Amino acid dipepetide frequency for Collinsella sp. An271

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.24AlaAla: 15.24 ± 0.239	2.354AlaCys: 2.354 ± 0.059	7.6AlaAsp: 7.6 ± 0.116	7.322AlaGlu: 7.322 ± 0.125	4.178AlaPhe: 4.178 ± 0.081	9.895AlaGly: 9.895 ± 0.139	2.408AlaHis: 2.408 ± 0.054	5.898AlaIle: 5.898 ± 0.103	3.414AlaLys: 3.414 ± 0.089	11.8AlaLeu: 11.8 ± 0.163	3.068AlaMet: 3.068 ± 0.065	2.669AlaAsn: 2.669 ± 0.076	4.765AlaPro: 4.765 ± 0.105	3.63AlaGln: 3.63 ± 0.08	8.14AlaArg: 8.14 ± 0.141	6.998AlaSer: 6.998 ± 0.121	5.572AlaThr: 5.572 ± 0.101	9.057AlaVal: 9.057 ± 0.148	1.388AlaTrp: 1.388 ± 0.044	3.061AlaTyr: 3.061 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	2.082CysAla: 2.082 ± 0.06	0.271CysCys: 0.271 ± 0.018	1.064CysAsp: 1.064 ± 0.037	0.974CysGlu: 0.974 ± 0.038	0.49CysPhe: 0.49 ± 0.024	1.808CysGly: 1.808 ± 0.054	0.303CysHis: 0.303 ± 0.022	0.803CysIle: 0.803 ± 0.034	0.332CysLys: 0.332 ± 0.023	1.251CysLeu: 1.251 ± 0.038	0.389CysMet: 0.389 ± 0.022	0.335CysAsn: 0.335 ± 0.021	0.88CysPro: 0.88 ± 0.038	0.334CysGln: 0.334 ± 0.022	0.925CysArg: 0.925 ± 0.029	0.956CysSer: 0.956 ± 0.04	0.943CysThr: 0.943 ± 0.034	1.21CysVal: 1.21 ± 0.04	0.151CysTrp: 0.151 ± 0.013	0.354CysTyr: 0.354 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	8.63AspAla: 8.63 ± 0.132	0.808AspCys: 0.808 ± 0.034	4.26AspAsp: 4.26 ± 0.101	5.461AspGlu: 5.461 ± 0.091	2.257AspPhe: 2.257 ± 0.052	5.943AspGly: 5.943 ± 0.122	1.123AspHis: 1.123 ± 0.041	3.641AspIle: 3.641 ± 0.069	1.735AspLys: 1.735 ± 0.051	5.644AspLeu: 5.644 ± 0.097	1.613AspMet: 1.613 ± 0.049	1.483AspAsn: 1.483 ± 0.048	3.179AspPro: 3.179 ± 0.067	1.502AspGln: 1.502 ± 0.046	4.026AspArg: 4.026 ± 0.086	2.828AspSer: 2.828 ± 0.067	3.158AspThr: 3.158 ± 0.066	5.033AspVal: 5.033 ± 0.078	0.749AspTrp: 0.749 ± 0.032	1.877AspTyr: 1.877 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	7.456GluAla: 7.456 ± 0.126	0.753GluCys: 0.753 ± 0.032	3.879GluAsp: 3.879 ± 0.074	4.347GluGlu: 4.347 ± 0.094	1.993GluPhe: 1.993 ± 0.051	5.173GluGly: 5.173 ± 0.084	1.672GluHis: 1.672 ± 0.047	3.229GluIle: 3.229 ± 0.065	2.193GluLys: 2.193 ± 0.057	7.066GluLeu: 7.066 ± 0.117	1.81GluMet: 1.81 ± 0.048	1.862GluAsn: 1.862 ± 0.048	2.777GluPro: 2.777 ± 0.071	2.666GluGln: 2.666 ± 0.058	5.86GluArg: 5.86 ± 0.116	3.058GluSer: 3.058 ± 0.068	3.067GluThr: 3.067 ± 0.07	4.651GluVal: 4.651 ± 0.093	0.581GluTrp: 0.581 ± 0.028	1.591GluTyr: 1.591 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	4.147PheAla: 4.147 ± 0.078	0.657PheCys: 0.657 ± 0.029	2.814PheAsp: 2.814 ± 0.055	2.261PheGlu: 2.261 ± 0.058	1.351PhePhe: 1.351 ± 0.048	3.333PheGly: 3.333 ± 0.065	0.661PheHis: 0.661 ± 0.031	1.836PheIle: 1.836 ± 0.058	0.993PheLys: 0.993 ± 0.039	2.688PheLeu: 2.688 ± 0.07	0.967PheMet: 0.967 ± 0.037	0.989PheAsn: 0.989 ± 0.037	1.232PhePro: 1.232 ± 0.038	0.811PheGln: 0.811 ± 0.032	1.763PheArg: 1.763 ± 0.048	2.579PheSer: 2.579 ± 0.053	2.132PheThr: 2.132 ± 0.048	2.742PheVal: 2.742 ± 0.066	0.386PheTrp: 0.386 ± 0.02	1.024PheTyr: 1.024 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	9.155GlyAla: 9.155 ± 0.12	1.592GlyCys: 1.592 ± 0.049	4.849GlyAsp: 4.849 ± 0.08	5.171GlyGlu: 5.171 ± 0.081	3.185GlyPhe: 3.185 ± 0.065	6.51GlyGly: 6.51 ± 0.12	1.538GlyHis: 1.538 ± 0.048	5.221GlyIle: 5.221 ± 0.084	3.063GlyLys: 3.063 ± 0.076	7.017GlyLeu: 7.017 ± 0.116	2.612GlyMet: 2.612 ± 0.063	2.141GlyAsn: 2.141 ± 0.06	2.444GlyPro: 2.444 ± 0.052	2.076GlyGln: 2.076 ± 0.054	5.249GlyArg: 5.249 ± 0.099	5.217GlySer: 5.217 ± 0.088	4.962GlyThr: 4.962 ± 0.089	6.717GlyVal: 6.717 ± 0.109	0.997GlyTrp: 0.997 ± 0.043	2.77GlyTyr: 2.77 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	2.421HisAla: 2.421 ± 0.054	0.295HisCys: 0.295 ± 0.02	1.34HisAsp: 1.34 ± 0.046	1.393HisGlu: 1.393 ± 0.049	0.606HisPhe: 0.606 ± 0.031	1.845HisGly: 1.845 ± 0.052	0.448HisHis: 0.448 ± 0.024	1.032HisIle: 1.032 ± 0.034	0.473HisLys: 0.473 ± 0.028	1.719HisLeu: 1.719 ± 0.052	0.53HisMet: 0.53 ± 0.026	0.502HisAsn: 0.502 ± 0.025	1.142HisPro: 1.142 ± 0.04	0.422HisGln: 0.422 ± 0.025	1.204HisArg: 1.204 ± 0.04	0.766HisSer: 0.766 ± 0.031	0.944HisThr: 0.944 ± 0.034	1.683HisVal: 1.683 ± 0.045	0.168HisTrp: 0.168 ± 0.014	0.544HisTyr: 0.544 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.778IleAla: 6.778 ± 0.097	0.898IleCys: 0.898 ± 0.038	4.261IleAsp: 4.261 ± 0.089	4.037IleGlu: 4.037 ± 0.079	1.535IlePhe: 1.535 ± 0.043	4.137IleGly: 4.137 ± 0.089	0.833IleHis: 0.833 ± 0.031	2.673IleIle: 2.673 ± 0.063	1.696IleLys: 1.696 ± 0.055	3.922IleLeu: 3.922 ± 0.084	1.465IleMet: 1.465 ± 0.055	1.495IleAsn: 1.495 ± 0.051	2.507IlePro: 2.507 ± 0.059	1.214IleGln: 1.214 ± 0.04	2.897IleArg: 2.897 ± 0.068	3.295IleSer: 3.295 ± 0.069	2.841IleThr: 2.841 ± 0.072	4.738IleVal: 4.738 ± 0.084	0.516IleTrp: 0.516 ± 0.025	1.261IleTyr: 1.261 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	3.111LysAla: 3.111 ± 0.078	0.334LysCys: 0.334 ± 0.02	1.628LysAsp: 1.628 ± 0.055	1.714LysGlu: 1.714 ± 0.053	0.847LysPhe: 0.847 ± 0.034	2.322LysGly: 2.322 ± 0.059	0.631LysHis: 0.631 ± 0.027	1.81LysIle: 1.81 ± 0.05	1.588LysLys: 1.588 ± 0.064	2.954LysLeu: 2.954 ± 0.073	0.876LysMet: 0.876 ± 0.032	1.106LysAsn: 1.106 ± 0.039	1.519LysPro: 1.519 ± 0.042	1.073LysGln: 1.073 ± 0.038	2.526LysArg: 2.526 ± 0.059	1.714LysSer: 1.714 ± 0.052	2.022LysThr: 2.022 ± 0.06	2.318LysVal: 2.318 ± 0.065	0.282LysTrp: 0.282 ± 0.023	0.804LysTyr: 0.804 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	11.623LeuAla: 11.623 ± 0.149	1.322LeuCys: 1.322 ± 0.05	6.406LeuAsp: 6.406 ± 0.095	5.667LeuGlu: 5.667 ± 0.1	3.326LeuPhe: 3.326 ± 0.069	7.297LeuGly: 7.297 ± 0.11	1.622LeuHis: 1.622 ± 0.048	4.5LeuIle: 4.5 ± 0.091	2.811LeuLys: 2.811 ± 0.072	8.061LeuLeu: 8.061 ± 0.139	2.653LeuMet: 2.653 ± 0.058	2.318LeuAsn: 2.318 ± 0.057	4.351LeuPro: 4.351 ± 0.079	2.134LeuGln: 2.134 ± 0.061	5.407LeuArg: 5.407 ± 0.095	6.119LeuSer: 6.119 ± 0.095	4.992LeuThr: 4.992 ± 0.087	7.651LeuVal: 7.651 ± 0.106	0.778LeuTrp: 0.778 ± 0.038	2.363LeuTyr: 2.363 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	3.242MetAla: 3.242 ± 0.062	0.39MetCys: 0.39 ± 0.022	1.559MetAsp: 1.559 ± 0.05	1.508MetGlu: 1.508 ± 0.045	0.834MetPhe: 0.834 ± 0.033	2.417MetGly: 2.417 ± 0.063	0.55MetHis: 0.55 ± 0.029	1.296MetIle: 1.296 ± 0.047	0.952MetLys: 0.952 ± 0.038	2.626MetLeu: 2.626 ± 0.06	0.652MetMet: 0.652 ± 0.027	0.893MetAsn: 0.893 ± 0.04	1.51MetPro: 1.51 ± 0.039	0.756MetGln: 0.756 ± 0.035	2.07MetArg: 2.07 ± 0.06	1.726MetSer: 1.726 ± 0.042	1.473MetThr: 1.473 ± 0.044	1.893MetVal: 1.893 ± 0.054	0.214MetTrp: 0.214 ± 0.016	0.595MetTyr: 0.595 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.788AsnAla: 2.788 ± 0.062	0.33AsnCys: 0.33 ± 0.021	1.591AsnAsp: 1.591 ± 0.05	1.678AsnGlu: 1.678 ± 0.055	0.855AsnPhe: 0.855 ± 0.035	2.253AsnGly: 2.253 ± 0.065	0.5AsnHis: 0.5 ± 0.027	1.555AsnIle: 1.555 ± 0.052	0.893AsnLys: 0.893 ± 0.039	2.556AsnLeu: 2.556 ± 0.056	0.762AsnMet: 0.762 ± 0.031	0.749AsnAsn: 0.749 ± 0.03	1.635AsnPro: 1.635 ± 0.05	0.774AsnGln: 0.774 ± 0.033	1.591AsnArg: 1.591 ± 0.039	1.22AsnSer: 1.22 ± 0.048	1.432AsnThr: 1.432 ± 0.047	2.17AsnVal: 2.17 ± 0.053	0.271AsnTrp: 0.271 ± 0.022	0.834AsnTyr: 0.834 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	5.434ProAla: 5.434 ± 0.116	0.647ProCys: 0.647 ± 0.028	3.091ProAsp: 3.091 ± 0.067	3.673ProGlu: 3.673 ± 0.076	1.671ProPhe: 1.671 ± 0.047	3.475ProGly: 3.475 ± 0.073	0.911ProHis: 0.911 ± 0.038	1.976ProIle: 1.976 ± 0.048	1.298ProLys: 1.298 ± 0.044	3.716ProLeu: 3.716 ± 0.073	0.956ProMet: 0.956 ± 0.033	1.182ProAsn: 1.182 ± 0.042	1.061ProPro: 1.061 ± 0.043	1.379ProGln: 1.379 ± 0.051	2.379ProArg: 2.379 ± 0.067	2.583ProSer: 2.583 ± 0.057	2.322ProThr: 2.322 ± 0.056	3.881ProVal: 3.881 ± 0.08	0.608ProTrp: 0.608 ± 0.029	1.332ProTyr: 1.332 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.336GlnAla: 3.336 ± 0.07	0.231GlnCys: 0.231 ± 0.016	1.434GlnAsp: 1.434 ± 0.044	1.57GlnGlu: 1.57 ± 0.046	0.919GlnPhe: 0.919 ± 0.037	2.107GlnGly: 2.107 ± 0.051	0.53GlnHis: 0.53 ± 0.029	1.656GlnIle: 1.656 ± 0.05	0.926GlnLys: 0.926 ± 0.037	2.786GlnLeu: 2.786 ± 0.062	0.93GlnMet: 0.93 ± 0.032	0.798GlnAsn: 0.798 ± 0.033	1.175GlnPro: 1.175 ± 0.045	1.178GlnGln: 1.178 ± 0.05	2.04GlnArg: 2.04 ± 0.062	1.365GlnSer: 1.365 ± 0.037	1.579GlnThr: 1.579 ± 0.051	2.191GlnVal: 2.191 ± 0.047	0.251GlnTrp: 0.251 ± 0.018	0.733GlnTyr: 0.733 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	8.017ArgAla: 8.017 ± 0.139	1.007ArgCys: 1.007 ± 0.036	3.99ArgAsp: 3.99 ± 0.07	4.912ArgGlu: 4.912 ± 0.08	2.394ArgPhe: 2.394 ± 0.053	4.728ArgGly: 4.728 ± 0.099	1.304ArgHis: 1.304 ± 0.046	3.827ArgIle: 3.827 ± 0.078	2.043ArgLys: 2.043 ± 0.06	5.912ArgLeu: 5.912 ± 0.118	2.031ArgMet: 2.031 ± 0.053	1.61ArgAsn: 1.61 ± 0.05	2.625ArgPro: 2.625 ± 0.07	1.787ArgGln: 1.787 ± 0.053	5.279ArgArg: 5.279 ± 0.103	3.608ArgSer: 3.608 ± 0.076	3.426ArgThr: 3.426 ± 0.069	5.004ArgVal: 5.004 ± 0.093	0.729ArgTrp: 0.729 ± 0.033	2.093ArgTyr: 2.093 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	6.324SerAla: 6.324 ± 0.102	0.993SerCys: 0.993 ± 0.036	3.786SerAsp: 3.786 ± 0.082	3.303SerGlu: 3.303 ± 0.066	2.406SerPhe: 2.406 ± 0.058	5.398SerGly: 5.398 ± 0.09	1.157SerHis: 1.157 ± 0.039	3.191SerIle: 3.191 ± 0.069	1.712SerLys: 1.712 ± 0.052	5.235SerLeu: 5.235 ± 0.095	1.612SerMet: 1.612 ± 0.05	1.529SerAsn: 1.529 ± 0.051	2.324SerPro: 2.324 ± 0.057	1.553SerGln: 1.553 ± 0.045	3.598SerArg: 3.598 ± 0.07	3.808SerSer: 3.808 ± 0.085	3.186SerThr: 3.186 ± 0.073	4.487SerVal: 4.487 ± 0.083	0.713SerTrp: 0.713 ± 0.033	1.962SerTyr: 1.962 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	5.362ThrAla: 5.362 ± 0.096	0.921ThrCys: 0.921 ± 0.036	3.231ThrAsp: 3.231 ± 0.071	2.851ThrGlu: 2.851 ± 0.067	2.139ThrPhe: 2.139 ± 0.055	4.964ThrGly: 4.964 ± 0.084	1.114ThrHis: 1.114 ± 0.043	2.919ThrIle: 2.919 ± 0.071	1.606ThrLys: 1.606 ± 0.054	4.903ThrLeu: 4.903 ± 0.083	1.364ThrMet: 1.364 ± 0.04	1.259ThrAsn: 1.259 ± 0.042	2.955ThrPro: 2.955 ± 0.061	1.313ThrGln: 1.313 ± 0.045	3.077ThrArg: 3.077 ± 0.061	3.233ThrSer: 3.233 ± 0.071	2.738ThrThr: 2.738 ± 0.072	5.024ThrVal: 5.024 ± 0.087	0.68ThrTrp: 0.68 ± 0.03	1.718ThrTyr: 1.718 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	9.205ValAla: 9.205 ± 0.134	1.428ValCys: 1.428 ± 0.044	5.494ValAsp: 5.494 ± 0.096	5.253ValGlu: 5.253 ± 0.103	2.929ValPhe: 2.929 ± 0.063	5.699ValGly: 5.699 ± 0.094	1.383ValHis: 1.383 ± 0.045	4.114ValIle: 4.114 ± 0.077	2.385ValLys: 2.385 ± 0.059	7.529ValLeu: 7.529 ± 0.112	1.936ValMet: 1.936 ± 0.05	2.354ValAsn: 2.354 ± 0.055	3.816ValPro: 3.816 ± 0.078	1.914ValGln: 1.914 ± 0.048	5.334ValArg: 5.334 ± 0.087	5.164ValSer: 5.164 ± 0.083	4.433ValThr: 4.433 ± 0.092	6.894ValVal: 6.894 ± 0.121	0.763ValTrp: 0.763 ± 0.03	2.138ValTyr: 2.138 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	1.078TrpAla: 1.078 ± 0.042	0.212TrpCys: 0.212 ± 0.019	0.684TrpAsp: 0.684 ± 0.036	0.662TrpGlu: 0.662 ± 0.032	0.412TrpPhe: 0.412 ± 0.024	0.856TrpGly: 0.856 ± 0.037	0.227TrpHis: 0.227 ± 0.016	0.554TrpIle: 0.554 ± 0.029	0.337TrpLys: 0.337 ± 0.022	1.012TrpLeu: 1.012 ± 0.033	0.345TrpMet: 0.345 ± 0.021	0.325TrpAsn: 0.325 ± 0.019	0.399TrpPro: 0.399 ± 0.027	0.354TrpGln: 0.354 ± 0.023	0.812TrpArg: 0.812 ± 0.035	0.612TrpSer: 0.612 ± 0.028	0.525TrpThr: 0.525 ± 0.03	0.69TrpVal: 0.69 ± 0.031	0.174TrpTrp: 0.174 ± 0.014	0.431TrpTyr: 0.431 ± 0.03	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.029TyrAla: 3.029 ± 0.061	0.412TyrCys: 0.412 ± 0.022	1.991TyrAsp: 1.991 ± 0.059	1.926TyrGlu: 1.926 ± 0.055	1.043TyrPhe: 1.043 ± 0.036	2.325TyrGly: 2.325 ± 0.056	0.562TyrHis: 0.562 ± 0.03	1.266TyrIle: 1.266 ± 0.042	0.73TyrLys: 0.73 ± 0.037	3.004TyrLeu: 3.004 ± 0.075	0.583TyrMet: 0.583 ± 0.027	0.837TyrAsn: 0.837 ± 0.039	1.278TyrPro: 1.278 ± 0.048	0.869TyrGln: 0.869 ± 0.026	2.15TyrArg: 2.15 ± 0.062	1.427TyrSer: 1.427 ± 0.05	1.623TyrThr: 1.623 ± 0.059	2.131TyrVal: 2.131 ± 0.049	0.3TyrTrp: 0.3 ± 0.019	0.912TyrTyr: 0.912 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2335 proteins (779385 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---