Amino acid dipepetide frequency for Psychrobacillus sp. FJAT-21963

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.261AlaAla: 5.261 ± 0.092	0.545AlaCys: 0.545 ± 0.023	3.198AlaAsp: 3.198 ± 0.06	4.38AlaGlu: 4.38 ± 0.077	3.349AlaPhe: 3.349 ± 0.055	4.948AlaGly: 4.948 ± 0.086	1.257AlaHis: 1.257 ± 0.032	6.407AlaIle: 6.407 ± 0.082	4.686AlaLys: 4.686 ± 0.072	6.906AlaLeu: 6.906 ± 0.083	1.925AlaMet: 1.925 ± 0.047	3.021AlaAsn: 3.021 ± 0.056	1.994AlaPro: 1.994 ± 0.045	2.146AlaGln: 2.146 ± 0.048	2.388AlaArg: 2.388 ± 0.047	4.221AlaSer: 4.221 ± 0.058	3.734AlaThr: 3.734 ± 0.065	4.918AlaVal: 4.918 ± 0.084	0.564AlaTrp: 0.564 ± 0.025	2.304AlaTyr: 2.304 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.399CysAla: 0.399 ± 0.022	0.075CysCys: 0.075 ± 0.009	0.361CysAsp: 0.361 ± 0.018	0.414CysGlu: 0.414 ± 0.02	0.281CysPhe: 0.281 ± 0.016	0.6CysGly: 0.6 ± 0.027	0.171CysHis: 0.171 ± 0.014	0.558CysIle: 0.558 ± 0.024	0.325CysLys: 0.325 ± 0.017	0.582CysLeu: 0.582 ± 0.025	0.17CysMet: 0.17 ± 0.014	0.269CysAsn: 0.269 ± 0.015	0.316CysPro: 0.316 ± 0.02	0.185CysGln: 0.185 ± 0.014	0.257CysArg: 0.257 ± 0.016	0.448CysSer: 0.448 ± 0.02	0.363CysThr: 0.363 ± 0.018	0.371CysVal: 0.371 ± 0.019	0.069CysTrp: 0.069 ± 0.008	0.223CysTyr: 0.223 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.427AspAla: 3.427 ± 0.059	0.314AspCys: 0.314 ± 0.016	2.297AspAsp: 2.297 ± 0.048	4.31AspGlu: 4.31 ± 0.067	2.565AspPhe: 2.565 ± 0.058	3.277AspGly: 3.277 ± 0.063	0.979AspHis: 0.979 ± 0.03	4.267AspIle: 4.267 ± 0.064	3.14AspLys: 3.14 ± 0.065	4.895AspLeu: 4.895 ± 0.063	1.288AspMet: 1.288 ± 0.036	1.93AspAsn: 1.93 ± 0.044	1.789AspPro: 1.789 ± 0.044	1.732AspGln: 1.732 ± 0.037	1.937AspArg: 1.937 ± 0.04	2.782AspSer: 2.782 ± 0.057	2.453AspThr: 2.453 ± 0.046	3.688AspVal: 3.688 ± 0.063	0.565AspTrp: 0.565 ± 0.021	2.101AspTyr: 2.101 ± 0.042	0.002AspXaa: 0.002 ± 0.001
Glu	5.322GluAla: 5.322 ± 0.088	0.374GluCys: 0.374 ± 0.019	3.871GluAsp: 3.871 ± 0.061	7.613GluGlu: 7.613 ± 0.105	2.691GluPhe: 2.691 ± 0.051	4.276GluGly: 4.276 ± 0.069	1.437GluHis: 1.437 ± 0.037	6.107GluIle: 6.107 ± 0.082	6.674GluLys: 6.674 ± 0.093	7.194GluLeu: 7.194 ± 0.099	2.275GluMet: 2.275 ± 0.051	4.133GluAsn: 4.133 ± 0.064	1.84GluPro: 1.84 ± 0.045	3.397GluGln: 3.397 ± 0.06	3.224GluArg: 3.224 ± 0.063	3.853GluSer: 3.853 ± 0.059	3.981GluThr: 3.981 ± 0.057	5.543GluVal: 5.543 ± 0.075	0.904GluTrp: 0.904 ± 0.036	2.273GluTyr: 2.273 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.066PheAla: 3.066 ± 0.053	0.31PheCys: 0.31 ± 0.017	2.39PheAsp: 2.39 ± 0.041	3.222PheGlu: 3.222 ± 0.056	2.448PhePhe: 2.448 ± 0.065	3.408PheGly: 3.408 ± 0.069	1.03PheHis: 1.03 ± 0.03	4.069PheIle: 4.069 ± 0.075	2.434PheLys: 2.434 ± 0.046	4.643PheLeu: 4.643 ± 0.08	1.18PheMet: 1.18 ± 0.037	2.13PheAsn: 2.13 ± 0.045	1.742PhePro: 1.742 ± 0.044	1.677PheGln: 1.677 ± 0.043	1.461PheArg: 1.461 ± 0.039	3.35PheSer: 3.35 ± 0.061	2.75PheThr: 2.75 ± 0.049	3.358PheVal: 3.358 ± 0.059	0.521PheTrp: 0.521 ± 0.025	1.827PheTyr: 1.827 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.705GlyAla: 4.705 ± 0.098	0.543GlyCys: 0.543 ± 0.024	3.094GlyAsp: 3.094 ± 0.063	4.504GlyGlu: 4.504 ± 0.073	3.337GlyPhe: 3.337 ± 0.056	4.462GlyGly: 4.462 ± 0.082	1.291GlyHis: 1.291 ± 0.03	6.081GlyIle: 6.081 ± 0.08	4.912GlyLys: 4.912 ± 0.07	6.27GlyLeu: 6.27 ± 0.086	2.015GlyMet: 2.015 ± 0.052	2.855GlyAsn: 2.855 ± 0.05	1.682GlyPro: 1.682 ± 0.043	2.195GlyGln: 2.195 ± 0.054	2.35GlyArg: 2.35 ± 0.05	3.854GlySer: 3.854 ± 0.063	3.961GlyThr: 3.961 ± 0.056	4.807GlyVal: 4.807 ± 0.071	0.721GlyTrp: 0.721 ± 0.028	2.749GlyTyr: 2.749 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.319HisAla: 1.319 ± 0.037	0.15HisCys: 0.15 ± 0.015	0.96HisAsp: 0.96 ± 0.031	1.288HisGlu: 1.288 ± 0.035	1.034HisPhe: 1.034 ± 0.031	1.334HisGly: 1.334 ± 0.038	0.608HisHis: 0.608 ± 0.026	1.558HisIle: 1.558 ± 0.039	1.0HisLys: 1.0 ± 0.029	2.111HisLeu: 2.111 ± 0.042	0.501HisMet: 0.501 ± 0.022	0.76HisAsn: 0.76 ± 0.026	1.082HisPro: 1.082 ± 0.031	0.754HisGln: 0.754 ± 0.028	0.763HisArg: 0.763 ± 0.027	1.138HisSer: 1.138 ± 0.032	1.084HisThr: 1.084 ± 0.032	1.3HisVal: 1.3 ± 0.036	0.191HisTrp: 0.191 ± 0.014	0.794HisTyr: 0.794 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.369IleAla: 6.369 ± 0.085	0.629IleCys: 0.629 ± 0.025	4.447IleAsp: 4.447 ± 0.064	6.255IleGlu: 6.255 ± 0.09	3.596IlePhe: 3.596 ± 0.071	6.188IleGly: 6.188 ± 0.094	1.727IleHis: 1.727 ± 0.038	6.861IleIle: 6.861 ± 0.088	4.655IleLys: 4.655 ± 0.078	7.849IleLeu: 7.849 ± 0.097	1.917IleMet: 1.917 ± 0.045	3.579IleAsn: 3.579 ± 0.062	3.498IlePro: 3.498 ± 0.065	3.289IleGln: 3.289 ± 0.053	3.17IleArg: 3.17 ± 0.053	5.471IleSer: 5.471 ± 0.077	4.569IleThr: 4.569 ± 0.06	6.243IleVal: 6.243 ± 0.089	0.686IleTrp: 0.686 ± 0.029	2.553IleTyr: 2.553 ± 0.055	0.003IleXaa: 0.003 ± 0.002
Lys	4.329LysAla: 4.329 ± 0.07	0.333LysCys: 0.333 ± 0.017	3.818LysAsp: 3.818 ± 0.061	7.017LysGlu: 7.017 ± 0.096	2.206LysPhe: 2.206 ± 0.046	4.27LysGly: 4.27 ± 0.069	1.268LysHis: 1.268 ± 0.035	4.879LysIle: 4.879 ± 0.075	5.721LysLys: 5.721 ± 0.073	6.106LysLeu: 6.106 ± 0.084	2.291LysMet: 2.291 ± 0.04	3.613LysAsn: 3.613 ± 0.065	2.077LysPro: 2.077 ± 0.043	2.844LysGln: 2.844 ± 0.046	2.984LysArg: 2.984 ± 0.053	3.809LysSer: 3.809 ± 0.064	3.741LysThr: 3.741 ± 0.061	4.841LysVal: 4.841 ± 0.064	0.857LysTrp: 0.857 ± 0.028	2.267LysTyr: 2.267 ± 0.052	0.001LysXaa: 0.001 ± 0.001
Leu	7.097LeuAla: 7.097 ± 0.09	0.611LeuCys: 0.611 ± 0.024	4.765LeuAsp: 4.765 ± 0.064	7.025LeuGlu: 7.025 ± 0.095	5.008LeuPhe: 5.008 ± 0.08	6.151LeuGly: 6.151 ± 0.092	1.942LeuHis: 1.942 ± 0.047	7.573LeuIle: 7.573 ± 0.103	6.657LeuLys: 6.657 ± 0.09	10.407LeuLeu: 10.407 ± 0.125	2.461LeuMet: 2.461 ± 0.05	4.47LeuAsn: 4.47 ± 0.067	3.781LeuPro: 3.781 ± 0.059	3.671LeuGln: 3.671 ± 0.061	3.381LeuArg: 3.381 ± 0.056	6.856LeuSer: 6.856 ± 0.073	5.606LeuThr: 5.606 ± 0.068	6.521LeuVal: 6.521 ± 0.088	0.8LeuTrp: 0.8 ± 0.033	3.109LeuTyr: 3.109 ± 0.047	0.001LeuXaa: 0.001 ± 0.001
Met	1.774MetAla: 1.774 ± 0.036	0.147MetCys: 0.147 ± 0.012	1.495MetAsp: 1.495 ± 0.039	2.196MetGlu: 2.196 ± 0.053	1.085MetPhe: 1.085 ± 0.031	1.638MetGly: 1.638 ± 0.046	0.481MetHis: 0.481 ± 0.023	2.106MetIle: 2.106 ± 0.046	2.512MetLys: 2.512 ± 0.048	2.461MetLeu: 2.461 ± 0.048	0.786MetMet: 0.786 ± 0.029	1.593MetAsn: 1.593 ± 0.035	0.959MetPro: 0.959 ± 0.029	0.93MetGln: 0.93 ± 0.032	1.042MetArg: 1.042 ± 0.028	1.747MetSer: 1.747 ± 0.037	1.74MetThr: 1.74 ± 0.04	1.56MetVal: 1.56 ± 0.038	0.196MetTrp: 0.196 ± 0.014	0.78MetTyr: 0.78 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.03AsnAla: 3.03 ± 0.055	0.296AsnCys: 0.296 ± 0.016	2.318AsnAsp: 2.318 ± 0.047	3.96AsnGlu: 3.96 ± 0.06	1.878AsnPhe: 1.878 ± 0.043	3.498AsnGly: 3.498 ± 0.064	0.959AsnHis: 0.959 ± 0.031	3.769AsnIle: 3.769 ± 0.061	3.322AsnLys: 3.322 ± 0.063	4.112AsnLeu: 4.112 ± 0.06	1.299AsnMet: 1.299 ± 0.033	2.466AsnAsn: 2.466 ± 0.052	2.173AsnPro: 2.173 ± 0.045	1.746AsnGln: 1.746 ± 0.045	1.986AsnArg: 1.986 ± 0.04	2.738AsnSer: 2.738 ± 0.057	2.366AsnThr: 2.366 ± 0.05	3.121AsnVal: 3.121 ± 0.059	0.544AsnTrp: 0.544 ± 0.025	1.76AsnTyr: 1.76 ± 0.044	0.003AsnXaa: 0.003 ± 0.002
Pro	2.067ProAla: 2.067 ± 0.049	0.179ProCys: 0.179 ± 0.014	1.728ProAsp: 1.728 ± 0.041	2.725ProGlu: 2.725 ± 0.058	2.044ProPhe: 2.044 ± 0.046	2.098ProGly: 2.098 ± 0.052	0.738ProHis: 0.738 ± 0.024	3.055ProIle: 3.055 ± 0.055	2.189ProLys: 2.189 ± 0.043	3.428ProLeu: 3.428 ± 0.062	0.824ProMet: 0.824 ± 0.029	1.774ProAsn: 1.774 ± 0.038	0.926ProPro: 0.926 ± 0.037	1.036ProGln: 1.036 ± 0.028	0.945ProArg: 0.945 ± 0.028	2.356ProSer: 2.356 ± 0.054	2.105ProThr: 2.105 ± 0.041	2.687ProVal: 2.687 ± 0.047	0.356ProTrp: 0.356 ± 0.021	1.354ProTyr: 1.354 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.606GlnAla: 2.606 ± 0.047	0.17GlnCys: 0.17 ± 0.013	1.581GlnAsp: 1.581 ± 0.039	2.635GlnGlu: 2.635 ± 0.051	1.615GlnPhe: 1.615 ± 0.038	1.99GlnGly: 1.99 ± 0.052	0.74GlnHis: 0.74 ± 0.024	2.744GlnIle: 2.744 ± 0.06	2.626GlnLys: 2.626 ± 0.052	4.082GlnLeu: 4.082 ± 0.066	1.073GlnMet: 1.073 ± 0.032	1.681GlnAsn: 1.681 ± 0.037	1.08GlnPro: 1.08 ± 0.033	1.649GlnGln: 1.649 ± 0.05	1.279GlnArg: 1.279 ± 0.037	2.239GlnSer: 2.239 ± 0.048	1.936GlnThr: 1.936 ± 0.045	2.469GlnVal: 2.469 ± 0.049	0.336GlnTrp: 0.336 ± 0.018	1.218GlnTyr: 1.218 ± 0.029	0.001GlnXaa: 0.001 ± 0.001
Arg	2.257ArgAla: 2.257 ± 0.042	0.2ArgCys: 0.2 ± 0.014	1.887ArgAsp: 1.887 ± 0.036	2.92ArgGlu: 2.92 ± 0.063	1.836ArgPhe: 1.836 ± 0.044	2.162ArgGly: 2.162 ± 0.047	0.665ArgHis: 0.665 ± 0.024	3.014ArgIle: 3.014 ± 0.055	2.965ArgLys: 2.965 ± 0.057	3.744ArgLeu: 3.744 ± 0.063	1.149ArgMet: 1.149 ± 0.033	1.833ArgAsn: 1.833 ± 0.043	1.203ArgPro: 1.203 ± 0.037	1.335ArgGln: 1.335 ± 0.033	1.508ArgArg: 1.508 ± 0.039	2.025ArgSer: 2.025 ± 0.048	1.907ArgThr: 1.907 ± 0.044	2.536ArgVal: 2.536 ± 0.052	0.339ArgTrp: 0.339 ± 0.016	1.312ArgTyr: 1.312 ± 0.032	0.001ArgXaa: 0.001 ± 0.001
Ser	3.634SerAla: 3.634 ± 0.05	0.348SerCys: 0.348 ± 0.018	2.834SerAsp: 2.834 ± 0.052	4.227SerGlu: 4.227 ± 0.067	3.543SerPhe: 3.543 ± 0.063	4.22SerGly: 4.22 ± 0.056	1.142SerHis: 1.142 ± 0.029	5.919SerIle: 5.919 ± 0.074	4.154SerLys: 4.154 ± 0.064	6.395SerLeu: 6.395 ± 0.076	1.724SerMet: 1.724 ± 0.038	3.041SerAsn: 3.041 ± 0.05	2.166SerPro: 2.166 ± 0.047	1.829SerGln: 1.829 ± 0.046	2.084SerArg: 2.084 ± 0.045	4.195SerSer: 4.195 ± 0.066	3.607SerThr: 3.607 ± 0.06	4.239SerVal: 4.239 ± 0.057	0.582SerTrp: 0.582 ± 0.026	2.321SerTyr: 2.321 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	3.81ThrAla: 3.81 ± 0.061	0.317ThrCys: 0.317 ± 0.019	2.658ThrAsp: 2.658 ± 0.049	3.874ThrGlu: 3.874 ± 0.068	2.775ThrPhe: 2.775 ± 0.049	4.09ThrGly: 4.09 ± 0.066	1.061ThrHis: 1.061 ± 0.036	5.099ThrIle: 5.099 ± 0.071	3.705ThrLys: 3.705 ± 0.058	5.335ThrLeu: 5.335 ± 0.066	1.328ThrMet: 1.328 ± 0.036	2.82ThrAsn: 2.82 ± 0.051	2.241ThrPro: 2.241 ± 0.043	1.482ThrGln: 1.482 ± 0.037	1.701ThrArg: 1.701 ± 0.034	3.693ThrSer: 3.693 ± 0.057	3.239ThrThr: 3.239 ± 0.063	4.053ThrVal: 4.053 ± 0.061	0.536ThrTrp: 0.536 ± 0.023	1.995ThrTyr: 1.995 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	4.878ValAla: 4.878 ± 0.069	0.515ValCys: 0.515 ± 0.024	3.636ValAsp: 3.636 ± 0.055	5.138ValGlu: 5.138 ± 0.085	3.296ValPhe: 3.296 ± 0.058	4.753ValGly: 4.753 ± 0.075	1.325ValHis: 1.325 ± 0.039	5.868ValIle: 5.868 ± 0.093	4.568ValLys: 4.568 ± 0.069	6.999ValLeu: 6.999 ± 0.085	1.809ValMet: 1.809 ± 0.045	3.186ValAsn: 3.186 ± 0.056	2.517ValPro: 2.517 ± 0.048	2.392ValGln: 2.392 ± 0.052	2.542ValArg: 2.542 ± 0.048	4.618ValSer: 4.618 ± 0.07	4.184ValThr: 4.184 ± 0.068	5.184ValVal: 5.184 ± 0.078	0.634ValTrp: 0.634 ± 0.024	2.232ValTyr: 2.232 ± 0.045	0.001ValXaa: 0.001 ± 0.001
Trp	0.571TrpAla: 0.571 ± 0.025	0.08TrpCys: 0.08 ± 0.008	0.497TrpAsp: 0.497 ± 0.023	0.661TrpGlu: 0.661 ± 0.028	0.518TrpPhe: 0.518 ± 0.022	0.644TrpGly: 0.644 ± 0.028	0.2TrpHis: 0.2 ± 0.013	0.881TrpIle: 0.881 ± 0.032	0.758TrpLys: 0.758 ± 0.032	1.04TrpLeu: 1.04 ± 0.035	0.355TrpMet: 0.355 ± 0.02	0.596TrpAsn: 0.596 ± 0.025	0.238TrpPro: 0.238 ± 0.017	0.298TrpGln: 0.298 ± 0.014	0.354TrpArg: 0.354 ± 0.019	0.638TrpSer: 0.638 ± 0.027	0.566TrpThr: 0.566 ± 0.024	0.588TrpVal: 0.588 ± 0.026	0.121TrpTrp: 0.121 ± 0.012	0.327TrpTyr: 0.327 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.23TyrAla: 2.23 ± 0.047	0.3TyrCys: 0.3 ± 0.017	1.902TyrAsp: 1.902 ± 0.046	2.619TyrGlu: 2.619 ± 0.058	1.907TyrPhe: 1.907 ± 0.051	2.379TyrGly: 2.379 ± 0.052	0.707TyrHis: 0.707 ± 0.026	2.737TyrIle: 2.737 ± 0.05	2.268TyrLys: 2.268 ± 0.05	3.332TyrLeu: 3.332 ± 0.052	0.858TyrMet: 0.858 ± 0.025	1.592TyrAsn: 1.592 ± 0.039	1.308TyrPro: 1.308 ± 0.038	1.16TyrGln: 1.16 ± 0.036	1.443TyrArg: 1.443 ± 0.035	2.173TyrSer: 2.173 ± 0.044	1.924TyrThr: 1.924 ± 0.044	2.249TyrVal: 2.249 ± 0.047	0.41TyrTrp: 0.41 ± 0.02	1.369TyrTyr: 1.369 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.002XaaIle: 0.002 ± 0.001	0.003XaaLys: 0.003 ± 0.002	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3910 proteins (1109097 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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