Amino acid dipepetide frequency for Variibacter gotjawalensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.422AlaAla: 17.422 ± 0.176
0.987AlaCys: 0.987 ± 0.029
6.472AlaAsp: 6.472 ± 0.079
7.331AlaGlu: 7.331 ± 0.084
4.616AlaPhe: 4.616 ± 0.068
10.146AlaGly: 10.146 ± 0.104
2.211AlaHis: 2.211 ± 0.05
7.04AlaIle: 7.04 ± 0.085
5.492AlaLys: 5.492 ± 0.084
12.883AlaLeu: 12.883 ± 0.131
3.611AlaMet: 3.611 ± 0.055
3.251AlaAsn: 3.251 ± 0.048
5.816AlaPro: 5.816 ± 0.087
4.25AlaGln: 4.25 ± 0.067
8.14AlaArg: 8.14 ± 0.099
6.384AlaSer: 6.384 ± 0.075
6.384AlaThr: 6.384 ± 0.073
8.597AlaVal: 8.597 ± 0.086
1.503AlaTrp: 1.503 ± 0.033
2.688AlaTyr: 2.688 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.955CysAla: 0.955 ± 0.027
0.09CysCys: 0.09 ± 0.008
0.482CysAsp: 0.482 ± 0.021
0.429CysGlu: 0.429 ± 0.019
0.322CysPhe: 0.322 ± 0.016
0.889CysGly: 0.889 ± 0.028
0.207CysHis: 0.207 ± 0.014
0.414CysIle: 0.414 ± 0.02
0.213CysLys: 0.213 ± 0.012
0.665CysLeu: 0.665 ± 0.021
0.145CysMet: 0.145 ± 0.01
0.212CysAsn: 0.212 ± 0.013
0.379CysPro: 0.379 ± 0.019
0.192CysGln: 0.192 ± 0.013
0.568CysArg: 0.568 ± 0.025
0.413CysSer: 0.413 ± 0.018
0.406CysThr: 0.406 ± 0.016
0.677CysVal: 0.677 ± 0.022
0.091CysTrp: 0.091 ± 0.007
0.197CysTyr: 0.197 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.911AspAla: 6.911 ± 0.071
0.419AspCys: 0.419 ± 0.019
2.999AspAsp: 2.999 ± 0.057
3.246AspGlu: 3.246 ± 0.054
2.236AspPhe: 2.236 ± 0.034
4.843AspGly: 4.843 ± 0.076
1.133AspHis: 1.133 ± 0.031
3.105AspIle: 3.105 ± 0.048
2.109AspLys: 2.109 ± 0.043
5.28AspLeu: 5.28 ± 0.066
1.214AspMet: 1.214 ± 0.028
1.386AspAsn: 1.386 ± 0.034
3.053AspPro: 3.053 ± 0.051
1.59AspGln: 1.59 ± 0.035
3.982AspArg: 3.982 ± 0.065
1.971AspSer: 1.971 ± 0.041
2.623AspThr: 2.623 ± 0.049
4.423AspVal: 4.423 ± 0.06
0.856AspTrp: 0.856 ± 0.027
1.431AspTyr: 1.431 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
6.91GluAla: 6.91 ± 0.1
0.375GluCys: 0.375 ± 0.017
2.384GluAsp: 2.384 ± 0.046
2.807GluGlu: 2.807 ± 0.054
1.826GluPhe: 1.826 ± 0.033
3.782GluGly: 3.782 ± 0.063
1.195GluHis: 1.195 ± 0.03
3.334GluIle: 3.334 ± 0.05
2.862GluLys: 2.862 ± 0.052
4.955GluLeu: 4.955 ± 0.065
1.468GluMet: 1.468 ± 0.034
1.603GluAsn: 1.603 ± 0.035
2.737GluPro: 2.737 ± 0.047
2.127GluGln: 2.127 ± 0.043
4.763GluArg: 4.763 ± 0.068
2.377GluSer: 2.377 ± 0.042
3.405GluThr: 3.405 ± 0.053
3.746GluVal: 3.746 ± 0.052
0.732GluTrp: 0.732 ± 0.02
1.047GluTyr: 1.047 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
5.069PheAla: 5.069 ± 0.063
0.387PheCys: 0.387 ± 0.017
2.575PheAsp: 2.575 ± 0.047
2.009PheGlu: 2.009 ± 0.047
1.519PhePhe: 1.519 ± 0.038
3.845PheGly: 3.845 ± 0.063
0.703PheHis: 0.703 ± 0.024
1.85PheIle: 1.85 ± 0.038
1.285PheLys: 1.285 ± 0.029
3.26PheLeu: 3.26 ± 0.054
0.789PheMet: 0.789 ± 0.023
1.182PheAsn: 1.182 ± 0.032
1.741PhePro: 1.741 ± 0.041
1.004PheGln: 1.004 ± 0.031
2.366PheArg: 2.366 ± 0.039
2.156PheSer: 2.156 ± 0.037
2.013PheThr: 2.013 ± 0.036
3.106PheVal: 3.106 ± 0.053
0.56PheTrp: 0.56 ± 0.022
0.941PheTyr: 0.941 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
9.262GlyAla: 9.262 ± 0.105
0.78GlyCys: 0.78 ± 0.025
4.32GlyAsp: 4.32 ± 0.06
4.64GlyGlu: 4.64 ± 0.057
3.634GlyPhe: 3.634 ± 0.051
7.639GlyGly: 7.639 ± 0.109
1.722GlyHis: 1.722 ± 0.035
4.787GlyIle: 4.787 ± 0.064
3.726GlyLys: 3.726 ± 0.061
8.212GlyLeu: 8.212 ± 0.096
2.21GlyMet: 2.21 ± 0.039
2.288GlyAsn: 2.288 ± 0.05
3.523GlyPro: 3.523 ± 0.059
2.679GlyGln: 2.679 ± 0.044
5.604GlyArg: 5.604 ± 0.064
4.682GlySer: 4.682 ± 0.058
4.688GlyThr: 4.688 ± 0.084
6.255GlyVal: 6.255 ± 0.066
1.367GlyTrp: 1.367 ± 0.034
2.356GlyTyr: 2.356 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.315HisAla: 2.315 ± 0.036
0.212HisCys: 0.212 ± 0.012
1.152HisAsp: 1.152 ± 0.031
0.976HisGlu: 0.976 ± 0.026
0.803HisPhe: 0.803 ± 0.026
1.86HisGly: 1.86 ± 0.041
0.59HisHis: 0.59 ± 0.025
0.998HisIle: 0.998 ± 0.027
0.568HisLys: 0.568 ± 0.02
1.784HisLeu: 1.784 ± 0.034
0.461HisMet: 0.461 ± 0.018
0.483HisAsn: 0.483 ± 0.02
1.178HisPro: 1.178 ± 0.031
0.565HisGln: 0.565 ± 0.018
1.312HisArg: 1.312 ± 0.032
0.867HisSer: 0.867 ± 0.027
0.878HisThr: 0.878 ± 0.028
1.509HisVal: 1.509 ± 0.034
0.3HisTrp: 0.3 ± 0.014
0.551HisTyr: 0.551 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
8.419IleAla: 8.419 ± 0.084
0.513IleCys: 0.513 ± 0.02
3.647IleAsp: 3.647 ± 0.056
3.637IleGlu: 3.637 ± 0.058
1.886IlePhe: 1.886 ± 0.04
5.18IleGly: 5.18 ± 0.076
0.813IleHis: 0.813 ± 0.025
2.543IleIle: 2.543 ± 0.046
1.938IleLys: 1.938 ± 0.041
4.379IleLeu: 4.379 ± 0.063
1.016IleMet: 1.016 ± 0.028
1.579IleAsn: 1.579 ± 0.032
2.453IlePro: 2.453 ± 0.043
1.219IleGln: 1.219 ± 0.03
3.04IleArg: 3.04 ± 0.047
2.89IleSer: 2.89 ± 0.052
3.022IleThr: 3.022 ± 0.046
4.944IleVal: 4.944 ± 0.063
0.599IleTrp: 0.599 ± 0.022
1.162IleTyr: 1.162 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
4.845LysAla: 4.845 ± 0.078
0.19LysCys: 0.19 ± 0.012
2.078LysAsp: 2.078 ± 0.05
1.884LysGlu: 1.884 ± 0.043
1.26LysPhe: 1.26 ± 0.032
2.826LysGly: 2.826 ± 0.062
0.763LysHis: 0.763 ± 0.025
2.288LysIle: 2.288 ± 0.042
2.045LysLys: 2.045 ± 0.055
4.201LysLeu: 4.201 ± 0.058
0.997LysMet: 0.997 ± 0.029
1.125LysAsn: 1.125 ± 0.03
2.56LysPro: 2.56 ± 0.051
1.336LysGln: 1.336 ± 0.033
2.986LysArg: 2.986 ± 0.046
2.236LysSer: 2.236 ± 0.039
2.381LysThr: 2.381 ± 0.041
2.902LysVal: 2.902 ± 0.044
0.47LysTrp: 0.47 ± 0.02
0.766LysTyr: 0.766 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
12.88LeuAla: 12.88 ± 0.12
0.813LeuCys: 0.813 ± 0.024
5.469LeuAsp: 5.469 ± 0.073
4.551LeuGlu: 4.551 ± 0.059
3.477LeuPhe: 3.477 ± 0.058
8.054LeuGly: 8.054 ± 0.092
1.683LeuHis: 1.683 ± 0.037
5.24LeuIle: 5.24 ± 0.081
4.01LeuLys: 4.01 ± 0.065
8.608LeuLeu: 8.608 ± 0.109
2.308LeuMet: 2.308 ± 0.046
2.6LeuAsn: 2.6 ± 0.052
5.18LeuPro: 5.18 ± 0.06
2.566LeuGln: 2.566 ± 0.039
6.429LeuArg: 6.429 ± 0.07
5.861LeuSer: 5.861 ± 0.07
5.526LeuThr: 5.526 ± 0.066
7.09LeuVal: 7.09 ± 0.091
1.116LeuTrp: 1.116 ± 0.035
2.022LeuTyr: 2.022 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.877MetAla: 2.877 ± 0.045
0.16MetCys: 0.16 ± 0.011
1.029MetAsp: 1.029 ± 0.03
0.937MetGlu: 0.937 ± 0.025
0.858MetPhe: 0.858 ± 0.024
1.679MetGly: 1.679 ± 0.034
0.468MetHis: 0.468 ± 0.021
1.423MetIle: 1.423 ± 0.032
1.127MetLys: 1.127 ± 0.03
2.554MetLeu: 2.554 ± 0.05
0.704MetMet: 0.704 ± 0.02
0.752MetAsn: 0.752 ± 0.024
1.601MetPro: 1.601 ± 0.038
0.911MetGln: 0.911 ± 0.026
2.056MetArg: 2.056 ± 0.042
1.688MetSer: 1.688 ± 0.035
1.85MetThr: 1.85 ± 0.032
1.607MetVal: 1.607 ± 0.037
0.263MetTrp: 0.263 ± 0.015
0.379MetTyr: 0.379 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.58AsnAla: 3.58 ± 0.048
0.24AsnCys: 0.24 ± 0.015
1.59AsnAsp: 1.59 ± 0.04
1.403AsnGlu: 1.403 ± 0.034
1.062AsnPhe: 1.062 ± 0.031
2.516AsnGly: 2.516 ± 0.053
0.476AsnHis: 0.476 ± 0.019
1.509AsnIle: 1.509 ± 0.034
0.872AsnLys: 0.872 ± 0.024
2.576AsnLeu: 2.576 ± 0.045
0.66AsnMet: 0.66 ± 0.023
0.789AsnAsn: 0.789 ± 0.025
1.837AsnPro: 1.837 ± 0.035
0.772AsnGln: 0.772 ± 0.024
1.846AsnArg: 1.846 ± 0.038
1.239AsnSer: 1.239 ± 0.031
1.406AsnThr: 1.406 ± 0.031
2.376AsnVal: 2.376 ± 0.044
0.421AsnTrp: 0.421 ± 0.02
0.776AsnTyr: 0.776 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
6.028ProAla: 6.028 ± 0.078
0.281ProCys: 0.281 ± 0.016
3.329ProAsp: 3.329 ± 0.055
3.324ProGlu: 3.324 ± 0.053
1.976ProPhe: 1.976 ± 0.042
4.344ProGly: 4.344 ± 0.067
1.098ProHis: 1.098 ± 0.028
2.758ProIle: 2.758 ± 0.045
2.176ProLys: 2.176 ± 0.038
4.507ProLeu: 4.507 ± 0.066
1.246ProMet: 1.246 ± 0.03
1.716ProAsn: 1.716 ± 0.033
2.901ProPro: 2.901 ± 0.081
1.907ProGln: 1.907 ± 0.043
3.108ProArg: 3.108 ± 0.05
2.868ProSer: 2.868 ± 0.045
2.772ProThr: 2.772 ± 0.042
3.841ProVal: 3.841 ± 0.055
0.676ProTrp: 0.676 ± 0.022
1.291ProTyr: 1.291 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.788GlnAla: 3.788 ± 0.057
0.21GlnCys: 0.21 ± 0.012
1.333GlnAsp: 1.333 ± 0.033
1.394GlnGlu: 1.394 ± 0.032
1.13GlnPhe: 1.13 ± 0.025
2.305GlnGly: 2.305 ± 0.038
0.688GlnHis: 0.688 ± 0.025
1.805GlnIle: 1.805 ± 0.042
1.344GlnLys: 1.344 ± 0.033
2.824GlnLeu: 2.824 ± 0.05
0.89GlnMet: 0.89 ± 0.027
0.979GlnAsn: 0.979 ± 0.031
1.823GlnPro: 1.823 ± 0.049
1.378GlnGln: 1.378 ± 0.043
2.595GlnArg: 2.595 ± 0.047
1.759GlnSer: 1.759 ± 0.033
1.813GlnThr: 1.813 ± 0.034
2.087GlnVal: 2.087 ± 0.043
0.409GlnTrp: 0.409 ± 0.015
0.67GlnTyr: 0.67 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
7.863ArgAla: 7.863 ± 0.084
0.466ArgCys: 0.466 ± 0.017
4.201ArgAsp: 4.201 ± 0.056
4.312ArgGlu: 4.312 ± 0.063
2.841ArgPhe: 2.841 ± 0.047
5.074ArgGly: 5.074 ± 0.07
1.418ArgHis: 1.418 ± 0.034
3.882ArgIle: 3.882 ± 0.059
2.625ArgLys: 2.625 ± 0.051
6.809ArgLeu: 6.809 ± 0.08
1.881ArgMet: 1.881 ± 0.038
1.958ArgAsn: 1.958 ± 0.041
3.383ArgPro: 3.383 ± 0.068
2.231ArgGln: 2.231 ± 0.04
5.047ArgArg: 5.047 ± 0.067
3.571ArgSer: 3.571 ± 0.06
3.388ArgThr: 3.388 ± 0.051
5.099ArgVal: 5.099 ± 0.071
1.026ArgTrp: 1.026 ± 0.028
1.784ArgTyr: 1.784 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.26SerAla: 6.26 ± 0.086
0.397SerCys: 0.397 ± 0.021
2.87SerAsp: 2.87 ± 0.049
2.807SerGlu: 2.807 ± 0.047
2.302SerPhe: 2.302 ± 0.036
5.361SerGly: 5.361 ± 0.073
1.001SerHis: 1.001 ± 0.027
2.834SerIle: 2.834 ± 0.044
1.694SerLys: 1.694 ± 0.038
5.143SerLeu: 5.143 ± 0.069
1.268SerMet: 1.268 ± 0.028
1.403SerAsn: 1.403 ± 0.034
2.765SerPro: 2.765 ± 0.045
1.566SerGln: 1.566 ± 0.034
3.632SerArg: 3.632 ± 0.053
2.875SerSer: 2.875 ± 0.061
2.652SerThr: 2.652 ± 0.051
4.086SerVal: 4.086 ± 0.059
0.703SerTrp: 0.703 ± 0.024
1.329SerTyr: 1.329 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
6.299ThrAla: 6.299 ± 0.068
0.422ThrCys: 0.422 ± 0.018
2.76ThrAsp: 2.76 ± 0.044
2.648ThrGlu: 2.648 ± 0.043
2.285ThrPhe: 2.285 ± 0.04
4.919ThrGly: 4.919 ± 0.068
1.11ThrHis: 1.11 ± 0.028
3.187ThrIle: 3.187 ± 0.054
1.92ThrLys: 1.92 ± 0.042
5.872ThrLeu: 5.872 ± 0.083
1.287ThrMet: 1.287 ± 0.032
1.466ThrAsn: 1.466 ± 0.038
3.401ThrPro: 3.401 ± 0.05
1.606ThrGln: 1.606 ± 0.04
3.486ThrArg: 3.486 ± 0.048
2.841ThrSer: 2.841 ± 0.054
3.156ThrThr: 3.156 ± 0.055
4.279ThrVal: 4.279 ± 0.061
0.724ThrTrp: 0.724 ± 0.022
1.302ThrTyr: 1.302 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
9.639ValAla: 9.639 ± 0.103
0.633ValCys: 0.633 ± 0.024
4.067ValAsp: 4.067 ± 0.058
4.343ValGlu: 4.343 ± 0.068
2.799ValPhe: 2.799 ± 0.052
5.858ValGly: 5.858 ± 0.075
1.347ValHis: 1.347 ± 0.03
4.196ValIle: 4.196 ± 0.059
2.872ValLys: 2.872 ± 0.052
7.138ValLeu: 7.138 ± 0.09
1.93ValMet: 1.93 ± 0.037
2.076ValAsn: 2.076 ± 0.038
3.902ValPro: 3.902 ± 0.056
2.035ValGln: 2.035 ± 0.037
4.946ValArg: 4.946 ± 0.061
4.373ValSer: 4.373 ± 0.061
4.615ValThr: 4.615 ± 0.059
6.23ValVal: 6.23 ± 0.071
0.922ValTrp: 0.922 ± 0.028
1.532ValTyr: 1.532 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.16TrpAla: 1.16 ± 0.031
0.133TrpCys: 0.133 ± 0.011
0.625TrpAsp: 0.625 ± 0.024
0.507TrpGlu: 0.507 ± 0.022
0.549TrpPhe: 0.549 ± 0.02
0.982TrpGly: 0.982 ± 0.03
0.307TrpHis: 0.307 ± 0.015
0.699TrpIle: 0.699 ± 0.024
0.542TrpLys: 0.542 ± 0.02
1.593TrpLeu: 1.593 ± 0.038
0.365TrpMet: 0.365 ± 0.014
0.473TrpAsn: 0.473 ± 0.019
0.717TrpPro: 0.717 ± 0.024
0.605TrpGln: 0.605 ± 0.024
1.117TrpArg: 1.117 ± 0.031
0.82TrpSer: 0.82 ± 0.025
0.812TrpThr: 0.812 ± 0.026
0.82TrpVal: 0.82 ± 0.026
0.242TrpTrp: 0.242 ± 0.015
0.292TrpTyr: 0.292 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.744TyrAla: 2.744 ± 0.05
0.239TyrCys: 0.239 ± 0.014
1.428TyrAsp: 1.428 ± 0.036
1.254TyrGlu: 1.254 ± 0.033
0.976TyrPhe: 0.976 ± 0.028
2.272TyrGly: 2.272 ± 0.041
0.428TyrHis: 0.428 ± 0.017
0.99TyrIle: 0.99 ± 0.028
0.719TyrLys: 0.719 ± 0.028
2.238TyrLeu: 2.238 ± 0.04
0.472TyrMet: 0.472 ± 0.02
0.622TyrAsn: 0.622 ± 0.024
1.194TyrPro: 1.194 ± 0.032
0.687TyrGln: 0.687 ± 0.023
1.838TyrArg: 1.838 ± 0.036
1.077TyrSer: 1.077 ± 0.025
1.18TyrThr: 1.18 ± 0.031
1.778TyrVal: 1.778 ± 0.035
0.381TyrTrp: 0.381 ± 0.017
0.645TyrTyr: 0.645 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4437 proteins (1358188 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski