Amino acid dipepetide frequency for Pseudomonas phage Lu11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.89AlaAla: 8.89 ± 0.477
0.857AlaCys: 0.857 ± 0.104
5.152AlaAsp: 5.152 ± 0.233
5.864AlaGlu: 5.864 ± 0.339
3.46AlaPhe: 3.46 ± 0.207
5.619AlaGly: 5.619 ± 0.353
1.814AlaHis: 1.814 ± 0.141
4.529AlaIle: 4.529 ± 0.209
6.22AlaLys: 6.22 ± 0.339
7.767AlaLeu: 7.767 ± 0.276
2.548AlaMet: 2.548 ± 0.169
3.338AlaAsn: 3.338 ± 0.176
4.039AlaPro: 4.039 ± 0.261
3.394AlaGln: 3.394 ± 0.213
4.039AlaArg: 4.039 ± 0.232
5.085AlaSer: 5.085 ± 0.31
4.74AlaThr: 4.74 ± 0.291
5.953AlaVal: 5.953 ± 0.331
0.868AlaTrp: 0.868 ± 0.097
3.071AlaTyr: 3.071 ± 0.212
0.0AlaXaa: 0.0 ± 0.0
Cys
1.024CysAla: 1.024 ± 0.118
0.223CysCys: 0.223 ± 0.057
0.868CysAsp: 0.868 ± 0.114
0.857CysGlu: 0.857 ± 0.108
0.412CysPhe: 0.412 ± 0.066
1.001CysGly: 1.001 ± 0.131
0.367CysHis: 0.367 ± 0.071
0.612CysIle: 0.612 ± 0.101
0.768CysLys: 0.768 ± 0.101
0.668CysLeu: 0.668 ± 0.09
0.423CysMet: 0.423 ± 0.073
0.378CysAsn: 0.378 ± 0.061
0.679CysPro: 0.679 ± 0.098
0.278CysGln: 0.278 ± 0.058
0.523CysArg: 0.523 ± 0.073
0.567CysSer: 0.567 ± 0.09
0.579CysThr: 0.579 ± 0.077
0.99CysVal: 0.99 ± 0.119
0.111CysTrp: 0.111 ± 0.032
0.423CysTyr: 0.423 ± 0.072
0.0CysXaa: 0.0 ± 0.0
Asp
5.196AspAla: 5.196 ± 0.221
0.612AspCys: 0.612 ± 0.095
4.317AspAsp: 4.317 ± 0.37
5.241AspGlu: 5.241 ± 0.537
3.138AspPhe: 3.138 ± 0.17
4.74AspGly: 4.74 ± 0.223
1.179AspHis: 1.179 ± 0.105
3.583AspIle: 3.583 ± 0.213
3.505AspLys: 3.505 ± 0.201
5.052AspLeu: 5.052 ± 0.244
1.647AspMet: 1.647 ± 0.139
2.103AspAsn: 2.103 ± 0.14
2.904AspPro: 2.904 ± 0.178
1.48AspGln: 1.48 ± 0.118
2.782AspArg: 2.782 ± 0.171
3.349AspSer: 3.349 ± 0.168
2.826AspThr: 2.826 ± 0.161
4.796AspVal: 4.796 ± 0.244
1.001AspTrp: 1.001 ± 0.108
2.492AspTyr: 2.492 ± 0.164
0.0AspXaa: 0.0 ± 0.0
Glu
5.296GluAla: 5.296 ± 0.289
0.523GluCys: 0.523 ± 0.085
4.562GluAsp: 4.562 ± 0.539
5.341GluGlu: 5.341 ± 0.489
3.104GluPhe: 3.104 ± 0.173
3.449GluGly: 3.449 ± 0.189
1.78GluHis: 1.78 ± 0.163
4.173GluIle: 4.173 ± 0.211
4.34GluLys: 4.34 ± 0.282
5.118GluLeu: 5.118 ± 0.301
1.936GluMet: 1.936 ± 0.16
2.993GluAsn: 2.993 ± 0.177
2.693GluPro: 2.693 ± 0.222
2.782GluGln: 2.782 ± 0.204
3.961GluArg: 3.961 ± 0.209
3.427GluSer: 3.427 ± 0.223
3.761GluThr: 3.761 ± 0.177
3.906GluVal: 3.906 ± 0.212
1.001GluTrp: 1.001 ± 0.101
2.292GluTyr: 2.292 ± 0.179
0.0GluXaa: 0.0 ± 0.0
Phe
3.416PheAla: 3.416 ± 0.214
0.534PheCys: 0.534 ± 0.077
3.36PheAsp: 3.36 ± 0.216
2.415PheGlu: 2.415 ± 0.168
1.58PhePhe: 1.58 ± 0.14
2.626PheGly: 2.626 ± 0.201
0.946PheHis: 0.946 ± 0.126
2.036PheIle: 2.036 ± 0.153
2.392PheLys: 2.392 ± 0.211
2.96PheLeu: 2.96 ± 0.18
0.957PheMet: 0.957 ± 0.107
2.181PheAsn: 2.181 ± 0.165
1.658PhePro: 1.658 ± 0.131
1.235PheGln: 1.235 ± 0.109
2.27PheArg: 2.27 ± 0.127
2.415PheSer: 2.415 ± 0.183
2.782PheThr: 2.782 ± 0.249
3.305PheVal: 3.305 ± 0.175
0.389PheTrp: 0.389 ± 0.067
1.769PheTyr: 1.769 ± 0.154
0.0PheXaa: 0.0 ± 0.0
Gly
5.196GlyAla: 5.196 ± 0.301
0.846GlyCys: 0.846 ± 0.112
3.928GlyAsp: 3.928 ± 0.228
3.817GlyGlu: 3.817 ± 0.222
2.771GlyPhe: 2.771 ± 0.183
4.974GlyGly: 4.974 ± 0.724
1.346GlyHis: 1.346 ± 0.116
3.082GlyIle: 3.082 ± 0.19
4.751GlyLys: 4.751 ± 0.336
4.529GlyLeu: 4.529 ± 0.29
2.114GlyMet: 2.114 ± 0.166
2.682GlyAsn: 2.682 ± 0.185
2.86GlyPro: 2.86 ± 0.423
2.214GlyGln: 2.214 ± 0.168
3.65GlyArg: 3.65 ± 0.2
4.395GlySer: 4.395 ± 0.321
4.406GlyThr: 4.406 ± 0.293
4.451GlyVal: 4.451 ± 0.236
0.835GlyTrp: 0.835 ± 0.103
2.459GlyTyr: 2.459 ± 0.173
0.0GlyXaa: 0.0 ± 0.0
His
1.769HisAla: 1.769 ± 0.152
0.256HisCys: 0.256 ± 0.049
1.357HisAsp: 1.357 ± 0.121
1.625HisGlu: 1.625 ± 0.135
0.912HisPhe: 0.912 ± 0.098
1.591HisGly: 1.591 ± 0.144
0.623HisHis: 0.623 ± 0.079
1.335HisIle: 1.335 ± 0.132
1.491HisLys: 1.491 ± 0.141
1.636HisLeu: 1.636 ± 0.142
0.612HisMet: 0.612 ± 0.084
1.102HisAsn: 1.102 ± 0.099
0.935HisPro: 0.935 ± 0.09
0.723HisGln: 0.723 ± 0.096
1.202HisArg: 1.202 ± 0.108
1.413HisSer: 1.413 ± 0.126
1.302HisThr: 1.302 ± 0.114
1.858HisVal: 1.858 ± 0.157
0.245HisTrp: 0.245 ± 0.054
0.79HisTyr: 0.79 ± 0.093
0.0HisXaa: 0.0 ± 0.0
Ile
4.662IleAla: 4.662 ± 0.23
0.779IleCys: 0.779 ± 0.095
3.561IleAsp: 3.561 ± 0.19
4.228IleGlu: 4.228 ± 0.224
1.736IlePhe: 1.736 ± 0.131
3.238IleGly: 3.238 ± 0.234
1.191IleHis: 1.191 ± 0.127
2.481IleIle: 2.481 ± 0.163
3.071IleLys: 3.071 ± 0.228
3.672IleLeu: 3.672 ± 0.198
1.413IleMet: 1.413 ± 0.131
2.225IleAsn: 2.225 ± 0.184
2.615IlePro: 2.615 ± 0.164
1.903IleGln: 1.903 ± 0.128
3.227IleArg: 3.227 ± 0.174
3.772IleSer: 3.772 ± 0.215
3.238IleThr: 3.238 ± 0.222
3.694IleVal: 3.694 ± 0.224
0.567IleTrp: 0.567 ± 0.075
1.947IleTyr: 1.947 ± 0.179
0.0IleXaa: 0.0 ± 0.0
Lys
6.264LysAla: 6.264 ± 0.367
0.712LysCys: 0.712 ± 0.094
3.249LysAsp: 3.249 ± 0.25
4.306LysGlu: 4.306 ± 0.286
2.147LysPhe: 2.147 ± 0.165
3.65LysGly: 3.65 ± 0.282
1.88LysHis: 1.88 ± 0.149
3.594LysIle: 3.594 ± 0.203
5.831LysLys: 5.831 ± 0.611
5.43LysLeu: 5.43 ± 0.329
1.914LysMet: 1.914 ± 0.179
2.637LysAsn: 2.637 ± 0.193
3.027LysPro: 3.027 ± 0.198
2.715LysGln: 2.715 ± 0.178
4.228LysArg: 4.228 ± 0.26
3.694LysSer: 3.694 ± 0.326
3.828LysThr: 3.828 ± 0.232
4.128LysVal: 4.128 ± 0.23
0.668LysTrp: 0.668 ± 0.084
2.125LysTyr: 2.125 ± 0.155
0.0LysXaa: 0.0 ± 0.0
Leu
6.776LeuAla: 6.776 ± 0.285
0.946LeuCys: 0.946 ± 0.091
4.84LeuAsp: 4.84 ± 0.235
4.907LeuGlu: 4.907 ± 0.229
3.238LeuPhe: 3.238 ± 0.226
4.25LeuGly: 4.25 ± 0.242
2.036LeuHis: 2.036 ± 0.147
3.861LeuIle: 3.861 ± 0.198
5.219LeuLys: 5.219 ± 0.257
6.198LeuLeu: 6.198 ± 0.278
2.125LeuMet: 2.125 ± 0.161
3.572LeuAsn: 3.572 ± 0.221
4.173LeuPro: 4.173 ± 0.217
2.693LeuGln: 2.693 ± 0.189
5.085LeuArg: 5.085 ± 0.253
5.352LeuSer: 5.352 ± 0.247
4.595LeuThr: 4.595 ± 0.235
4.985LeuVal: 4.985 ± 0.266
0.746LeuTrp: 0.746 ± 0.087
2.537LeuTyr: 2.537 ± 0.162
0.0LeuXaa: 0.0 ± 0.0
Met
2.492MetAla: 2.492 ± 0.161
0.356MetCys: 0.356 ± 0.07
1.335MetAsp: 1.335 ± 0.138
1.691MetGlu: 1.691 ± 0.145
1.168MetPhe: 1.168 ± 0.133
1.435MetGly: 1.435 ± 0.119
0.612MetHis: 0.612 ± 0.083
1.613MetIle: 1.613 ± 0.139
1.892MetLys: 1.892 ± 0.167
2.292MetLeu: 2.292 ± 0.173
0.712MetMet: 0.712 ± 0.102
1.28MetAsn: 1.28 ± 0.119
1.569MetPro: 1.569 ± 0.136
1.369MetGln: 1.369 ± 0.133
2.292MetArg: 2.292 ± 0.182
1.558MetSer: 1.558 ± 0.124
1.747MetThr: 1.747 ± 0.136
1.558MetVal: 1.558 ± 0.122
0.289MetTrp: 0.289 ± 0.062
0.846MetTyr: 0.846 ± 0.095
0.0MetXaa: 0.0 ± 0.0
Asn
3.661AsnAla: 3.661 ± 0.196
0.534AsnCys: 0.534 ± 0.089
2.281AsnAsp: 2.281 ± 0.174
2.303AsnGlu: 2.303 ± 0.16
1.658AsnPhe: 1.658 ± 0.162
3.894AsnGly: 3.894 ± 0.242
0.835AsnHis: 0.835 ± 0.089
2.237AsnIle: 2.237 ± 0.149
2.559AsnLys: 2.559 ± 0.19
3.093AsnLeu: 3.093 ± 0.188
1.346AsnMet: 1.346 ± 0.128
1.747AsnAsn: 1.747 ± 0.125
2.314AsnPro: 2.314 ± 0.182
1.435AsnGln: 1.435 ± 0.14
2.225AsnArg: 2.225 ± 0.169
2.559AsnSer: 2.559 ± 0.188
2.615AsnThr: 2.615 ± 0.18
3.138AsnVal: 3.138 ± 0.181
0.512AsnTrp: 0.512 ± 0.072
1.435AsnTyr: 1.435 ± 0.123
0.0AsnXaa: 0.0 ± 0.0
Pro
4.64ProAla: 4.64 ± 0.351
0.679ProCys: 0.679 ± 0.11
2.971ProAsp: 2.971 ± 0.19
3.561ProGlu: 3.561 ± 0.218
1.725ProPhe: 1.725 ± 0.113
2.938ProGly: 2.938 ± 0.201
1.157ProHis: 1.157 ± 0.114
2.281ProIle: 2.281 ± 0.183
3.205ProLys: 3.205 ± 0.237
3.205ProLeu: 3.205 ± 0.196
1.135ProMet: 1.135 ± 0.106
1.969ProAsn: 1.969 ± 0.163
1.936ProPro: 1.936 ± 0.172
1.602ProGln: 1.602 ± 0.162
2.081ProArg: 2.081 ± 0.166
2.426ProSer: 2.426 ± 0.16
2.982ProThr: 2.982 ± 0.188
3.805ProVal: 3.805 ± 0.238
0.49ProTrp: 0.49 ± 0.074
1.491ProTyr: 1.491 ± 0.135
0.0ProXaa: 0.0 ± 0.0
Gln
2.848GlnAla: 2.848 ± 0.189
0.345GlnCys: 0.345 ± 0.067
1.447GlnAsp: 1.447 ± 0.124
1.992GlnGlu: 1.992 ± 0.187
1.658GlnPhe: 1.658 ± 0.152
2.159GlnGly: 2.159 ± 0.188
0.935GlnHis: 0.935 ± 0.106
2.27GlnIle: 2.27 ± 0.158
2.359GlnLys: 2.359 ± 0.174
3.082GlnLeu: 3.082 ± 0.183
1.179GlnMet: 1.179 ± 0.107
1.391GlnAsn: 1.391 ± 0.12
1.48GlnPro: 1.48 ± 0.13
1.558GlnGln: 1.558 ± 0.175
2.403GlnArg: 2.403 ± 0.163
1.914GlnSer: 1.914 ± 0.137
1.791GlnThr: 1.791 ± 0.138
2.481GlnVal: 2.481 ± 0.166
0.512GlnTrp: 0.512 ± 0.082
1.613GlnTyr: 1.613 ± 0.141
0.0GlnXaa: 0.0 ± 0.0
Arg
4.974ArgAla: 4.974 ± 0.257
0.69ArgCys: 0.69 ± 0.082
3.639ArgAsp: 3.639 ± 0.188
3.639ArgGlu: 3.639 ± 0.185
2.459ArgPhe: 2.459 ± 0.192
2.926ArgGly: 2.926 ± 0.21
1.213ArgHis: 1.213 ± 0.121
3.216ArgIle: 3.216 ± 0.197
4.161ArgLys: 4.161 ± 0.27
4.773ArgLeu: 4.773 ± 0.228
1.992ArgMet: 1.992 ± 0.16
2.648ArgAsn: 2.648 ± 0.168
2.303ArgPro: 2.303 ± 0.14
1.803ArgGln: 1.803 ± 0.162
3.405ArgArg: 3.405 ± 0.23
3.093ArgSer: 3.093 ± 0.187
2.871ArgThr: 2.871 ± 0.17
4.117ArgVal: 4.117 ± 0.261
0.701ArgTrp: 0.701 ± 0.091
2.081ArgTyr: 2.081 ± 0.151
0.0ArgXaa: 0.0 ± 0.0
Ser
4.807SerAla: 4.807 ± 0.252
0.668SerCys: 0.668 ± 0.091
4.084SerAsp: 4.084 ± 0.243
3.127SerGlu: 3.127 ± 0.205
2.504SerPhe: 2.504 ± 0.174
4.54SerGly: 4.54 ± 0.294
1.313SerHis: 1.313 ± 0.118
3.26SerIle: 3.26 ± 0.198
3.772SerLys: 3.772 ± 0.295
5.052SerLeu: 5.052 ± 0.341
1.691SerMet: 1.691 ± 0.125
2.548SerAsn: 2.548 ± 0.184
2.693SerPro: 2.693 ± 0.167
1.88SerGln: 1.88 ± 0.148
3.093SerArg: 3.093 ± 0.198
3.861SerSer: 3.861 ± 0.277
2.96SerThr: 2.96 ± 0.264
4.54SerVal: 4.54 ± 0.228
0.734SerTrp: 0.734 ± 0.108
2.581SerTyr: 2.581 ± 0.159
0.0SerXaa: 0.0 ± 0.0
Thr
5.174ThrAla: 5.174 ± 0.287
0.656ThrCys: 0.656 ± 0.088
3.505ThrAsp: 3.505 ± 0.207
3.549ThrGlu: 3.549 ± 0.204
2.604ThrPhe: 2.604 ± 0.177
4.751ThrGly: 4.751 ± 0.338
1.268ThrHis: 1.268 ± 0.111
3.116ThrIle: 3.116 ± 0.238
3.327ThrLys: 3.327 ± 0.226
4.673ThrLeu: 4.673 ± 0.238
1.213ThrMet: 1.213 ± 0.126
2.281ThrAsn: 2.281 ± 0.182
3.127ThrPro: 3.127 ± 0.233
2.058ThrGln: 2.058 ± 0.147
2.593ThrArg: 2.593 ± 0.158
3.015ThrSer: 3.015 ± 0.197
3.371ThrThr: 3.371 ± 0.226
4.651ThrVal: 4.651 ± 0.271
0.623ThrTrp: 0.623 ± 0.087
2.103ThrTyr: 2.103 ± 0.144
0.0ThrXaa: 0.0 ± 0.0
Val
5.986ValAla: 5.986 ± 0.296
0.823ValCys: 0.823 ± 0.095
4.495ValAsp: 4.495 ± 0.229
4.785ValGlu: 4.785 ± 0.249
2.915ValPhe: 2.915 ± 0.202
4.284ValGly: 4.284 ± 0.203
1.38ValHis: 1.38 ± 0.125
3.516ValIle: 3.516 ± 0.187
4.44ValLys: 4.44 ± 0.247
5.285ValLeu: 5.285 ± 0.303
1.78ValMet: 1.78 ± 0.132
2.982ValAsn: 2.982 ± 0.196
3.449ValPro: 3.449 ± 0.187
2.593ValGln: 2.593 ± 0.209
4.584ValArg: 4.584 ± 0.243
4.94ValSer: 4.94 ± 0.26
4.228ValThr: 4.228 ± 0.246
5.419ValVal: 5.419 ± 0.321
0.846ValTrp: 0.846 ± 0.084
2.804ValTyr: 2.804 ± 0.206
0.0ValXaa: 0.0 ± 0.0
Trp
0.946TrpAla: 0.946 ± 0.116
0.2TrpCys: 0.2 ± 0.044
0.634TrpAsp: 0.634 ± 0.083
0.656TrpGlu: 0.656 ± 0.084
0.512TrpPhe: 0.512 ± 0.071
0.757TrpGly: 0.757 ± 0.093
0.278TrpHis: 0.278 ± 0.062
0.523TrpIle: 0.523 ± 0.082
0.712TrpLys: 0.712 ± 0.095
1.102TrpLeu: 1.102 ± 0.098
0.323TrpMet: 0.323 ± 0.061
0.601TrpAsn: 0.601 ± 0.075
0.456TrpPro: 0.456 ± 0.071
0.556TrpGln: 0.556 ± 0.083
0.935TrpArg: 0.935 ± 0.104
0.679TrpSer: 0.679 ± 0.083
0.512TrpThr: 0.512 ± 0.084
0.59TrpVal: 0.59 ± 0.09
0.178TrpTrp: 0.178 ± 0.042
0.49TrpTyr: 0.49 ± 0.073
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.227TyrAla: 3.227 ± 0.212
0.512TyrCys: 0.512 ± 0.068
2.359TyrAsp: 2.359 ± 0.168
2.548TyrGlu: 2.548 ± 0.18
1.524TyrPhe: 1.524 ± 0.114
2.481TyrGly: 2.481 ± 0.186
0.623TyrHis: 0.623 ± 0.081
1.903TyrIle: 1.903 ± 0.147
2.014TyrLys: 2.014 ± 0.163
2.548TyrLeu: 2.548 ± 0.175
1.035TyrMet: 1.035 ± 0.108
1.725TyrAsn: 1.725 ± 0.129
1.369TyrPro: 1.369 ± 0.132
1.146TyrGln: 1.146 ± 0.108
2.125TyrArg: 2.125 ± 0.177
2.192TyrSer: 2.192 ± 0.181
2.526TyrThr: 2.526 ± 0.226
3.171TyrVal: 3.171 ± 0.239
0.323TyrTrp: 0.323 ± 0.058
1.157TyrTyr: 1.157 ± 0.104
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 391 proteins (89873 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski