Amino acid dipepetide frequency for Salisaeta icosahedral phage 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.151AlaAla: 10.151 ± 0.881
0.611AlaCys: 0.611 ± 0.256
6.793AlaAsp: 6.793 ± 0.8
8.243AlaGlu: 8.243 ± 1.171
3.358AlaPhe: 3.358 ± 0.568
6.793AlaGly: 6.793 ± 0.931
2.9AlaHis: 2.9 ± 0.554
4.579AlaIle: 4.579 ± 0.551
4.427AlaLys: 4.427 ± 0.81
10.075AlaLeu: 10.075 ± 0.94
1.755AlaMet: 1.755 ± 0.34
2.9AlaAsn: 2.9 ± 0.511
3.816AlaPro: 3.816 ± 0.574
4.045AlaGln: 4.045 ± 0.582
5.495AlaArg: 5.495 ± 0.814
5.648AlaSer: 5.648 ± 0.731
5.266AlaThr: 5.266 ± 0.765
5.801AlaVal: 5.801 ± 0.696
1.298AlaTrp: 1.298 ± 0.32
3.206AlaTyr: 3.206 ± 0.529
0.0AlaXaa: 0.0 ± 0.0
Cys
0.687CysAla: 0.687 ± 0.258
0.076CysCys: 0.076 ± 0.071
0.611CysAsp: 0.611 ± 0.216
0.534CysGlu: 0.534 ± 0.215
0.076CysPhe: 0.076 ± 0.071
0.382CysGly: 0.382 ± 0.172
0.076CysHis: 0.076 ± 0.067
0.305CysIle: 0.305 ± 0.19
0.305CysLys: 0.305 ± 0.15
1.069CysLeu: 1.069 ± 0.367
0.076CysMet: 0.076 ± 0.079
0.229CysAsn: 0.229 ± 0.158
0.458CysPro: 0.458 ± 0.183
0.153CysGln: 0.153 ± 0.108
0.305CysArg: 0.305 ± 0.148
0.229CysSer: 0.229 ± 0.139
0.611CysThr: 0.611 ± 0.169
0.382CysVal: 0.382 ± 0.19
0.0CysTrp: 0.0 ± 0.0
0.153CysTyr: 0.153 ± 0.118
0.0CysXaa: 0.0 ± 0.0
Asp
7.174AspAla: 7.174 ± 1.044
0.382AspCys: 0.382 ± 0.182
5.648AspAsp: 5.648 ± 0.799
6.03AspGlu: 6.03 ± 0.952
2.061AspPhe: 2.061 ± 0.479
5.801AspGly: 5.801 ± 0.623
0.916AspHis: 0.916 ± 0.197
2.977AspIle: 2.977 ± 0.49
2.137AspLys: 2.137 ± 0.504
5.572AspLeu: 5.572 ± 0.594
1.221AspMet: 1.221 ± 0.264
1.984AspAsn: 1.984 ± 0.469
4.198AspPro: 4.198 ± 0.649
1.374AspGln: 1.374 ± 0.297
3.664AspArg: 3.664 ± 0.566
3.893AspSer: 3.893 ± 0.886
4.427AspThr: 4.427 ± 0.949
5.419AspVal: 5.419 ± 0.722
1.832AspTrp: 1.832 ± 0.304
2.519AspTyr: 2.519 ± 0.406
0.0AspXaa: 0.0 ± 0.0
Glu
8.09GluAla: 8.09 ± 0.915
0.076GluCys: 0.076 ± 0.089
4.274GluAsp: 4.274 ± 0.713
6.946GluGlu: 6.946 ± 1.02
1.374GluPhe: 1.374 ± 0.379
5.724GluGly: 5.724 ± 0.668
1.603GluHis: 1.603 ± 0.434
3.816GluIle: 3.816 ± 0.555
3.206GluLys: 3.206 ± 0.618
4.579GluLeu: 4.579 ± 0.572
2.061GluMet: 2.061 ± 0.418
2.213GluAsn: 2.213 ± 0.427
4.198GluPro: 4.198 ± 0.689
4.961GluGln: 4.961 ± 0.873
7.098GluArg: 7.098 ± 1.204
3.511GluSer: 3.511 ± 0.666
2.9GluThr: 2.9 ± 0.452
5.114GluVal: 5.114 ± 0.595
0.992GluTrp: 0.992 ± 0.284
2.213GluTyr: 2.213 ± 0.418
0.0GluXaa: 0.0 ± 0.0
Phe
2.9PheAla: 2.9 ± 0.526
0.458PheCys: 0.458 ± 0.207
3.358PheAsp: 3.358 ± 0.55
3.816PheGlu: 3.816 ± 0.586
1.069PhePhe: 1.069 ± 0.242
1.832PheGly: 1.832 ± 0.409
0.534PheHis: 0.534 ± 0.252
0.687PheIle: 0.687 ± 0.174
1.221PheLys: 1.221 ± 0.353
2.213PheLeu: 2.213 ± 0.304
0.458PheMet: 0.458 ± 0.155
0.763PheAsn: 0.763 ± 0.274
0.992PhePro: 0.992 ± 0.318
1.374PheGln: 1.374 ± 0.342
2.442PheArg: 2.442 ± 0.531
2.137PheSer: 2.137 ± 0.405
1.45PheThr: 1.45 ± 0.435
2.29PheVal: 2.29 ± 0.392
0.534PheTrp: 0.534 ± 0.145
0.687PheTyr: 0.687 ± 0.292
0.0PheXaa: 0.0 ± 0.0
Gly
6.64GlyAla: 6.64 ± 0.763
0.534GlyCys: 0.534 ± 0.206
4.35GlyAsp: 4.35 ± 0.584
3.816GlyGlu: 3.816 ± 0.494
2.824GlyPhe: 2.824 ± 0.477
7.098GlyGly: 7.098 ± 1.825
1.832GlyHis: 1.832 ± 0.461
2.748GlyIle: 2.748 ± 0.532
3.282GlyLys: 3.282 ± 0.52
5.114GlyLeu: 5.114 ± 0.695
1.908GlyMet: 1.908 ± 0.37
1.679GlyAsn: 1.679 ± 0.331
2.519GlyPro: 2.519 ± 0.405
3.358GlyGln: 3.358 ± 0.407
5.19GlyArg: 5.19 ± 0.654
3.358GlySer: 3.358 ± 0.475
4.808GlyThr: 4.808 ± 0.826
5.419GlyVal: 5.419 ± 0.837
1.45GlyTrp: 1.45 ± 0.397
2.29GlyTyr: 2.29 ± 0.374
0.0GlyXaa: 0.0 ± 0.0
His
2.137HisAla: 2.137 ± 0.477
0.153HisCys: 0.153 ± 0.099
1.298HisAsp: 1.298 ± 0.277
2.29HisGlu: 2.29 ± 0.414
0.916HisPhe: 0.916 ± 0.307
0.916HisGly: 0.916 ± 0.276
0.458HisHis: 0.458 ± 0.184
0.992HisIle: 0.992 ± 0.205
0.84HisLys: 0.84 ± 0.294
1.298HisLeu: 1.298 ± 0.366
0.687HisMet: 0.687 ± 0.212
0.382HisAsn: 0.382 ± 0.159
0.763HisPro: 0.763 ± 0.229
0.611HisGln: 0.611 ± 0.215
1.603HisArg: 1.603 ± 0.363
1.755HisSer: 1.755 ± 0.328
1.221HisThr: 1.221 ± 0.29
2.366HisVal: 2.366 ± 0.44
0.076HisTrp: 0.076 ± 0.061
0.763HisTyr: 0.763 ± 0.189
0.0HisXaa: 0.0 ± 0.0
Ile
6.106IleAla: 6.106 ± 0.599
0.382IleCys: 0.382 ± 0.171
3.129IleAsp: 3.129 ± 0.431
2.9IleGlu: 2.9 ± 0.585
1.526IlePhe: 1.526 ± 0.315
2.442IleGly: 2.442 ± 0.383
0.992IleHis: 0.992 ± 0.22
1.221IleIle: 1.221 ± 0.303
2.213IleLys: 2.213 ± 0.436
3.282IleLeu: 3.282 ± 0.438
0.611IleMet: 0.611 ± 0.257
1.374IleAsn: 1.374 ± 0.349
1.221IlePro: 1.221 ± 0.318
1.755IleGln: 1.755 ± 0.409
3.358IleArg: 3.358 ± 0.53
2.29IleSer: 2.29 ± 0.407
2.366IleThr: 2.366 ± 0.355
3.053IleVal: 3.053 ± 0.487
0.992IleTrp: 0.992 ± 0.282
1.526IleTyr: 1.526 ± 0.435
0.0IleXaa: 0.0 ± 0.0
Lys
4.656LysAla: 4.656 ± 0.549
0.153LysCys: 0.153 ± 0.113
3.053LysAsp: 3.053 ± 0.503
4.198LysGlu: 4.198 ± 0.64
0.916LysPhe: 0.916 ± 0.322
3.129LysGly: 3.129 ± 0.632
0.458LysHis: 0.458 ± 0.168
1.984LysIle: 1.984 ± 0.35
3.129LysLys: 3.129 ± 0.479
3.129LysLeu: 3.129 ± 0.435
0.992LysMet: 0.992 ± 0.299
0.763LysAsn: 0.763 ± 0.201
1.603LysPro: 1.603 ± 0.352
1.679LysGln: 1.679 ± 0.396
4.35LysArg: 4.35 ± 0.541
2.9LysSer: 2.9 ± 0.52
2.977LysThr: 2.977 ± 0.531
2.29LysVal: 2.29 ± 0.465
0.687LysTrp: 0.687 ± 0.199
0.687LysTyr: 0.687 ± 0.223
0.0LysXaa: 0.0 ± 0.0
Leu
8.243LeuAla: 8.243 ± 0.837
0.458LeuCys: 0.458 ± 0.208
4.579LeuAsp: 4.579 ± 0.553
6.488LeuGlu: 6.488 ± 0.621
2.671LeuPhe: 2.671 ± 0.479
4.045LeuGly: 4.045 ± 0.449
1.755LeuHis: 1.755 ± 0.354
3.511LeuIle: 3.511 ± 0.457
3.969LeuLys: 3.969 ± 0.571
7.556LeuLeu: 7.556 ± 1.063
2.213LeuMet: 2.213 ± 0.432
2.9LeuAsn: 2.9 ± 0.448
4.732LeuPro: 4.732 ± 0.737
4.198LeuGln: 4.198 ± 0.568
6.717LeuArg: 6.717 ± 0.826
6.182LeuSer: 6.182 ± 0.632
4.045LeuThr: 4.045 ± 0.519
5.114LeuVal: 5.114 ± 0.528
1.145LeuTrp: 1.145 ± 0.296
3.053LeuTyr: 3.053 ± 0.486
0.0LeuXaa: 0.0 ± 0.0
Met
2.366MetAla: 2.366 ± 0.664
0.458MetCys: 0.458 ± 0.205
1.145MetAsp: 1.145 ± 0.421
1.374MetGlu: 1.374 ± 0.251
0.458MetPhe: 0.458 ± 0.191
1.984MetGly: 1.984 ± 0.371
0.229MetHis: 0.229 ± 0.121
0.84MetIle: 0.84 ± 0.246
1.45MetLys: 1.45 ± 0.291
2.061MetLeu: 2.061 ± 0.315
0.763MetMet: 0.763 ± 0.263
0.84MetAsn: 0.84 ± 0.287
1.755MetPro: 1.755 ± 0.327
0.84MetGln: 0.84 ± 0.208
2.671MetArg: 2.671 ± 0.567
1.298MetSer: 1.298 ± 0.335
1.221MetThr: 1.221 ± 0.349
0.992MetVal: 0.992 ± 0.254
0.076MetTrp: 0.076 ± 0.071
0.534MetTyr: 0.534 ± 0.197
0.0MetXaa: 0.0 ± 0.0
Asn
3.358AsnAla: 3.358 ± 0.517
0.076AsnCys: 0.076 ± 0.095
2.366AsnAsp: 2.366 ± 0.498
2.213AsnGlu: 2.213 ± 0.51
0.84AsnPhe: 0.84 ± 0.221
3.053AsnGly: 3.053 ± 0.592
0.305AsnHis: 0.305 ± 0.166
1.298AsnIle: 1.298 ± 0.306
1.221AsnLys: 1.221 ± 0.333
2.29AsnLeu: 2.29 ± 0.367
0.458AsnMet: 0.458 ± 0.153
0.687AsnAsn: 0.687 ± 0.233
2.137AsnPro: 2.137 ± 0.4
0.992AsnGln: 0.992 ± 0.419
1.679AsnArg: 1.679 ± 0.388
1.755AsnSer: 1.755 ± 0.491
1.755AsnThr: 1.755 ± 0.388
2.213AsnVal: 2.213 ± 0.552
0.382AsnTrp: 0.382 ± 0.16
0.611AsnTyr: 0.611 ± 0.226
0.0AsnXaa: 0.0 ± 0.0
Pro
4.122ProAla: 4.122 ± 0.668
0.153ProCys: 0.153 ± 0.112
4.656ProAsp: 4.656 ± 0.511
2.824ProGlu: 2.824 ± 0.471
1.832ProPhe: 1.832 ± 0.299
3.358ProGly: 3.358 ± 0.449
0.611ProHis: 0.611 ± 0.232
2.137ProIle: 2.137 ± 0.526
1.526ProLys: 1.526 ± 0.298
3.587ProLeu: 3.587 ± 0.54
0.84ProMet: 0.84 ± 0.252
1.526ProAsn: 1.526 ± 0.332
2.977ProPro: 2.977 ± 0.491
2.595ProGln: 2.595 ± 0.517
2.9ProArg: 2.9 ± 0.529
3.587ProSer: 3.587 ± 0.663
3.664ProThr: 3.664 ± 0.636
2.977ProVal: 2.977 ± 0.452
0.229ProTrp: 0.229 ± 0.109
1.832ProTyr: 1.832 ± 0.341
0.0ProXaa: 0.0 ± 0.0
Gln
3.969GlnAla: 3.969 ± 0.538
0.305GlnCys: 0.305 ± 0.15
3.053GlnAsp: 3.053 ± 0.55
2.748GlnGlu: 2.748 ± 0.502
1.298GlnPhe: 1.298 ± 0.349
2.748GlnGly: 2.748 ± 0.425
0.458GlnHis: 0.458 ± 0.195
2.595GlnIle: 2.595 ± 0.415
1.755GlnLys: 1.755 ± 0.336
3.435GlnLeu: 3.435 ± 0.635
1.069GlnMet: 1.069 ± 0.304
1.603GlnAsn: 1.603 ± 0.387
2.519GlnPro: 2.519 ± 0.514
3.74GlnGln: 3.74 ± 1.325
4.274GlnArg: 4.274 ± 0.592
3.129GlnSer: 3.129 ± 0.635
2.061GlnThr: 2.061 ± 0.298
1.908GlnVal: 1.908 ± 0.386
0.382GlnTrp: 0.382 ± 0.13
1.679GlnTyr: 1.679 ± 0.496
0.0GlnXaa: 0.0 ± 0.0
Arg
6.259ArgAla: 6.259 ± 0.62
0.916ArgCys: 0.916 ± 0.344
4.503ArgAsp: 4.503 ± 0.862
5.724ArgGlu: 5.724 ± 0.655
3.358ArgPhe: 3.358 ± 0.5
4.274ArgGly: 4.274 ± 0.588
2.595ArgHis: 2.595 ± 0.512
3.358ArgIle: 3.358 ± 0.603
3.587ArgLys: 3.587 ± 0.719
7.022ArgLeu: 7.022 ± 0.779
1.755ArgMet: 1.755 ± 0.359
2.671ArgAsn: 2.671 ± 0.505
2.824ArgPro: 2.824 ± 0.505
2.671ArgGln: 2.671 ± 0.441
7.785ArgArg: 7.785 ± 0.874
3.969ArgSer: 3.969 ± 0.652
4.961ArgThr: 4.961 ± 0.503
5.037ArgVal: 5.037 ± 0.757
1.679ArgTrp: 1.679 ± 0.292
2.671ArgTyr: 2.671 ± 0.477
0.0ArgXaa: 0.0 ± 0.0
Ser
5.266SerAla: 5.266 ± 0.587
0.458SerCys: 0.458 ± 0.24
4.427SerAsp: 4.427 ± 0.533
4.656SerGlu: 4.656 ± 0.804
1.832SerPhe: 1.832 ± 0.285
5.19SerGly: 5.19 ± 0.766
1.069SerHis: 1.069 ± 0.336
2.748SerIle: 2.748 ± 0.334
2.824SerLys: 2.824 ± 0.524
5.19SerLeu: 5.19 ± 0.503
1.298SerMet: 1.298 ± 0.272
1.984SerAsn: 1.984 ± 0.323
1.832SerPro: 1.832 ± 0.358
2.442SerGln: 2.442 ± 0.472
3.664SerArg: 3.664 ± 0.5
3.511SerSer: 3.511 ± 0.598
4.579SerThr: 4.579 ± 0.733
3.587SerVal: 3.587 ± 0.47
1.221SerTrp: 1.221 ± 0.271
2.366SerTyr: 2.366 ± 0.472
0.0SerXaa: 0.0 ± 0.0
Thr
4.656ThrAla: 4.656 ± 0.519
0.229ThrCys: 0.229 ± 0.123
3.893ThrAsp: 3.893 ± 0.767
3.053ThrGlu: 3.053 ± 0.403
2.137ThrPhe: 2.137 ± 0.365
4.35ThrGly: 4.35 ± 0.589
1.526ThrHis: 1.526 ± 0.352
2.29ThrIle: 2.29 ± 0.417
1.984ThrLys: 1.984 ± 0.452
6.259ThrLeu: 6.259 ± 0.583
1.755ThrMet: 1.755 ± 0.415
1.908ThrAsn: 1.908 ± 0.407
3.893ThrPro: 3.893 ± 0.639
2.9ThrGln: 2.9 ± 0.628
3.511ThrArg: 3.511 ± 0.426
3.816ThrSer: 3.816 ± 0.65
5.19ThrThr: 5.19 ± 0.944
4.503ThrVal: 4.503 ± 0.651
0.992ThrTrp: 0.992 ± 0.249
1.374ThrTyr: 1.374 ± 0.376
0.0ThrXaa: 0.0 ± 0.0
Val
6.564ValAla: 6.564 ± 0.581
0.534ValCys: 0.534 ± 0.158
5.19ValAsp: 5.19 ± 0.703
4.579ValGlu: 4.579 ± 0.615
1.603ValPhe: 1.603 ± 0.311
4.198ValGly: 4.198 ± 0.648
1.679ValHis: 1.679 ± 0.29
2.442ValIle: 2.442 ± 0.548
2.213ValLys: 2.213 ± 0.444
5.266ValLeu: 5.266 ± 0.643
1.755ValMet: 1.755 ± 0.393
1.832ValAsn: 1.832 ± 0.288
3.664ValPro: 3.664 ± 0.651
3.282ValGln: 3.282 ± 0.465
6.411ValArg: 6.411 ± 0.697
4.427ValSer: 4.427 ± 0.595
3.664ValThr: 3.664 ± 0.814
4.961ValVal: 4.961 ± 0.722
0.763ValTrp: 0.763 ± 0.198
2.366ValTyr: 2.366 ± 0.468
0.0ValXaa: 0.0 ± 0.0
Trp
1.145TrpAla: 1.145 ± 0.343
0.153TrpCys: 0.153 ± 0.115
0.84TrpAsp: 0.84 ± 0.25
0.611TrpGlu: 0.611 ± 0.198
0.458TrpPhe: 0.458 ± 0.193
0.763TrpGly: 0.763 ± 0.287
0.382TrpHis: 0.382 ± 0.149
0.763TrpIle: 0.763 ± 0.218
0.687TrpLys: 0.687 ± 0.18
2.061TrpLeu: 2.061 ± 0.363
0.611TrpMet: 0.611 ± 0.175
0.611TrpAsn: 0.611 ± 0.197
0.382TrpPro: 0.382 ± 0.192
0.534TrpGln: 0.534 ± 0.199
1.679TrpArg: 1.679 ± 0.385
1.298TrpSer: 1.298 ± 0.333
0.229TrpThr: 0.229 ± 0.136
1.526TrpVal: 1.526 ± 0.257
0.458TrpTrp: 0.458 ± 0.176
0.305TrpTyr: 0.305 ± 0.123
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.671TyrAla: 2.671 ± 0.402
0.153TyrCys: 0.153 ± 0.158
2.061TyrAsp: 2.061 ± 0.411
1.908TyrGlu: 1.908 ± 0.316
0.611TyrPhe: 0.611 ± 0.222
2.137TyrGly: 2.137 ± 0.372
1.145TyrHis: 1.145 ± 0.301
1.45TyrIle: 1.45 ± 0.325
1.755TyrLys: 1.755 ± 0.389
2.519TyrLeu: 2.519 ± 0.492
0.992TyrMet: 0.992 ± 0.294
0.84TyrAsn: 0.84 ± 0.249
1.45TyrPro: 1.45 ± 0.278
1.221TyrGln: 1.221 ± 0.299
2.824TyrArg: 2.824 ± 0.389
1.45TyrSer: 1.45 ± 0.336
2.824TyrThr: 2.824 ± 0.541
2.442TyrVal: 2.442 ± 0.401
0.305TyrTrp: 0.305 ± 0.141
1.603TyrTyr: 1.603 ± 0.357
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (13103 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski