Amino acid dipepetide frequency for Rubrivivax gelatinosus (strain NBRC 100245 / IL144)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.096AlaAla: 25.096 ± 0.258	1.375AlaCys: 1.375 ± 0.034	7.55AlaAsp: 7.55 ± 0.072	8.891AlaGlu: 8.891 ± 0.096	4.259AlaPhe: 4.259 ± 0.063	12.907AlaGly: 12.907 ± 0.121	2.647AlaHis: 2.647 ± 0.047	4.719AlaIle: 4.719 ± 0.057	3.063AlaLys: 3.063 ± 0.06	17.807AlaLeu: 17.807 ± 0.171	3.414AlaMet: 3.414 ± 0.05	2.438AlaAsn: 2.438 ± 0.043	7.601AlaPro: 7.601 ± 0.115	5.085AlaGln: 5.085 ± 0.069	11.416AlaArg: 11.416 ± 0.118	6.696AlaSer: 6.696 ± 0.075	6.644AlaThr: 6.644 ± 0.068	10.413AlaVal: 10.413 ± 0.1	2.402AlaTrp: 2.402 ± 0.045	2.401AlaTyr: 2.401 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.221CysAla: 1.221 ± 0.028	0.112CysCys: 0.112 ± 0.009	0.496CysAsp: 0.496 ± 0.018	0.524CysGlu: 0.524 ± 0.019	0.285CysPhe: 0.285 ± 0.013	1.032CysGly: 1.032 ± 0.025	0.283CysHis: 0.283 ± 0.017	0.327CysIle: 0.327 ± 0.015	0.164CysLys: 0.164 ± 0.01	0.781CysLeu: 0.781 ± 0.023	0.166CysMet: 0.166 ± 0.01	0.204CysAsn: 0.204 ± 0.011	0.495CysPro: 0.495 ± 0.02	0.197CysGln: 0.197 ± 0.011	0.721CysArg: 0.721 ± 0.022	0.493CysSer: 0.493 ± 0.017	0.455CysThr: 0.455 ± 0.017	0.652CysVal: 0.652 ± 0.022	0.141CysTrp: 0.141 ± 0.009	0.182CysTyr: 0.182 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.37AspAla: 8.37 ± 0.089	0.463AspCys: 0.463 ± 0.019	2.966AspAsp: 2.966 ± 0.048	3.839AspGlu: 3.839 ± 0.05	1.828AspPhe: 1.828 ± 0.036	5.619AspGly: 5.619 ± 0.069	1.001AspHis: 1.001 ± 0.029	1.846AspIle: 1.846 ± 0.039	1.274AspLys: 1.274 ± 0.037	5.343AspLeu: 5.343 ± 0.065	0.839AspMet: 0.839 ± 0.023	1.007AspAsn: 1.007 ± 0.029	3.14AspPro: 3.14 ± 0.05	1.285AspGln: 1.285 ± 0.031	3.641AspArg: 3.641 ± 0.052	2.178AspSer: 2.178 ± 0.038	2.569AspThr: 2.569 ± 0.041	3.74AspVal: 3.74 ± 0.051	1.045AspTrp: 1.045 ± 0.024	1.256AspTyr: 1.256 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	8.217GluAla: 8.217 ± 0.088	0.402GluCys: 0.402 ± 0.015	2.486GluAsp: 2.486 ± 0.038	2.206GluGlu: 2.206 ± 0.049	1.763GluPhe: 1.763 ± 0.039	3.695GluGly: 3.695 ± 0.052	1.528GluHis: 1.528 ± 0.036	2.556GluIle: 2.556 ± 0.047	1.32GluLys: 1.32 ± 0.037	6.854GluLeu: 6.854 ± 0.069	1.09GluMet: 1.09 ± 0.028	1.04GluAsn: 1.04 ± 0.027	3.131GluPro: 3.131 ± 0.047	2.497GluGln: 2.497 ± 0.048	6.378GluArg: 6.378 ± 0.084	2.226GluSer: 2.226 ± 0.039	2.722GluThr: 2.722 ± 0.042	4.156GluVal: 4.156 ± 0.065	0.673GluTrp: 0.673 ± 0.018	0.969GluTyr: 0.969 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.336PheAla: 4.336 ± 0.054	0.355PheCys: 0.355 ± 0.014	2.442PheAsp: 2.442 ± 0.04	2.116PheGlu: 2.116 ± 0.04	1.197PhePhe: 1.197 ± 0.036	3.293PheGly: 3.293 ± 0.051	0.671PheHis: 0.671 ± 0.024	1.097PheIle: 1.097 ± 0.032	0.862PheLys: 0.862 ± 0.027	2.567PheLeu: 2.567 ± 0.042	0.635PheMet: 0.635 ± 0.021	0.848PheAsn: 0.848 ± 0.025	1.319PhePro: 1.319 ± 0.033	0.912PheGln: 0.912 ± 0.025	1.951PheArg: 1.951 ± 0.04	1.774PheSer: 1.774 ± 0.04	1.623PheThr: 1.623 ± 0.032	3.094PheVal: 3.094 ± 0.051	0.505PheTrp: 0.505 ± 0.02	0.739PheTyr: 0.739 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	10.6GlyAla: 10.6 ± 0.108	1.016GlyCys: 1.016 ± 0.028	4.322GlyAsp: 4.322 ± 0.054	4.855GlyGlu: 4.855 ± 0.057	3.208GlyPhe: 3.208 ± 0.049	7.537GlyGly: 7.537 ± 0.111	1.991GlyHis: 1.991 ± 0.04	3.385GlyIle: 3.385 ± 0.053	2.312GlyLys: 2.312 ± 0.051	9.505GlyLeu: 9.505 ± 0.088	1.849GlyMet: 1.849 ± 0.04	1.766GlyAsn: 1.766 ± 0.042	3.448GlyPro: 3.448 ± 0.053	2.935GlyGln: 2.935 ± 0.045	7.311GlyArg: 7.311 ± 0.082	4.691GlySer: 4.691 ± 0.087	4.513GlyThr: 4.513 ± 0.08	6.849GlyVal: 6.849 ± 0.06	1.73GlyTrp: 1.73 ± 0.037	2.089GlyTyr: 2.089 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	3.072HisAla: 3.072 ± 0.045	0.245HisCys: 0.245 ± 0.012	1.353HisAsp: 1.353 ± 0.032	1.415HisGlu: 1.415 ± 0.032	0.788HisPhe: 0.788 ± 0.025	2.267HisGly: 2.267 ± 0.04	0.603HisHis: 0.603 ± 0.025	0.564HisIle: 0.564 ± 0.02	0.418HisLys: 0.418 ± 0.015	2.12HisLeu: 2.12 ± 0.04	0.318HisMet: 0.318 ± 0.015	0.398HisAsn: 0.398 ± 0.018	1.446HisPro: 1.446 ± 0.036	0.604HisGln: 0.604 ± 0.017	1.68HisArg: 1.68 ± 0.037	0.779HisSer: 0.779 ± 0.022	0.904HisThr: 0.904 ± 0.026	1.621HisVal: 1.621 ± 0.037	0.418HisTrp: 0.418 ± 0.017	0.602HisTyr: 0.602 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.617IleAla: 5.617 ± 0.066	0.304IleCys: 0.304 ± 0.015	2.521IleAsp: 2.521 ± 0.042	2.7IleGlu: 2.7 ± 0.046	0.91IlePhe: 0.91 ± 0.028	3.727IleGly: 3.727 ± 0.058	0.607IleHis: 0.607 ± 0.022	0.926IleIle: 0.926 ± 0.031	0.953IleLys: 0.953 ± 0.028	2.493IleLeu: 2.493 ± 0.049	0.457IleMet: 0.457 ± 0.018	0.899IleAsn: 0.899 ± 0.025	1.608IlePro: 1.608 ± 0.037	0.915IleGln: 0.915 ± 0.025	2.256IleArg: 2.256 ± 0.046	1.777IleSer: 1.777 ± 0.04	1.974IleThr: 1.974 ± 0.039	3.614IleVal: 3.614 ± 0.053	0.366IleTrp: 0.366 ± 0.016	0.683IleTyr: 0.683 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.255LysAla: 3.255 ± 0.065	0.143LysCys: 0.143 ± 0.01	1.106LysAsp: 1.106 ± 0.031	1.017LysGlu: 1.017 ± 0.03	0.655LysPhe: 0.655 ± 0.02	1.762LysGly: 1.762 ± 0.037	0.452LysHis: 0.452 ± 0.018	1.041LysIle: 1.041 ± 0.026	0.978LysLys: 0.978 ± 0.041	2.781LysLeu: 2.781 ± 0.051	0.538LysMet: 0.538 ± 0.021	0.63LysAsn: 0.63 ± 0.025	1.72LysPro: 1.72 ± 0.045	0.817LysGln: 0.817 ± 0.024	1.875LysArg: 1.875 ± 0.039	1.341LysSer: 1.341 ± 0.034	1.522LysThr: 1.522 ± 0.037	1.911LysVal: 1.911 ± 0.046	0.239LysTrp: 0.239 ± 0.014	0.506LysTyr: 0.506 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	18.607LeuAla: 18.607 ± 0.169	0.905LeuCys: 0.905 ± 0.025	6.572LeuAsp: 6.572 ± 0.077	5.559LeuGlu: 5.559 ± 0.068	3.192LeuPhe: 3.192 ± 0.054	9.067LeuGly: 9.067 ± 0.091	2.465LeuHis: 2.465 ± 0.043	3.388LeuIle: 3.388 ± 0.045	3.079LeuLys: 3.079 ± 0.057	11.991LeuLeu: 11.991 ± 0.133	2.186LeuMet: 2.186 ± 0.045	2.174LeuAsn: 2.174 ± 0.041	6.829LeuPro: 6.829 ± 0.074	4.281LeuGln: 4.281 ± 0.063	9.174LeuArg: 9.174 ± 0.096	5.333LeuSer: 5.333 ± 0.061	4.626LeuThr: 4.626 ± 0.07	8.885LeuVal: 8.885 ± 0.09	1.325LeuTrp: 1.325 ± 0.031	1.915LeuTyr: 1.915 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.799MetAla: 2.799 ± 0.049	0.124MetCys: 0.124 ± 0.009	0.984MetAsp: 0.984 ± 0.024	0.762MetGlu: 0.762 ± 0.023	0.569MetPhe: 0.569 ± 0.021	1.43MetGly: 1.43 ± 0.035	0.437MetHis: 0.437 ± 0.017	0.755MetIle: 0.755 ± 0.025	0.823MetLys: 0.823 ± 0.025	2.424MetLeu: 2.424 ± 0.04	0.419MetMet: 0.419 ± 0.015	0.707MetAsn: 0.707 ± 0.02	1.371MetPro: 1.371 ± 0.036	0.82MetGln: 0.82 ± 0.023	1.672MetArg: 1.672 ± 0.033	1.439MetSer: 1.439 ± 0.03	1.278MetThr: 1.278 ± 0.03	1.369MetVal: 1.369 ± 0.029	0.15MetTrp: 0.15 ± 0.009	0.301MetTyr: 0.301 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.78AsnAla: 2.78 ± 0.05	0.198AsnCys: 0.198 ± 0.012	1.069AsnAsp: 1.069 ± 0.028	0.97AsnGlu: 0.97 ± 0.027	0.699AsnPhe: 0.699 ± 0.022	1.793AsnGly: 1.793 ± 0.048	0.397AsnHis: 0.397 ± 0.018	0.777AsnIle: 0.777 ± 0.022	0.534AsnLys: 0.534 ± 0.02	2.17AsnLeu: 2.17 ± 0.035	0.37AsnMet: 0.37 ± 0.017	0.491AsnAsn: 0.491 ± 0.023	1.513AsnPro: 1.513 ± 0.034	0.642AsnGln: 0.642 ± 0.02	1.393AsnArg: 1.393 ± 0.034	0.867AsnSer: 0.867 ± 0.031	1.156AsnThr: 1.156 ± 0.032	1.667AsnVal: 1.667 ± 0.038	0.315AsnTrp: 0.315 ± 0.015	0.507AsnTyr: 0.507 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	8.995ProAla: 8.995 ± 0.128	0.385ProCys: 0.385 ± 0.017	3.121ProAsp: 3.121 ± 0.044	3.799ProGlu: 3.799 ± 0.049	1.673ProPhe: 1.673 ± 0.031	5.355ProGly: 5.355 ± 0.066	1.028ProHis: 1.028 ± 0.025	1.524ProIle: 1.524 ± 0.035	1.263ProLys: 1.263 ± 0.031	5.658ProLeu: 5.658 ± 0.071	1.127ProMet: 1.127 ± 0.027	0.996ProAsn: 0.996 ± 0.024	3.549ProPro: 3.549 ± 0.071	1.996ProGln: 1.996 ± 0.037	3.81ProArg: 3.81 ± 0.054	2.585ProSer: 2.585 ± 0.042	2.494ProThr: 2.494 ± 0.045	4.462ProVal: 4.462 ± 0.065	0.854ProTrp: 0.854 ± 0.026	1.073ProTyr: 1.073 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	5.619GlnAla: 5.619 ± 0.074	0.216GlnCys: 0.216 ± 0.011	1.449GlnAsp: 1.449 ± 0.031	1.281GlnGlu: 1.281 ± 0.033	0.964GlnPhe: 0.964 ± 0.027	2.577GlnGly: 2.577 ± 0.042	0.811GlnHis: 0.811 ± 0.023	1.449GlnIle: 1.449 ± 0.029	0.739GlnLys: 0.739 ± 0.022	3.689GlnLeu: 3.689 ± 0.052	0.75GlnMet: 0.75 ± 0.024	0.647GlnAsn: 0.647 ± 0.023	2.095GlnPro: 2.095 ± 0.037	1.634GlnGln: 1.634 ± 0.04	3.767GlnArg: 3.767 ± 0.062	1.563GlnSer: 1.563 ± 0.035	1.74GlnThr: 1.74 ± 0.031	2.779GlnVal: 2.779 ± 0.045	0.534GlnTrp: 0.534 ± 0.019	0.638GlnTyr: 0.638 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	10.093ArgAla: 10.093 ± 0.095	0.786ArgCys: 0.786 ± 0.022	3.983ArgAsp: 3.983 ± 0.055	5.079ArgGlu: 5.079 ± 0.065	3.043ArgPhe: 3.043 ± 0.045	5.635ArgGly: 5.635 ± 0.068	2.286ArgHis: 2.286 ± 0.043	3.257ArgIle: 3.257 ± 0.05	1.601ArgLys: 1.601 ± 0.035	10.308ArgLeu: 10.308 ± 0.089	1.897ArgMet: 1.897 ± 0.036	1.486ArgAsn: 1.486 ± 0.031	4.254ArgPro: 4.254 ± 0.054	3.115ArgGln: 3.115 ± 0.052	8.052ArgArg: 8.052 ± 0.114	3.796ArgSer: 3.796 ± 0.051	3.356ArgThr: 3.356 ± 0.053	6.102ArgVal: 6.102 ± 0.072	1.668ArgTrp: 1.668 ± 0.039	1.84ArgTyr: 1.84 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.54SerAla: 6.54 ± 0.075	0.404SerCys: 0.404 ± 0.017	2.223SerAsp: 2.223 ± 0.041	2.2SerGlu: 2.2 ± 0.038	1.864SerPhe: 1.864 ± 0.038	4.879SerGly: 4.879 ± 0.089	0.955SerHis: 0.955 ± 0.025	1.792SerIle: 1.792 ± 0.039	1.085SerLys: 1.085 ± 0.032	5.241SerLeu: 5.241 ± 0.069	1.066SerMet: 1.066 ± 0.025	1.043SerAsn: 1.043 ± 0.031	2.662SerPro: 2.662 ± 0.043	1.488SerGln: 1.488 ± 0.035	3.679SerArg: 3.679 ± 0.054	2.558SerSer: 2.558 ± 0.063	2.64SerThr: 2.64 ± 0.06	3.669SerVal: 3.669 ± 0.054	0.765SerTrp: 0.765 ± 0.025	1.051SerTyr: 1.051 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	6.042ThrAla: 6.042 ± 0.075	0.335ThrCys: 0.335 ± 0.016	2.096ThrAsp: 2.096 ± 0.038	2.251ThrGlu: 2.251 ± 0.039	1.268ThrPhe: 1.268 ± 0.031	4.325ThrGly: 4.325 ± 0.07	0.988ThrHis: 0.988 ± 0.026	1.967ThrIle: 1.967 ± 0.043	1.041ThrLys: 1.041 ± 0.032	6.737ThrLeu: 6.737 ± 0.078	1.152ThrMet: 1.152 ± 0.03	0.969ThrAsn: 0.969 ± 0.031	3.601ThrPro: 3.601 ± 0.053	1.546ThrGln: 1.546 ± 0.032	3.665ThrArg: 3.665 ± 0.051	2.217ThrSer: 2.217 ± 0.045	2.758ThrThr: 2.758 ± 0.064	4.235ThrVal: 4.235 ± 0.059	0.646ThrTrp: 0.646 ± 0.024	0.834ThrTyr: 0.834 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.274ValAla: 11.274 ± 0.107	0.774ValCys: 0.774 ± 0.025	4.618ValAsp: 4.618 ± 0.059	4.751ValGlu: 4.751 ± 0.058	2.886ValPhe: 2.886 ± 0.048	6.057ValGly: 6.057 ± 0.062	1.687ValHis: 1.687 ± 0.032	2.748ValIle: 2.748 ± 0.048	1.945ValLys: 1.945 ± 0.046	8.796ValLeu: 8.796 ± 0.095	1.675ValMet: 1.675 ± 0.036	1.732ValAsn: 1.732 ± 0.031	4.193ValPro: 4.193 ± 0.066	2.803ValGln: 2.803 ± 0.042	5.759ValArg: 5.759 ± 0.057	3.745ValSer: 3.745 ± 0.057	3.83ValThr: 3.83 ± 0.059	7.206ValVal: 7.206 ± 0.083	1.081ValTrp: 1.081 ± 0.028	1.468ValTyr: 1.468 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.679TrpAla: 1.679 ± 0.033	0.186TrpCys: 0.186 ± 0.011	0.678TrpAsp: 0.678 ± 0.024	0.499TrpGlu: 0.499 ± 0.017	0.561TrpPhe: 0.561 ± 0.02	1.062TrpGly: 1.062 ± 0.031	0.409TrpHis: 0.409 ± 0.014	0.646TrpIle: 0.646 ± 0.019	0.366TrpLys: 0.366 ± 0.015	2.203TrpLeu: 2.203 ± 0.042	0.377TrpMet: 0.377 ± 0.017	0.369TrpAsn: 0.369 ± 0.017	0.807TrpPro: 0.807 ± 0.028	0.754TrpGln: 0.754 ± 0.021	1.655TrpArg: 1.655 ± 0.034	0.791TrpSer: 0.791 ± 0.023	0.805TrpThr: 0.805 ± 0.024	1.055TrpVal: 1.055 ± 0.028	0.303TrpTrp: 0.303 ± 0.016	0.292TrpTyr: 0.292 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.61TyrAla: 2.61 ± 0.046	0.203TyrCys: 0.203 ± 0.011	1.214TyrAsp: 1.214 ± 0.027	1.195TyrGlu: 1.195 ± 0.03	0.723TyrPhe: 0.723 ± 0.022	1.896TyrGly: 1.896 ± 0.039	0.368TyrHis: 0.368 ± 0.015	0.542TyrIle: 0.542 ± 0.021	0.469TyrLys: 0.469 ± 0.02	2.086TyrLeu: 2.086 ± 0.037	0.309TyrMet: 0.309 ± 0.015	0.466TyrAsn: 0.466 ± 0.02	0.965TyrPro: 0.965 ± 0.026	0.613TyrGln: 0.613 ± 0.023	1.785TyrArg: 1.785 ± 0.039	0.955TyrSer: 0.955 ± 0.027	1.065TyrThr: 1.065 ± 0.03	1.549TyrVal: 1.549 ± 0.031	0.334TyrTrp: 0.334 ± 0.016	0.461TyrTyr: 0.461 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4686 proteins (1556812 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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