Amino acid dipepetide frequency for Rhodopirellula sallentina SM41

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.378AlaAla: 10.378 ± 0.092	1.119AlaCys: 1.119 ± 0.022	6.133AlaAsp: 6.133 ± 0.064	6.252AlaGlu: 6.252 ± 0.068	3.312AlaPhe: 3.312 ± 0.037	7.424AlaGly: 7.424 ± 0.067	1.535AlaHis: 1.535 ± 0.028	5.726AlaIle: 5.726 ± 0.05	3.848AlaLys: 3.848 ± 0.053	7.168AlaLeu: 7.168 ± 0.06	2.751AlaMet: 2.751 ± 0.037	3.347AlaAsn: 3.347 ± 0.042	3.853AlaPro: 3.853 ± 0.047	2.775AlaGln: 2.775 ± 0.039	5.318AlaArg: 5.318 ± 0.054	7.176AlaSer: 7.176 ± 0.061	6.007AlaThr: 6.007 ± 0.054	6.688AlaVal: 6.688 ± 0.058	1.237AlaTrp: 1.237 ± 0.026	1.975AlaTyr: 1.975 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	0.72CysAla: 0.72 ± 0.019	0.227CysCys: 0.227 ± 0.012	0.819CysAsp: 0.819 ± 0.02	0.755CysGlu: 0.755 ± 0.018	0.453CysPhe: 0.453 ± 0.016	1.085CysGly: 1.085 ± 0.027	0.429CysHis: 0.429 ± 0.018	0.43CysIle: 0.43 ± 0.013	0.276CysLys: 0.276 ± 0.012	1.1CysLeu: 1.1 ± 0.022	0.223CysMet: 0.223 ± 0.01	0.317CysAsn: 0.317 ± 0.012	0.609CysPro: 0.609 ± 0.02	0.409CysGln: 0.409 ± 0.014	0.857CysArg: 0.857 ± 0.022	0.744CysSer: 0.744 ± 0.02	0.493CysThr: 0.493 ± 0.017	0.911CysVal: 0.911 ± 0.024	0.163CysTrp: 0.163 ± 0.008	0.294CysTyr: 0.294 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.953AspAla: 6.953 ± 0.085	0.651AspCys: 0.651 ± 0.016	4.712AspAsp: 4.712 ± 0.068	4.785AspGlu: 4.785 ± 0.051	2.409AspPhe: 2.409 ± 0.038	5.606AspGly: 5.606 ± 0.082	1.462AspHis: 1.462 ± 0.028	2.616AspIle: 2.616 ± 0.041	1.567AspLys: 1.567 ± 0.029	5.802AspLeu: 5.802 ± 0.056	1.132AspMet: 1.132 ± 0.024	1.929AspAsn: 1.929 ± 0.039	3.742AspPro: 3.742 ± 0.047	2.619AspGln: 2.619 ± 0.039	4.626AspArg: 4.626 ± 0.058	4.472AspSer: 4.472 ± 0.057	3.047AspThr: 3.047 ± 0.05	4.759AspVal: 4.759 ± 0.053	1.104AspTrp: 1.104 ± 0.024	1.616AspTyr: 1.616 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	5.477GluAla: 5.477 ± 0.057	0.54GluCys: 0.54 ± 0.02	3.24GluAsp: 3.24 ± 0.041	3.684GluGlu: 3.684 ± 0.061	2.353GluPhe: 2.353 ± 0.032	3.798GluGly: 3.798 ± 0.045	1.46GluHis: 1.46 ± 0.028	3.698GluIle: 3.698 ± 0.045	2.628GluLys: 2.628 ± 0.041	6.472GluLeu: 6.472 ± 0.061	1.669GluMet: 1.669 ± 0.033	2.428GluAsn: 2.428 ± 0.036	2.851GluPro: 2.851 ± 0.044	2.886GluGln: 2.886 ± 0.036	4.137GluArg: 4.137 ± 0.057	4.952GluSer: 4.952 ± 0.052	4.107GluThr: 4.107 ± 0.052	4.166GluVal: 4.166 ± 0.045	0.757GluTrp: 0.757 ± 0.017	1.411GluTyr: 1.411 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.797PheAla: 3.797 ± 0.042	0.504PheCys: 0.504 ± 0.015	3.041PheAsp: 3.041 ± 0.042	2.366PheGlu: 2.366 ± 0.039	1.414PhePhe: 1.414 ± 0.027	3.2PheGly: 3.2 ± 0.043	0.815PheHis: 0.815 ± 0.021	1.443PheIle: 1.443 ± 0.029	0.864PheLys: 0.864 ± 0.02	3.194PheLeu: 3.194 ± 0.039	0.653PheMet: 0.653 ± 0.015	1.16PheAsn: 1.16 ± 0.028	1.605PhePro: 1.605 ± 0.028	1.231PheGln: 1.231 ± 0.021	2.423PheArg: 2.423 ± 0.032	2.405PheSer: 2.405 ± 0.029	2.045PheThr: 2.045 ± 0.045	2.825PheVal: 2.825 ± 0.034	0.563PheTrp: 0.563 ± 0.019	0.942PheTyr: 0.942 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	5.625GlyAla: 5.625 ± 0.068	1.03GlyCys: 1.03 ± 0.027	5.213GlyAsp: 5.213 ± 0.076	5.1GlyGlu: 5.1 ± 0.047	2.971GlyPhe: 2.971 ± 0.036	6.818GlyGly: 6.818 ± 0.105	1.651GlyHis: 1.651 ± 0.029	3.941GlyIle: 3.941 ± 0.046	3.46GlyLys: 3.46 ± 0.053	6.592GlyLeu: 6.592 ± 0.054	1.99GlyMet: 1.99 ± 0.034	2.871GlyAsn: 2.871 ± 0.055	2.98GlyPro: 2.98 ± 0.039	2.758GlyGln: 2.758 ± 0.041	5.061GlyArg: 5.061 ± 0.051	5.13GlySer: 5.13 ± 0.072	4.666GlyThr: 4.666 ± 0.093	5.678GlyVal: 5.678 ± 0.054	1.27GlyTrp: 1.27 ± 0.026	2.18GlyTyr: 2.18 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.095HisAla: 2.095 ± 0.034	0.321HisCys: 0.321 ± 0.012	1.439HisAsp: 1.439 ± 0.025	1.293HisGlu: 1.293 ± 0.022	0.936HisPhe: 0.936 ± 0.021	1.798HisGly: 1.798 ± 0.028	0.738HisHis: 0.738 ± 0.02	0.792HisIle: 0.792 ± 0.021	0.454HisLys: 0.454 ± 0.015	2.14HisLeu: 2.14 ± 0.031	0.349HisMet: 0.349 ± 0.012	0.66HisAsn: 0.66 ± 0.018	1.472HisPro: 1.472 ± 0.029	0.927HisGln: 0.927 ± 0.024	1.766HisArg: 1.766 ± 0.031	1.402HisSer: 1.402 ± 0.03	0.968HisThr: 0.968 ± 0.021	1.609HisVal: 1.609 ± 0.027	0.445HisTrp: 0.445 ± 0.013	0.643HisTyr: 0.643 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.179IleAla: 6.179 ± 0.051	0.597IleCys: 0.597 ± 0.016	4.316IleAsp: 4.316 ± 0.048	4.139IleGlu: 4.139 ± 0.046	1.353IlePhe: 1.353 ± 0.025	4.415IleGly: 4.415 ± 0.043	1.15IleHis: 1.15 ± 0.021	1.838IleIle: 1.838 ± 0.034	1.357IleLys: 1.357 ± 0.026	3.773IleLeu: 3.773 ± 0.045	0.73IleMet: 0.73 ± 0.019	1.677IleAsn: 1.677 ± 0.035	2.396IlePro: 2.396 ± 0.033	1.642IleGln: 1.642 ± 0.028	3.573IleArg: 3.573 ± 0.038	3.089IleSer: 3.089 ± 0.045	2.8IleThr: 2.8 ± 0.051	3.899IleVal: 3.899 ± 0.04	0.596IleTrp: 0.596 ± 0.017	1.086IleTyr: 1.086 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.816LysAla: 2.816 ± 0.045	0.3LysCys: 0.3 ± 0.012	1.688LysAsp: 1.688 ± 0.031	1.924LysGlu: 1.924 ± 0.034	1.132LysPhe: 1.132 ± 0.023	2.003LysGly: 2.003 ± 0.039	0.851LysHis: 0.851 ± 0.022	1.865LysIle: 1.865 ± 0.033	1.688LysLys: 1.688 ± 0.043	3.377LysLeu: 3.377 ± 0.048	0.878LysMet: 0.878 ± 0.023	1.205LysAsn: 1.205 ± 0.027	2.097LysPro: 2.097 ± 0.031	1.578LysGln: 1.578 ± 0.032	2.637LysArg: 2.637 ± 0.039	2.262LysSer: 2.262 ± 0.033	2.306LysThr: 2.306 ± 0.036	2.183LysVal: 2.183 ± 0.038	0.552LysTrp: 0.552 ± 0.015	0.805LysTyr: 0.805 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	9.585LeuAla: 9.585 ± 0.075	1.077LeuCys: 1.077 ± 0.024	5.805LeuAsp: 5.805 ± 0.059	5.014LeuGlu: 5.014 ± 0.053	3.185LeuPhe: 3.185 ± 0.039	6.537LeuGly: 6.537 ± 0.051	1.95LeuHis: 1.95 ± 0.032	4.543LeuIle: 4.543 ± 0.052	3.139LeuLys: 3.139 ± 0.048	8.613LeuLeu: 8.613 ± 0.076	2.001LeuMet: 2.001 ± 0.03	2.81LeuAsn: 2.81 ± 0.041	5.286LeuPro: 5.286 ± 0.059	3.456LeuGln: 3.456 ± 0.044	6.336LeuArg: 6.336 ± 0.068	6.632LeuSer: 6.632 ± 0.063	5.316LeuThr: 5.316 ± 0.064	6.572LeuVal: 6.572 ± 0.058	1.158LeuTrp: 1.158 ± 0.024	1.918LeuTyr: 1.918 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.049MetAla: 2.049 ± 0.035	0.218MetCys: 0.218 ± 0.01	1.125MetAsp: 1.125 ± 0.023	1.067MetGlu: 1.067 ± 0.022	0.791MetPhe: 0.791 ± 0.018	1.532MetGly: 1.532 ± 0.027	0.528MetHis: 0.528 ± 0.013	1.324MetIle: 1.324 ± 0.025	1.029MetLys: 1.029 ± 0.021	2.388MetLeu: 2.388 ± 0.034	0.617MetMet: 0.617 ± 0.017	0.922MetAsn: 0.922 ± 0.019	1.394MetPro: 1.394 ± 0.03	1.032MetGln: 1.032 ± 0.024	1.595MetArg: 1.595 ± 0.028	1.772MetSer: 1.772 ± 0.031	1.563MetThr: 1.563 ± 0.028	1.529MetVal: 1.529 ± 0.029	0.266MetTrp: 0.266 ± 0.012	0.373MetTyr: 0.373 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.387AsnAla: 3.387 ± 0.045	0.351AsnCys: 0.351 ± 0.014	2.354AsnAsp: 2.354 ± 0.053	2.225AsnGlu: 2.225 ± 0.033	1.103AsnPhe: 1.103 ± 0.026	2.902AsnGly: 2.902 ± 0.059	0.798AsnHis: 0.798 ± 0.021	1.417AsnIle: 1.417 ± 0.028	0.823AsnLys: 0.823 ± 0.021	2.891AsnLeu: 2.891 ± 0.04	0.608AsnMet: 0.608 ± 0.015	1.197AsnAsn: 1.197 ± 0.034	2.1AsnPro: 2.1 ± 0.039	1.467AsnGln: 1.467 ± 0.028	2.493AsnArg: 2.493 ± 0.035	2.189AsnSer: 2.189 ± 0.039	1.852AsnThr: 1.852 ± 0.035	2.613AsnVal: 2.613 ± 0.037	0.511AsnTrp: 0.511 ± 0.016	0.911AsnTyr: 0.911 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	4.826ProAla: 4.826 ± 0.055	0.376ProCys: 0.376 ± 0.013	3.499ProAsp: 3.499 ± 0.044	3.725ProGlu: 3.725 ± 0.043	1.834ProPhe: 1.834 ± 0.033	3.916ProGly: 3.916 ± 0.052	1.177ProHis: 1.177 ± 0.025	2.736ProIle: 2.736 ± 0.042	1.847ProLys: 1.847 ± 0.032	4.149ProLeu: 4.149 ± 0.053	1.267ProMet: 1.267 ± 0.026	2.096ProAsn: 2.096 ± 0.035	2.765ProPro: 2.765 ± 0.045	1.799ProGln: 1.799 ± 0.029	2.806ProArg: 2.806 ± 0.034	3.909ProSer: 3.909 ± 0.058	3.384ProThr: 3.384 ± 0.04	3.794ProVal: 3.794 ± 0.046	0.732ProTrp: 0.732 ± 0.02	1.098ProTyr: 1.098 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.217GlnAla: 3.217 ± 0.042	0.41GlnCys: 0.41 ± 0.015	1.674GlnAsp: 1.674 ± 0.028	1.767GlnGlu: 1.767 ± 0.031	1.528GlnPhe: 1.528 ± 0.025	2.128GlnGly: 2.128 ± 0.039	0.871GlnHis: 0.871 ± 0.019	2.171GlnIle: 2.171 ± 0.034	1.343GlnLys: 1.343 ± 0.023	3.777GlnLeu: 3.777 ± 0.046	0.922GlnMet: 0.922 ± 0.023	1.321GlnAsn: 1.321 ± 0.024	2.228GlnPro: 2.228 ± 0.035	1.839GlnGln: 1.839 ± 0.035	2.94GlnArg: 2.94 ± 0.046	3.071GlnSer: 3.071 ± 0.04	2.767GlnThr: 2.767 ± 0.04	2.318GlnVal: 2.318 ± 0.037	0.762GlnTrp: 0.762 ± 0.02	0.969GlnTyr: 0.969 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	4.776ArgAla: 4.776 ± 0.053	0.908ArgCys: 0.908 ± 0.022	4.252ArgAsp: 4.252 ± 0.05	4.299ArgGlu: 4.299 ± 0.053	3.029ArgPhe: 3.029 ± 0.037	4.622ArgGly: 4.622 ± 0.054	1.572ArgHis: 1.572 ± 0.025	3.661ArgIle: 3.661 ± 0.045	2.402ArgLys: 2.402 ± 0.043	6.921ArgLeu: 6.921 ± 0.069	1.891ArgMet: 1.891 ± 0.03	2.189ArgAsn: 2.189 ± 0.03	3.183ArgPro: 3.183 ± 0.042	2.653ArgGln: 2.653 ± 0.043	5.48ArgArg: 5.48 ± 0.069	4.713ArgSer: 4.713 ± 0.052	3.421ArgThr: 3.421 ± 0.039	4.903ArgVal: 4.903 ± 0.056	1.277ArgTrp: 1.277 ± 0.024	1.959ArgTyr: 1.959 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.002SerAla: 6.002 ± 0.053	0.673SerCys: 0.673 ± 0.018	4.931SerAsp: 4.931 ± 0.066	4.371SerGlu: 4.371 ± 0.04	2.358SerPhe: 2.358 ± 0.037	6.215SerGly: 6.215 ± 0.081	1.474SerHis: 1.474 ± 0.026	3.661SerIle: 3.661 ± 0.044	2.26SerLys: 2.26 ± 0.035	6.572SerLeu: 6.572 ± 0.065	1.647SerMet: 1.647 ± 0.031	2.494SerAsn: 2.494 ± 0.043	3.96SerPro: 3.96 ± 0.049	2.693SerGln: 2.693 ± 0.038	4.548SerArg: 4.548 ± 0.058	5.041SerSer: 5.041 ± 0.071	3.938SerThr: 3.938 ± 0.053	5.195SerVal: 5.195 ± 0.051	0.902SerTrp: 0.902 ± 0.021	1.441SerTyr: 1.441 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	5.495ThrAla: 5.495 ± 0.066	0.532ThrCys: 0.532 ± 0.016	3.799ThrAsp: 3.799 ± 0.061	3.233ThrGlu: 3.233 ± 0.039	2.187ThrPhe: 2.187 ± 0.041	4.763ThrGly: 4.763 ± 0.062	1.226ThrHis: 1.226 ± 0.024	3.333ThrIle: 3.333 ± 0.061	1.821ThrLys: 1.821 ± 0.032	5.669ThrLeu: 5.669 ± 0.059	1.263ThrMet: 1.263 ± 0.025	1.971ThrAsn: 1.971 ± 0.038	3.846ThrPro: 3.846 ± 0.052	2.078ThrGln: 2.078 ± 0.029	3.534ThrArg: 3.534 ± 0.046	3.855ThrSer: 3.855 ± 0.066	3.596ThrThr: 3.596 ± 0.064	4.267ThrVal: 4.267 ± 0.081	0.757ThrTrp: 0.757 ± 0.017	1.379ThrTyr: 1.379 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	7.431ValAla: 7.431 ± 0.06	0.941ValCys: 0.941 ± 0.023	5.19ValAsp: 5.19 ± 0.056	4.461ValGlu: 4.461 ± 0.05	2.572ValPhe: 2.572 ± 0.035	5.36ValGly: 5.36 ± 0.055	1.509ValHis: 1.509 ± 0.028	3.763ValIle: 3.763 ± 0.04	2.072ValLys: 2.072 ± 0.033	6.488ValLeu: 6.488 ± 0.058	1.653ValMet: 1.653 ± 0.026	2.26ValAsn: 2.26 ± 0.039	3.478ValPro: 3.478 ± 0.046	2.321ValGln: 2.321 ± 0.033	4.849ValArg: 4.849 ± 0.054	5.159ValSer: 5.159 ± 0.058	4.3ValThr: 4.3 ± 0.066	5.786ValVal: 5.786 ± 0.054	1.007ValTrp: 1.007 ± 0.023	1.661ValTyr: 1.661 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.095TrpAla: 1.095 ± 0.026	0.207TrpCys: 0.207 ± 0.01	0.828TrpAsp: 0.828 ± 0.021	0.764TrpGlu: 0.764 ± 0.018	0.548TrpPhe: 0.548 ± 0.015	0.951TrpGly: 0.951 ± 0.023	0.407TrpHis: 0.407 ± 0.015	0.859TrpIle: 0.859 ± 0.017	0.691TrpLys: 0.691 ± 0.018	1.535TrpLeu: 1.535 ± 0.03	0.475TrpMet: 0.475 ± 0.014	0.605TrpAsn: 0.605 ± 0.018	0.678TrpPro: 0.678 ± 0.02	0.696TrpGln: 0.696 ± 0.018	0.987TrpArg: 0.987 ± 0.022	0.98TrpSer: 0.98 ± 0.023	0.836TrpThr: 0.836 ± 0.023	0.958TrpVal: 0.958 ± 0.021	0.274TrpTrp: 0.274 ± 0.01	0.366TrpTyr: 0.366 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.117TyrAla: 2.117 ± 0.032	0.331TyrCys: 0.331 ± 0.012	1.551TyrAsp: 1.551 ± 0.027	1.491TyrGlu: 1.491 ± 0.026	1.022TyrPhe: 1.022 ± 0.023	1.914TyrGly: 1.914 ± 0.027	0.644TyrHis: 0.644 ± 0.018	0.789TyrIle: 0.789 ± 0.018	0.58TyrLys: 0.58 ± 0.019	2.311TyrLeu: 2.311 ± 0.034	0.393TyrMet: 0.393 ± 0.013	0.734TyrAsn: 0.734 ± 0.02	1.213TyrPro: 1.213 ± 0.027	1.166TyrGln: 1.166 ± 0.023	2.144TyrArg: 2.144 ± 0.035	1.426TyrSer: 1.426 ± 0.022	1.188TyrThr: 1.188 ± 0.031	1.609TyrVal: 1.609 ± 0.03	0.408TyrTrp: 0.408 ± 0.015	0.752TyrTyr: 0.752 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6872 proteins (2353469 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---