Amino acid dipepetide frequency for Flavobacterium phage vB_FspS_snork6-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.84AlaAla: 0.84 ± 0.381
0.84AlaCys: 0.84 ± 0.256
1.849AlaAsp: 1.849 ± 0.337
2.857AlaGlu: 2.857 ± 0.685
2.185AlaPhe: 2.185 ± 0.404
2.185AlaGly: 2.185 ± 0.419
0.42AlaHis: 0.42 ± 0.228
3.782AlaIle: 3.782 ± 0.544
5.295AlaLys: 5.295 ± 0.692
4.79AlaLeu: 4.79 ± 0.734
1.597AlaMet: 1.597 ± 0.549
4.538AlaAsn: 4.538 ± 0.597
0.84AlaPro: 0.84 ± 0.259
2.353AlaGln: 2.353 ± 0.494
1.345AlaArg: 1.345 ± 0.442
2.941AlaSer: 2.941 ± 0.682
4.202AlaThr: 4.202 ± 0.582
3.446AlaVal: 3.446 ± 0.672
0.672AlaTrp: 0.672 ± 0.195
1.933AlaTyr: 1.933 ± 0.372
0.0AlaXaa: 0.0 ± 0.0
Cys
0.336CysAla: 0.336 ± 0.193
0.252CysCys: 0.252 ± 0.144
0.84CysAsp: 0.84 ± 0.229
1.093CysGlu: 1.093 ± 0.276
0.756CysPhe: 0.756 ± 0.223
0.924CysGly: 0.924 ± 0.28
0.168CysHis: 0.168 ± 0.118
0.42CysIle: 0.42 ± 0.169
0.924CysLys: 0.924 ± 0.328
1.597CysLeu: 1.597 ± 0.373
0.084CysMet: 0.084 ± 0.082
0.252CysAsn: 0.252 ± 0.143
0.588CysPro: 0.588 ± 0.212
0.252CysGln: 0.252 ± 0.147
0.336CysArg: 0.336 ± 0.167
0.84CysSer: 0.84 ± 0.266
0.756CysThr: 0.756 ± 0.195
0.672CysVal: 0.672 ± 0.238
0.084CysTrp: 0.084 ± 0.101
0.588CysTyr: 0.588 ± 0.188
0.0CysXaa: 0.0 ± 0.0
Asp
3.782AspAla: 3.782 ± 0.414
0.924AspCys: 0.924 ± 0.252
1.933AspAsp: 1.933 ± 0.444
4.286AspGlu: 4.286 ± 0.703
3.53AspPhe: 3.53 ± 0.558
2.689AspGly: 2.689 ± 0.488
0.588AspHis: 0.588 ± 0.201
3.53AspIle: 3.53 ± 0.531
6.051AspLys: 6.051 ± 0.935
4.958AspLeu: 4.958 ± 0.509
1.345AspMet: 1.345 ± 0.382
4.79AspAsn: 4.79 ± 0.712
0.42AspPro: 0.42 ± 0.16
0.42AspGln: 0.42 ± 0.222
1.513AspArg: 1.513 ± 0.292
3.614AspSer: 3.614 ± 0.445
3.866AspThr: 3.866 ± 0.68
2.941AspVal: 2.941 ± 0.556
0.756AspTrp: 0.756 ± 0.184
3.194AspTyr: 3.194 ± 0.578
0.0AspXaa: 0.0 ± 0.0
Glu
2.941GluAla: 2.941 ± 0.794
0.924GluCys: 0.924 ± 0.257
3.278GluAsp: 3.278 ± 0.596
4.202GluGlu: 4.202 ± 0.653
4.958GluPhe: 4.958 ± 0.791
2.017GluGly: 2.017 ± 0.372
1.008GluHis: 1.008 ± 0.28
7.648GluIle: 7.648 ± 0.691
7.143GluLys: 7.143 ± 0.97
7.648GluLeu: 7.648 ± 0.99
1.765GluMet: 1.765 ± 0.36
6.723GluAsn: 6.723 ± 0.744
2.017GluPro: 2.017 ± 0.383
3.278GluGln: 3.278 ± 0.438
2.437GluArg: 2.437 ± 0.599
4.034GluSer: 4.034 ± 0.555
4.202GluThr: 4.202 ± 0.577
3.866GluVal: 3.866 ± 0.612
0.336GluTrp: 0.336 ± 0.164
3.362GluTyr: 3.362 ± 0.511
0.0GluXaa: 0.0 ± 0.0
Phe
2.185PheAla: 2.185 ± 0.383
0.672PheCys: 0.672 ± 0.245
3.614PheAsp: 3.614 ± 0.541
4.286PheGlu: 4.286 ± 0.591
2.269PhePhe: 2.269 ± 0.374
2.941PheGly: 2.941 ± 0.554
0.336PheHis: 0.336 ± 0.154
3.446PheIle: 3.446 ± 0.567
4.37PheLys: 4.37 ± 0.683
3.614PheLeu: 3.614 ± 0.558
1.261PheMet: 1.261 ± 0.285
4.622PheAsn: 4.622 ± 0.702
1.177PhePro: 1.177 ± 0.29
1.597PheGln: 1.597 ± 0.403
0.924PheArg: 0.924 ± 0.302
3.53PheSer: 3.53 ± 0.582
4.37PheThr: 4.37 ± 0.714
2.689PheVal: 2.689 ± 0.501
0.42PheTrp: 0.42 ± 0.161
1.933PheTyr: 1.933 ± 0.424
0.0PheXaa: 0.0 ± 0.0
Gly
3.11GlyAla: 3.11 ± 0.625
0.42GlyCys: 0.42 ± 0.152
2.605GlyAsp: 2.605 ± 0.54
2.185GlyGlu: 2.185 ± 0.428
2.605GlyPhe: 2.605 ± 0.621
2.017GlyGly: 2.017 ± 0.631
0.504GlyHis: 0.504 ± 0.237
3.698GlyIle: 3.698 ± 0.372
3.53GlyLys: 3.53 ± 0.572
3.614GlyLeu: 3.614 ± 0.513
1.429GlyMet: 1.429 ± 0.322
4.622GlyAsn: 4.622 ± 0.639
0.0GlyPro: 0.0 ± 0.0
1.681GlyGln: 1.681 ± 0.392
1.681GlyArg: 1.681 ± 0.363
2.941GlySer: 2.941 ± 0.48
4.706GlyThr: 4.706 ± 0.765
2.773GlyVal: 2.773 ± 0.446
0.168GlyTrp: 0.168 ± 0.122
2.353GlyTyr: 2.353 ± 0.449
0.0GlyXaa: 0.0 ± 0.0
His
0.252HisAla: 0.252 ± 0.139
0.336HisCys: 0.336 ± 0.162
1.008HisAsp: 1.008 ± 0.25
0.672HisGlu: 0.672 ± 0.23
1.093HisPhe: 1.093 ± 0.276
0.924HisGly: 0.924 ± 0.324
0.672HisHis: 0.672 ± 0.314
1.345HisIle: 1.345 ± 0.35
1.177HisLys: 1.177 ± 0.304
1.008HisLeu: 1.008 ± 0.296
0.084HisMet: 0.084 ± 0.081
1.008HisAsn: 1.008 ± 0.3
0.504HisPro: 0.504 ± 0.203
0.42HisGln: 0.42 ± 0.148
0.504HisArg: 0.504 ± 0.235
0.924HisSer: 0.924 ± 0.288
0.84HisThr: 0.84 ± 0.211
0.588HisVal: 0.588 ± 0.28
0.0HisTrp: 0.0 ± 0.0
0.504HisTyr: 0.504 ± 0.163
0.0HisXaa: 0.0 ± 0.0
Ile
4.706IleAla: 4.706 ± 0.706
0.756IleCys: 0.756 ± 0.276
5.211IleAsp: 5.211 ± 0.621
7.9IleGlu: 7.9 ± 0.696
3.025IlePhe: 3.025 ± 0.461
3.53IleGly: 3.53 ± 0.572
1.345IleHis: 1.345 ± 0.481
5.379IleIle: 5.379 ± 0.679
8.32IleLys: 8.32 ± 0.787
6.807IleLeu: 6.807 ± 0.773
1.093IleMet: 1.093 ± 0.304
6.303IleAsn: 6.303 ± 0.927
2.353IlePro: 2.353 ± 0.335
2.521IleGln: 2.521 ± 0.483
1.681IleArg: 1.681 ± 0.402
5.463IleSer: 5.463 ± 0.774
4.706IleThr: 4.706 ± 0.74
4.622IleVal: 4.622 ± 0.702
0.756IleTrp: 0.756 ± 0.225
3.194IleTyr: 3.194 ± 0.477
0.0IleXaa: 0.0 ± 0.0
Lys
4.706LysAla: 4.706 ± 0.541
1.345LysCys: 1.345 ± 0.374
5.211LysAsp: 5.211 ± 0.654
8.908LysGlu: 8.908 ± 1.271
3.194LysPhe: 3.194 ± 0.426
4.034LysGly: 4.034 ± 0.572
1.933LysHis: 1.933 ± 0.428
7.648LysIle: 7.648 ± 0.808
7.396LysLys: 7.396 ± 0.924
8.152LysLeu: 8.152 ± 0.895
3.446LysMet: 3.446 ± 0.534
5.883LysAsn: 5.883 ± 0.644
2.857LysPro: 2.857 ± 0.451
5.463LysGln: 5.463 ± 1.111
3.782LysArg: 3.782 ± 0.764
5.547LysSer: 5.547 ± 0.606
6.135LysThr: 6.135 ± 0.794
5.463LysVal: 5.463 ± 0.735
1.093LysTrp: 1.093 ± 0.382
4.286LysTyr: 4.286 ± 0.621
0.0LysXaa: 0.0 ± 0.0
Leu
4.118LeuAla: 4.118 ± 0.851
0.588LeuCys: 0.588 ± 0.228
5.631LeuAsp: 5.631 ± 0.656
6.051LeuGlu: 6.051 ± 0.961
3.698LeuPhe: 3.698 ± 0.445
3.362LeuGly: 3.362 ± 0.414
0.924LeuHis: 0.924 ± 0.218
7.227LeuIle: 7.227 ± 0.799
9.497LeuLys: 9.497 ± 0.899
6.807LeuLeu: 6.807 ± 0.701
2.101LeuMet: 2.101 ± 0.488
7.732LeuAsn: 7.732 ± 0.843
4.034LeuPro: 4.034 ± 0.545
4.286LeuGln: 4.286 ± 0.5
2.941LeuArg: 2.941 ± 0.563
5.547LeuSer: 5.547 ± 0.652
6.135LeuThr: 6.135 ± 0.871
4.538LeuVal: 4.538 ± 0.69
1.008LeuTrp: 1.008 ± 0.266
3.614LeuTyr: 3.614 ± 0.498
0.0LeuXaa: 0.0 ± 0.0
Met
1.681MetAla: 1.681 ± 0.349
0.084MetCys: 0.084 ± 0.081
0.924MetAsp: 0.924 ± 0.26
1.849MetGlu: 1.849 ± 0.353
1.261MetPhe: 1.261 ± 0.296
1.008MetGly: 1.008 ± 0.245
0.168MetHis: 0.168 ± 0.119
1.345MetIle: 1.345 ± 0.405
2.773MetLys: 2.773 ± 0.597
1.681MetLeu: 1.681 ± 0.351
0.336MetMet: 0.336 ± 0.151
1.345MetAsn: 1.345 ± 0.324
0.924MetPro: 0.924 ± 0.263
1.008MetGln: 1.008 ± 0.28
1.093MetArg: 1.093 ± 0.282
1.765MetSer: 1.765 ± 0.361
1.093MetThr: 1.093 ± 0.236
0.84MetVal: 0.84 ± 0.199
0.336MetTrp: 0.336 ± 0.17
0.42MetTyr: 0.42 ± 0.165
0.0MetXaa: 0.0 ± 0.0
Asn
4.454AsnAla: 4.454 ± 0.611
0.756AsnCys: 0.756 ± 0.25
4.286AsnAsp: 4.286 ± 0.728
6.219AsnGlu: 6.219 ± 0.824
3.95AsnPhe: 3.95 ± 0.608
4.202AsnGly: 4.202 ± 0.582
1.008AsnHis: 1.008 ± 0.265
5.042AsnIle: 5.042 ± 0.524
9.244AsnLys: 9.244 ± 1.314
7.312AsnLeu: 7.312 ± 0.928
0.924AsnMet: 0.924 ± 0.356
4.622AsnAsn: 4.622 ± 1.123
2.437AsnPro: 2.437 ± 0.414
2.773AsnGln: 2.773 ± 0.524
2.017AsnArg: 2.017 ± 0.421
5.126AsnSer: 5.126 ± 0.669
4.37AsnThr: 4.37 ± 0.492
5.295AsnVal: 5.295 ± 0.542
0.84AsnTrp: 0.84 ± 0.327
4.622AsnTyr: 4.622 ± 0.551
0.0AsnXaa: 0.0 ± 0.0
Pro
1.345ProAla: 1.345 ± 0.295
0.42ProCys: 0.42 ± 0.187
1.261ProAsp: 1.261 ± 0.286
2.017ProGlu: 2.017 ± 0.508
1.597ProPhe: 1.597 ± 0.377
0.0ProGly: 0.0 ± 0.0
0.084ProHis: 0.084 ± 0.081
1.681ProIle: 1.681 ± 0.324
1.765ProLys: 1.765 ± 0.386
3.446ProLeu: 3.446 ± 0.503
0.756ProMet: 0.756 ± 0.277
2.353ProAsn: 2.353 ± 0.402
0.588ProPro: 0.588 ± 0.289
1.261ProGln: 1.261 ± 0.346
0.336ProArg: 0.336 ± 0.202
2.185ProSer: 2.185 ± 0.424
2.185ProThr: 2.185 ± 0.403
1.177ProVal: 1.177 ± 0.307
0.0ProTrp: 0.0 ± 0.0
1.429ProTyr: 1.429 ± 0.406
0.0ProXaa: 0.0 ± 0.0
Gln
2.101GlnAla: 2.101 ± 0.665
0.336GlnCys: 0.336 ± 0.171
1.345GlnAsp: 1.345 ± 0.347
1.849GlnGlu: 1.849 ± 0.422
1.177GlnPhe: 1.177 ± 0.211
2.437GlnGly: 2.437 ± 0.484
0.756GlnHis: 0.756 ± 0.246
4.37GlnIle: 4.37 ± 0.64
4.202GlnLys: 4.202 ± 0.803
3.95GlnLeu: 3.95 ± 0.647
1.261GlnMet: 1.261 ± 0.417
2.353GlnAsn: 2.353 ± 0.451
1.177GlnPro: 1.177 ± 0.309
2.101GlnGln: 2.101 ± 0.759
1.849GlnArg: 1.849 ± 0.386
2.437GlnSer: 2.437 ± 0.463
2.101GlnThr: 2.101 ± 0.401
2.017GlnVal: 2.017 ± 0.458
0.42GlnTrp: 0.42 ± 0.198
1.513GlnTyr: 1.513 ± 0.379
0.0GlnXaa: 0.0 ± 0.0
Arg
0.84ArgAla: 0.84 ± 0.358
0.42ArgCys: 0.42 ± 0.209
1.093ArgAsp: 1.093 ± 0.241
2.101ArgGlu: 2.101 ± 0.472
1.093ArgPhe: 1.093 ± 0.339
1.093ArgGly: 1.093 ± 0.327
0.42ArgHis: 0.42 ± 0.219
2.941ArgIle: 2.941 ± 0.595
2.689ArgLys: 2.689 ± 0.391
3.614ArgLeu: 3.614 ± 0.465
0.588ArgMet: 0.588 ± 0.211
2.605ArgAsn: 2.605 ± 0.494
0.252ArgPro: 0.252 ± 0.139
0.924ArgGln: 0.924 ± 0.297
0.84ArgArg: 0.84 ± 0.247
2.353ArgSer: 2.353 ± 0.4
2.269ArgThr: 2.269 ± 0.319
2.269ArgVal: 2.269 ± 0.367
0.084ArgTrp: 0.084 ± 0.079
1.513ArgTyr: 1.513 ± 0.403
0.0ArgXaa: 0.0 ± 0.0
Ser
2.353SerAla: 2.353 ± 0.369
0.336SerCys: 0.336 ± 0.17
3.95SerAsp: 3.95 ± 0.697
5.463SerGlu: 5.463 ± 0.814
4.202SerPhe: 4.202 ± 0.644
4.454SerGly: 4.454 ± 0.564
0.84SerHis: 0.84 ± 0.209
5.547SerIle: 5.547 ± 0.588
5.883SerLys: 5.883 ± 0.672
5.379SerLeu: 5.379 ± 0.558
1.261SerMet: 1.261 ± 0.359
5.379SerAsn: 5.379 ± 0.813
1.345SerPro: 1.345 ± 0.339
2.605SerGln: 2.605 ± 0.458
1.849SerArg: 1.849 ± 0.377
3.278SerSer: 3.278 ± 0.668
2.773SerThr: 2.773 ± 0.48
4.79SerVal: 4.79 ± 0.543
0.588SerTrp: 0.588 ± 0.248
1.429SerTyr: 1.429 ± 0.3
0.0SerXaa: 0.0 ± 0.0
Thr
3.866ThrAla: 3.866 ± 0.671
0.84ThrCys: 0.84 ± 0.219
4.706ThrAsp: 4.706 ± 0.557
4.79ThrGlu: 4.79 ± 0.747
4.286ThrPhe: 4.286 ± 0.643
3.11ThrGly: 3.11 ± 0.622
0.84ThrHis: 0.84 ± 0.241
6.303ThrIle: 6.303 ± 0.821
4.958ThrLys: 4.958 ± 0.649
5.967ThrLeu: 5.967 ± 0.672
0.924ThrMet: 0.924 ± 0.27
5.126ThrAsn: 5.126 ± 0.79
1.933ThrPro: 1.933 ± 0.437
2.857ThrGln: 2.857 ± 0.505
1.513ThrArg: 1.513 ± 0.28
3.614ThrSer: 3.614 ± 0.672
5.463ThrThr: 5.463 ± 1.0
1.681ThrVal: 1.681 ± 0.417
0.588ThrTrp: 0.588 ± 0.181
2.269ThrTyr: 2.269 ± 0.42
0.0ThrXaa: 0.0 ± 0.0
Val
3.278ValAla: 3.278 ± 0.483
0.756ValCys: 0.756 ± 0.298
3.278ValAsp: 3.278 ± 0.593
3.446ValGlu: 3.446 ± 0.644
2.521ValPhe: 2.521 ± 0.48
3.278ValGly: 3.278 ± 0.339
0.672ValHis: 0.672 ± 0.247
4.118ValIle: 4.118 ± 0.41
5.463ValLys: 5.463 ± 0.617
4.79ValLeu: 4.79 ± 0.582
1.177ValMet: 1.177 ± 0.381
4.874ValAsn: 4.874 ± 0.728
1.093ValPro: 1.093 ± 0.275
2.269ValGln: 2.269 ± 0.421
1.849ValArg: 1.849 ± 0.424
4.286ValSer: 4.286 ± 0.585
2.269ValThr: 2.269 ± 0.416
3.11ValVal: 3.11 ± 0.584
0.756ValTrp: 0.756 ± 0.23
2.017ValTyr: 2.017 ± 0.328
0.0ValXaa: 0.0 ± 0.0
Trp
0.504TrpAla: 0.504 ± 0.19
0.168TrpCys: 0.168 ± 0.103
0.588TrpAsp: 0.588 ± 0.246
0.756TrpGlu: 0.756 ± 0.225
0.42TrpPhe: 0.42 ± 0.174
0.336TrpGly: 0.336 ± 0.157
0.336TrpHis: 0.336 ± 0.187
0.84TrpIle: 0.84 ± 0.274
1.008TrpLys: 1.008 ± 0.356
1.177TrpLeu: 1.177 ± 0.28
0.0TrpMet: 0.0 ± 0.083
0.756TrpAsn: 0.756 ± 0.279
0.0TrpPro: 0.0 ± 0.0
0.252TrpGln: 0.252 ± 0.134
0.336TrpArg: 0.336 ± 0.151
0.588TrpSer: 0.588 ± 0.273
0.336TrpThr: 0.336 ± 0.134
0.252TrpVal: 0.252 ± 0.165
0.0TrpTrp: 0.0 ± 0.0
0.504TrpTyr: 0.504 ± 0.208
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.513TyrAla: 1.513 ± 0.225
0.588TyrCys: 0.588 ± 0.204
2.521TyrAsp: 2.521 ± 0.437
2.857TyrGlu: 2.857 ± 0.436
2.437TyrPhe: 2.437 ± 0.459
2.101TyrGly: 2.101 ± 0.378
0.84TyrHis: 0.84 ± 0.284
3.362TyrIle: 3.362 ± 0.496
4.79TyrLys: 4.79 ± 0.61
3.53TyrLeu: 3.53 ± 0.515
0.42TyrMet: 0.42 ± 0.175
3.614TyrAsn: 3.614 ± 0.608
1.345TyrPro: 1.345 ± 0.389
1.429TyrGln: 1.429 ± 0.269
1.177TyrArg: 1.177 ± 0.326
2.689TyrSer: 2.689 ± 0.466
2.857TyrThr: 2.857 ± 0.555
2.269TyrVal: 2.269 ± 0.472
0.336TyrTrp: 0.336 ± 0.139
2.101TyrTyr: 2.101 ± 0.479
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (11900 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski