Amino acid dipepetide frequency for Aminipila sp. CBA3637

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.268AlaAla: 6.268 ± 0.121	0.927AlaCys: 0.927 ± 0.034	4.074AlaAsp: 4.074 ± 0.076	5.004AlaGlu: 5.004 ± 0.079	2.91AlaPhe: 2.91 ± 0.061	5.576AlaGly: 5.576 ± 0.096	0.936AlaHis: 0.936 ± 0.034	5.6AlaIle: 5.6 ± 0.089	4.612AlaLys: 4.612 ± 0.083	6.514AlaLeu: 6.514 ± 0.098	2.198AlaMet: 2.198 ± 0.051	2.895AlaAsn: 2.895 ± 0.066	1.836AlaPro: 1.836 ± 0.043	2.116AlaGln: 2.116 ± 0.054	2.316AlaArg: 2.316 ± 0.053	3.912AlaSer: 3.912 ± 0.085	3.535AlaThr: 3.535 ± 0.085	5.618AlaVal: 5.618 ± 0.093	0.466AlaTrp: 0.466 ± 0.022	2.558AlaTyr: 2.558 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.87CysAla: 0.87 ± 0.032	0.247CysCys: 0.247 ± 0.018	0.709CysAsp: 0.709 ± 0.024	0.833CysGlu: 0.833 ± 0.033	0.651CysPhe: 0.651 ± 0.03	1.275CysGly: 1.275 ± 0.045	0.263CysHis: 0.263 ± 0.019	1.272CysIle: 1.272 ± 0.039	0.901CysLys: 0.901 ± 0.03	1.036CysLeu: 1.036 ± 0.038	0.386CysMet: 0.386 ± 0.021	0.689CysAsn: 0.689 ± 0.027	0.544CysPro: 0.544 ± 0.03	0.41CysGln: 0.41 ± 0.022	0.498CysArg: 0.498 ± 0.025	0.94CysSer: 0.94 ± 0.032	0.692CysThr: 0.692 ± 0.028	0.83CysVal: 0.83 ± 0.031	0.086CysTrp: 0.086 ± 0.008	0.502CysTyr: 0.502 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	3.326AspAla: 3.326 ± 0.064	0.735AspCys: 0.735 ± 0.035	2.527AspAsp: 2.527 ± 0.058	3.93AspGlu: 3.93 ± 0.069	2.621AspPhe: 2.621 ± 0.06	3.901AspGly: 3.901 ± 0.083	0.717AspHis: 0.717 ± 0.03	5.14AspIle: 5.14 ± 0.086	4.676AspLys: 4.676 ± 0.079	4.512AspLeu: 4.512 ± 0.069	1.717AspMet: 1.717 ± 0.05	2.846AspAsn: 2.846 ± 0.057	1.435AspPro: 1.435 ± 0.039	1.439AspGln: 1.439 ± 0.038	1.815AspArg: 1.815 ± 0.048	3.461AspSer: 3.461 ± 0.071	2.927AspThr: 2.927 ± 0.061	3.596AspVal: 3.596 ± 0.063	0.435AspTrp: 0.435 ± 0.025	2.72AspTyr: 2.72 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	4.634GluAla: 4.634 ± 0.096	0.787GluCys: 0.787 ± 0.031	3.651GluAsp: 3.651 ± 0.066	5.845GluGlu: 5.845 ± 0.107	2.648GluPhe: 2.648 ± 0.06	4.106GluGly: 4.106 ± 0.07	1.09GluHis: 1.09 ± 0.038	6.008GluIle: 6.008 ± 0.098	6.911GluLys: 6.911 ± 0.1	6.343GluLeu: 6.343 ± 0.093	2.194GluMet: 2.194 ± 0.054	4.5GluAsn: 4.5 ± 0.077	1.678GluPro: 1.678 ± 0.043	2.533GluGln: 2.533 ± 0.051	2.664GluArg: 2.664 ± 0.063	3.617GluSer: 3.617 ± 0.068	3.292GluThr: 3.292 ± 0.057	4.116GluVal: 4.116 ± 0.073	0.499GluTrp: 0.499 ± 0.021	2.738GluTyr: 2.738 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	2.802PheAla: 2.802 ± 0.06	0.66PheCys: 0.66 ± 0.031	2.48PheAsp: 2.48 ± 0.059	2.587PheGlu: 2.587 ± 0.063	1.847PhePhe: 1.847 ± 0.057	2.987PheGly: 2.987 ± 0.054	0.667PheHis: 0.667 ± 0.032	3.687PheIle: 3.687 ± 0.079	2.894PheLys: 2.894 ± 0.058	3.59PheLeu: 3.59 ± 0.083	1.242PheMet: 1.242 ± 0.035	2.187PheAsn: 2.187 ± 0.045	1.212PhePro: 1.212 ± 0.037	1.228PheGln: 1.228 ± 0.039	1.309PheArg: 1.309 ± 0.038	3.214PheSer: 3.214 ± 0.059	2.62PheThr: 2.62 ± 0.065	2.682PheVal: 2.682 ± 0.063	0.321PheTrp: 0.321 ± 0.021	1.663PheTyr: 1.663 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.641GlyAla: 4.641 ± 0.094	1.079GlyCys: 1.079 ± 0.045	3.419GlyAsp: 3.419 ± 0.068	4.152GlyGlu: 4.152 ± 0.063	3.112GlyPhe: 3.112 ± 0.059	4.697GlyGly: 4.697 ± 0.11	1.108GlyHis: 1.108 ± 0.041	6.677GlyIle: 6.677 ± 0.09	5.571GlyLys: 5.571 ± 0.098	5.726GlyLeu: 5.726 ± 0.087	2.168GlyMet: 2.168 ± 0.057	3.638GlyAsn: 3.638 ± 0.08	1.203GlyPro: 1.203 ± 0.039	2.137GlyGln: 2.137 ± 0.055	2.49GlyArg: 2.49 ± 0.058	4.236GlySer: 4.236 ± 0.09	4.646GlyThr: 4.646 ± 0.121	4.699GlyVal: 4.699 ± 0.078	0.64GlyTrp: 0.64 ± 0.033	3.163GlyTyr: 3.163 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	0.861HisAla: 0.861 ± 0.032	0.247HisCys: 0.247 ± 0.016	0.762HisAsp: 0.762 ± 0.03	0.909HisGlu: 0.909 ± 0.031	0.692HisPhe: 0.692 ± 0.028	1.119HisGly: 1.119 ± 0.039	0.324HisHis: 0.324 ± 0.02	1.363HisIle: 1.363 ± 0.038	1.138HisLys: 1.138 ± 0.042	1.288HisLeu: 1.288 ± 0.038	0.464HisMet: 0.464 ± 0.023	0.701HisAsn: 0.701 ± 0.028	0.65HisPro: 0.65 ± 0.026	0.481HisGln: 0.481 ± 0.023	0.569HisArg: 0.569 ± 0.026	0.904HisSer: 0.904 ± 0.033	0.831HisThr: 0.831 ± 0.036	0.917HisVal: 0.917 ± 0.034	0.173HisTrp: 0.173 ± 0.015	0.683HisTyr: 0.683 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.996IleAla: 5.996 ± 0.097	1.402IleCys: 1.402 ± 0.042	4.673IleAsp: 4.673 ± 0.077	5.564IleGlu: 5.564 ± 0.092	3.61IlePhe: 3.61 ± 0.081	5.487IleGly: 5.487 ± 0.095	1.234IleHis: 1.234 ± 0.039	7.253IleIle: 7.253 ± 0.11	6.45IleLys: 6.45 ± 0.089	7.711IleLeu: 7.711 ± 0.129	2.369IleMet: 2.369 ± 0.056	4.722IleAsn: 4.722 ± 0.07	3.104IlePro: 3.104 ± 0.057	2.504IleGln: 2.504 ± 0.051	2.906IleArg: 2.906 ± 0.063	6.303IleSer: 6.303 ± 0.088	5.187IleThr: 5.187 ± 0.091	5.547IleVal: 5.547 ± 0.098	0.61IleTrp: 0.61 ± 0.025	3.069IleTyr: 3.069 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.257LysAla: 5.257 ± 0.068	0.802LysCys: 0.802 ± 0.038	4.55LysAsp: 4.55 ± 0.089	6.693LysGlu: 6.693 ± 0.093	2.352LysPhe: 2.352 ± 0.057	4.835LysGly: 4.835 ± 0.09	1.053LysHis: 1.053 ± 0.03	6.294LysIle: 6.294 ± 0.098	6.48LysLys: 6.48 ± 0.109	6.157LysLeu: 6.157 ± 0.077	2.423LysMet: 2.423 ± 0.053	4.892LysAsn: 4.892 ± 0.086	2.187LysPro: 2.187 ± 0.044	2.677LysGln: 2.677 ± 0.066	2.778LysArg: 2.778 ± 0.064	4.469LysSer: 4.469 ± 0.072	4.266LysThr: 4.266 ± 0.076	4.979LysVal: 4.979 ± 0.077	0.659LysTrp: 0.659 ± 0.033	3.389LysTyr: 3.389 ± 0.081	0.0LysXaa: 0.0 ± 0.0
Leu	6.157LeuAla: 6.157 ± 0.091	1.349LeuCys: 1.349 ± 0.046	4.675LeuAsp: 4.675 ± 0.067	5.748LeuGlu: 5.748 ± 0.091	3.675LeuPhe: 3.675 ± 0.087	5.889LeuGly: 5.889 ± 0.094	1.293LeuHis: 1.293 ± 0.04	7.184LeuIle: 7.184 ± 0.116	6.989LeuLys: 6.989 ± 0.088	7.874LeuLeu: 7.874 ± 0.116	2.726LeuMet: 2.726 ± 0.066	4.785LeuAsn: 4.785 ± 0.075	3.051LeuPro: 3.051 ± 0.06	2.655LeuGln: 2.655 ± 0.054	3.12LeuArg: 3.12 ± 0.057	6.277LeuSer: 6.277 ± 0.082	5.011LeuThr: 5.011 ± 0.077	5.226LeuVal: 5.226 ± 0.086	0.725LeuTrp: 0.725 ± 0.032	3.212LeuTyr: 3.212 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.471MetAla: 2.471 ± 0.062	0.336MetCys: 0.336 ± 0.021	1.719MetAsp: 1.719 ± 0.042	2.302MetGlu: 2.302 ± 0.046	0.99MetPhe: 0.99 ± 0.038	2.122MetGly: 2.122 ± 0.055	0.405MetHis: 0.405 ± 0.023	2.342MetIle: 2.342 ± 0.052	2.559MetLys: 2.559 ± 0.05	2.682MetLeu: 2.682 ± 0.062	0.895MetMet: 0.895 ± 0.03	1.724MetAsn: 1.724 ± 0.043	1.15MetPro: 1.15 ± 0.042	0.959MetGln: 0.959 ± 0.035	1.004MetArg: 1.004 ± 0.034	1.757MetSer: 1.757 ± 0.047	1.579MetThr: 1.579 ± 0.046	2.008MetVal: 2.008 ± 0.053	0.184MetTrp: 0.184 ± 0.015	0.858MetTyr: 0.858 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.357AsnAla: 3.357 ± 0.07	0.789AsnCys: 0.789 ± 0.031	2.527AsnAsp: 2.527 ± 0.057	3.297AsnGlu: 3.297 ± 0.066	2.062AsnPhe: 2.062 ± 0.047	3.885AsnGly: 3.885 ± 0.098	0.898AsnHis: 0.898 ± 0.032	4.99AsnIle: 4.99 ± 0.083	4.091AsnLys: 4.091 ± 0.072	4.829AsnLeu: 4.829 ± 0.082	1.551AsnMet: 1.551 ± 0.039	3.032AsnAsn: 3.032 ± 0.068	2.216AsnPro: 2.216 ± 0.054	1.942AsnGln: 1.942 ± 0.056	1.979AsnArg: 1.979 ± 0.051	3.266AsnSer: 3.266 ± 0.068	2.931AsnThr: 2.931 ± 0.068	3.459AsnVal: 3.459 ± 0.064	0.501AsnTrp: 0.501 ± 0.019	2.221AsnTyr: 2.221 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.276ProAla: 2.276 ± 0.054	0.345ProCys: 0.345 ± 0.021	2.049ProAsp: 2.049 ± 0.058	2.779ProGlu: 2.779 ± 0.063	1.51ProPhe: 1.51 ± 0.043	2.026ProGly: 2.026 ± 0.05	0.473ProHis: 0.473 ± 0.026	2.282ProIle: 2.282 ± 0.048	1.875ProLys: 1.875 ± 0.045	2.61ProLeu: 2.61 ± 0.053	0.887ProMet: 0.887 ± 0.037	1.321ProAsn: 1.321 ± 0.038	0.692ProPro: 0.692 ± 0.028	0.986ProGln: 0.986 ± 0.031	0.818ProArg: 0.818 ± 0.03	1.726ProSer: 1.726 ± 0.05	1.526ProThr: 1.526 ± 0.051	2.829ProVal: 2.829 ± 0.057	0.249ProTrp: 0.249 ± 0.015	1.371ProTyr: 1.371 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.163GlnAla: 2.163 ± 0.058	0.368GlnCys: 0.368 ± 0.021	1.542GlnAsp: 1.542 ± 0.041	2.26GlnGlu: 2.26 ± 0.057	1.258GlnPhe: 1.258 ± 0.04	1.939GlnGly: 1.939 ± 0.049	0.49GlnHis: 0.49 ± 0.024	2.811GlnIle: 2.811 ± 0.059	2.525GlnLys: 2.525 ± 0.05	2.915GlnLeu: 2.915 ± 0.06	1.066GlnMet: 1.066 ± 0.035	1.934GlnAsn: 1.934 ± 0.058	0.813GlnPro: 0.813 ± 0.034	1.154GlnGln: 1.154 ± 0.044	1.101GlnArg: 1.101 ± 0.032	1.832GlnSer: 1.832 ± 0.044	1.655GlnThr: 1.655 ± 0.047	2.159GlnVal: 2.159 ± 0.049	0.286GlnTrp: 0.286 ± 0.019	1.357GlnTyr: 1.357 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.166ArgAla: 2.166 ± 0.054	0.405ArgCys: 0.405 ± 0.022	1.802ArgAsp: 1.802 ± 0.041	2.823ArgGlu: 2.823 ± 0.058	1.506ArgPhe: 1.506 ± 0.047	2.048ArgGly: 2.048 ± 0.044	0.585ArgHis: 0.585 ± 0.026	3.1ArgIle: 3.1 ± 0.067	2.996ArgLys: 2.996 ± 0.065	3.143ArgLeu: 3.143 ± 0.059	1.183ArgMet: 1.183 ± 0.044	2.107ArgAsn: 2.107 ± 0.052	1.014ArgPro: 1.014 ± 0.042	1.196ArgGln: 1.196 ± 0.04	1.508ArgArg: 1.508 ± 0.049	1.658ArgSer: 1.658 ± 0.044	1.841ArgThr: 1.841 ± 0.047	2.197ArgVal: 2.197 ± 0.05	0.286ArgTrp: 0.286 ± 0.016	1.467ArgTyr: 1.467 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.387SerAla: 4.387 ± 0.081	0.769SerCys: 0.769 ± 0.026	3.618SerAsp: 3.618 ± 0.071	3.952SerGlu: 3.952 ± 0.072	2.92SerPhe: 2.92 ± 0.069	4.961SerGly: 4.961 ± 0.11	0.985SerHis: 0.985 ± 0.037	5.258SerIle: 5.258 ± 0.083	4.564SerLys: 4.564 ± 0.081	5.475SerLeu: 5.475 ± 0.08	1.858SerMet: 1.858 ± 0.043	3.09SerAsn: 3.09 ± 0.061	1.791SerPro: 1.791 ± 0.048	2.129SerGln: 2.129 ± 0.057	2.254SerArg: 2.254 ± 0.053	4.125SerSer: 4.125 ± 0.097	3.24SerThr: 3.24 ± 0.082	4.467SerVal: 4.467 ± 0.074	0.519SerTrp: 0.519 ± 0.028	2.479SerTyr: 2.479 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	4.428ThrAla: 4.428 ± 0.098	0.624ThrCys: 0.624 ± 0.028	3.089ThrAsp: 3.089 ± 0.071	3.733ThrGlu: 3.733 ± 0.071	2.318ThrPhe: 2.318 ± 0.065	4.723ThrGly: 4.723 ± 0.108	0.845ThrHis: 0.845 ± 0.032	4.647ThrIle: 4.647 ± 0.086	3.488ThrLys: 3.488 ± 0.063	4.909ThrLeu: 4.909 ± 0.084	1.377ThrMet: 1.377 ± 0.037	2.581ThrAsn: 2.581 ± 0.063	2.173ThrPro: 2.173 ± 0.063	1.568ThrGln: 1.568 ± 0.041	1.787ThrArg: 1.787 ± 0.044	3.328ThrSer: 3.328 ± 0.072	3.142ThrThr: 3.142 ± 0.105	4.508ThrVal: 4.508 ± 0.102	0.419ThrTrp: 0.419 ± 0.022	2.102ThrTyr: 2.102 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	4.65ValAla: 4.65 ± 0.084	1.033ValCys: 1.033 ± 0.033	3.614ValAsp: 3.614 ± 0.057	4.318ValGlu: 4.318 ± 0.079	2.901ValPhe: 2.901 ± 0.062	4.23ValGly: 4.23 ± 0.07	0.896ValHis: 0.896 ± 0.028	5.838ValIle: 5.838 ± 0.092	4.886ValLys: 4.886 ± 0.077	6.094ValLeu: 6.094 ± 0.087	2.058ValMet: 2.058 ± 0.05	3.506ValAsn: 3.506 ± 0.063	2.364ValPro: 2.364 ± 0.055	1.935ValGln: 1.935 ± 0.047	2.278ValArg: 2.278 ± 0.053	4.761ValSer: 4.761 ± 0.087	4.173ValThr: 4.173 ± 0.106	4.704ValVal: 4.704 ± 0.083	0.499ValTrp: 0.499 ± 0.023	2.6ValTyr: 2.6 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.565TrpAla: 0.565 ± 0.029	0.108TrpCys: 0.108 ± 0.012	0.433TrpAsp: 0.433 ± 0.023	0.471TrpGlu: 0.471 ± 0.024	0.383TrpPhe: 0.383 ± 0.02	0.57TrpGly: 0.57 ± 0.026	0.147TrpHis: 0.147 ± 0.015	0.657TrpIle: 0.657 ± 0.031	0.608TrpLys: 0.608 ± 0.022	0.697TrpLeu: 0.697 ± 0.026	0.231TrpMet: 0.231 ± 0.017	0.514TrpAsn: 0.514 ± 0.026	0.195TrpPro: 0.195 ± 0.016	0.296TrpGln: 0.296 ± 0.019	0.296TrpArg: 0.296 ± 0.018	0.481TrpSer: 0.481 ± 0.025	0.386TrpThr: 0.386 ± 0.025	0.473TrpVal: 0.473 ± 0.025	0.095TrpTrp: 0.095 ± 0.011	0.359TrpTyr: 0.359 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.598TyrAla: 2.598 ± 0.072	0.62TyrCys: 0.62 ± 0.027	2.562TyrAsp: 2.562 ± 0.066	2.657TyrGlu: 2.657 ± 0.055	1.914TyrPhe: 1.914 ± 0.057	2.828TyrGly: 2.828 ± 0.055	0.665TyrHis: 0.665 ± 0.026	3.297TyrIle: 3.297 ± 0.072	2.979TyrLys: 2.979 ± 0.066	3.513TyrLeu: 3.513 ± 0.068	1.055TyrMet: 1.055 ± 0.033	2.162TyrAsn: 2.162 ± 0.057	1.321TyrPro: 1.321 ± 0.037	1.282TyrGln: 1.282 ± 0.04	1.54TyrArg: 1.54 ± 0.041	2.572TyrSer: 2.572 ± 0.058	2.308TyrThr: 2.308 ± 0.077	2.325TyrVal: 2.325 ± 0.045	0.313TyrTrp: 0.313 ± 0.019	1.89TyrTyr: 1.89 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3071 proteins (934980 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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