Amino acid dipepetide frequency for Amycolatopsis cihanbeyliensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.924AlaAla: 19.924 ± 0.148	1.092AlaCys: 1.092 ± 0.026	7.813AlaAsp: 7.813 ± 0.064	10.784AlaGlu: 10.784 ± 0.097	3.337AlaPhe: 3.337 ± 0.047	14.098AlaGly: 14.098 ± 0.109	2.551AlaHis: 2.551 ± 0.037	3.961AlaIle: 3.961 ± 0.055	2.38AlaLys: 2.38 ± 0.039	13.686AlaLeu: 13.686 ± 0.117	2.45AlaMet: 2.45 ± 0.036	2.124AlaAsn: 2.124 ± 0.032	5.942AlaPro: 5.942 ± 0.059	3.363AlaGln: 3.363 ± 0.044	10.261AlaArg: 10.261 ± 0.081	5.268AlaSer: 5.268 ± 0.046	7.115AlaThr: 7.115 ± 0.064	11.46AlaVal: 11.46 ± 0.091	1.748AlaTrp: 1.748 ± 0.028	2.25AlaTyr: 2.25 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.159CysAla: 1.159 ± 0.024	0.103CysCys: 0.103 ± 0.007	0.414CysAsp: 0.414 ± 0.014	0.403CysGlu: 0.403 ± 0.013	0.23CysPhe: 0.23 ± 0.01	0.963CysGly: 0.963 ± 0.022	0.186CysHis: 0.186 ± 0.01	0.167CysIle: 0.167 ± 0.007	0.101CysLys: 0.101 ± 0.007	0.751CysLeu: 0.751 ± 0.02	0.114CysMet: 0.114 ± 0.008	0.134CysAsn: 0.134 ± 0.009	0.513CysPro: 0.513 ± 0.017	0.181CysGln: 0.181 ± 0.011	0.655CysArg: 0.655 ± 0.018	0.45CysSer: 0.45 ± 0.015	0.532CysThr: 0.532 ± 0.015	0.671CysVal: 0.671 ± 0.019	0.156CysTrp: 0.156 ± 0.009	0.2CysTyr: 0.2 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.9AspAla: 6.9 ± 0.058	0.418AspCys: 0.418 ± 0.014	2.929AspAsp: 2.929 ± 0.042	3.953AspGlu: 3.953 ± 0.047	1.532AspPhe: 1.532 ± 0.027	5.748AspGly: 5.748 ± 0.077	1.268AspHis: 1.268 ± 0.026	1.909AspIle: 1.909 ± 0.033	0.946AspLys: 0.946 ± 0.025	6.305AspLeu: 6.305 ± 0.056	0.742AspMet: 0.742 ± 0.02	1.036AspAsn: 1.036 ± 0.021	4.672AspPro: 4.672 ± 0.05	1.642AspGln: 1.642 ± 0.03	5.067AspArg: 5.067 ± 0.056	2.557AspSer: 2.557 ± 0.035	3.357AspThr: 3.357 ± 0.042	4.401AspVal: 4.401 ± 0.047	0.98AspTrp: 0.98 ± 0.025	1.262AspTyr: 1.262 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.95GluAla: 6.95 ± 0.074	0.412GluCys: 0.412 ± 0.012	2.911GluAsp: 2.911 ± 0.039	3.263GluGlu: 3.263 ± 0.045	1.89GluPhe: 1.89 ± 0.032	4.311GluGly: 4.311 ± 0.046	1.966GluHis: 1.966 ± 0.028	2.409GluIle: 2.409 ± 0.036	1.044GluLys: 1.044 ± 0.028	8.443GluLeu: 8.443 ± 0.073	0.895GluMet: 0.895 ± 0.023	1.067GluAsn: 1.067 ± 0.022	4.142GluPro: 4.142 ± 0.061	2.785GluGln: 2.785 ± 0.041	6.283GluArg: 6.283 ± 0.053	2.778GluSer: 2.778 ± 0.036	2.819GluThr: 2.819 ± 0.039	5.47GluVal: 5.47 ± 0.056	0.906GluTrp: 0.906 ± 0.02	1.223GluTyr: 1.223 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.894PheAla: 3.894 ± 0.047	0.269PheCys: 0.269 ± 0.011	2.112PheAsp: 2.112 ± 0.032	1.485PheGlu: 1.485 ± 0.024	0.863PhePhe: 0.863 ± 0.024	3.282PheGly: 3.282 ± 0.038	0.604PheHis: 0.604 ± 0.017	0.687PheIle: 0.687 ± 0.019	0.327PheLys: 0.327 ± 0.013	2.747PheLeu: 2.747 ± 0.042	0.347PheMet: 0.347 ± 0.013	0.53PheAsn: 0.53 ± 0.015	1.378PhePro: 1.378 ± 0.024	0.68PheGln: 0.68 ± 0.017	1.892PheArg: 1.892 ± 0.028	1.423PheSer: 1.423 ± 0.031	1.96PheThr: 1.96 ± 0.033	2.331PheVal: 2.331 ± 0.038	0.396PheTrp: 0.396 ± 0.015	0.579PheTyr: 0.579 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.605GlyAla: 10.605 ± 0.089	0.874GlyCys: 0.874 ± 0.019	4.945GlyAsp: 4.945 ± 0.048	6.039GlyGlu: 6.039 ± 0.074	2.931GlyPhe: 2.931 ± 0.037	8.866GlyGly: 8.866 ± 0.093	2.155GlyHis: 2.155 ± 0.033	3.608GlyIle: 3.608 ± 0.044	2.281GlyLys: 2.281 ± 0.037	9.582GlyLeu: 9.582 ± 0.082	2.207GlyMet: 2.207 ± 0.033	1.976GlyAsn: 1.976 ± 0.038	4.834GlyPro: 4.834 ± 0.055	2.878GlyGln: 2.878 ± 0.044	7.487GlyArg: 7.487 ± 0.07	5.416GlySer: 5.416 ± 0.06	6.225GlyThr: 6.225 ± 0.071	7.879GlyVal: 7.879 ± 0.067	1.821GlyTrp: 1.821 ± 0.033	2.539GlyTyr: 2.539 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.736HisAla: 2.736 ± 0.038	0.218HisCys: 0.218 ± 0.01	1.271HisAsp: 1.271 ± 0.025	1.306HisGlu: 1.306 ± 0.025	0.591HisPhe: 0.591 ± 0.017	2.523HisGly: 2.523 ± 0.035	0.649HisHis: 0.649 ± 0.022	0.635HisIle: 0.635 ± 0.016	0.296HisLys: 0.296 ± 0.011	2.346HisLeu: 2.346 ± 0.037	0.27HisMet: 0.27 ± 0.012	0.42HisAsn: 0.42 ± 0.017	1.686HisPro: 1.686 ± 0.034	0.666HisGln: 0.666 ± 0.018	2.111HisArg: 2.111 ± 0.031	1.027HisSer: 1.027 ± 0.022	1.264HisThr: 1.264 ± 0.028	1.623HisVal: 1.623 ± 0.028	0.365HisTrp: 0.365 ± 0.013	0.533HisTyr: 0.533 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.822IleAla: 4.822 ± 0.055	0.277IleCys: 0.277 ± 0.011	2.246IleAsp: 2.246 ± 0.034	2.361IleGlu: 2.361 ± 0.036	0.731IlePhe: 0.731 ± 0.02	3.874IleGly: 3.874 ± 0.043	0.596IleHis: 0.596 ± 0.019	0.957IleIle: 0.957 ± 0.027	0.619IleLys: 0.619 ± 0.019	2.434IleLeu: 2.434 ± 0.04	0.418IleMet: 0.418 ± 0.015	0.748IleAsn: 0.748 ± 0.018	1.866IlePro: 1.866 ± 0.031	0.734IleGln: 0.734 ± 0.02	2.457IleArg: 2.457 ± 0.035	1.745IleSer: 1.745 ± 0.032	2.313IleThr: 2.313 ± 0.034	2.803IleVal: 2.803 ± 0.044	0.388IleTrp: 0.388 ± 0.013	0.608IleTyr: 0.608 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.138LysAla: 2.138 ± 0.038	0.097LysCys: 0.097 ± 0.007	0.929LysAsp: 0.929 ± 0.025	0.901LysGlu: 0.901 ± 0.026	0.381LysPhe: 0.381 ± 0.013	1.284LysGly: 1.284 ± 0.028	0.419LysHis: 0.419 ± 0.015	0.726LysIle: 0.726 ± 0.019	0.485LysLys: 0.485 ± 0.02	1.964LysLeu: 1.964 ± 0.038	0.305LysMet: 0.305 ± 0.012	0.362LysAsn: 0.362 ± 0.015	1.191LysPro: 1.191 ± 0.03	0.65LysGln: 0.65 ± 0.019	1.353LysArg: 1.353 ± 0.032	0.891LysSer: 0.891 ± 0.023	0.947LysThr: 0.947 ± 0.023	1.605LysVal: 1.605 ± 0.026	0.222LysTrp: 0.222 ± 0.011	0.362LysTyr: 0.362 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.576LeuAla: 16.576 ± 0.135	0.884LeuCys: 0.884 ± 0.018	7.049LeuAsp: 7.049 ± 0.071	5.181LeuGlu: 5.181 ± 0.057	2.68LeuPhe: 2.68 ± 0.039	9.998LeuGly: 9.998 ± 0.081	2.333LeuHis: 2.333 ± 0.039	3.321LeuIle: 3.321 ± 0.05	1.29LeuLys: 1.29 ± 0.03	12.036LeuLeu: 12.036 ± 0.129	1.365LeuMet: 1.365 ± 0.025	1.771LeuAsn: 1.771 ± 0.029	6.68LeuPro: 6.68 ± 0.075	1.843LeuGln: 1.843 ± 0.03	9.804LeuArg: 9.804 ± 0.084	5.391LeuSer: 5.391 ± 0.056	6.56LeuThr: 6.56 ± 0.057	9.436LeuVal: 9.436 ± 0.083	1.261LeuTrp: 1.261 ± 0.027	1.717LeuTyr: 1.717 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.075MetAla: 2.075 ± 0.034	0.114MetCys: 0.114 ± 0.007	0.817MetAsp: 0.817 ± 0.019	0.63MetGlu: 0.63 ± 0.017	0.511MetPhe: 0.511 ± 0.015	1.156MetGly: 1.156 ± 0.022	0.352MetHis: 0.352 ± 0.013	0.712MetIle: 0.712 ± 0.02	0.323MetLys: 0.323 ± 0.014	1.872MetLeu: 1.872 ± 0.026	0.26MetMet: 0.26 ± 0.013	0.42MetAsn: 0.42 ± 0.015	1.097MetPro: 1.097 ± 0.023	0.387MetGln: 0.387 ± 0.013	1.476MetArg: 1.476 ± 0.029	1.315MetSer: 1.315 ± 0.025	1.445MetThr: 1.445 ± 0.027	1.384MetVal: 1.384 ± 0.026	0.201MetTrp: 0.201 ± 0.01	0.272MetTyr: 0.272 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.168AsnAla: 2.168 ± 0.031	0.178AsnCys: 0.178 ± 0.009	0.923AsnAsp: 0.923 ± 0.024	0.964AsnGlu: 0.964 ± 0.022	0.486AsnPhe: 0.486 ± 0.016	1.897AsnGly: 1.897 ± 0.037	0.41AsnHis: 0.41 ± 0.013	0.63AsnIle: 0.63 ± 0.017	0.365AsnLys: 0.365 ± 0.014	1.92AsnLeu: 1.92 ± 0.033	0.293AsnMet: 0.293 ± 0.013	0.441AsnAsn: 0.441 ± 0.017	1.449AsnPro: 1.449 ± 0.029	0.593AsnGln: 0.593 ± 0.018	1.428AsnArg: 1.428 ± 0.027	0.94AsnSer: 0.94 ± 0.024	1.19AsnThr: 1.19 ± 0.024	1.428AsnVal: 1.428 ± 0.025	0.298AsnTrp: 0.298 ± 0.012	0.459AsnTyr: 0.459 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.362ProAla: 8.362 ± 0.097	0.378ProCys: 0.378 ± 0.016	4.437ProAsp: 4.437 ± 0.05	4.906ProGlu: 4.906 ± 0.053	1.537ProPhe: 1.537 ± 0.028	6.485ProGly: 6.485 ± 0.068	1.233ProHis: 1.233 ± 0.024	1.653ProIle: 1.653 ± 0.026	0.985ProLys: 0.985 ± 0.023	5.148ProLeu: 5.148 ± 0.055	1.022ProMet: 1.022 ± 0.021	1.124ProAsn: 1.124 ± 0.026	3.696ProPro: 3.696 ± 0.07	1.436ProGln: 1.436 ± 0.031	4.214ProArg: 4.214 ± 0.045	2.927ProSer: 2.927 ± 0.041	3.176ProThr: 3.176 ± 0.048	5.359ProVal: 5.359 ± 0.052	0.85ProTrp: 0.85 ± 0.021	1.113ProTyr: 1.113 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.738GlnAla: 3.738 ± 0.053	0.178GlnCys: 0.178 ± 0.009	1.352GlnAsp: 1.352 ± 0.024	1.348GlnGlu: 1.348 ± 0.025	0.705GlnPhe: 0.705 ± 0.018	2.034GlnGly: 2.034 ± 0.032	0.733GlnHis: 0.733 ± 0.02	0.943GlnIle: 0.943 ± 0.024	0.385GlnLys: 0.385 ± 0.014	3.137GlnLeu: 3.137 ± 0.038	0.385GlnMet: 0.385 ± 0.015	0.459GlnAsn: 0.459 ± 0.016	1.933GlnPro: 1.933 ± 0.042	1.325GlnGln: 1.325 ± 0.032	2.888GlnArg: 2.888 ± 0.037	1.132GlnSer: 1.132 ± 0.026	1.136GlnThr: 1.136 ± 0.026	2.671GlnVal: 2.671 ± 0.035	0.44GlnTrp: 0.44 ± 0.014	0.544GlnTyr: 0.544 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.327ArgAla: 10.327 ± 0.088	0.691ArgCys: 0.691 ± 0.019	4.316ArgAsp: 4.316 ± 0.045	5.109ArgGlu: 5.109 ± 0.053	2.585ArgPhe: 2.585 ± 0.036	6.241ArgGly: 6.241 ± 0.057	2.151ArgHis: 2.151 ± 0.033	3.295ArgIle: 3.295 ± 0.04	1.738ArgLys: 1.738 ± 0.031	9.323ArgLeu: 9.323 ± 0.086	1.915ArgMet: 1.915 ± 0.03	1.59ArgAsn: 1.59 ± 0.026	4.967ArgPro: 4.967 ± 0.054	2.637ArgGln: 2.637 ± 0.037	7.977ArgArg: 7.977 ± 0.079	4.163ArgSer: 4.163 ± 0.043	5.145ArgThr: 5.145 ± 0.046	6.399ArgVal: 6.399 ± 0.054	1.526ArgTrp: 1.526 ± 0.025	2.03ArgTyr: 2.03 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.42SerAla: 6.42 ± 0.06	0.441SerCys: 0.441 ± 0.017	2.4SerAsp: 2.4 ± 0.035	2.514SerGlu: 2.514 ± 0.04	1.569SerPhe: 1.569 ± 0.026	5.896SerGly: 5.896 ± 0.059	0.881SerHis: 0.881 ± 0.02	1.585SerIle: 1.585 ± 0.03	0.884SerLys: 0.884 ± 0.025	4.615SerLeu: 4.615 ± 0.048	1.142SerMet: 1.142 ± 0.024	0.895SerAsn: 0.895 ± 0.021	2.972SerPro: 2.972 ± 0.038	1.105SerGln: 1.105 ± 0.025	3.727SerArg: 3.727 ± 0.044	2.775SerSer: 2.775 ± 0.04	3.425SerThr: 3.425 ± 0.039	4.163SerVal: 4.163 ± 0.051	0.967SerTrp: 0.967 ± 0.02	1.249SerTyr: 1.249 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	7.879ThrAla: 7.879 ± 0.067	0.419ThrCys: 0.419 ± 0.014	3.385ThrAsp: 3.385 ± 0.04	4.111ThrGlu: 4.111 ± 0.045	1.659ThrPhe: 1.659 ± 0.027	6.778ThrGly: 6.778 ± 0.058	1.124ThrHis: 1.124 ± 0.025	2.0ThrIle: 2.0 ± 0.03	1.0ThrLys: 1.0 ± 0.024	5.656ThrLeu: 5.656 ± 0.053	1.113ThrMet: 1.113 ± 0.022	0.945ThrAsn: 0.945 ± 0.025	3.644ThrPro: 3.644 ± 0.045	1.267ThrGln: 1.267 ± 0.025	4.058ThrArg: 4.058 ± 0.043	3.064ThrSer: 3.064 ± 0.037	3.675ThrThr: 3.675 ± 0.054	6.037ThrVal: 6.037 ± 0.056	0.869ThrTrp: 0.869 ± 0.023	1.163ThrTyr: 1.163 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	10.995ValAla: 10.995 ± 0.078	0.687ValCys: 0.687 ± 0.019	5.399ValAsp: 5.399 ± 0.05	4.954ValGlu: 4.954 ± 0.048	2.391ValPhe: 2.391 ± 0.035	6.718ValGly: 6.718 ± 0.056	2.027ValHis: 2.027 ± 0.028	2.791ValIle: 2.791 ± 0.04	1.228ValLys: 1.228 ± 0.026	10.773ValLeu: 10.773 ± 0.097	1.08ValMet: 1.08 ± 0.02	1.64ValAsn: 1.64 ± 0.029	5.265ValPro: 5.265 ± 0.059	1.975ValGln: 1.975 ± 0.03	7.442ValArg: 7.442 ± 0.065	4.467ValSer: 4.467 ± 0.048	5.488ValThr: 5.488 ± 0.058	8.021ValVal: 8.021 ± 0.07	1.054ValTrp: 1.054 ± 0.024	1.476ValTyr: 1.476 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.525TrpAla: 1.525 ± 0.026	0.163TrpCys: 0.163 ± 0.009	0.747TrpAsp: 0.747 ± 0.02	0.688TrpGlu: 0.688 ± 0.018	0.525TrpPhe: 0.525 ± 0.015	0.965TrpGly: 0.965 ± 0.024	0.408TrpHis: 0.408 ± 0.017	0.576TrpIle: 0.576 ± 0.017	0.246TrpLys: 0.246 ± 0.01	1.971TrpLeu: 1.971 ± 0.034	0.307TrpMet: 0.307 ± 0.013	0.384TrpAsn: 0.384 ± 0.012	0.878TrpPro: 0.878 ± 0.023	0.642TrpGln: 0.642 ± 0.018	1.522TrpArg: 1.522 ± 0.023	0.923TrpSer: 0.923 ± 0.021	0.935TrpThr: 0.935 ± 0.023	1.105TrpVal: 1.105 ± 0.025	0.367TrpTrp: 0.367 ± 0.015	0.332TrpTyr: 0.332 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.415TyrAla: 2.415 ± 0.032	0.19TyrCys: 0.19 ± 0.01	1.23TyrAsp: 1.23 ± 0.031	1.069TyrGlu: 1.069 ± 0.026	0.653TyrPhe: 0.653 ± 0.021	2.031TyrGly: 2.031 ± 0.037	0.488TyrHis: 0.488 ± 0.015	0.428TyrIle: 0.428 ± 0.015	0.287TyrLys: 0.287 ± 0.013	2.469TyrLeu: 2.469 ± 0.035	0.191TyrMet: 0.191 ± 0.01	0.392TyrAsn: 0.392 ± 0.014	1.237TyrPro: 1.237 ± 0.026	0.681TyrGln: 0.681 ± 0.018	2.021TyrArg: 2.021 ± 0.032	0.972TyrSer: 0.972 ± 0.019	1.141TyrThr: 1.141 ± 0.027	1.623TyrVal: 1.623 ± 0.028	0.394TyrTrp: 0.394 ± 0.013	0.492TyrTyr: 0.492 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6558 proteins (2202454 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---