605
1.705AlaTrp: 1.705 ± 0.354
2.473AlaTyr: 2.473 ± 0.462
0.0AlaXaa: 0.0 ± 0.0
Cys
0.682CysAla: 0.682 ± 0.334
0.171CysCys: 0.171 ± 0.12
0.767CysAsp: 0.767 ± 0.344
0.426CysGlu: 0.426 ± 0.207
0.512CysPhe: 0.512 ± 0.287
0.426CysGly: 0.426 ± 0.178
0.426CysHis: 0.426 ± 0.23
0.597CysIle: 0.597 ± 0.228
0.426CysLys: 0.426 ± 0.27
0.512CysLeu: 0.512 ± 0.199
0.0CysMet: 0.0 ± 0.0
0.256CysAsn: 0.256 ± 0.173
0.256CysPro: 0.256 ± 0.142
0.512CysGln: 0.512 ± 0.249
0.512CysArg: 0.512 ± 0.288
0.341CysSer: 0.341 ± 0.214
0.256CysThr: 0.256 ± 0.193
0.426CysVal: 0.426 ± 0.222
0.171CysTrp: 0.171 ± 0.126
0.256CysTyr: 0.256 ± 0.17
0.0CysXaa: 0.0 ± 0.0
Asp
6.054AspAla: 6.054 ± 0.609
0.597AspCys: 0.597 ± 0.304
4.178AspAsp: 4.178 ± 0.452
4.349AspGlu: 4.349 ± 0.762
2.899AspPhe: 2.899 ± 0.569
6.736AspGly: 6.736 ± 1.141
1.023AspHis: 1.023 ± 0.273
2.643AspIle: 2.643 ± 0.551
4.434AspLys: 4.434 ± 0.755
4.349AspLeu: 4.349 ± 0.789
2.217AspMet: 2.217 ± 0.497
2.814AspAsn: 2.814 ± 0.437
2.899AspPro: 2.899 ± 0.466
1.876AspGln: 1.876 ± 0.445
2.643AspArg: 2.643 ± 0.449
2.899AspSer: 2.899 ± 0.519
3.496AspThr: 3.496 ± 0.482
3.666AspVal: 3.666 ± 0.473
1.023AspTrp: 1.023 ± 0.388
1.876AspTyr: 1.876 ± 0.431
0.0AspXaa: 0.0 ± 0.0
Glu
7.503GluAla: 7.503 ± 0.938
0.597GluCys: 0.597 ± 0.224
4.69GluAsp: 4.69 ± 0.659
5.031GluGlu: 5.031 ± 0.847
2.984GluPhe: 2.984 ± 0.315
5.116GluGly: 5.116 ± 0.658
1.62GluHis: 1.62 ± 0.378
3.581GluIle: 3.581 ± 0.581
4.093GluLys: 4.093 ± 0.751
6.054GluLeu: 6.054 ± 0.725
2.558GluMet: 2.558 ± 0.538
2.046GluAsn: 2.046 ± 0.417
1.62GluPro: 1.62 ± 0.344
4.178GluGln: 4.178 ± 0.841
4.178GluArg: 4.178 ± 0.513
4.093GluSer: 4.093 ± 0.565
3.155GluThr: 3.155 ± 0.509
3.922GluVal: 3.922 ± 0.551
1.194GluTrp: 1.194 ± 0.312
3.411GluTyr: 3.411 ± 0.431
0.0GluXaa: 0.0 ± 0.0
Phe
2.899PheAla: 2.899 ± 0.432
0.512PheCys: 0.512 ± 0.222
2.558PheAsp: 2.558 ± 0.465
1.961PheGlu: 1.961 ± 0.351
1.279PhePhe: 1.279 ± 0.363
3.496PheGly: 3.496 ± 0.566
0.512PheHis: 0.512 ± 0.264
2.217PheIle: 2.217 ± 0.484
2.984PheLys: 2.984 ± 0.582
2.729PheLeu: 2.729 ± 0.511
0.938PheMet: 0.938 ± 0.283
2.387PheAsn: 2.387 ± 0.488
1.62PhePro: 1.62 ± 0.416
1.364PheGln: 1.364 ± 0.31
1.62PheArg: 1.62 ± 0.291
1.876PheSer: 1.876 ± 0.443
2.473PheThr: 2.473 ± 0.499
1.961PheVal: 1.961 ± 0.362
0.341PheTrp: 0.341 ± 0.125
0.938PheTyr: 0.938 ± 0.265
0.0PheXaa: 0.0 ± 0.0
Gly
6.565GlyAla: 6.565 ± 0.954
0.682GlyCys: 0.682 ± 0.351
5.628GlyAsp: 5.628 ± 0.845
5.628GlyGlu: 5.628 ± 0.689
3.496GlyPhe: 3.496 ± 0.493
5.457GlyGly: 5.457 ± 0.852
1.108GlyHis: 1.108 ± 0.336
4.86GlyIle: 4.86 ± 0.655
5.372GlyLys: 5.372 ± 0.718
6.31GlyLeu: 6.31 ± 0.873
2.302GlyMet: 2.302 ± 0.403
3.837GlyAsn: 3.837 ± 0.598
0.767GlyPro: 0.767 ± 0.247
2.643GlyGln: 2.643 ± 0.471
4.604GlyArg: 4.604 ± 0.491
4.349GlySer: 4.349 ± 0.532
3.752GlyThr: 3.752 ± 0.728
4.775GlyVal: 4.775 ± 0.607
1.535GlyTrp: 1.535 ± 0.49
2.473GlyTyr: 2.473 ± 0.415
0.0GlyXaa: 0.0 ± 0.0
His
1.62HisAla: 1.62 ± 0.375
0.256HisCys: 0.256 ± 0.166
0.853HisAsp: 0.853 ± 0.221
1.194HisGlu: 1.194 ± 0.443
0.853HisPhe: 0.853 ± 0.297
1.62HisGly: 1.62 ± 0.304
0.512HisHis: 0.512 ± 0.213
1.108HisIle: 1.108 ± 0.286
1.364HisLys: 1.364 ± 0.327
1.961HisLeu: 1.961 ± 0.444
0.767HisMet: 0.767 ± 0.259
0.682HisAsn: 0.682 ± 0.184
0.512HisPro: 0.512 ± 0.195
0.085HisGln: 0.085 ± 0.109
0.682HisArg: 0.682 ± 0.239
1.364HisSer: 1.364 ± 0.46
0.938HisThr: 0.938 ± 0.24
1.364HisVal: 1.364 ± 0.344
0.682HisTrp: 0.682 ± 0.258
0.767HisTyr: 0.767 ± 0.219
0.0HisXaa: 0.0 ± 0.0
Ile
4.178IleAla: 4.178 ± 0.616
0.256IleCys: 0.256 ± 0.131
3.24IleAsp: 3.24 ± 0.565
4.349IleGlu: 4.349 ± 0.713
0.938IlePhe: 0.938 ± 0.253
3.411IleGly: 3.411 ± 0.582
1.705IleHis: 1.705 ± 0.305
2.984IleIle: 2.984 ± 0.544
3.837IleLys: 3.837 ± 0.622
3.411IleLeu: 3.411 ± 0.52
0.853IleMet: 0.853 ± 0.356
2.643IleAsn: 2.643 ± 0.716
2.473IlePro: 2.473 ± 0.431
1.791IleGln: 1.791 ± 0.374
3.581IleArg: 3.581 ± 0.633
3.155IleSer: 3.155 ± 0.548
2.132IleThr: 2.132 ± 0.429
3.155IleVal: 3.155 ± 0.429
0.512IleTrp: 0.512 ± 0.236
2.387IleTyr: 2.387 ± 0.301
0.0IleXaa: 0.0 ± 0.0
Lys
8.356LysAla: 8.356 ± 1.149
0.512LysCys: 0.512 ± 0.256
3.496LysAsp: 3.496 ± 0.444
4.86LysGlu: 4.86 ± 0.669
2.046LysPhe: 2.046 ± 0.406
4.945LysGly: 4.945 ± 0.659
1.45LysHis: 1.45 ± 0.397
2.046LysIle: 2.046 ± 0.352
4.263LysLys: 4.263 ± 0.973
5.457LysLeu: 5.457 ± 0.903
1.876LysMet: 1.876 ± 0.41
1.961LysAsn: 1.961 ± 0.414
3.07LysPro: 3.07 ± 0.733
2.814LysGln: 2.814 ± 0.624
4.178LysArg: 4.178 ± 0.696
3.411LysSer: 3.411 ± 0.606
2.899LysThr: 2.899 ± 0.554
5.542LysVal: 5.542 ± 0.714
0.767LysTrp: 0.767 ± 0.251
1.791LysTyr: 1.791 ± 0.348
0.0LysXaa: 0.0 ± 0.0
Leu
8.1LeuAla: 8.1 ± 1.527
0.171LeuCys: 0.171 ± 0.146
4.775LeuAsp: 4.775 ± 0.419
6.48LeuGlu: 6.48 ± 0.858
2.302LeuPhe: 2.302 ± 0.454
4.093LeuGly: 4.093 ± 0.475
1.108LeuHis: 1.108 ± 0.305
4.434LeuIle: 4.434 ± 0.529
5.798LeuLys: 5.798 ± 0.823
5.031LeuLeu: 5.031 ± 0.848
2.558LeuMet: 2.558 ± 0.455
4.093LeuAsn: 4.093 ± 0.521
3.666LeuPro: 3.666 ± 0.545
3.752LeuGln: 3.752 ± 0.598
5.286LeuArg: 5.286 ± 0.665
4.86LeuSer: 4.86 ± 0.741
5.201LeuThr: 5.201 ± 0.623
4.604LeuVal: 4.604 ± 0.705
1.364LeuTrp: 1.364 ± 0.428
2.473LeuTyr: 2.473 ± 0.443
0.0LeuXaa: 0.0 ± 0.0
Met
2.814MetAla: 2.814 ± 0.383
0.171MetCys: 0.171 ± 0.132
1.876MetAsp: 1.876 ± 0.578
1.62MetGlu: 1.62 ± 0.414
1.194MetPhe: 1.194 ± 0.303
2.387MetGly: 2.387 ± 0.481
0.341MetHis: 0.341 ± 0.198
1.45MetIle: 1.45 ± 0.297
0.853MetLys: 0.853 ± 0.247
3.325MetLeu: 3.325 ± 0.508
1.194MetMet: 1.194 ± 0.339
1.364MetAsn: 1.364 ± 0.269
1.45MetPro: 1.45 ± 0.377
1.279MetGln: 1.279 ± 0.436
1.45MetArg: 1.45 ± 0.347
1.279MetSer: 1.279 ± 0.35
1.791MetThr: 1.791 ± 0.469
2.132MetVal: 2.132 ± 0.456
0.085MetTrp: 0.085 ± 0.093
0.426MetTyr: 0.426 ± 0.204
0.0MetXaa: 0.0 ± 0.0
Asn
3.922AsnAla: 3.922 ± 0.447
0.426AsnCys: 0.426 ± 0.261
2.814AsnAsp: 2.814 ± 0.507
2.729AsnGlu: 2.729 ± 0.398
1.535AsnPhe: 1.535 ± 0.389
3.922AsnGly: 3.922 ± 0.578
0.597AsnHis: 0.597 ± 0.232
2.984AsnIle: 2.984 ± 0.578
2.387AsnLys: 2.387 ± 0.366
3.07AsnLeu: 3.07 ± 0.485
1.023AsnMet: 1.023 ± 0.28
2.132AsnAsn: 2.132 ± 0.369
3.07AsnPro: 3.07 ± 0.566
2.132AsnGln: 2.132 ± 0.381
2.729AsnArg: 2.729 ± 0.761
2.387AsnSer: 2.387 ± 0.632
2.046AsnThr: 2.046 ± 0.359
2.217AsnVal: 2.217 ± 0.611
0.682AsnTrp: 0.682 ± 0.228
2.217AsnTyr: 2.217 ± 0.542
0.0AsnXaa: 0.0 ± 0.0
Pro
2.899ProAla: 2.899 ± 0.445
0.171ProCys: 0.171 ± 0.108
2.814ProAsp: 2.814 ± 0.529
3.752ProGlu: 3.752 ± 0.844
1.45ProPhe: 1.45 ± 0.347
1.961ProGly: 1.961 ± 0.41
0.426ProHis: 0.426 ± 0.166
1.705ProIle: 1.705 ± 0.467
2.899ProLys: 2.899 ± 0.626
2.558ProLeu: 2.558 ± 0.589
1.194ProMet: 1.194 ± 0.338
2.217ProAsn: 2.217 ± 0.477
0.938ProPro: 0.938 ± 0.375
1.108ProGln: 1.108 ± 0.272
2.046ProArg: 2.046 ± 0.422
2.302ProSer: 2.302 ± 0.332
1.876ProThr: 1.876 ± 0.37
2.302ProVal: 2.302 ± 0.553
0.767ProTrp: 0.767 ± 0.161
1.45ProTyr: 1.45 ± 0.391
0.0ProXaa: 0.0 ± 0.0
Gln
4.604GlnAla: 4.604 ± 0.922
0.256GlnCys: 0.256 ± 0.158
2.046GlnAsp: 2.046 ± 0.433
3.581GlnGlu: 3.581 ± 0.587
1.705GlnPhe: 1.705 ± 0.33
3.24GlnGly: 3.24 ± 0.429
0.682GlnHis: 0.682 ± 0.211
1.791GlnIle: 1.791 ± 0.311
2.558GlnLys: 2.558 ± 0.494
3.496GlnLeu: 3.496 ± 0.629
0.938GlnMet: 0.938 ± 0.3
1.45GlnAsn: 1.45 ± 0.398
1.45GlnPro: 1.45 ± 0.403
1.705GlnGln: 1.705 ± 0.322
2.387GlnArg: 2.387 ± 0.483
2.387GlnSer: 2.387 ± 0.533
2.046GlnThr: 2.046 ± 0.545
2.899GlnVal: 2.899 ± 0.477
0.853GlnTrp: 0.853 ± 0.236
1.364GlnTyr: 1.364 ± 0.407
0.0GlnXaa: 0.0 ± 0.0
Arg
6.224ArgAla: 6.224 ± 0.728
0.853ArgCys: 0.853 ± 0.282
3.922ArgAsp: 3.922 ± 0.575
4.69ArgGlu: 4.69 ± 0.62
2.729ArgPhe: 2.729 ± 0.479
3.325ArgGly: 3.325 ± 0.546
1.364ArgHis: 1.364 ± 0.4
2.217ArgIle: 2.217 ± 0.545
3.666ArgLys: 3.666 ± 0.69
5.286ArgLeu: 5.286 ± 0.642
1.705ArgMet: 1.705 ± 0.551
2.558ArgAsn: 2.558 ± 0.535
1.62ArgPro: 1.62 ± 0.339
1.791ArgGln: 1.791 ± 0.374
3.07ArgArg: 3.07 ± 0.423
4.263ArgSer: 4.263 ± 0.818
3.155ArgThr: 3.155 ± 0.48
3.496ArgVal: 3.496 ± 0.557
0.597ArgTrp: 0.597 ± 0.246
1.45ArgTyr: 1.45 ± 0.266
0.0ArgXaa: 0.0 ± 0.0
Ser
5.713SerAla: 5.713 ± 0.819
0.512SerCys: 0.512 ± 0.207
4.519SerAsp: 4.519 ± 0.668
3.581SerGlu: 3.581 ± 0.811
2.814SerPhe: 2.814 ± 0.46
4.519SerGly: 4.519 ± 0.745
1.279SerHis: 1.279 ± 0.313
2.899SerIle: 2.899 ± 0.745
3.24SerLys: 3.24 ± 0.496
3.496SerLeu: 3.496 ± 0.47
0.938SerMet: 0.938 ± 0.327
1.791SerAsn: 1.791 ± 0.378
2.132SerPro: 2.132 ± 0.611
2.132SerGln: 2.132 ± 0.384
3.496SerArg: 3.496 ± 0.593
3.496SerSer: 3.496 ± 0.749
3.155SerThr: 3.155 ± 0.549
4.519SerVal: 4.519 ± 0.538
0.512SerTrp: 0.512 ± 0.131
2.558SerTyr: 2.558 ± 0.551
0.0SerXaa: 0.0 ± 0.0
Thr
4.349ThrAla: 4.349 ± 0.761
0.426ThrCys: 0.426 ± 0.244
2.302ThrAsp: 2.302 ± 0.446
3.24ThrGlu: 3.24 ± 0.545
1.705ThrPhe: 1.705 ± 0.391
5.116ThrGly: 5.116 ± 0.848
1.364ThrHis: 1.364 ± 0.289
3.325ThrIle: 3.325 ± 0.531
3.581ThrLys: 3.581 ± 0.382
5.286ThrLeu: 5.286 ± 0.818
1.279ThrMet: 1.279 ± 0.33
1.876ThrAsn: 1.876 ± 0.39
2.643ThrPro: 2.643 ± 0.541
1.791ThrGln: 1.791 ± 0.361
2.217ThrArg: 2.217 ± 0.373
3.325ThrSer: 3.325 ± 0.575
2.643ThrThr: 2.643 ± 0.506
3.752ThrVal: 3.752 ± 0.526
0.426ThrTrp: 0.426 ± 0.211
1.791ThrTyr: 1.791 ± 0.339
0.0ThrXaa: 0.0 ± 0.0
Val
4.178ValAla: 4.178 ± 0.54
0.256ValCys: 0.256 ± 0.146
3.411ValAsp: 3.411 ± 0.428
4.519ValGlu: 4.519 ± 0.613
1.791ValPhe: 1.791 ± 0.493
4.945ValGly: 4.945 ± 0.774
1.194ValHis: 1.194 ± 0.335
2.387ValIle: 2.387 ± 0.457
4.434ValLys: 4.434 ± 0.749
5.201ValLeu: 5.201 ± 0.674
1.876ValMet: 1.876 ± 0.415
3.666ValAsn: 3.666 ± 0.558
2.643ValPro: 2.643 ± 0.48
3.325ValGln: 3.325 ± 0.61
4.519ValArg: 4.519 ± 0.639
3.666ValSer: 3.666 ± 0.523
4.519ValThr: 4.519 ± 0.539
5.201ValVal: 5.201 ± 0.778
1.023ValTrp: 1.023 ± 0.342
2.387ValTyr: 2.387 ± 0.475
0.0ValXaa: 0.0 ± 0.0
Trp
0.853TrpAla: 0.853 ± 0.183
0.256TrpCys: 0.256 ± 0.181
0.597TrpAsp: 0.597 ± 0.219
1.023TrpGlu: 1.023 ± 0.283
0.341TrpPhe: 0.341 ± 0.161
1.194TrpGly: 1.194 ± 0.377
0.341TrpHis: 0.341 ± 0.175
0.597TrpIle: 0.597 ± 0.322
1.194TrpLys: 1.194 ± 0.372
1.62TrpLeu: 1.62 ± 0.449
0.341TrpMet: 0.341 ± 0.162
1.279TrpAsn: 1.279 ± 0.329
0.341TrpPro: 0.341 ± 0.166
0.938TrpGln: 0.938 ± 0.312
1.023TrpArg: 1.023 ± 0.28
0.682TrpSer: 0.682 ± 0.362
0.767TrpThr: 0.767 ± 0.254
1.194TrpVal: 1.194 ± 0.374
0.426TrpTrp: 0.426 ± 0.253
0.426TrpTyr: 0.426 ± 0.227
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.899TyrAla: 2.899 ± 0.413
0.085TyrCys: 0.085 ± 0.08
2.643TyrAsp: 2.643 ± 0.619
2.387TyrGlu: 2.387 ± 0.422
0.938TyrPhe: 0.938 ± 0.397
2.473TyrGly: 2.473 ± 0.474
0.512TyrHis: 0.512 ± 0.223
1.876TyrIle: 1.876 ± 0.507
1.791TyrLys: 1.791 ± 0.297
2.729TyrLeu: 2.729 ± 0.478
1.023TyrMet: 1.023 ± 0.274
1.45TyrAsn: 1.45 ± 0.287
1.108TyrPro: 1.108 ± 0.292
1.876TyrGln: 1.876 ± 0.45
2.558TyrArg: 2.558 ± 0.393
1.45TyrSer: 1.45 ± 0.337
2.046TyrThr: 2.046 ± 0.481
2.302TyrVal: 2.302 ± 0.454
0.767TyrTrp: 0.767 ± 0.319
0.512TyrTyr: 0.512 ± 0.211
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (11729 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski