Amino acid dipepetide frequency for Polaribacter sp. ALD11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.261AlaAla: 4.261 ± 0.076	0.463AlaCys: 0.463 ± 0.019	3.132AlaAsp: 3.132 ± 0.067	3.608AlaGlu: 3.608 ± 0.073	3.286AlaPhe: 3.286 ± 0.061	3.959AlaGly: 3.959 ± 0.078	1.013AlaHis: 1.013 ± 0.032	5.763AlaIle: 5.763 ± 0.08	4.948AlaLys: 4.948 ± 0.079	5.559AlaLeu: 5.559 ± 0.079	1.348AlaMet: 1.348 ± 0.039	3.498AlaAsn: 3.498 ± 0.087	1.707AlaPro: 1.707 ± 0.04	2.043AlaGln: 2.043 ± 0.047	1.785AlaArg: 1.785 ± 0.044	4.186AlaSer: 4.186 ± 0.072	3.961AlaThr: 3.961 ± 0.088	4.019AlaVal: 4.019 ± 0.071	0.514AlaTrp: 0.514 ± 0.024	2.209AlaTyr: 2.209 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.393CysAla: 0.393 ± 0.02	0.089CysCys: 0.089 ± 0.009	0.354CysAsp: 0.354 ± 0.018	0.407CysGlu: 0.407 ± 0.024	0.387CysPhe: 0.387 ± 0.019	0.538CysGly: 0.538 ± 0.026	0.13CysHis: 0.13 ± 0.011	0.535CysIle: 0.535 ± 0.026	0.504CysLys: 0.504 ± 0.023	0.593CysLeu: 0.593 ± 0.026	0.119CysMet: 0.119 ± 0.011	0.399CysAsn: 0.399 ± 0.022	0.276CysPro: 0.276 ± 0.019	0.167CysGln: 0.167 ± 0.012	0.158CysArg: 0.158 ± 0.012	0.484CysSer: 0.484 ± 0.025	0.394CysThr: 0.394 ± 0.022	0.392CysVal: 0.392 ± 0.022	0.057CysTrp: 0.057 ± 0.007	0.25CysTyr: 0.25 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.758AspAla: 3.758 ± 0.073	0.375AspCys: 0.375 ± 0.02	2.608AspAsp: 2.608 ± 0.076	3.559AspGlu: 3.559 ± 0.058	3.779AspPhe: 3.779 ± 0.058	3.503AspGly: 3.503 ± 0.169	0.681AspHis: 0.681 ± 0.025	4.332AspIle: 4.332 ± 0.069	4.445AspLys: 4.445 ± 0.066	5.126AspLeu: 5.126 ± 0.07	0.883AspMet: 0.883 ± 0.034	3.231AspAsn: 3.231 ± 0.088	1.28AspPro: 1.28 ± 0.04	1.112AspGln: 1.112 ± 0.035	1.65AspArg: 1.65 ± 0.04	3.129AspSer: 3.129 ± 0.07	2.853AspThr: 2.853 ± 0.11	3.677AspVal: 3.677 ± 0.059	0.682AspTrp: 0.682 ± 0.029	2.433AspTyr: 2.433 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	3.994GluAla: 3.994 ± 0.064	0.297GluCys: 0.297 ± 0.018	3.516GluAsp: 3.516 ± 0.076	5.09GluGlu: 5.09 ± 0.094	3.026GluPhe: 3.026 ± 0.057	3.626GluGly: 3.626 ± 0.06	1.014GluHis: 1.014 ± 0.03	6.234GluIle: 6.234 ± 0.094	6.743GluLys: 6.743 ± 0.102	6.015GluLeu: 6.015 ± 0.081	1.435GluMet: 1.435 ± 0.039	5.396GluAsn: 5.396 ± 0.087	1.328GluPro: 1.328 ± 0.036	1.926GluGln: 1.926 ± 0.048	2.31GluArg: 2.31 ± 0.055	3.188GluSer: 3.188 ± 0.05	3.908GluThr: 3.908 ± 0.061	4.414GluVal: 4.414 ± 0.066	0.53GluTrp: 0.53 ± 0.021	2.367GluTyr: 2.367 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.841PheAla: 2.841 ± 0.053	0.435PheCys: 0.435 ± 0.021	3.194PheAsp: 3.194 ± 0.052	3.308PheGlu: 3.308 ± 0.067	2.988PhePhe: 2.988 ± 0.064	3.754PheGly: 3.754 ± 0.076	0.8PheHis: 0.8 ± 0.029	4.628PheIle: 4.628 ± 0.081	4.489PheLys: 4.489 ± 0.064	5.19PheLeu: 5.19 ± 0.091	1.097PheMet: 1.097 ± 0.037	3.7PheAsn: 3.7 ± 0.064	1.67PhePro: 1.67 ± 0.038	1.469PheGln: 1.469 ± 0.041	1.556PheArg: 1.556 ± 0.043	4.634PheSer: 4.634 ± 0.082	3.422PheThr: 3.422 ± 0.064	3.022PheVal: 3.022 ± 0.059	0.568PheTrp: 0.568 ± 0.026	2.285PheTyr: 2.285 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	4.015GlyAla: 4.015 ± 0.079	0.467GlyCys: 0.467 ± 0.027	3.174GlyAsp: 3.174 ± 0.071	3.372GlyGlu: 3.372 ± 0.064	3.864GlyPhe: 3.864 ± 0.069	4.359GlyGly: 4.359 ± 0.096	0.976GlyHis: 0.976 ± 0.03	5.444GlyIle: 5.444 ± 0.083	5.268GlyLys: 5.268 ± 0.088	5.334GlyLeu: 5.334 ± 0.08	1.427GlyMet: 1.427 ± 0.043	3.825GlyAsn: 3.825 ± 0.074	1.103GlyPro: 1.103 ± 0.035	1.581GlyGln: 1.581 ± 0.043	1.939GlyArg: 1.939 ± 0.044	3.858GlySer: 3.858 ± 0.086	4.082GlyThr: 4.082 ± 0.128	4.312GlyVal: 4.312 ± 0.069	0.656GlyTrp: 0.656 ± 0.027	2.62GlyTyr: 2.62 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	0.882HisAla: 0.882 ± 0.028	0.128HisCys: 0.128 ± 0.01	0.666HisAsp: 0.666 ± 0.027	0.888HisGlu: 0.888 ± 0.029	1.112HisPhe: 1.112 ± 0.038	0.872HisGly: 0.872 ± 0.032	0.456HisHis: 0.456 ± 0.025	1.288HisIle: 1.288 ± 0.037	1.318HisLys: 1.318 ± 0.038	1.693HisLeu: 1.693 ± 0.043	0.258HisMet: 0.258 ± 0.014	0.941HisAsn: 0.941 ± 0.034	0.776HisPro: 0.776 ± 0.029	0.721HisGln: 0.721 ± 0.032	0.569HisArg: 0.569 ± 0.025	0.956HisSer: 0.956 ± 0.032	0.902HisThr: 0.902 ± 0.036	0.828HisVal: 0.828 ± 0.032	0.182HisTrp: 0.182 ± 0.013	0.686HisTyr: 0.686 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.616IleAla: 5.616 ± 0.086	0.624IleCys: 0.624 ± 0.029	5.017IleAsp: 5.017 ± 0.083	5.763IleGlu: 5.763 ± 0.085	4.088IlePhe: 4.088 ± 0.077	5.132IleGly: 5.132 ± 0.088	1.403IleHis: 1.403 ± 0.041	6.934IleIle: 6.934 ± 0.106	6.923IleLys: 6.923 ± 0.099	7.671IleLeu: 7.671 ± 0.103	1.352IleMet: 1.352 ± 0.04	5.251IleAsn: 5.251 ± 0.075	3.211IlePro: 3.211 ± 0.057	2.5IleGln: 2.5 ± 0.053	2.479IleArg: 2.479 ± 0.055	6.344IleSer: 6.344 ± 0.084	5.347IleThr: 5.347 ± 0.086	4.903IleVal: 4.903 ± 0.077	0.706IleTrp: 0.706 ± 0.028	2.934IleTyr: 2.934 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.992LysAla: 4.992 ± 0.078	0.344LysCys: 0.344 ± 0.022	4.811LysAsp: 4.811 ± 0.083	7.775LysGlu: 7.775 ± 0.13	3.376LysPhe: 3.376 ± 0.063	4.92LysGly: 4.92 ± 0.081	1.433LysHis: 1.433 ± 0.039	7.461LysIle: 7.461 ± 0.102	8.681LysLys: 8.681 ± 0.128	7.161LysLeu: 7.161 ± 0.1	2.281LysMet: 2.281 ± 0.051	6.722LysAsn: 6.722 ± 0.104	2.552LysPro: 2.552 ± 0.05	2.794LysGln: 2.794 ± 0.059	2.964LysArg: 2.964 ± 0.063	4.879LysSer: 4.879 ± 0.083	5.399LysThr: 5.399 ± 0.068	5.177LysVal: 5.177 ± 0.073	0.858LysTrp: 0.858 ± 0.028	3.398LysTyr: 3.398 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	5.46LeuAla: 5.46 ± 0.08	0.568LeuCys: 0.568 ± 0.024	5.025LeuAsp: 5.025 ± 0.089	6.612LeuGlu: 6.612 ± 0.094	5.278LeuPhe: 5.278 ± 0.097	5.666LeuGly: 5.666 ± 0.084	1.453LeuHis: 1.453 ± 0.04	7.227LeuIle: 7.227 ± 0.109	8.642LeuLys: 8.642 ± 0.114	8.587LeuLeu: 8.587 ± 0.125	1.86LeuMet: 1.86 ± 0.041	5.931LeuAsn: 5.931 ± 0.073	3.253LeuPro: 3.253 ± 0.056	3.161LeuGln: 3.161 ± 0.061	2.912LeuArg: 2.912 ± 0.054	6.495LeuSer: 6.495 ± 0.095	5.135LeuThr: 5.135 ± 0.078	5.172LeuVal: 5.172 ± 0.074	0.732LeuTrp: 0.732 ± 0.024	2.987LeuTyr: 2.987 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	1.347MetAla: 1.347 ± 0.04	0.132MetCys: 0.132 ± 0.012	0.955MetAsp: 0.955 ± 0.03	1.136MetGlu: 1.136 ± 0.038	0.824MetPhe: 0.824 ± 0.03	1.194MetGly: 1.194 ± 0.033	0.351MetHis: 0.351 ± 0.019	1.558MetIle: 1.558 ± 0.045	2.225MetLys: 2.225 ± 0.049	1.825MetLeu: 1.825 ± 0.042	0.553MetMet: 0.553 ± 0.025	1.271MetAsn: 1.271 ± 0.039	0.705MetPro: 0.705 ± 0.027	0.758MetGln: 0.758 ± 0.032	0.744MetArg: 0.744 ± 0.028	1.384MetSer: 1.384 ± 0.041	0.998MetThr: 0.998 ± 0.033	1.206MetVal: 1.206 ± 0.039	0.143MetTrp: 0.143 ± 0.014	0.692MetTyr: 0.692 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.98AsnAla: 3.98 ± 0.072	0.438AsnCys: 0.438 ± 0.021	3.288AsnAsp: 3.288 ± 0.127	3.858AsnGlu: 3.858 ± 0.059	3.579AsnPhe: 3.579 ± 0.068	4.126AsnGly: 4.126 ± 0.094	1.062AsnHis: 1.062 ± 0.038	5.412AsnIle: 5.412 ± 0.081	5.455AsnLys: 5.455 ± 0.094	6.131AsnLeu: 6.131 ± 0.096	1.212AsnMet: 1.212 ± 0.035	4.639AsnAsn: 4.639 ± 0.092	2.602AsnPro: 2.602 ± 0.054	2.146AsnGln: 2.146 ± 0.046	2.063AsnArg: 2.063 ± 0.05	4.546AsnSer: 4.546 ± 0.077	4.142AsnThr: 4.142 ± 0.08	3.782AsnVal: 3.782 ± 0.064	0.838AsnTrp: 0.838 ± 0.031	3.147AsnTyr: 3.147 ± 0.067	0.0AsnXaa: 0.0 ± 0.0
Pro	1.658ProAla: 1.658 ± 0.044	0.186ProCys: 0.186 ± 0.015	1.623ProAsp: 1.623 ± 0.043	2.382ProGlu: 2.382 ± 0.054	1.881ProPhe: 1.881 ± 0.052	1.622ProGly: 1.622 ± 0.049	0.492ProHis: 0.492 ± 0.024	2.722ProIle: 2.722 ± 0.053	2.754ProLys: 2.754 ± 0.056	2.737ProLeu: 2.737 ± 0.054	0.633ProMet: 0.633 ± 0.029	2.172ProAsn: 2.172 ± 0.047	0.631ProPro: 0.631 ± 0.029	0.917ProGln: 0.917 ± 0.033	0.812ProArg: 0.812 ± 0.028	1.965ProSer: 1.965 ± 0.043	2.032ProThr: 2.032 ± 0.054	1.947ProVal: 1.947 ± 0.061	0.309ProTrp: 0.309 ± 0.018	1.177ProTyr: 1.177 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.632GlnAla: 1.632 ± 0.045	0.129GlnCys: 0.129 ± 0.013	1.389GlnAsp: 1.389 ± 0.042	2.267GlnGlu: 2.267 ± 0.05	1.722GlnPhe: 1.722 ± 0.039	1.574GlnGly: 1.574 ± 0.04	0.543GlnHis: 0.543 ± 0.023	2.564GlnIle: 2.564 ± 0.054	3.057GlnLys: 3.057 ± 0.056	3.186GlnLeu: 3.186 ± 0.063	0.694GlnMet: 0.694 ± 0.027	2.019GlnAsn: 2.019 ± 0.04	0.923GlnPro: 0.923 ± 0.03	1.338GlnGln: 1.338 ± 0.038	1.043GlnArg: 1.043 ± 0.035	1.645GlnSer: 1.645 ± 0.039	1.727GlnThr: 1.727 ± 0.041	1.79GlnVal: 1.79 ± 0.046	0.25GlnTrp: 0.25 ± 0.018	1.12GlnTyr: 1.12 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	1.926ArgAla: 1.926 ± 0.05	0.174ArgCys: 0.174 ± 0.014	1.617ArgAsp: 1.617 ± 0.039	2.041ArgGlu: 2.041 ± 0.048	1.821ArgPhe: 1.821 ± 0.041	1.786ArgGly: 1.786 ± 0.05	0.482ArgHis: 0.482 ± 0.023	2.724ArgIle: 2.724 ± 0.056	3.0ArgLys: 3.0 ± 0.059	2.87ArgLeu: 2.87 ± 0.06	0.741ArgMet: 0.741 ± 0.03	2.143ArgAsn: 2.143 ± 0.053	0.917ArgPro: 0.917 ± 0.028	0.929ArgGln: 0.929 ± 0.034	1.126ArgArg: 1.126 ± 0.039	1.749ArgSer: 1.749 ± 0.047	1.794ArgThr: 1.794 ± 0.041	1.943ArgVal: 1.943 ± 0.044	0.304ArgTrp: 0.304 ± 0.017	1.308ArgTyr: 1.308 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.584SerAla: 3.584 ± 0.059	0.607SerCys: 0.607 ± 0.028	3.349SerAsp: 3.349 ± 0.073	4.363SerGlu: 4.363 ± 0.067	4.251SerPhe: 4.251 ± 0.075	4.4SerGly: 4.4 ± 0.07	0.969SerHis: 0.969 ± 0.027	5.635SerIle: 5.635 ± 0.076	5.807SerLys: 5.807 ± 0.081	6.278SerLeu: 6.278 ± 0.091	1.189SerMet: 1.189 ± 0.034	4.238SerAsn: 4.238 ± 0.083	1.883SerPro: 1.883 ± 0.045	1.836SerGln: 1.836 ± 0.042	1.921SerArg: 1.921 ± 0.055	4.506SerSer: 4.506 ± 0.082	3.609SerThr: 3.609 ± 0.069	3.986SerVal: 3.986 ± 0.063	0.741SerTrp: 0.741 ± 0.029	2.944SerTyr: 2.944 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	3.88ThrAla: 3.88 ± 0.09	0.339ThrCys: 0.339 ± 0.02	3.418ThrAsp: 3.418 ± 0.098	3.588ThrGlu: 3.588 ± 0.064	3.239ThrPhe: 3.239 ± 0.065	3.845ThrGly: 3.845 ± 0.087	0.98ThrHis: 0.98 ± 0.034	5.379ThrIle: 5.379 ± 0.083	4.636ThrLys: 4.636 ± 0.072	5.317ThrLeu: 5.317 ± 0.091	0.876ThrMet: 0.876 ± 0.033	3.774ThrAsn: 3.774 ± 0.083	2.37ThrPro: 2.37 ± 0.072	1.769ThrGln: 1.769 ± 0.046	1.647ThrArg: 1.647 ± 0.042	4.263ThrSer: 4.263 ± 0.091	3.772ThrThr: 3.772 ± 0.098	4.003ThrVal: 4.003 ± 0.14	0.54ThrTrp: 0.54 ± 0.025	2.413ThrTyr: 2.413 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	4.249ValAla: 4.249 ± 0.084	0.448ValCys: 0.448 ± 0.023	3.457ValAsp: 3.457 ± 0.063	3.71ValGlu: 3.71 ± 0.062	3.539ValPhe: 3.539 ± 0.054	3.809ValGly: 3.809 ± 0.07	0.968ValHis: 0.968 ± 0.032	4.871ValIle: 4.871 ± 0.08	4.695ValLys: 4.695 ± 0.084	6.11ValLeu: 6.11 ± 0.082	1.116ValMet: 1.116 ± 0.033	3.739ValAsn: 3.739 ± 0.07	1.947ValPro: 1.947 ± 0.055	1.62ValGln: 1.62 ± 0.042	1.888ValArg: 1.888 ± 0.045	4.586ValSer: 4.586 ± 0.077	3.671ValThr: 3.671 ± 0.109	4.064ValVal: 4.064 ± 0.082	0.582ValTrp: 0.582 ± 0.025	2.189ValTyr: 2.189 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.529TrpAla: 0.529 ± 0.023	0.097TrpCys: 0.097 ± 0.01	0.507TrpAsp: 0.507 ± 0.025	0.595TrpGlu: 0.595 ± 0.024	0.601TrpPhe: 0.601 ± 0.023	0.621TrpGly: 0.621 ± 0.029	0.178TrpHis: 0.178 ± 0.013	0.67TrpIle: 0.67 ± 0.025	0.812TrpLys: 0.812 ± 0.034	0.95TrpLeu: 0.95 ± 0.034	0.281TrpMet: 0.281 ± 0.017	0.748TrpAsn: 0.748 ± 0.027	0.185TrpPro: 0.185 ± 0.015	0.347TrpGln: 0.347 ± 0.017	0.375TrpArg: 0.375 ± 0.017	0.622TrpSer: 0.622 ± 0.027	0.493TrpThr: 0.493 ± 0.022	0.597TrpVal: 0.597 ± 0.026	0.138TrpTrp: 0.138 ± 0.011	0.394TrpTyr: 0.394 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.264TyrAla: 2.264 ± 0.054	0.283TyrCys: 0.283 ± 0.018	1.993TyrAsp: 1.993 ± 0.043	2.035TyrGlu: 2.035 ± 0.047	2.411TyrPhe: 2.411 ± 0.053	2.368TyrGly: 2.368 ± 0.056	0.741TyrHis: 0.741 ± 0.027	2.817TyrIle: 2.817 ± 0.051	3.578TyrLys: 3.578 ± 0.069	3.824TyrLeu: 3.824 ± 0.069	0.644TyrMet: 0.644 ± 0.03	2.808TyrAsn: 2.808 ± 0.065	1.334TyrPro: 1.334 ± 0.033	1.479TyrGln: 1.479 ± 0.037	1.454TyrArg: 1.454 ± 0.035	2.679TyrSer: 2.679 ± 0.057	2.405TyrThr: 2.405 ± 0.064	2.025TyrVal: 2.025 ± 0.05	0.41TyrTrp: 0.41 ± 0.022	1.673TyrTyr: 1.673 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2976 proteins (1034009 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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