Amino acid dipepetide frequency for Leptospira licerasiae serovar Varillal str. VAR 010

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.628AlaAla: 4.628 ± 0.073
0.581AlaCys: 0.581 ± 0.025
3.2AlaAsp: 3.2 ± 0.055
4.459AlaGlu: 4.459 ± 0.059
3.136AlaPhe: 3.136 ± 0.053
4.936AlaGly: 4.936 ± 0.074
0.959AlaHis: 0.959 ± 0.027
4.424AlaIle: 4.424 ± 0.059
4.69AlaLys: 4.69 ± 0.076
6.454AlaLeu: 6.454 ± 0.084
1.33AlaMet: 1.33 ± 0.037
2.539AlaAsn: 2.539 ± 0.047
2.024AlaPro: 2.024 ± 0.038
1.821AlaGln: 1.821 ± 0.047
2.739AlaArg: 2.739 ± 0.051
4.628AlaSer: 4.628 ± 0.072
2.755AlaThr: 2.755 ± 0.062
4.101AlaVal: 4.101 ± 0.063
0.755AlaTrp: 0.755 ± 0.025
2.167AlaTyr: 2.167 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.492CysAla: 0.492 ± 0.019
0.055CysCys: 0.055 ± 0.008
0.381CysAsp: 0.381 ± 0.018
0.424CysGlu: 0.424 ± 0.018
0.441CysPhe: 0.441 ± 0.019
0.649CysGly: 0.649 ± 0.027
0.171CysHis: 0.171 ± 0.014
0.576CysIle: 0.576 ± 0.019
0.504CysLys: 0.504 ± 0.024
0.79CysLeu: 0.79 ± 0.025
0.15CysMet: 0.15 ± 0.01
0.292CysAsn: 0.292 ± 0.017
0.355CysPro: 0.355 ± 0.018
0.167CysGln: 0.167 ± 0.011
0.296CysArg: 0.296 ± 0.015
0.656CysSer: 0.656 ± 0.026
0.361CysThr: 0.361 ± 0.017
0.478CysVal: 0.478 ± 0.019
0.067CysTrp: 0.067 ± 0.008
0.289CysTyr: 0.289 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
2.767AspAla: 2.767 ± 0.05
0.447AspCys: 0.447 ± 0.019
1.885AspAsp: 1.885 ± 0.047
2.898AspGlu: 2.898 ± 0.052
2.977AspPhe: 2.977 ± 0.048
3.2AspGly: 3.2 ± 0.056
0.892AspHis: 0.892 ± 0.029
3.415AspIle: 3.415 ± 0.056
3.446AspLys: 3.446 ± 0.055
6.22AspLeu: 6.22 ± 0.071
0.925AspMet: 0.925 ± 0.028
1.527AspAsn: 1.527 ± 0.044
3.147AspPro: 3.147 ± 0.049
1.627AspGln: 1.627 ± 0.035
2.742AspArg: 2.742 ± 0.051
4.132AspSer: 4.132 ± 0.072
2.26AspThr: 2.26 ± 0.044
2.45AspVal: 2.45 ± 0.046
0.879AspTrp: 0.879 ± 0.024
1.985AspTyr: 1.985 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
4.506GluAla: 4.506 ± 0.063
0.401GluCys: 0.401 ± 0.02
3.68GluAsp: 3.68 ± 0.057
6.631GluGlu: 6.631 ± 0.101
3.58GluPhe: 3.58 ± 0.055
4.366GluGly: 4.366 ± 0.064
0.965GluHis: 0.965 ± 0.029
6.027GluIle: 6.027 ± 0.075
6.702GluLys: 6.702 ± 0.084
6.832GluLeu: 6.832 ± 0.078
1.496GluMet: 1.496 ± 0.033
3.807GluAsn: 3.807 ± 0.052
2.014GluPro: 2.014 ± 0.042
1.804GluGln: 1.804 ± 0.038
3.347GluArg: 3.347 ± 0.062
4.885GluSer: 4.885 ± 0.075
3.868GluThr: 3.868 ± 0.059
4.111GluVal: 4.111 ± 0.062
