Amino acid dipepetide frequency for Streptococcus phage Javan122

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.349AlaAla: 4.349 ± 1.22
0.492AlaCys: 0.492 ± 0.162
4.349AlaAsp: 4.349 ± 0.726
3.528AlaGlu: 3.528 ± 0.648
2.051AlaPhe: 2.051 ± 0.508
4.267AlaGly: 4.267 ± 0.681
0.656AlaHis: 0.656 ± 0.234
4.677AlaIle: 4.677 ± 0.87
5.416AlaLys: 5.416 ± 0.579
5.826AlaLeu: 5.826 ± 0.879
1.805AlaMet: 1.805 ± 0.347
3.036AlaAsn: 3.036 ± 0.465
1.477AlaPro: 1.477 ± 0.396
2.708AlaGln: 2.708 ± 0.665
3.528AlaArg: 3.528 ± 0.456
4.185AlaSer: 4.185 ± 0.556
4.267AlaThr: 4.267 ± 0.649
4.513AlaVal: 4.513 ± 0.587
0.738AlaTrp: 0.738 ± 0.32
2.872AlaTyr: 2.872 ± 0.471
0.0AlaXaa: 0.0 ± 0.0
Cys
0.574CysAla: 0.574 ± 0.22
0.246CysCys: 0.246 ± 0.154
0.492CysAsp: 0.492 ± 0.206
0.492CysGlu: 0.492 ± 0.172
0.246CysPhe: 0.246 ± 0.134
0.574CysGly: 0.574 ± 0.218
0.164CysHis: 0.164 ± 0.109
0.246CysIle: 0.246 ± 0.141
0.328CysLys: 0.328 ± 0.197
0.656CysLeu: 0.656 ± 0.254
0.082CysMet: 0.082 ± 0.088
0.328CysAsn: 0.328 ± 0.193
0.41CysPro: 0.41 ± 0.18
0.574CysGln: 0.574 ± 0.184
0.656CysArg: 0.656 ± 0.241
0.821CysSer: 0.821 ± 0.283
0.328CysThr: 0.328 ± 0.147
0.492CysVal: 0.492 ± 0.205
0.0CysTrp: 0.0 ± 0.0
0.574CysTyr: 0.574 ± 0.211
0.0CysXaa: 0.0 ± 0.0
Asp
3.364AspAla: 3.364 ± 0.562
0.656AspCys: 0.656 ± 0.214
2.954AspAsp: 2.954 ± 0.68
4.841AspGlu: 4.841 ± 0.65
3.2AspPhe: 3.2 ± 0.455
5.169AspGly: 5.169 ± 0.651
1.149AspHis: 1.149 ± 0.367
3.364AspIle: 3.364 ± 0.638
3.857AspLys: 3.857 ± 0.524
5.416AspLeu: 5.416 ± 0.897
2.051AspMet: 2.051 ± 0.417
2.708AspAsn: 2.708 ± 0.456
1.313AspPro: 1.313 ± 0.42
1.805AspGln: 1.805 ± 0.477
2.544AspArg: 2.544 ± 0.531
3.857AspSer: 3.857 ± 0.635
2.708AspThr: 2.708 ± 0.481
3.446AspVal: 3.446 ± 0.607
0.903AspTrp: 0.903 ± 0.255
2.462AspTyr: 2.462 ± 0.451
0.0AspXaa: 0.0 ± 0.0
Glu
5.087GluAla: 5.087 ± 0.651
0.656GluCys: 0.656 ± 0.22
4.103GluAsp: 4.103 ± 0.537
6.4GluGlu: 6.4 ± 1.055
2.626GluPhe: 2.626 ± 0.518
4.349GluGly: 4.349 ± 0.563
1.149GluHis: 1.149 ± 0.346
4.185GluIle: 4.185 ± 0.694
6.072GluLys: 6.072 ± 0.752
8.37GluLeu: 8.37 ± 0.709
2.215GluMet: 2.215 ± 0.641
4.349GluAsn: 4.349 ± 0.581
1.477GluPro: 1.477 ± 0.399
3.446GluGln: 3.446 ± 0.581
2.79GluArg: 2.79 ± 0.487
3.282GluSer: 3.282 ± 0.548
4.267GluThr: 4.267 ± 0.591
4.267GluVal: 4.267 ± 0.474
0.903GluTrp: 0.903 ± 0.293
2.133GluTyr: 2.133 ± 0.334
0.0GluXaa: 0.0 ± 0.0
Phe
2.872PheAla: 2.872 ± 0.468
0.492PheCys: 0.492 ± 0.189
2.626PheAsp: 2.626 ± 0.449
3.118PheGlu: 3.118 ± 0.46
2.051PhePhe: 2.051 ± 0.43
3.446PheGly: 3.446 ± 0.5
0.574PheHis: 0.574 ± 0.21
2.298PheIle: 2.298 ± 0.519
3.528PheLys: 3.528 ± 0.655
2.872PheLeu: 2.872 ± 0.542
0.903PheMet: 0.903 ± 0.305
2.133PheAsn: 2.133 ± 0.312
0.574PhePro: 0.574 ± 0.214
1.559PheGln: 1.559 ± 0.265
1.723PheArg: 1.723 ± 0.296
2.954PheSer: 2.954 ± 0.426
1.969PheThr: 1.969 ± 0.329
1.887PheVal: 1.887 ± 0.41
0.492PheTrp: 0.492 ± 0.199
2.298PheTyr: 2.298 ± 0.371
0.0PheXaa: 0.0 ± 0.0
Gly
3.61GlyAla: 3.61 ± 0.475
0.246GlyCys: 0.246 ± 0.131
3.857GlyAsp: 3.857 ± 0.704
3.446GlyGlu: 3.446 ± 0.543
2.708GlyPhe: 2.708 ± 0.373
4.759GlyGly: 4.759 ± 0.834
1.969GlyHis: 1.969 ± 0.379
5.744GlyIle: 5.744 ± 0.842
4.923GlyLys: 4.923 ± 0.585
5.334GlyLeu: 5.334 ± 0.614
2.215GlyMet: 2.215 ± 0.352
3.692GlyAsn: 3.692 ± 0.689
0.903GlyPro: 0.903 ± 0.242
3.364GlyGln: 3.364 ± 0.547
4.103GlyArg: 4.103 ± 0.518
4.677GlySer: 4.677 ± 0.853
4.021GlyThr: 4.021 ± 0.518
4.103GlyVal: 4.103 ± 0.574
0.656GlyTrp: 0.656 ± 0.208
2.79GlyTyr: 2.79 ± 0.431
0.0GlyXaa: 0.0 ± 0.0
His
0.821HisAla: 0.821 ± 0.27
0.082HisCys: 0.082 ± 0.079
0.903HisAsp: 0.903 ± 0.251
0.985HisGlu: 0.985 ± 0.304
1.395HisPhe: 1.395 ± 0.33
1.641HisGly: 1.641 ± 0.31
0.738HisHis: 0.738 ± 0.25
1.559HisIle: 1.559 ± 0.314
0.656HisLys: 0.656 ± 0.222
2.133HisLeu: 2.133 ± 0.309
0.41HisMet: 0.41 ± 0.201
1.149HisAsn: 1.149 ± 0.284
1.231HisPro: 1.231 ± 0.389
0.492HisGln: 0.492 ± 0.213
1.067HisArg: 1.067 ± 0.297
1.067HisSer: 1.067 ± 0.266
0.985HisThr: 0.985 ± 0.379
0.985HisVal: 0.985 ± 0.306
0.164HisTrp: 0.164 ± 0.108
0.492HisTyr: 0.492 ± 0.281
0.0HisXaa: 0.0 ± 0.0
Ile
4.185IleAla: 4.185 ± 0.467
0.903IleCys: 0.903 ± 0.291
5.58IleAsp: 5.58 ± 0.585
3.61IleGlu: 3.61 ± 0.548
1.559IlePhe: 1.559 ± 0.4
4.431IleGly: 4.431 ± 0.63
0.985IleHis: 0.985 ± 0.265
4.021IleIle: 4.021 ± 0.995
5.169IleLys: 5.169 ± 0.617
5.087IleLeu: 5.087 ± 0.589
0.821IleMet: 0.821 ± 0.256
3.036IleAsn: 3.036 ± 0.582
2.708IlePro: 2.708 ± 0.377
2.954IleGln: 2.954 ± 0.376
2.708IleArg: 2.708 ± 0.501
5.005IleSer: 5.005 ± 0.761
4.759IleThr: 4.759 ± 0.963
3.857IleVal: 3.857 ± 0.622
1.149IleTrp: 1.149 ± 0.363
2.051IleTyr: 2.051 ± 0.328
0.0IleXaa: 0.0 ± 0.0
Lys
5.58LysAla: 5.58 ± 0.686
0.328LysCys: 0.328 ± 0.128
3.61LysAsp: 3.61 ± 0.584
5.416LysGlu: 5.416 ± 0.494
2.298LysPhe: 2.298 ± 0.524
4.349LysGly: 4.349 ± 0.472
1.805LysHis: 1.805 ± 0.504
4.185LysIle: 4.185 ± 0.594
4.595LysLys: 4.595 ± 0.626
5.005LysLeu: 5.005 ± 0.629
1.723LysMet: 1.723 ± 0.416
3.036LysAsn: 3.036 ± 0.465
2.133LysPro: 2.133 ± 0.389
3.528LysGln: 3.528 ± 0.502
3.692LysArg: 3.692 ± 0.619
5.005LysSer: 5.005 ± 0.669
4.759LysThr: 4.759 ± 0.571
5.005LysVal: 5.005 ± 0.757
0.985LysTrp: 0.985 ± 0.267
2.215LysTyr: 2.215 ± 0.593
0.0LysXaa: 0.0 ± 0.0
Leu
5.826LeuAla: 5.826 ± 0.826
0.492LeuCys: 0.492 ± 0.177
5.087LeuAsp: 5.087 ± 0.51
6.811LeuGlu: 6.811 ± 0.783
2.708LeuPhe: 2.708 ± 0.53
5.251LeuGly: 5.251 ± 0.641
1.559LeuHis: 1.559 ± 0.421
4.185LeuIle: 4.185 ± 0.397
7.467LeuLys: 7.467 ± 0.796
7.549LeuLeu: 7.549 ± 0.735
1.969LeuMet: 1.969 ± 0.371
4.923LeuAsn: 4.923 ± 0.696
3.364LeuPro: 3.364 ± 0.644
3.61LeuGln: 3.61 ± 0.557
4.103LeuArg: 4.103 ± 0.57
6.893LeuSer: 6.893 ± 0.674
6.893LeuThr: 6.893 ± 0.8
6.154LeuVal: 6.154 ± 0.76
0.903LeuTrp: 0.903 ± 0.177
4.267LeuTyr: 4.267 ± 0.624
0.0LeuXaa: 0.0 ± 0.0
Met
1.723MetAla: 1.723 ± 0.425
0.082MetCys: 0.082 ± 0.079
1.313MetAsp: 1.313 ± 0.357
1.887MetGlu: 1.887 ± 0.501
0.656MetPhe: 0.656 ± 0.249
2.051MetGly: 2.051 ± 0.457
0.0MetHis: 0.0 ± 0.0
1.887MetIle: 1.887 ± 0.332
1.887MetLys: 1.887 ± 0.378
1.313MetLeu: 1.313 ± 0.319
0.985MetMet: 0.985 ± 0.321
0.738MetAsn: 0.738 ± 0.219
0.41MetPro: 0.41 ± 0.179
0.985MetGln: 0.985 ± 0.298
1.067MetArg: 1.067 ± 0.262
2.462MetSer: 2.462 ± 0.381
2.051MetThr: 2.051 ± 0.378
1.477MetVal: 1.477 ± 0.309
0.082MetTrp: 0.082 ± 0.083
0.738MetTyr: 0.738 ± 0.236
0.0MetXaa: 0.0 ± 0.0
Asn
3.939AsnAla: 3.939 ± 0.773
0.246AsnCys: 0.246 ± 0.15
2.215AsnAsp: 2.215 ± 0.379
3.61AsnGlu: 3.61 ± 0.525
2.38AsnPhe: 2.38 ± 0.461
4.677AsnGly: 4.677 ± 0.598
1.395AsnHis: 1.395 ± 0.321
2.872AsnIle: 2.872 ± 0.707
3.036AsnLys: 3.036 ± 0.595
4.267AsnLeu: 4.267 ± 0.629
1.149AsnMet: 1.149 ± 0.264
2.544AsnAsn: 2.544 ± 0.591
2.051AsnPro: 2.051 ± 0.364
2.215AsnGln: 2.215 ± 0.318
2.133AsnArg: 2.133 ± 0.342
3.036AsnSer: 3.036 ± 0.676
2.462AsnThr: 2.462 ± 0.496
2.626AsnVal: 2.626 ± 0.468
1.231AsnTrp: 1.231 ± 0.331
1.231AsnTyr: 1.231 ± 0.341
0.0AsnXaa: 0.0 ± 0.0
Pro
0.821ProAla: 0.821 ± 0.273
0.246ProCys: 0.246 ± 0.132
1.969ProAsp: 1.969 ± 0.426
2.215ProGlu: 2.215 ± 0.51
0.903ProPhe: 0.903 ± 0.232
1.149ProGly: 1.149 ± 0.332
0.985ProHis: 0.985 ± 0.246
2.215ProIle: 2.215 ± 0.384
2.133ProLys: 2.133 ± 0.415
2.79ProLeu: 2.79 ± 0.459
0.492ProMet: 0.492 ± 0.175
1.805ProAsn: 1.805 ± 0.387
0.903ProPro: 0.903 ± 0.338
1.231ProGln: 1.231 ± 0.317
1.641ProArg: 1.641 ± 0.359
3.118ProSer: 3.118 ± 0.485
2.298ProThr: 2.298 ± 0.491
1.887ProVal: 1.887 ± 0.456
0.41ProTrp: 0.41 ± 0.182
1.395ProTyr: 1.395 ± 0.351
0.0ProXaa: 0.0 ± 0.0
Gln
4.103GlnAla: 4.103 ± 0.667
0.246GlnCys: 0.246 ± 0.137
2.298GlnAsp: 2.298 ± 0.38
3.364GlnGlu: 3.364 ± 0.548
1.969GlnPhe: 1.969 ± 0.321
2.133GlnGly: 2.133 ± 0.334
0.246GlnHis: 0.246 ± 0.148
2.872GlnIle: 2.872 ± 0.528
2.544GlnLys: 2.544 ± 0.389
5.005GlnLeu: 5.005 ± 0.627
1.149GlnMet: 1.149 ± 0.339
2.133GlnAsn: 2.133 ± 0.573
1.559GlnPro: 1.559 ± 0.4
2.298GlnGln: 2.298 ± 0.369
1.559GlnArg: 1.559 ± 0.347
2.954GlnSer: 2.954 ± 0.557
2.462GlnThr: 2.462 ± 0.419
3.118GlnVal: 3.118 ± 0.443
0.738GlnTrp: 0.738 ± 0.259
0.985GlnTyr: 0.985 ± 0.231
0.0GlnXaa: 0.0 ± 0.0
Arg
2.708ArgAla: 2.708 ± 0.583
0.738ArgCys: 0.738 ± 0.277
2.133ArgAsp: 2.133 ± 0.428
3.857ArgGlu: 3.857 ± 0.486
2.38ArgPhe: 2.38 ± 0.586
2.051ArgGly: 2.051 ± 0.355
0.903ArgHis: 0.903 ± 0.283
2.462ArgIle: 2.462 ± 0.395
3.446ArgLys: 3.446 ± 0.59
5.169ArgLeu: 5.169 ± 0.734
0.41ArgMet: 0.41 ± 0.153
2.954ArgAsn: 2.954 ± 0.589
1.231ArgPro: 1.231 ± 0.371
3.446ArgGln: 3.446 ± 0.4
2.298ArgArg: 2.298 ± 0.467
2.462ArgSer: 2.462 ± 0.304
2.38ArgThr: 2.38 ± 0.53
3.61ArgVal: 3.61 ± 0.521
0.985ArgTrp: 0.985 ± 0.312
1.969ArgTyr: 1.969 ± 0.443
0.0ArgXaa: 0.0 ± 0.0
Ser
4.185SerAla: 4.185 ± 0.714
0.492SerCys: 0.492 ± 0.303
4.349SerAsp: 4.349 ± 0.51
4.595SerGlu: 4.595 ± 0.496
3.282SerPhe: 3.282 ± 0.569
5.58SerGly: 5.58 ± 0.761
1.641SerHis: 1.641 ± 0.318
5.416SerIle: 5.416 ± 0.769
4.349SerLys: 4.349 ± 0.497
5.826SerLeu: 5.826 ± 0.661
0.985SerMet: 0.985 ± 0.231
3.118SerAsn: 3.118 ± 0.735
2.298SerPro: 2.298 ± 0.36
2.626SerGln: 2.626 ± 0.392
3.282SerArg: 3.282 ± 0.612
6.154SerSer: 6.154 ± 0.936
5.005SerThr: 5.005 ± 0.601
4.267SerVal: 4.267 ± 0.553
1.231SerTrp: 1.231 ± 0.203
2.626SerTyr: 2.626 ± 0.369
0.0SerXaa: 0.0 ± 0.0
Thr
4.431ThrAla: 4.431 ± 0.633
0.246ThrCys: 0.246 ± 0.155
2.708ThrAsp: 2.708 ± 0.49
4.677ThrGlu: 4.677 ± 0.59
3.364ThrPhe: 3.364 ± 0.546
4.185ThrGly: 4.185 ± 0.557
0.821ThrHis: 0.821 ± 0.242
5.416ThrIle: 5.416 ± 1.065
3.692ThrLys: 3.692 ± 0.516
5.908ThrLeu: 5.908 ± 0.618
1.395ThrMet: 1.395 ± 0.338
2.708ThrAsn: 2.708 ± 0.431
2.626ThrPro: 2.626 ± 0.567
1.887ThrGln: 1.887 ± 0.383
2.544ThrArg: 2.544 ± 0.436
5.416ThrSer: 5.416 ± 0.62
4.431ThrThr: 4.431 ± 0.582
5.169ThrVal: 5.169 ± 0.634
1.067ThrTrp: 1.067 ± 0.327
2.133ThrTyr: 2.133 ± 0.494
0.0ThrXaa: 0.0 ± 0.0
Val
3.61ValAla: 3.61 ± 0.566
0.574ValCys: 0.574 ± 0.23
3.282ValAsp: 3.282 ± 0.512
5.334ValGlu: 5.334 ± 0.724
2.298ValPhe: 2.298 ± 0.375
4.021ValGly: 4.021 ± 0.656
0.985ValHis: 0.985 ± 0.242
4.677ValIle: 4.677 ± 0.563
3.939ValLys: 3.939 ± 0.534
6.4ValLeu: 6.4 ± 0.646
1.641ValMet: 1.641 ± 0.4
2.298ValAsn: 2.298 ± 0.401
2.544ValPro: 2.544 ± 0.415
2.215ValGln: 2.215 ± 0.445
2.954ValArg: 2.954 ± 0.489
4.677ValSer: 4.677 ± 0.649
5.416ValThr: 5.416 ± 0.841
3.857ValVal: 3.857 ± 0.611
0.985ValTrp: 0.985 ± 0.23
2.38ValTyr: 2.38 ± 0.438
0.0ValXaa: 0.0 ± 0.0
Trp
0.821TrpAla: 0.821 ± 0.249
0.164TrpCys: 0.164 ± 0.141
0.574TrpAsp: 0.574 ± 0.244
1.149TrpGlu: 1.149 ± 0.323
0.821TrpPhe: 0.821 ± 0.259
0.574TrpGly: 0.574 ± 0.212
0.246TrpHis: 0.246 ± 0.13
0.656TrpIle: 0.656 ± 0.257
0.574TrpLys: 0.574 ± 0.252
1.395TrpLeu: 1.395 ± 0.277
0.574TrpMet: 0.574 ± 0.159
1.231TrpAsn: 1.231 ± 0.293
0.164TrpPro: 0.164 ± 0.093
0.656TrpGln: 0.656 ± 0.217
1.067TrpArg: 1.067 ± 0.346
0.985TrpSer: 0.985 ± 0.339
0.985TrpThr: 0.985 ± 0.337
0.985TrpVal: 0.985 ± 0.307
0.164TrpTrp: 0.164 ± 0.111
0.164TrpTyr: 0.164 ± 0.095
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.133TyrAla: 2.133 ± 0.304
0.656TyrCys: 0.656 ± 0.242
3.364TyrAsp: 3.364 ± 0.624
2.79TyrGlu: 2.79 ± 0.398
1.477TyrPhe: 1.477 ± 0.345
2.462TyrGly: 2.462 ± 0.502
0.985TyrHis: 0.985 ± 0.31
1.641TyrIle: 1.641 ± 0.325
1.641TyrLys: 1.641 ± 0.387
3.692TyrLeu: 3.692 ± 0.619
0.738TyrMet: 0.738 ± 0.248
1.477TyrAsn: 1.477 ± 0.356
1.231TyrPro: 1.231 ± 0.268
2.133TyrGln: 2.133 ± 0.376
2.133TyrArg: 2.133 ± 0.434
2.298TyrSer: 2.298 ± 0.414
2.38TyrThr: 2.38 ± 0.446
2.38TyrVal: 2.38 ± 0.39
0.164TyrTrp: 0.164 ± 0.122
1.805TyrTyr: 1.805 ± 0.514
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 44 proteins (12188 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski