Amino acid dipepetide frequency for Halobacteroides halobius (strain ATCC 35273 / DSM 5150 / MD-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.807AlaAla: 4.807 ± 0.092	0.538AlaCys: 0.538 ± 0.035	3.815AlaAsp: 3.815 ± 0.081	4.36AlaGlu: 4.36 ± 0.082	2.037AlaPhe: 2.037 ± 0.054	5.59AlaGly: 5.59 ± 0.089	1.031AlaHis: 1.031 ± 0.042	5.597AlaIle: 5.597 ± 0.108	6.032AlaLys: 6.032 ± 0.096	6.322AlaLeu: 6.322 ± 0.103	1.444AlaMet: 1.444 ± 0.043	3.384AlaAsn: 3.384 ± 0.068	1.828AlaPro: 1.828 ± 0.05	3.055AlaGln: 3.055 ± 0.063	2.488AlaArg: 2.488 ± 0.061	3.364AlaSer: 3.364 ± 0.073	3.81AlaThr: 3.81 ± 0.076	4.705AlaVal: 4.705 ± 0.083	0.496AlaTrp: 0.496 ± 0.028	1.973AlaTyr: 1.973 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.416CysAla: 0.416 ± 0.029	0.118CysCys: 0.118 ± 0.013	0.496CysAsp: 0.496 ± 0.024	0.407CysGlu: 0.407 ± 0.027	0.266CysPhe: 0.266 ± 0.019	0.797CysGly: 0.797 ± 0.036	0.159CysHis: 0.159 ± 0.016	0.526CysIle: 0.526 ± 0.033	0.462CysLys: 0.462 ± 0.024	0.657CysLeu: 0.657 ± 0.028	0.151CysMet: 0.151 ± 0.015	0.416CysAsn: 0.416 ± 0.028	0.456CysPro: 0.456 ± 0.034	0.38CysGln: 0.38 ± 0.023	0.3CysArg: 0.3 ± 0.019	0.513CysSer: 0.513 ± 0.024	0.355CysThr: 0.355 ± 0.022	0.439CysVal: 0.439 ± 0.03	0.056CysTrp: 0.056 ± 0.008	0.257CysTyr: 0.257 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	2.829AspAla: 2.829 ± 0.068	0.531AspCys: 0.531 ± 0.032	3.03AspAsp: 3.03 ± 0.082	3.989AspGlu: 3.989 ± 0.093	2.568AspPhe: 2.568 ± 0.061	3.216AspGly: 3.216 ± 0.072	0.888AspHis: 0.888 ± 0.031	4.928AspIle: 4.928 ± 0.093	5.261AspLys: 5.261 ± 0.085	6.659AspLeu: 6.659 ± 0.108	1.144AspMet: 1.144 ± 0.039	3.143AspAsn: 3.143 ± 0.066	1.683AspPro: 1.683 ± 0.05	2.648AspGln: 2.648 ± 0.065	2.171AspArg: 2.171 ± 0.054	2.762AspSer: 2.762 ± 0.062	2.394AspThr: 2.394 ± 0.059	3.267AspVal: 3.267 ± 0.063	0.616AspTrp: 0.616 ± 0.036	3.063AspTyr: 3.063 ± 0.076	0.0AspXaa: 0.0 ± 0.0
Glu	5.223GluAla: 5.223 ± 0.089	0.513GluCys: 0.513 ± 0.032	4.368GluAsp: 4.368 ± 0.086	8.58GluGlu: 8.58 ± 0.157	2.844GluPhe: 2.844 ± 0.065	4.377GluGly: 4.377 ± 0.087	1.073GluHis: 1.073 ± 0.04	7.164GluIle: 7.164 ± 0.111	5.852GluLys: 5.852 ± 0.094	7.957GluLeu: 7.957 ± 0.121	1.87GluMet: 1.87 ± 0.054	3.234GluAsn: 3.234 ± 0.071	1.674GluPro: 1.674 ± 0.047	2.799GluGln: 2.799 ± 0.077	2.916GluArg: 2.916 ± 0.062	3.073GluSer: 3.073 ± 0.067	3.169GluThr: 3.169 ± 0.077	6.696GluVal: 6.696 ± 0.103	0.496GluTrp: 0.496 ± 0.027	2.575GluTyr: 2.575 ± 0.07	0.0GluXaa: 0.0 ± 0.0
Phe	2.466PheAla: 2.466 ± 0.056	0.35PheCys: 0.35 ± 0.022	2.222PheAsp: 2.222 ± 0.058	2.096PheGlu: 2.096 ± 0.048	1.63PhePhe: 1.63 ± 0.053	2.703PheGly: 2.703 ± 0.06	0.514PheHis: 0.514 ± 0.027	3.41PheIle: 3.41 ± 0.073	3.233PheLys: 3.233 ± 0.067	3.586PheLeu: 3.586 ± 0.089	0.9PheMet: 0.9 ± 0.036	2.422PheAsn: 2.422 ± 0.049	1.176PhePro: 1.176 ± 0.041	0.995PheGln: 0.995 ± 0.039	1.279PheArg: 1.279 ± 0.049	2.792PheSer: 2.792 ± 0.069	2.112PheThr: 2.112 ± 0.051	2.223PheVal: 2.223 ± 0.054	0.365PheTrp: 0.365 ± 0.023	1.396PheTyr: 1.396 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	4.859GlyAla: 4.859 ± 0.095	0.698GlyCys: 0.698 ± 0.032	3.406GlyAsp: 3.406 ± 0.066	4.45GlyGlu: 4.45 ± 0.098	2.834GlyPhe: 2.834 ± 0.062	4.716GlyGly: 4.716 ± 0.09	1.135GlyHis: 1.135 ± 0.039	5.901GlyIle: 5.901 ± 0.085	4.49GlyLys: 4.49 ± 0.081	7.219GlyLeu: 7.219 ± 0.121	1.734GlyMet: 1.734 ± 0.049	2.871GlyAsn: 2.871 ± 0.079	1.779GlyPro: 1.779 ± 0.057	2.791GlyGln: 2.791 ± 0.069	2.708GlyArg: 2.708 ± 0.067	3.737GlySer: 3.737 ± 0.07	3.596GlyThr: 3.596 ± 0.075	5.595GlyVal: 5.595 ± 0.094	0.704GlyTrp: 0.704 ± 0.035	2.944GlyTyr: 2.944 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	0.828HisAla: 0.828 ± 0.032	0.171HisCys: 0.171 ± 0.012	0.712HisAsp: 0.712 ± 0.032	0.713HisGlu: 0.713 ± 0.029	0.61HisPhe: 0.61 ± 0.025	1.058HisGly: 1.058 ± 0.041	0.378HisHis: 0.378 ± 0.019	1.09HisIle: 1.09 ± 0.038	1.026HisLys: 1.026 ± 0.038	1.578HisLeu: 1.578 ± 0.045	0.243HisMet: 0.243 ± 0.018	0.834HisAsn: 0.834 ± 0.038	0.832HisPro: 0.832 ± 0.034	0.871HisGln: 0.871 ± 0.029	0.594HisArg: 0.594 ± 0.029	0.791HisSer: 0.791 ± 0.027	0.738HisThr: 0.738 ± 0.036	0.745HisVal: 0.745 ± 0.028	0.14HisTrp: 0.14 ± 0.016	0.637HisTyr: 0.637 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.913IleAla: 5.913 ± 0.09	0.658IleCys: 0.658 ± 0.034	5.252IleAsp: 5.252 ± 0.085	6.259IleGlu: 6.259 ± 0.1	3.116IlePhe: 3.116 ± 0.071	5.587IleGly: 5.587 ± 0.096	1.019IleHis: 1.019 ± 0.042	7.563IleIle: 7.563 ± 0.124	8.014IleLys: 8.014 ± 0.125	7.568IleLeu: 7.568 ± 0.135	1.705IleMet: 1.705 ± 0.053	5.017IleAsn: 5.017 ± 0.089	3.196IlePro: 3.196 ± 0.08	2.007IleGln: 2.007 ± 0.05	2.733IleArg: 2.733 ± 0.065	5.225IleSer: 5.225 ± 0.09	4.808IleThr: 4.808 ± 0.081	5.337IleVal: 5.337 ± 0.103	0.51IleTrp: 0.51 ± 0.024	2.551IleTyr: 2.551 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	5.039LysAla: 5.039 ± 0.085	0.447LysCys: 0.447 ± 0.026	4.538LysAsp: 4.538 ± 0.082	9.314LysGlu: 9.314 ± 0.129	2.691LysPhe: 2.691 ± 0.063	4.408LysGly: 4.408 ± 0.089	0.964LysHis: 0.964 ± 0.039	6.843LysIle: 6.843 ± 0.123	7.406LysLys: 7.406 ± 0.134	9.466LysLeu: 9.466 ± 0.136	1.949LysMet: 1.949 ± 0.062	3.634LysAsn: 3.634 ± 0.083	2.093LysPro: 2.093 ± 0.061	3.638LysGln: 3.638 ± 0.078	3.468LysArg: 3.468 ± 0.069	3.881LysSer: 3.881 ± 0.069	3.427LysThr: 3.427 ± 0.063	6.303LysVal: 6.303 ± 0.107	0.586LysTrp: 0.586 ± 0.03	2.91LysTyr: 2.91 ± 0.077	0.0LysXaa: 0.0 ± 0.0
Leu	8.363LeuAla: 8.363 ± 0.124	0.565LeuCys: 0.565 ± 0.03	6.3LeuAsp: 6.3 ± 0.1	8.35LeuGlu: 8.35 ± 0.139	3.596LeuPhe: 3.596 ± 0.092	7.569LeuGly: 7.569 ± 0.138	1.326LeuHis: 1.326 ± 0.044	8.239LeuIle: 8.239 ± 0.137	8.191LeuLys: 8.191 ± 0.136	9.618LeuLeu: 9.618 ± 0.156	1.984LeuMet: 1.984 ± 0.05	5.276LeuAsn: 5.276 ± 0.089	3.556LeuPro: 3.556 ± 0.069	3.467LeuGln: 3.467 ± 0.074	3.442LeuArg: 3.442 ± 0.07	6.214LeuSer: 6.214 ± 0.104	5.662LeuThr: 5.662 ± 0.099	7.683LeuVal: 7.683 ± 0.123	0.656LeuTrp: 0.656 ± 0.032	2.811LeuTyr: 2.811 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.642MetAla: 1.642 ± 0.049	0.093MetCys: 0.093 ± 0.011	1.132MetAsp: 1.132 ± 0.039	1.431MetGlu: 1.431 ± 0.042	0.67MetPhe: 0.67 ± 0.031	1.527MetGly: 1.527 ± 0.045	0.275MetHis: 0.275 ± 0.019	1.886MetIle: 1.886 ± 0.053	2.012MetLys: 2.012 ± 0.048	2.046MetLeu: 2.046 ± 0.045	0.593MetMet: 0.593 ± 0.03	1.18MetAsn: 1.18 ± 0.033	0.742MetPro: 0.742 ± 0.033	0.658MetGln: 0.658 ± 0.029	0.832MetArg: 0.832 ± 0.033	1.351MetSer: 1.351 ± 0.04	1.242MetThr: 1.242 ± 0.037	1.521MetVal: 1.521 ± 0.046	0.134MetTrp: 0.134 ± 0.013	0.501MetTyr: 0.501 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.234AsnAla: 2.234 ± 0.053	0.403AsnCys: 0.403 ± 0.024	2.421AsnAsp: 2.421 ± 0.066	2.733AsnGlu: 2.733 ± 0.052	2.154AsnPhe: 2.154 ± 0.055	2.632AsnGly: 2.632 ± 0.077	0.821AsnHis: 0.821 ± 0.037	4.093AsnIle: 4.093 ± 0.072	4.867AsnLys: 4.867 ± 0.079	6.583AsnLeu: 6.583 ± 0.12	1.056AsnMet: 1.056 ± 0.039	3.39AsnAsn: 3.39 ± 0.091	2.315AsnPro: 2.315 ± 0.057	3.219AsnGln: 3.219 ± 0.075	2.063AsnArg: 2.063 ± 0.053	2.972AsnSer: 2.972 ± 0.06	2.024AsnThr: 2.024 ± 0.053	2.501AsnVal: 2.501 ± 0.054	0.626AsnTrp: 0.626 ± 0.026	2.543AsnTyr: 2.543 ± 0.07	0.0AsnXaa: 0.0 ± 0.0
Pro	2.156ProAla: 2.156 ± 0.053	0.227ProCys: 0.227 ± 0.015	1.81ProAsp: 1.81 ± 0.053	2.387ProGlu: 2.387 ± 0.07	1.284ProPhe: 1.284 ± 0.047	2.215ProGly: 2.215 ± 0.061	0.614ProHis: 0.614 ± 0.028	2.458ProIle: 2.458 ± 0.057	2.344ProLys: 2.344 ± 0.065	3.077ProLeu: 3.077 ± 0.063	0.59ProMet: 0.59 ± 0.027	1.604ProAsn: 1.604 ± 0.044	0.849ProPro: 0.849 ± 0.034	1.719ProGln: 1.719 ± 0.058	1.083ProArg: 1.083 ± 0.036	1.482ProSer: 1.482 ± 0.049	1.864ProThr: 1.864 ± 0.049	2.513ProVal: 2.513 ± 0.056	0.312ProTrp: 0.312 ± 0.017	1.183ProTyr: 1.183 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.221GlnAla: 3.221 ± 0.077	0.206GlnCys: 0.206 ± 0.018	2.306GlnAsp: 2.306 ± 0.054	4.09GlnGlu: 4.09 ± 0.092	1.36GlnPhe: 1.36 ± 0.042	2.891GlnGly: 2.891 ± 0.065	0.496GlnHis: 0.496 ± 0.024	3.325GlnIle: 3.325 ± 0.08	2.752GlnLys: 2.752 ± 0.076	4.336GlnLeu: 4.336 ± 0.102	0.821GlnMet: 0.821 ± 0.032	1.579GlnAsn: 1.579 ± 0.047	1.156GlnPro: 1.156 ± 0.04	2.259GlnGln: 2.259 ± 0.072	1.609GlnArg: 1.609 ± 0.057	1.634GlnSer: 1.634 ± 0.052	1.82GlnThr: 1.82 ± 0.047	3.322GlnVal: 3.322 ± 0.074	0.281GlnTrp: 0.281 ± 0.019	1.027GlnTyr: 1.027 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.245ArgAla: 2.245 ± 0.056	0.327ArgCys: 0.327 ± 0.02	2.139ArgAsp: 2.139 ± 0.051	3.137ArgGlu: 3.137 ± 0.066	1.494ArgPhe: 1.494 ± 0.047	2.415ArgGly: 2.415 ± 0.059	0.568ArgHis: 0.568 ± 0.026	3.154ArgIle: 3.154 ± 0.073	3.023ArgLys: 3.023 ± 0.062	4.088ArgLeu: 4.088 ± 0.072	0.888ArgMet: 0.888 ± 0.035	1.692ArgAsn: 1.692 ± 0.054	1.2ArgPro: 1.2 ± 0.041	1.436ArgGln: 1.436 ± 0.042	1.735ArgArg: 1.735 ± 0.053	1.809ArgSer: 1.809 ± 0.052	1.659ArgThr: 1.659 ± 0.048	2.794ArgVal: 2.794 ± 0.06	0.265ArgTrp: 0.265 ± 0.017	1.426ArgTyr: 1.426 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	3.244SerAla: 3.244 ± 0.072	0.491SerCys: 0.491 ± 0.028	2.917SerAsp: 2.917 ± 0.065	3.108SerGlu: 3.108 ± 0.066	2.588SerPhe: 2.588 ± 0.06	3.933SerGly: 3.933 ± 0.078	0.845SerHis: 0.845 ± 0.031	4.206SerIle: 4.206 ± 0.077	4.622SerLys: 4.622 ± 0.078	6.32SerLeu: 6.32 ± 0.103	1.108SerMet: 1.108 ± 0.036	3.077SerAsn: 3.077 ± 0.067	1.57SerPro: 1.57 ± 0.043	2.512SerGln: 2.512 ± 0.056	2.143SerArg: 2.143 ± 0.049	3.436SerSer: 3.436 ± 0.094	2.76SerThr: 2.76 ± 0.067	2.998SerVal: 2.998 ± 0.068	0.564SerTrp: 0.564 ± 0.026	2.165SerTyr: 2.165 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	3.645ThrAla: 3.645 ± 0.076	0.323ThrCys: 0.323 ± 0.024	2.885ThrAsp: 2.885 ± 0.068	3.553ThrGlu: 3.553 ± 0.071	1.7ThrPhe: 1.7 ± 0.051	4.362ThrGly: 4.362 ± 0.077	0.711ThrHis: 0.711 ± 0.035	4.398ThrIle: 4.398 ± 0.076	4.211ThrLys: 4.211 ± 0.083	4.573ThrLeu: 4.573 ± 0.088	0.935ThrMet: 0.935 ± 0.033	2.588ThrAsn: 2.588 ± 0.057	2.066ThrPro: 2.066 ± 0.058	1.301ThrGln: 1.301 ± 0.039	1.834ThrArg: 1.834 ± 0.048	2.871ThrSer: 2.871 ± 0.071	3.284ThrThr: 3.284 ± 0.078	3.676ThrVal: 3.676 ± 0.079	0.353ThrTrp: 0.353 ± 0.022	1.675ThrTyr: 1.675 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	5.346ValAla: 5.346 ± 0.091	0.536ValCys: 0.536 ± 0.029	4.361ValAsp: 4.361 ± 0.077	5.14ValGlu: 5.14 ± 0.094	2.381ValPhe: 2.381 ± 0.063	5.266ValGly: 5.266 ± 0.098	0.905ValHis: 0.905 ± 0.034	6.065ValIle: 6.065 ± 0.107	6.044ValLys: 6.044 ± 0.11	6.34ValLeu: 6.34 ± 0.096	1.538ValMet: 1.538 ± 0.034	3.608ValAsn: 3.608 ± 0.071	2.074ValPro: 2.074 ± 0.048	1.676ValGln: 1.676 ± 0.044	2.356ValArg: 2.356 ± 0.052	4.117ValSer: 4.117 ± 0.089	4.142ValThr: 4.142 ± 0.085	5.332ValVal: 5.332 ± 0.096	0.451ValTrp: 0.451 ± 0.023	2.053ValTyr: 2.053 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.502TrpAla: 0.502 ± 0.03	0.066TrpCys: 0.066 ± 0.011	0.477TrpAsp: 0.477 ± 0.029	0.56TrpGlu: 0.56 ± 0.028	0.34TrpPhe: 0.34 ± 0.023	0.58TrpGly: 0.58 ± 0.029	0.13TrpHis: 0.13 ± 0.015	0.606TrpIle: 0.606 ± 0.029	0.539TrpLys: 0.539 ± 0.026	0.921TrpLeu: 0.921 ± 0.035	0.198TrpMet: 0.198 ± 0.017	0.383TrpAsn: 0.383 ± 0.022	0.265TrpPro: 0.265 ± 0.02	0.471TrpGln: 0.471 ± 0.023	0.346TrpArg: 0.346 ± 0.021	0.496TrpSer: 0.496 ± 0.026	0.352TrpThr: 0.352 ± 0.024	0.434TrpVal: 0.434 ± 0.024	0.142TrpTrp: 0.142 ± 0.013	0.286TrpTyr: 0.286 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.697TyrAla: 1.697 ± 0.047	0.369TyrCys: 0.369 ± 0.024	2.201TyrAsp: 2.201 ± 0.089	1.794TyrGlu: 1.794 ± 0.051	1.708TyrPhe: 1.708 ± 0.05	2.324TyrGly: 2.324 ± 0.063	0.738TyrHis: 0.738 ± 0.032	2.588TyrIle: 2.588 ± 0.053	2.627TyrLys: 2.627 ± 0.071	3.953TyrLeu: 3.953 ± 0.074	0.616TyrMet: 0.616 ± 0.028	2.316TyrAsn: 2.316 ± 0.076	1.263TyrPro: 1.263 ± 0.052	2.588TyrGln: 2.588 ± 0.068	1.394TyrArg: 1.394 ± 0.041	2.088TyrSer: 2.088 ± 0.058	1.726TyrThr: 1.726 ± 0.047	1.645TyrVal: 1.645 ± 0.046	0.34TyrTrp: 0.34 ± 0.02	1.696TyrTyr: 1.696 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2452 proteins (762441 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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