0.843GluTrp: 0.843 ± 0.028
2.503GluTyr: 2.503 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
3.401PheAla: 3.401 ± 0.057
0.557PheCys: 0.557 ± 0.021
2.437PheAsp: 2.437 ± 0.045
3.021PheGlu: 3.021 ± 0.051
3.597PhePhe: 3.597 ± 0.075
4.082PheGly: 4.082 ± 0.068
1.125PheHis: 1.125 ± 0.03
3.122PheIle: 3.122 ± 0.046
2.911PheLys: 2.911 ± 0.048
7.027PheLeu: 7.027 ± 0.083
0.842PheMet: 0.842 ± 0.027
1.667PheAsn: 1.667 ± 0.04
2.777PhePro: 2.777 ± 0.051
2.108PheGln: 2.108 ± 0.039
2.921PheArg: 2.921 ± 0.049
5.001PheSer: 5.001 ± 0.067
2.467PheThr: 2.467 ± 0.045
3.081PheVal: 3.081 ± 0.052
0.76PheTrp: 0.76 ± 0.023
2.197PheTyr: 2.197 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
4.475GlyAla: 4.475 ± 0.078
0.528GlyCys: 0.528 ± 0.024
3.346GlyAsp: 3.346 ± 0.054
4.587GlyGlu: 4.587 ± 0.068
4.021GlyPhe: 4.021 ± 0.067
5.058GlyGly: 5.058 ± 0.095
1.123GlyHis: 1.123 ± 0.034
6.076GlyIle: 6.076 ± 0.079
6.167GlyLys: 6.167 ± 0.069
6.949GlyLeu: 6.949 ± 0.089
1.648GlyMet: 1.648 ± 0.038
3.242GlyAsn: 3.242 ± 0.059
2.095GlyPro: 2.095 ± 0.045
1.801GlyGln: 1.801 ± 0.04
2.943GlyArg: 2.943 ± 0.049
4.997GlySer: 4.997 ± 0.071
3.903GlyThr: 3.903 ± 0.073
4.321GlyVal: 4.321 ± 0.069
0.912GlyTrp: 0.912 ± 0.027
2.61GlyTyr: 2.61 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
0.846HisAla: 0.846 ± 0.027
0.175HisCys: 0.175 ± 0.012
0.603HisAsp: 0.603 ± 0.022
0.875HisGlu: 0.875 ± 0.029
0.981HisPhe: 0.981 ± 0.034
1.15HisGly: 1.15 ± 0.03
0.394HisHis: 0.394 ± 0.02
1.108HisIle: 1.108 ± 0.03
1.03HisLys: 1.03 ± 0.035
1.786HisLeu: 1.786 ± 0.048
0.28HisMet: 0.28 ± 0.016
0.575HisAsn: 0.575 ± 0.021
1.141HisPro: 1.141 ± 0.034
0.456HisGln: 0.456 ± 0.018
0.844HisArg: 0.844 ± 0.03
1.48HisSer: 1.48 ± 0.038
0.916HisThr: 0.916 ± 0.029
0.797HisVal: 0.797 ± 0.03
0.255HisTrp: 0.255 ± 0.014
0.652HisTyr: 0.652 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
4.692IleAla: 4.692 ± 0.068
0.592IleCys: 0.592 ± 0.022
3.182IleAsp: 3.182 ± 0.056
4.318IleGlu: 4.318 ± 0.061
3.946IlePhe: 3.946 ± 0.064
4.959IleGly: 4.959 ± 0.071
1.489IleHis: 1.489 ± 0.037
3.962IleIle: 3.962 ± 0.074
3.991IleLys: 3.991 ± 0.062
9.523IleLeu: 9.523 ± 0.107
1.015IleMet: 1.015 ± 0.025
2.323IleAsn: 2.323 ± 0.041
3.671IlePro: 3.671 ± 0.057
2.837IleGln: 2.837 ± 0.052
4.352IleArg: 4.352 ± 0.064
6.33IleSer: 6.33 ± 0.075
3.178IleThr: 3.178 ± 0.059
4.29IleVal: 4.29 ± 0.061
0.791IleTrp: 0.791 ± 0.028
2.328IleTyr: 2.328 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
4.539LysAla: 4.539 ± 0.072
0.281LysCys: 0.281 ± 0.015
4.359LysAsp: 4.359 ± 0.065
7.387LysGlu: 7.387 ± 0.093
3.312LysPhe: 3.312 ± 0.051
4.617LysGly: 4.617 ± 0.061
0.986LysHis: 0.986 ± 0.032
6.163LysIle: 6.163 ± 0.072
6.894LysLys: 6.894 ± 0.089
6.443LysLeu: 6.443 ± 0.075
1.617LysMet: 1.617 ± 0.033
4.05LysAsn: 4.05 ± 0.053
2.572LysPro: 2.572 ± 0.048
1.942LysGln: 1.942 ± 0.035
3.223LysArg: 3.223 ± 0.054
4.885LysSer: 4.885 ± 0.077
4.079LysThr: 4.079 ± 0.06
4.507LysVal: 4.507 ± 0.064
0.576LysTrp: 0.576 ± 0.022
2.472LysTyr: 2.472 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
6.885LeuAla: 6.885 ± 0.078
0.793LeuCys: 0.793 ± 0.025
5.504LeuAsp: 5.504 ± 0.065
7.903LeuGlu: 7.903 ± 0.1
5.923LeuPhe: 5.923 ± 0.083
7.85LeuGly: 7.85 ± 0.084
1.662LeuHis: 1.662 ± 0.041
6.751LeuIle: 6.751 ± 0.082
7.717LeuLys: 7.717 ± 0.086
10.811LeuLeu: 10.811 ± 0.132
1.659LeuMet: 1.659 ± 0.036
4.39LeuAsn: 4.39 ± 0.056
4.638LeuPro: 4.638 ± 0.057
3.034LeuGln: 3.034 ± 0.051
4.764LeuArg: 4.764 ± 0.07
8.825LeuSer: 8.825 ± 0.083
4.913LeuThr: 4.913 ± 0.067
6.551LeuVal: 6.551 ± 0.079
1.009LeuTrp: 1.009 ± 0.031
3.392LeuTyr: 3.392 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
1.422MetAla: 1.422 ± 0.034
0.088MetCys: 0.088 ± 0.008
1.263MetAsp: 1.263 ± 0.034
1.587MetGlu: 1.587 ± 0.035
0.779MetPhe: 0.779 ± 0.027
1.447MetGly: 1.447 ± 0.037
0.259MetHis: 0.259 ± 0.013
1.405MetIle: 1.405 ± 0.033
1.675MetLys: 1.675 ± 0.039
1.465MetLeu: 1.465 ± 0.035
0.379MetMet: 0.379 ± 0.018
1.042MetAsn: 1.042 ± 0.029
0.715MetPro: 0.715 ± 0.022
0.578MetGln: 0.578 ± 0.022
0.881MetArg: 0.881 ± 0.027
1.367MetSer: 1.367 ± 0.039
0.892MetThr: 0.892 ± 0.029
1.104MetVal: 1.104 ± 0.03
0.115MetTrp: 0.115 ± 0.011
0.497MetTyr: 0.497 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.451AsnAla: 2.451 ± 0.057
0.433AsnCys: 0.433 ± 0.019
1.717AsnAsp: 1.717 ± 0.039
2.305AsnGlu: 2.305 ± 0.044
2.514AsnPhe: 2.514 ± 0.039
3.077AsnGly: 3.077 ± 0.069
0.807AsnHis: 0.807 ± 0.031
2.893AsnIle: 2.893 ± 0.056
2.56AsnLys: 2.56 ± 0.053
4.987AsnLeu: 4.987 ± 0.071
0.816AsnMet: 0.816 ± 0.026
1.434AsnAsn: 1.434 ± 0.039
2.56AsnPro: 2.56 ± 0.047
1.542AsnGln: 1.542 ± 0.035
2.312AsnArg: 2.312 ± 0.043
3.461AsnSer: 3.461 ± 0.061
2.143AsnThr: 2.143 ± 0.044
2.277AsnVal: 2.277 ± 0.047
0.592AsnTrp: 0.592 ± 0.023
1.651AsnTyr: 1.651 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
2.385ProAla: 2.385 ± 0.044
0.234ProCys: 0.234 ± 0.013
2.581ProAsp: 2.581 ± 0.049
4.128ProGlu: 4.128 ± 0.064
2.261ProPhe: 2.261 ± 0.044
3.389ProGly: 3.389 ± 0.048
0.581ProHis: 0.581 ± 0.02
2.991ProIle: 2.991 ± 0.054
3.26ProLys: 3.26 ± 0.056
3.482ProLeu: 3.482 ± 0.053
0.786ProMet: 0.786 ± 0.026
2.109ProAsn: 2.109 ± 0.046
1.479ProPro: 1.479 ± 0.044
1.096ProGln: 1.096 ± 0.03
1.386ProArg: 1.386 ± 0.038
3.143ProSer: 3.143 ± 0.055
1.884ProThr: 1.884 ± 0.037
2.712ProVal: 2.712 ± 0.04
0.535ProTrp: 0.535 ± 0.019
1.42ProTyr: 1.42 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
2.143GlnAla: 2.143 ± 0.049
0.171GlnCys: 0.171 ± 0.011
1.627GlnAsp: 1.627 ± 0.037
2.4GlnGlu: 2.4 ± 0.052
1.413GlnPhe: 1.413 ± 0.032
2.019GlnGly: 2.019 ± 0.04
0.352GlnHis: 0.352 ± 0.017
2.503GlnIle: 2.503 ± 0.046
2.723GlnLys: 2.723 ± 0.045
2.387GlnLeu: 2.387 ± 0.047
0.634GlnMet: 0.634 ± 0.019
1.69GlnAsn: 1.69 ± 0.037
0.936GlnPro: 0.936 ± 0.027
0.635GlnGln: 0.635 ± 0.029
1.298GlnArg: 1.298 ± 0.033
2.037GlnSer: 2.037 ± 0.044
1.746GlnThr: 1.746 ± 0.043
1.903GlnVal: 1.903 ± 0.038
0.268GlnTrp: 0.268 ± 0.014
0.958GlnTyr: 0.958 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.542ArgAla: 2.542 ± 0.047
0.256ArgCys: 0.256 ± 0.013
2.209ArgAsp: 2.209 ± 0.049
3.512ArgGlu: 3.512 ± 0.053
2.609ArgPhe: 2.609 ± 0.046
2.461ArgGly: 2.461 ± 0.057
0.658ArgHis: 0.658 ± 0.023
4.391ArgIle: 4.391 ± 0.067
4.383ArgLys: 4.383 ± 0.062
4.423ArgLeu: 4.423 ± 0.061
1.219ArgMet: 1.219 ± 0.031
2.423ArgAsn: 2.423 ± 0.042
1.672ArgPro: 1.672 ± 0.036
1.201ArgGln: 1.201 ± 0.029
2.087ArgArg: 2.087 ± 0.045
3.454ArgSer: 3.454 ± 0.05
2.536ArgThr: 2.536 ± 0.049
2.554ArgVal: 2.554 ± 0.045
0.532ArgTrp: 0.532 ± 0.023
1.666ArgTyr: 1.666 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
4.719SerAla: 4.719 ± 0.067
0.645SerCys: 0.645 ± 0.023
3.909SerAsp: 3.909 ± 0.075
5.85SerGlu: 5.85 ± 0.091
4.581SerPhe: 4.581 ± 0.068
6.467SerGly: 6.467 ± 0.08
1.211SerHis: 1.211 ± 0.031
5.454SerIle: 5.454 ± 0.072
5.74SerLys: 5.74 ± 0.075
8.426SerLeu: 8.426 ± 0.089
1.348SerMet: 1.348 ± 0.031
2.968SerAsn: 2.968 ± 0.056
3.282SerPro: 3.282 ± 0.053
2.459SerGln: 2.459 ± 0.054
3.272SerArg: 3.272 ± 0.06
6.496SerSer: 6.496 ± 0.1
3.125SerThr: 3.125 ± 0.061
4.988SerVal: 4.988 ± 0.063
0.945SerTrp: 0.945 ± 0.028
2.747SerTyr: 2.747 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
3.134ThrAla: 3.134 ± 0.067
0.352ThrCys: 0.352 ± 0.015
2.623ThrAsp: 2.623 ± 0.047
3.354ThrGlu: 3.354 ± 0.054
2.512ThrPhe: 2.512 ± 0.043
4.023ThrGly: 4.023 ± 0.071
0.875ThrHis: 0.875 ± 0.024
3.441ThrIle: 3.441 ± 0.053
3.286ThrLys: 3.286 ± 0.06
4.886ThrLeu: 4.886 ± 0.053
0.821ThrMet: 0.821 ± 0.028
2.092ThrAsn: 2.092 ± 0.047
2.284ThrPro: 2.284 ± 0.042
1.395ThrGln: 1.395 ± 0.035
2.011ThrArg: 2.011 ± 0.046
3.575ThrSer: 3.575 ± 0.066
2.288ThrThr: 2.288 ± 0.051
3.373ThrVal: 3.373 ± 0.06
0.575ThrTrp: 0.575 ± 0.021
1.712ThrTyr: 1.712 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
3.662ValAla: 3.662 ± 0.058
0.578ValCys: 0.578 ± 0.022
2.85ValAsp: 2.85 ± 0.05
3.571ValGlu: 3.571 ± 0.056
3.632ValPhe: 3.632 ± 0.057
3.941ValGly: 3.941 ± 0.07
1.029ValHis: 1.029 ± 0.032
3.868ValIle: 3.868 ± 0.063
3.603ValLys: 3.603 ± 0.066
7.064ValLeu: 7.064 ± 0.084
1.106ValMet: 1.106 ± 0.033
2.26ValAsn: 2.26 ± 0.047
2.612ValPro: 2.612 ± 0.052
1.904ValGln: 1.904 ± 0.039
3.076ValArg: 3.076 ± 0.058
5.316ValSer: 5.316 ± 0.068
2.962ValThr: 2.962 ± 0.055
3.654ValVal: 3.654 ± 0.074
0.796ValTrp: 0.796 ± 0.029
2.213ValTyr: 2.213 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.701TrpAla: 0.701 ± 0.024
0.076TrpCys: 0.076 ± 0.007
0.678TrpAsp: 0.678 ± 0.022
0.994TrpGlu: 0.994 ± 0.033
0.606TrpPhe: 0.606 ± 0.024
0.814TrpGly: 0.814 ± 0.026
0.16TrpHis: 0.16 ± 0.013
1.072TrpIle: 1.072 ± 0.034
1.203TrpLys: 1.203 ± 0.032
0.937TrpLeu: 0.937 ± 0.029
0.295TrpMet: 0.295 ± 0.014
0.74TrpAsn: 0.74 ± 0.023
0.298TrpPro: 0.298 ± 0.016
0.302TrpGln: 0.302 ± 0.015
0.455TrpArg: 0.455 ± 0.019
0.715TrpSer: 0.715 ± 0.028
0.633TrpThr: 0.633 ± 0.026
0.703TrpVal: 0.703 ± 0.023
0.136TrpTrp: 0.136 ± 0.011
0.315TrpTyr: 0.315 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.938TyrAla: 1.938 ± 0.042
0.352TyrCys: 0.352 ± 0.018
1.786TyrAsp: 1.786 ± 0.056
2.161TyrGlu: 2.161 ± 0.042
2.281TyrPhe: 2.281 ± 0.048
2.3TyrGly: 2.3 ± 0.043
0.647TyrHis: 0.647 ± 0.022
2.128TyrIle: 2.128 ± 0.043
2.421TyrLys: 2.421 ± 0.046
4.081TyrLeu: 4.081 ± 0.059
0.591TyrMet: 0.591 ± 0.021
1.362TyrAsn: 1.362 ± 0.033
1.569TyrPro: 1.569 ± 0.035
1.133TyrGln: 1.133 ± 0.03
1.84TyrArg: 1.84 ± 0.044
3.248TyrSer: 3.248 ± 0.059
1.703TyrThr: 1.703 ± 0.041
1.743TyrVal: 1.743 ± 0.038
0.491TyrTrp: 0.491 ± 0.021
1.489TyrTyr: 1.489 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3927 proteins (1283000 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski