Amino acid dipepetide frequency for Muribaculaceae bacterium Isolate-013 (NCI)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.437AlaAla: 10.437 ± 0.202	0.958AlaCys: 0.958 ± 0.031	6.466AlaAsp: 6.466 ± 0.095	5.774AlaGlu: 5.774 ± 0.105	3.336AlaPhe: 3.336 ± 0.061	7.195AlaGly: 7.195 ± 0.106	1.406AlaHis: 1.406 ± 0.041	5.212AlaIle: 5.212 ± 0.078	3.788AlaLys: 3.788 ± 0.083	8.294AlaLeu: 8.294 ± 0.114	2.566AlaMet: 2.566 ± 0.064	3.163AlaAsn: 3.163 ± 0.059	4.031AlaPro: 4.031 ± 0.098	2.851AlaGln: 2.851 ± 0.056	5.159AlaArg: 5.159 ± 0.1	5.555AlaSer: 5.555 ± 0.082	5.389AlaThr: 5.389 ± 0.095	6.746AlaVal: 6.746 ± 0.103	0.994AlaTrp: 0.994 ± 0.035	2.86AlaTyr: 2.86 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	1.042CysAla: 1.042 ± 0.04	0.204CysCys: 0.204 ± 0.017	0.73CysAsp: 0.73 ± 0.032	0.573CysGlu: 0.573 ± 0.023	0.502CysPhe: 0.502 ± 0.022	1.186CysGly: 1.186 ± 0.038	0.314CysHis: 0.314 ± 0.019	0.661CysIle: 0.661 ± 0.028	0.488CysLys: 0.488 ± 0.024	0.967CysLeu: 0.967 ± 0.034	0.299CysMet: 0.299 ± 0.019	0.491CysAsn: 0.491 ± 0.026	0.565CysPro: 0.565 ± 0.028	0.333CysGln: 0.333 ± 0.021	0.955CysArg: 0.955 ± 0.036	0.811CysSer: 0.811 ± 0.031	0.638CysThr: 0.638 ± 0.028	0.845CysVal: 0.845 ± 0.033	0.151CysTrp: 0.151 ± 0.012	0.5CysTyr: 0.5 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	5.26AspAla: 5.26 ± 0.084	0.728AspCys: 0.728 ± 0.031	3.385AspAsp: 3.385 ± 0.07	3.798AspGlu: 3.798 ± 0.074	3.179AspPhe: 3.179 ± 0.059	5.003AspGly: 5.003 ± 0.081	0.837AspHis: 0.837 ± 0.031	3.958AspIle: 3.958 ± 0.059	3.024AspLys: 3.024 ± 0.071	4.562AspLeu: 4.562 ± 0.067	1.674AspMet: 1.674 ± 0.043	3.038AspAsn: 3.038 ± 0.063	2.231AspPro: 2.231 ± 0.052	1.102AspGln: 1.102 ± 0.036	3.265AspArg: 3.265 ± 0.055	3.672AspSer: 3.672 ± 0.074	3.337AspThr: 3.337 ± 0.069	3.656AspVal: 3.656 ± 0.065	0.807AspTrp: 0.807 ± 0.03	2.752AspTyr: 2.752 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	5.637GluAla: 5.637 ± 0.097	0.687GluCys: 0.687 ± 0.03	2.734GluAsp: 2.734 ± 0.057	4.093GluGlu: 4.093 ± 0.088	2.46GluPhe: 2.46 ± 0.056	3.92GluGly: 3.92 ± 0.07	1.089GluHis: 1.089 ± 0.038	4.514GluIle: 4.514 ± 0.077	3.925GluLys: 3.925 ± 0.087	5.66GluLeu: 5.66 ± 0.087	1.818GluMet: 1.818 ± 0.045	2.891GluAsn: 2.891 ± 0.06	2.186GluPro: 2.186 ± 0.054	2.17GluGln: 2.17 ± 0.056	3.757GluArg: 3.757 ± 0.083	3.134GluSer: 3.134 ± 0.061	3.067GluThr: 3.067 ± 0.065	4.039GluVal: 4.039 ± 0.069	0.735GluTrp: 0.735 ± 0.026	2.474GluTyr: 2.474 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.509PheAla: 3.509 ± 0.065	0.613PheCys: 0.613 ± 0.024	2.921PheAsp: 2.921 ± 0.057	2.145PheGlu: 2.145 ± 0.05	1.928PhePhe: 1.928 ± 0.05	3.219PheGly: 3.219 ± 0.065	0.851PheHis: 0.851 ± 0.033	2.685PheIle: 2.685 ± 0.063	1.833PheLys: 1.833 ± 0.045	3.372PheLeu: 3.372 ± 0.065	1.174PheMet: 1.174 ± 0.033	2.26PheAsn: 2.26 ± 0.055	1.72PhePro: 1.72 ± 0.041	0.981PheGln: 0.981 ± 0.032	2.439PheArg: 2.439 ± 0.058	3.186PheSer: 3.186 ± 0.058	2.866PheThr: 2.866 ± 0.065	2.681PheVal: 2.681 ± 0.051	0.453PheTrp: 0.453 ± 0.022	1.651PheTyr: 1.651 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	6.309GlyAla: 6.309 ± 0.09	1.098GlyCys: 1.098 ± 0.041	4.043GlyAsp: 4.043 ± 0.073	4.387GlyGlu: 4.387 ± 0.076	3.267GlyPhe: 3.267 ± 0.062	5.096GlyGly: 5.096 ± 0.106	1.465GlyHis: 1.465 ± 0.039	4.8GlyIle: 4.8 ± 0.081	4.241GlyLys: 4.241 ± 0.074	5.872GlyLeu: 5.872 ± 0.099	2.145GlyMet: 2.145 ± 0.058	3.383GlyAsn: 3.383 ± 0.071	1.577GlyPro: 1.577 ± 0.045	2.077GlyGln: 2.077 ± 0.056	4.238GlyArg: 4.238 ± 0.078	4.663GlySer: 4.663 ± 0.076	4.177GlyThr: 4.177 ± 0.082	5.32GlyVal: 5.32 ± 0.075	1.055GlyTrp: 1.055 ± 0.039	3.192GlyTyr: 3.192 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.325HisAla: 1.325 ± 0.035	0.286HisCys: 0.286 ± 0.017	1.023HisAsp: 1.023 ± 0.033	0.907HisGlu: 0.907 ± 0.035	0.855HisPhe: 0.855 ± 0.027	1.35HisGly: 1.35 ± 0.043	0.49HisHis: 0.49 ± 0.032	1.414HisIle: 1.414 ± 0.036	0.832HisLys: 0.832 ± 0.03	1.617HisLeu: 1.617 ± 0.05	0.34HisMet: 0.34 ± 0.016	0.997HisAsn: 0.997 ± 0.035	1.088HisPro: 1.088 ± 0.039	0.488HisGln: 0.488 ± 0.021	1.092HisArg: 1.092 ± 0.035	1.203HisSer: 1.203 ± 0.041	1.253HisThr: 1.253 ± 0.037	0.964HisVal: 0.964 ± 0.032	0.236HisTrp: 0.236 ± 0.014	0.725HisTyr: 0.725 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.664IleAla: 5.664 ± 0.079	0.825IleCys: 0.825 ± 0.033	4.282IleAsp: 4.282 ± 0.065	3.877IleGlu: 3.877 ± 0.079	2.448IlePhe: 2.448 ± 0.055	4.157IleGly: 4.157 ± 0.076	1.064IleHis: 1.064 ± 0.034	3.878IleIle: 3.878 ± 0.088	3.016IleLys: 3.016 ± 0.071	4.786IleLeu: 4.786 ± 0.085	1.325IleMet: 1.325 ± 0.043	2.733IleAsn: 2.733 ± 0.062	2.99IlePro: 2.99 ± 0.057	1.51IleGln: 1.51 ± 0.046	3.126IleArg: 3.126 ± 0.061	4.374IleSer: 4.374 ± 0.078	3.925IleThr: 3.925 ± 0.067	4.097IleVal: 4.097 ± 0.073	0.592IleTrp: 0.592 ± 0.026	2.257IleTyr: 2.257 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.739LysAla: 4.739 ± 0.078	0.49LysCys: 0.49 ± 0.026	2.728LysAsp: 2.728 ± 0.067	3.743LysGlu: 3.743 ± 0.086	1.951LysPhe: 1.951 ± 0.042	3.594LysGly: 3.594 ± 0.061	0.893LysHis: 0.893 ± 0.034	3.28LysIle: 3.28 ± 0.065	3.418LysLys: 3.418 ± 0.082	3.792LysLeu: 3.792 ± 0.08	1.528LysMet: 1.528 ± 0.045	2.35LysAsn: 2.35 ± 0.058	1.916LysPro: 1.916 ± 0.042	1.52LysGln: 1.52 ± 0.038	2.5LysArg: 2.5 ± 0.066	2.998LysSer: 2.998 ± 0.066	2.79LysThr: 2.79 ± 0.062	3.499LysVal: 3.499 ± 0.06	0.631LysTrp: 0.631 ± 0.027	1.994LysTyr: 1.994 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	7.923LeuAla: 7.923 ± 0.118	1.278LeuCys: 1.278 ± 0.041	4.953LeuAsp: 4.953 ± 0.083	4.655LeuGlu: 4.655 ± 0.078	3.51LeuPhe: 3.51 ± 0.077	5.713LeuGly: 5.713 ± 0.088	1.736LeuHis: 1.736 ± 0.046	4.49LeuIle: 4.49 ± 0.093	4.525LeuLys: 4.525 ± 0.072	7.953LeuLeu: 7.953 ± 0.129	2.337LeuMet: 2.337 ± 0.049	3.822LeuAsn: 3.822 ± 0.082	4.555LeuPro: 4.555 ± 0.089	2.748LeuGln: 2.748 ± 0.059	5.828LeuArg: 5.828 ± 0.104	6.414LeuSer: 6.414 ± 0.086	5.711LeuThr: 5.711 ± 0.081	4.967LeuVal: 4.967 ± 0.077	1.048LeuTrp: 1.048 ± 0.038	3.18LeuTyr: 3.18 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.832MetAla: 2.832 ± 0.061	0.262MetCys: 0.262 ± 0.017	1.288MetAsp: 1.288 ± 0.037	1.763MetGlu: 1.763 ± 0.048	0.943MetPhe: 0.943 ± 0.031	1.724MetGly: 1.724 ± 0.047	0.509MetHis: 0.509 ± 0.026	1.44MetIle: 1.44 ± 0.043	1.858MetLys: 1.858 ± 0.037	2.517MetLeu: 2.517 ± 0.059	0.857MetMet: 0.857 ± 0.031	1.176MetAsn: 1.176 ± 0.036	1.315MetPro: 1.315 ± 0.037	0.901MetGln: 0.901 ± 0.036	1.621MetArg: 1.621 ± 0.043	1.498MetSer: 1.498 ± 0.045	1.655MetThr: 1.655 ± 0.045	1.637MetVal: 1.637 ± 0.048	0.317MetTrp: 0.317 ± 0.017	0.703MetTyr: 0.703 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.577AsnAla: 3.577 ± 0.065	0.464AsnCys: 0.464 ± 0.023	2.386AsnAsp: 2.386 ± 0.052	2.421AsnGlu: 2.421 ± 0.054	1.945AsnPhe: 1.945 ± 0.053	3.671AsnGly: 3.671 ± 0.068	0.881AsnHis: 0.881 ± 0.029	3.033AsnIle: 3.033 ± 0.06	2.001AsnLys: 2.001 ± 0.053	3.904AsnLeu: 3.904 ± 0.072	1.058AsnMet: 1.058 ± 0.03	2.246AsnAsn: 2.246 ± 0.079	2.624AsnPro: 2.624 ± 0.047	1.116AsnGln: 1.116 ± 0.038	2.509AsnArg: 2.509 ± 0.065	2.654AsnSer: 2.654 ± 0.065	2.505AsnThr: 2.505 ± 0.064	2.849AsnVal: 2.849 ± 0.059	0.552AsnTrp: 0.552 ± 0.023	1.729AsnTyr: 1.729 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	4.949ProAla: 4.949 ± 0.108	0.415ProCys: 0.415 ± 0.022	3.259ProAsp: 3.259 ± 0.064	3.652ProGlu: 3.652 ± 0.059	1.766ProPhe: 1.766 ± 0.049	3.591ProGly: 3.591 ± 0.074	0.763ProHis: 0.763 ± 0.029	1.72ProIle: 1.72 ± 0.04	1.686ProLys: 1.686 ± 0.048	3.621ProLeu: 3.621 ± 0.065	1.128ProMet: 1.128 ± 0.035	1.284ProAsn: 1.284 ± 0.04	1.289ProPro: 1.289 ± 0.045	1.665ProGln: 1.665 ± 0.044	2.102ProArg: 2.102 ± 0.054	2.7ProSer: 2.7 ± 0.056	2.115ProThr: 2.115 ± 0.05	3.697ProVal: 3.697 ± 0.069	0.499ProTrp: 0.499 ± 0.025	1.646ProTyr: 1.646 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.78GlnAla: 2.78 ± 0.064	0.318GlnCys: 0.318 ± 0.017	1.23GlnAsp: 1.23 ± 0.04	1.753GlnGlu: 1.753 ± 0.052	1.193GlnPhe: 1.193 ± 0.03	1.994GlnGly: 1.994 ± 0.048	0.482GlnHis: 0.482 ± 0.026	1.814GlnIle: 1.814 ± 0.052	1.757GlnLys: 1.757 ± 0.054	2.873GlnLeu: 2.873 ± 0.065	0.952GlnMet: 0.952 ± 0.031	1.27GlnAsn: 1.27 ± 0.039	1.424GlnPro: 1.424 ± 0.043	1.438GlnGln: 1.438 ± 0.053	1.862GlnArg: 1.862 ± 0.052	1.743GlnSer: 1.743 ± 0.048	1.848GlnThr: 1.848 ± 0.045	1.797GlnVal: 1.797 ± 0.04	0.49GlnTrp: 0.49 ± 0.026	1.155GlnTyr: 1.155 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	4.328ArgAla: 4.328 ± 0.077	0.675ArgCys: 0.675 ± 0.027	2.836ArgAsp: 2.836 ± 0.058	3.57ArgGlu: 3.57 ± 0.08	2.703ArgPhe: 2.703 ± 0.044	3.398ArgGly: 3.398 ± 0.061	1.474ArgHis: 1.474 ± 0.044	3.857ArgIle: 3.857 ± 0.065	3.084ArgLys: 3.084 ± 0.058	5.844ArgLeu: 5.844 ± 0.087	1.85ArgMet: 1.85 ± 0.045	2.692ArgAsn: 2.692 ± 0.057	2.479ArgPro: 2.479 ± 0.062	2.462ArgGln: 2.462 ± 0.063	4.709ArgArg: 4.709 ± 0.097	2.959ArgSer: 2.959 ± 0.063	2.96ArgThr: 2.96 ± 0.052	3.396ArgVal: 3.396 ± 0.061	0.818ArgTrp: 0.818 ± 0.028	2.497ArgTyr: 2.497 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.818SerAla: 5.818 ± 0.089	0.73SerCys: 0.73 ± 0.027	3.814SerAsp: 3.814 ± 0.075	3.557SerGlu: 3.557 ± 0.063	2.914SerPhe: 2.914 ± 0.07	5.256SerGly: 5.256 ± 0.093	1.172SerHis: 1.172 ± 0.03	3.563SerIle: 3.563 ± 0.066	2.711SerLys: 2.711 ± 0.056	5.968SerLeu: 5.968 ± 0.091	1.521SerMet: 1.521 ± 0.039	2.339SerAsn: 2.339 ± 0.061	2.779SerPro: 2.779 ± 0.052	2.021SerGln: 2.021 ± 0.043	3.675SerArg: 3.675 ± 0.072	3.915SerSer: 3.915 ± 0.086	3.327SerThr: 3.327 ± 0.063	4.587SerVal: 4.587 ± 0.082	0.777SerTrp: 0.777 ± 0.031	2.485SerTyr: 2.485 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	5.729ThrAla: 5.729 ± 0.103	0.557ThrCys: 0.557 ± 0.024	4.016ThrAsp: 4.016 ± 0.083	3.237ThrGlu: 3.237 ± 0.062	2.603ThrPhe: 2.603 ± 0.062	4.601ThrGly: 4.601 ± 0.095	0.959ThrHis: 0.959 ± 0.033	3.415ThrIle: 3.415 ± 0.064	2.087ThrLys: 2.087 ± 0.051	5.662ThrLeu: 5.662 ± 0.086	1.232ThrMet: 1.232 ± 0.033	1.963ThrAsn: 1.963 ± 0.05	3.836ThrPro: 3.836 ± 0.079	1.538ThrGln: 1.538 ± 0.044	2.796ThrArg: 2.796 ± 0.054	3.552ThrSer: 3.552 ± 0.075	3.248ThrThr: 3.248 ± 0.071	4.852ThrVal: 4.852 ± 0.096	0.674ThrTrp: 0.674 ± 0.032	2.277ThrTyr: 2.277 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	6.552ValAla: 6.552 ± 0.103	0.93ValCys: 0.93 ± 0.035	4.05ValAsp: 4.05 ± 0.062	4.346ValGlu: 4.346 ± 0.08	2.717ValPhe: 2.717 ± 0.056	4.022ValGly: 4.022 ± 0.074	1.028ValHis: 1.028 ± 0.034	3.965ValIle: 3.965 ± 0.074	3.781ValLys: 3.781 ± 0.073	5.355ValLeu: 5.355 ± 0.082	1.763ValMet: 1.763 ± 0.055	3.24ValAsn: 3.24 ± 0.06	2.902ValPro: 2.902 ± 0.052	1.664ValGln: 1.664 ± 0.052	3.71ValArg: 3.71 ± 0.065	4.493ValSer: 4.493 ± 0.08	4.755ValThr: 4.755 ± 0.102	4.689ValVal: 4.689 ± 0.091	0.735ValTrp: 0.735 ± 0.032	2.502ValTyr: 2.502 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.8TrpAla: 0.8 ± 0.027	0.194TrpCys: 0.194 ± 0.014	0.695TrpAsp: 0.695 ± 0.031	0.725TrpGlu: 0.725 ± 0.028	0.515TrpPhe: 0.515 ± 0.023	0.913TrpGly: 0.913 ± 0.038	0.291TrpHis: 0.291 ± 0.018	0.733TrpIle: 0.733 ± 0.029	0.595TrpLys: 0.595 ± 0.026	1.39TrpLeu: 1.39 ± 0.048	0.345TrpMet: 0.345 ± 0.02	0.608TrpAsn: 0.608 ± 0.024	0.324TrpPro: 0.324 ± 0.021	0.503TrpGln: 0.503 ± 0.025	0.784TrpArg: 0.784 ± 0.033	0.757TrpSer: 0.757 ± 0.03	0.723TrpThr: 0.723 ± 0.029	0.673TrpVal: 0.673 ± 0.028	0.22TrpTrp: 0.22 ± 0.013	0.473TrpTyr: 0.473 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.97TyrAla: 2.97 ± 0.051	0.542TyrCys: 0.542 ± 0.026	2.429TyrAsp: 2.429 ± 0.053	2.016TyrGlu: 2.016 ± 0.047	1.752TyrPhe: 1.752 ± 0.045	2.8TyrGly: 2.8 ± 0.051	0.781TyrHis: 0.781 ± 0.032	2.494TyrIle: 2.494 ± 0.063	1.705TyrLys: 1.705 ± 0.054	3.336TyrLeu: 3.336 ± 0.06	0.902TyrMet: 0.902 ± 0.033	2.182TyrAsn: 2.182 ± 0.057	1.717TyrPro: 1.717 ± 0.041	1.085TyrGln: 1.085 ± 0.035	2.464TyrArg: 2.464 ± 0.053	2.649TyrSer: 2.649 ± 0.059	2.544TyrThr: 2.544 ± 0.07	2.207TyrVal: 2.207 ± 0.042	0.477TyrTrp: 0.477 ± 0.027	1.781TyrTyr: 1.781 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2762 proteins (955877 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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