Amino acid dipepetide frequency for Colletotrichum higginsianum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.583AlaAla: 11.583 ± 0.082	1.148AlaCys: 1.148 ± 0.015	4.927AlaAsp: 4.927 ± 0.033	5.587AlaGlu: 5.587 ± 0.048	3.38AlaPhe: 3.38 ± 0.024	6.81AlaGly: 6.81 ± 0.038	1.829AlaHis: 1.829 ± 0.019	4.158AlaIle: 4.158 ± 0.033	4.151AlaLys: 4.151 ± 0.033	8.163AlaLeu: 8.163 ± 0.042	2.108AlaMet: 2.108 ± 0.022	3.116AlaAsn: 3.116 ± 0.021	5.3AlaPro: 5.3 ± 0.042	3.436AlaGln: 3.436 ± 0.027	5.421AlaArg: 5.421 ± 0.036	7.6AlaSer: 7.6 ± 0.041	5.7AlaThr: 5.7 ± 0.031	6.469AlaVal: 6.469 ± 0.041	1.365AlaTrp: 1.365 ± 0.016	2.303AlaTyr: 2.303 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.991CysAla: 0.991 ± 0.016	0.24CysCys: 0.24 ± 0.008	0.674CysAsp: 0.674 ± 0.011	0.584CysGlu: 0.584 ± 0.01	0.537CysPhe: 0.537 ± 0.01	0.97CysGly: 0.97 ± 0.015	0.304CysHis: 0.304 ± 0.007	0.653CysIle: 0.653 ± 0.011	0.495CysLys: 0.495 ± 0.011	1.188CysLeu: 1.188 ± 0.015	0.265CysMet: 0.265 ± 0.007	0.429CysAsn: 0.429 ± 0.008	0.652CysPro: 0.652 ± 0.012	0.416CysGln: 0.416 ± 0.008	0.781CysArg: 0.781 ± 0.013	0.876CysSer: 0.876 ± 0.013	0.661CysThr: 0.661 ± 0.011	0.848CysVal: 0.848 ± 0.013	0.217CysTrp: 0.217 ± 0.006	0.356CysTyr: 0.356 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.416AspAla: 5.416 ± 0.033	0.647AspCys: 0.647 ± 0.011	4.77AspAsp: 4.77 ± 0.042	4.523AspGlu: 4.523 ± 0.034	2.315AspPhe: 2.315 ± 0.02	4.615AspGly: 4.615 ± 0.033	1.22AspHis: 1.22 ± 0.014	2.824AspIle: 2.824 ± 0.026	2.451AspLys: 2.451 ± 0.026	5.029AspLeu: 5.029 ± 0.036	1.301AspMet: 1.301 ± 0.016	1.889AspAsn: 1.889 ± 0.019	3.376AspPro: 3.376 ± 0.025	1.747AspGln: 1.747 ± 0.016	3.137AspArg: 3.137 ± 0.029	3.804AspSer: 3.804 ± 0.028	2.874AspThr: 2.874 ± 0.026	4.064AspVal: 4.064 ± 0.026	0.949AspTrp: 0.949 ± 0.012	1.54AspTyr: 1.54 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.862GluAla: 5.862 ± 0.05	0.6GluCys: 0.6 ± 0.011	4.131GluAsp: 4.131 ± 0.037	5.1GluGlu: 5.1 ± 0.053	1.879GluPhe: 1.879 ± 0.021	3.84GluGly: 3.84 ± 0.029	1.345GluHis: 1.345 ± 0.016	2.683GluIle: 2.683 ± 0.024	3.497GluLys: 3.497 ± 0.028	4.934GluLeu: 4.934 ± 0.035	1.445GluMet: 1.445 ± 0.016	2.073GluAsn: 2.073 ± 0.019	2.869GluPro: 2.869 ± 0.036	2.239GluGln: 2.239 ± 0.024	3.811GluArg: 3.811 ± 0.031	3.961GluSer: 3.961 ± 0.032	3.51GluThr: 3.51 ± 0.026	3.636GluVal: 3.636 ± 0.029	0.901GluTrp: 0.901 ± 0.012	1.574GluTyr: 1.574 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.314PheAla: 3.314 ± 0.028	0.55PheCys: 0.55 ± 0.009	2.385PheAsp: 2.385 ± 0.019	2.096PheGlu: 2.096 ± 0.019	1.673PhePhe: 1.673 ± 0.02	3.044PheGly: 3.044 ± 0.032	0.904PheHis: 0.904 ± 0.012	1.658PheIle: 1.658 ± 0.02	1.46PheLys: 1.46 ± 0.016	3.437PheLeu: 3.437 ± 0.031	0.801PheMet: 0.801 ± 0.012	1.437PheAsn: 1.437 ± 0.016	1.912PhePro: 1.912 ± 0.02	1.34PheGln: 1.34 ± 0.015	2.034PheArg: 2.034 ± 0.021	2.882PheSer: 2.882 ± 0.024	2.153PheThr: 2.153 ± 0.026	2.643PheVal: 2.643 ± 0.023	0.673PheTrp: 0.673 ± 0.01	1.124PheTyr: 1.124 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	6.194GlyAla: 6.194 ± 0.04	0.938GlyCys: 0.938 ± 0.012	4.018GlyAsp: 4.018 ± 0.027	3.725GlyGlu: 3.725 ± 0.028	3.024GlyPhe: 3.024 ± 0.024	6.995GlyGly: 6.995 ± 0.068	1.79GlyHis: 1.79 ± 0.017	3.498GlyIle: 3.498 ± 0.026	3.385GlyLys: 3.385 ± 0.027	6.437GlyLeu: 6.437 ± 0.039	1.644GlyMet: 1.644 ± 0.023	2.672GlyAsn: 2.672 ± 0.025	3.686GlyPro: 3.686 ± 0.03	2.613GlyGln: 2.613 ± 0.025	4.45GlyArg: 4.45 ± 0.034	5.883GlySer: 5.883 ± 0.049	4.241GlyThr: 4.241 ± 0.041	4.846GlyVal: 4.846 ± 0.034	1.27GlyTrp: 1.27 ± 0.016	2.172GlyTyr: 2.172 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.918HisAla: 1.918 ± 0.017	0.346HisCys: 0.346 ± 0.008	1.322HisAsp: 1.322 ± 0.014	1.272HisGlu: 1.272 ± 0.015	0.901HisPhe: 0.901 ± 0.014	1.767HisGly: 1.767 ± 0.019	0.89HisHis: 0.89 ± 0.017	1.051HisIle: 1.051 ± 0.015	0.862HisLys: 0.862 ± 0.013	2.144HisLeu: 2.144 ± 0.019	0.501HisMet: 0.501 ± 0.009	0.789HisAsn: 0.789 ± 0.011	1.587HisPro: 1.587 ± 0.017	0.977HisGln: 0.977 ± 0.014	1.493HisArg: 1.493 ± 0.017	1.585HisSer: 1.585 ± 0.017	1.152HisThr: 1.152 ± 0.013	1.524HisVal: 1.524 ± 0.016	0.347HisTrp: 0.347 ± 0.008	0.672HisTyr: 0.672 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.096IleAla: 4.096 ± 0.028	0.645IleCys: 0.645 ± 0.01	2.656IleAsp: 2.656 ± 0.02	2.57IleGlu: 2.57 ± 0.025	1.83IlePhe: 1.83 ± 0.021	3.115IleGly: 3.115 ± 0.026	1.089IleHis: 1.089 ± 0.014	2.222IleIle: 2.222 ± 0.021	1.991IleLys: 1.991 ± 0.021	4.123IleLeu: 4.123 ± 0.031	0.973IleMet: 0.973 ± 0.013	1.641IleAsn: 1.641 ± 0.018	2.785IlePro: 2.785 ± 0.026	1.677IleGln: 1.677 ± 0.018	2.633IleArg: 2.633 ± 0.021	3.28IleSer: 3.28 ± 0.025	2.638IleThr: 2.638 ± 0.03	3.204IleVal: 3.204 ± 0.025	0.685IleTrp: 0.685 ± 0.011	1.248IleTyr: 1.248 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.341LysAla: 4.341 ± 0.035	0.483LysCys: 0.483 ± 0.011	2.663LysAsp: 2.663 ± 0.025	3.102LysGlu: 3.102 ± 0.033	1.358LysPhe: 1.358 ± 0.015	2.994LysGly: 2.994 ± 0.024	1.061LysHis: 1.061 ± 0.013	2.045LysIle: 2.045 ± 0.021	3.241LysLys: 3.241 ± 0.042	3.854LysLeu: 3.854 ± 0.028	0.996LysMet: 0.996 ± 0.014	1.654LysAsn: 1.654 ± 0.018	2.64LysPro: 2.64 ± 0.025	1.685LysGln: 1.685 ± 0.017	3.135LysArg: 3.135 ± 0.029	3.165LysSer: 3.165 ± 0.026	2.88LysThr: 2.88 ± 0.024	2.743LysVal: 2.743 ± 0.028	0.67LysTrp: 0.67 ± 0.01	1.272LysTyr: 1.272 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	8.494LeuAla: 8.494 ± 0.045	1.137LeuCys: 1.137 ± 0.015	5.188LeuAsp: 5.188 ± 0.035	5.266LeuGlu: 5.266 ± 0.036	3.302LeuPhe: 3.302 ± 0.028	6.307LeuGly: 6.307 ± 0.037	2.079LeuHis: 2.079 ± 0.019	3.513LeuIle: 3.513 ± 0.028	3.871LeuLys: 3.871 ± 0.029	8.084LeuLeu: 8.084 ± 0.054	1.795LeuMet: 1.795 ± 0.018	2.887LeuAsn: 2.887 ± 0.025	5.395LeuPro: 5.395 ± 0.052	3.518LeuGln: 3.518 ± 0.03	5.799LeuArg: 5.799 ± 0.04	6.733LeuSer: 6.733 ± 0.038	4.779LeuThr: 4.779 ± 0.031	5.798LeuVal: 5.798 ± 0.038	1.245LeuTrp: 1.245 ± 0.016	2.219LeuTyr: 2.219 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	2.45MetAla: 2.45 ± 0.021	0.238MetCys: 0.238 ± 0.007	1.25MetAsp: 1.25 ± 0.017	1.208MetGlu: 1.208 ± 0.015	0.767MetPhe: 0.767 ± 0.011	1.509MetGly: 1.509 ± 0.018	0.463MetHis: 0.463 ± 0.009	0.935MetIle: 0.935 ± 0.014	0.981MetLys: 0.981 ± 0.013	1.859MetLeu: 1.859 ± 0.02	0.615MetMet: 0.615 ± 0.011	0.746MetAsn: 0.746 ± 0.012	1.317MetPro: 1.317 ± 0.017	0.814MetGln: 0.814 ± 0.015	1.316MetArg: 1.316 ± 0.018	1.825MetSer: 1.825 ± 0.02	1.354MetThr: 1.354 ± 0.014	1.366MetVal: 1.366 ± 0.016	0.278MetTrp: 0.278 ± 0.007	0.527MetTyr: 0.527 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	3.13AsnAla: 3.13 ± 0.026	0.445AsnCys: 0.445 ± 0.01	1.928AsnAsp: 1.928 ± 0.022	1.86AsnGlu: 1.86 ± 0.019	1.339AsnPhe: 1.339 ± 0.014	3.066AsnGly: 3.066 ± 0.029	0.788AsnHis: 0.788 ± 0.011	1.845AsnIle: 1.845 ± 0.02	1.489AsnLys: 1.489 ± 0.018	3.064AsnLeu: 3.064 ± 0.027	0.816AsnMet: 0.816 ± 0.013	1.518AsnAsn: 1.518 ± 0.024	2.362AsnPro: 2.362 ± 0.022	1.216AsnGln: 1.216 ± 0.018	1.846AsnArg: 1.846 ± 0.017	2.481AsnSer: 2.481 ± 0.021	2.072AsnThr: 2.072 ± 0.021	2.319AsnVal: 2.319 ± 0.017	0.547AsnTrp: 0.547 ± 0.009	1.009AsnTyr: 1.009 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.954ProAla: 5.954 ± 0.048	0.502ProCys: 0.502 ± 0.01	3.373ProAsp: 3.373 ± 0.022	3.891ProGlu: 3.891 ± 0.034	2.106ProPhe: 2.106 ± 0.019	4.344ProGly: 4.344 ± 0.039	1.251ProHis: 1.251 ± 0.016	2.323ProIle: 2.323 ± 0.022	2.574ProLys: 2.574 ± 0.021	4.619ProLeu: 4.619 ± 0.03	1.092ProMet: 1.092 ± 0.014	2.063ProAsn: 2.063 ± 0.023	5.27ProPro: 5.27 ± 0.07	2.378ProGln: 2.378 ± 0.025	3.488ProArg: 3.488 ± 0.027	5.596ProSer: 5.596 ± 0.055	3.914ProThr: 3.914 ± 0.038	3.856ProVal: 3.856 ± 0.032	0.795ProTrp: 0.795 ± 0.012	1.461ProTyr: 1.461 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	3.472GlnAla: 3.472 ± 0.029	0.424GlnCys: 0.424 ± 0.01	2.003GlnAsp: 2.003 ± 0.021	2.179GlnGlu: 2.179 ± 0.022	1.199GlnPhe: 1.199 ± 0.015	2.422GlnGly: 2.422 ± 0.024	1.068GlnHis: 1.068 ± 0.016	1.667GlnIle: 1.667 ± 0.02	1.787GlnLys: 1.787 ± 0.018	3.225GlnLeu: 3.225 ± 0.026	0.88GlnMet: 0.88 ± 0.014	1.343GlnAsn: 1.343 ± 0.016	2.47GlnPro: 2.47 ± 0.027	2.786GlnGln: 2.786 ± 0.062	2.528GlnArg: 2.528 ± 0.023	2.723GlnSer: 2.723 ± 0.024	2.263GlnThr: 2.263 ± 0.038	2.147GlnVal: 2.147 ± 0.018	0.568GlnTrp: 0.568 ± 0.01	1.083GlnTyr: 1.083 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	5.007ArgAla: 5.007 ± 0.034	0.742ArgCys: 0.742 ± 0.012	3.663ArgAsp: 3.663 ± 0.031	3.788ArgGlu: 3.788 ± 0.029	2.214ArgPhe: 2.214 ± 0.019	3.996ArgGly: 3.996 ± 0.035	1.579ArgHis: 1.579 ± 0.019	2.706ArgIle: 2.706 ± 0.024	3.221ArgLys: 3.221 ± 0.029	5.561ArgLeu: 5.561 ± 0.037	1.322ArgMet: 1.322 ± 0.018	2.176ArgAsn: 2.176 ± 0.019	3.674ArgPro: 3.674 ± 0.032	2.564ArgGln: 2.564 ± 0.022	5.293ArgArg: 5.293 ± 0.044	4.511ArgSer: 4.511 ± 0.032	3.262ArgThr: 3.262 ± 0.024	3.606ArgVal: 3.606 ± 0.029	0.996ArgTrp: 0.996 ± 0.012	1.606ArgTyr: 1.606 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.851SerAla: 6.851 ± 0.041	0.836SerCys: 0.836 ± 0.013	4.021SerAsp: 4.021 ± 0.028	3.768SerGlu: 3.768 ± 0.03	2.938SerPhe: 2.938 ± 0.024	5.671SerGly: 5.671 ± 0.045	1.735SerHis: 1.735 ± 0.019	3.522SerIle: 3.522 ± 0.031	3.344SerLys: 3.344 ± 0.031	6.714SerLeu: 6.714 ± 0.042	1.657SerMet: 1.657 ± 0.015	2.706SerAsn: 2.706 ± 0.022	5.182SerPro: 5.182 ± 0.042	2.919SerGln: 2.919 ± 0.026	4.778SerArg: 4.778 ± 0.036	8.01SerSer: 8.01 ± 0.069	5.123SerThr: 5.123 ± 0.063	4.709SerVal: 4.709 ± 0.041	1.141SerTrp: 1.141 ± 0.013	1.959SerTyr: 1.959 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.8ThrAla: 5.8 ± 0.034	0.739ThrCys: 0.739 ± 0.013	2.863ThrAsp: 2.863 ± 0.021	3.053ThrGlu: 3.053 ± 0.026	2.22ThrPhe: 2.22 ± 0.019	4.397ThrGly: 4.397 ± 0.045	1.199ThrHis: 1.199 ± 0.015	2.893ThrIle: 2.893 ± 0.03	2.516ThrLys: 2.516 ± 0.021	5.109ThrLeu: 5.109 ± 0.039	1.199ThrMet: 1.199 ± 0.015	2.03ThrAsn: 2.03 ± 0.02	4.362ThrPro: 4.362 ± 0.039	1.978ThrGln: 1.978 ± 0.02	3.149ThrArg: 3.149 ± 0.022	4.98ThrSer: 4.98 ± 0.067	4.544ThrThr: 4.544 ± 0.085	4.02ThrVal: 4.02 ± 0.069	0.898ThrTrp: 0.898 ± 0.013	1.607ThrTyr: 1.607 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	6.195ValAla: 6.195 ± 0.039	0.863ValCys: 0.863 ± 0.015	4.023ValAsp: 4.023 ± 0.034	3.974ValGlu: 3.974 ± 0.03	2.758ValPhe: 2.758 ± 0.028	4.474ValGly: 4.474 ± 0.033	1.384ValHis: 1.384 ± 0.016	2.913ValIle: 2.913 ± 0.034	2.872ValLys: 2.872 ± 0.026	5.956ValLeu: 5.956 ± 0.038	1.409ValMet: 1.409 ± 0.016	2.239ValAsn: 2.239 ± 0.024	3.925ValPro: 3.925 ± 0.032	2.314ValGln: 2.314 ± 0.02	3.762ValArg: 3.762 ± 0.028	4.739ValSer: 4.739 ± 0.028	3.876ValThr: 3.876 ± 0.049	5.026ValVal: 5.026 ± 0.043	0.971ValTrp: 0.971 ± 0.012	1.812ValTyr: 1.812 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	1.272TrpAla: 1.272 ± 0.016	0.206TrpCys: 0.206 ± 0.006	0.965TrpAsp: 0.965 ± 0.014	0.862TrpGlu: 0.862 ± 0.012	0.593TrpPhe: 0.593 ± 0.009	1.019TrpGly: 1.019 ± 0.013	0.395TrpHis: 0.395 ± 0.008	0.736TrpIle: 0.736 ± 0.012	0.769TrpLys: 0.769 ± 0.011	1.385TrpLeu: 1.385 ± 0.018	0.39TrpMet: 0.39 ± 0.009	0.646TrpAsn: 0.646 ± 0.011	0.66TrpPro: 0.66 ± 0.012	0.594TrpGln: 0.594 ± 0.011	1.021TrpArg: 1.021 ± 0.014	1.064TrpSer: 1.064 ± 0.013	0.989TrpThr: 0.989 ± 0.014	0.958TrpVal: 0.958 ± 0.013	0.31TrpTrp: 0.31 ± 0.007	0.463TrpTyr: 0.463 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.217TyrAla: 2.217 ± 0.019	0.409TyrCys: 0.409 ± 0.009	1.666TyrAsp: 1.666 ± 0.02	1.483TyrGlu: 1.483 ± 0.018	1.185TyrPhe: 1.185 ± 0.014	2.125TyrGly: 2.125 ± 0.022	0.727TyrHis: 0.727 ± 0.011	1.252TyrIle: 1.252 ± 0.014	1.026TyrLys: 1.026 ± 0.014	2.524TyrLeu: 2.524 ± 0.022	0.611TyrMet: 0.611 ± 0.011	1.087TyrAsn: 1.087 ± 0.013	1.428TyrPro: 1.428 ± 0.015	1.027TyrGln: 1.027 ± 0.015	1.611TyrArg: 1.611 ± 0.016	1.883TyrSer: 1.883 ± 0.016	1.572TyrThr: 1.572 ± 0.021	1.703TyrVal: 1.703 ± 0.018	0.472TyrTrp: 0.472 ± 0.008	0.878TyrTyr: 0.878 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12820 proteins (6257554 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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