Amino acid dipepetide frequency for Cylicostephanus goldi (Nematode worm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.502AlaAla: 6.502 ± 0.066	1.26AlaCys: 1.26 ± 0.022	3.646AlaAsp: 3.646 ± 0.044	5.084AlaGlu: 5.084 ± 0.056	2.86AlaPhe: 2.86 ± 0.036	3.979AlaGly: 3.979 ± 0.045	1.646AlaHis: 1.646 ± 0.026	3.937AlaIle: 3.937 ± 0.047	4.243AlaLys: 4.243 ± 0.044	6.584AlaLeu: 6.584 ± 0.06	1.959AlaMet: 1.959 ± 0.026	2.803AlaAsn: 2.803 ± 0.033	3.593AlaPro: 3.593 ± 0.055	2.847AlaGln: 2.847 ± 0.042	3.95AlaArg: 3.95 ± 0.044	5.055AlaSer: 5.055 ± 0.056	3.899AlaThr: 3.899 ± 0.042	5.283AlaVal: 5.283 ± 0.051	0.663AlaTrp: 0.663 ± 0.017	2.008AlaTyr: 2.008 ± 0.032	0.021AlaXaa: 0.021 ± 0.003
Cys	1.436CysAla: 1.436 ± 0.028	0.574CysCys: 0.574 ± 0.021	1.153CysAsp: 1.153 ± 0.026	1.239CysGlu: 1.239 ± 0.021	0.957CysPhe: 0.957 ± 0.019	1.359CysGly: 1.359 ± 0.027	0.501CysHis: 0.501 ± 0.013	1.107CysIle: 1.107 ± 0.025	1.026CysLys: 1.026 ± 0.023	1.833CysLeu: 1.833 ± 0.029	0.561CysMet: 0.561 ± 0.018	0.771CysAsn: 0.771 ± 0.018	1.152CysPro: 1.152 ± 0.029	0.699CysGln: 0.699 ± 0.021	1.194CysArg: 1.194 ± 0.024	1.71CysSer: 1.71 ± 0.034	1.106CysThr: 1.106 ± 0.026	1.33CysVal: 1.33 ± 0.026	0.239CysTrp: 0.239 ± 0.01	0.644CysTyr: 0.644 ± 0.019	0.008CysXaa: 0.008 ± 0.002
Asp	3.809AspAla: 3.809 ± 0.047	0.996AspCys: 0.996 ± 0.021	3.822AspAsp: 3.822 ± 0.049	4.523AspGlu: 4.523 ± 0.047	2.248AspPhe: 2.248 ± 0.027	3.55AspGly: 3.55 ± 0.044	1.185AspHis: 1.185 ± 0.023	3.002AspIle: 3.002 ± 0.038	2.777AspLys: 2.777 ± 0.038	4.703AspLeu: 4.703 ± 0.042	1.38AspMet: 1.38 ± 0.026	1.93AspAsn: 1.93 ± 0.027	2.513AspPro: 2.513 ± 0.034	1.77AspGln: 1.77 ± 0.03	3.0AspArg: 3.0 ± 0.045	3.674AspSer: 3.674 ± 0.043	2.539AspThr: 2.539 ± 0.029	3.817AspVal: 3.817 ± 0.04	0.665AspTrp: 0.665 ± 0.018	1.857AspTyr: 1.857 ± 0.029	0.013AspXaa: 0.013 ± 0.002
Glu	4.802GluAla: 4.802 ± 0.053	1.16GluCys: 1.16 ± 0.025	3.99GluAsp: 3.99 ± 0.048	6.64GluGlu: 6.64 ± 0.096	2.386GluPhe: 2.386 ± 0.03	3.329GluGly: 3.329 ± 0.041	1.584GluHis: 1.584 ± 0.027	3.482GluIle: 3.482 ± 0.039	5.3GluLys: 5.3 ± 0.058	5.954GluLeu: 5.954 ± 0.059	1.956GluMet: 1.956 ± 0.028	3.107GluAsn: 3.107 ± 0.036	2.549GluPro: 2.549 ± 0.04	2.94GluGln: 2.94 ± 0.04	4.37GluArg: 4.37 ± 0.062	4.196GluSer: 4.196 ± 0.048	3.414GluThr: 3.414 ± 0.041	4.328GluVal: 4.328 ± 0.045	0.785GluTrp: 0.785 ± 0.017	1.794GluTyr: 1.794 ± 0.026	0.018GluXaa: 0.018 ± 0.002
Phe	3.016PheAla: 3.016 ± 0.037	1.108PheCys: 1.108 ± 0.021	2.484PheAsp: 2.484 ± 0.034	2.493PheGlu: 2.493 ± 0.032	2.271PhePhe: 2.271 ± 0.037	2.667PheGly: 2.667 ± 0.033	1.045PheHis: 1.045 ± 0.021	2.286PheIle: 2.286 ± 0.034	1.808PheLys: 1.808 ± 0.025	4.125PheLeu: 4.125 ± 0.041	1.117PheMet: 1.117 ± 0.021	1.591PheAsn: 1.591 ± 0.025	1.911PhePro: 1.911 ± 0.027	1.499PheGln: 1.499 ± 0.026	2.325PheArg: 2.325 ± 0.03	3.408PheSer: 3.408 ± 0.033	2.28PheThr: 2.28 ± 0.033	3.016PheVal: 3.016 ± 0.04	0.534PheTrp: 0.534 ± 0.017	1.545PheTyr: 1.545 ± 0.024	0.015PheXaa: 0.015 ± 0.002
Gly	3.875GlyAla: 3.875 ± 0.048	1.131GlyCys: 1.131 ± 0.024	3.139GlyAsp: 3.139 ± 0.04	3.726GlyGlu: 3.726 ± 0.055	2.43GlyPhe: 2.43 ± 0.037	4.46GlyGly: 4.46 ± 0.084	1.351GlyHis: 1.351 ± 0.025	3.007GlyIle: 3.007 ± 0.037	3.482GlyLys: 3.482 ± 0.042	4.527GlyLeu: 4.527 ± 0.058	1.633GlyMet: 1.633 ± 0.03	2.368GlyAsn: 2.368 ± 0.033	2.682GlyPro: 2.682 ± 0.057	2.046GlyGln: 2.046 ± 0.034	3.43GlyArg: 3.43 ± 0.043	4.318GlySer: 4.318 ± 0.052	3.301GlyThr: 3.301 ± 0.042	3.706GlyVal: 3.706 ± 0.043	0.69GlyTrp: 0.69 ± 0.014	1.993GlyTyr: 1.993 ± 0.037	0.019GlyXaa: 0.019 ± 0.003
His	1.505HisAla: 1.505 ± 0.026	0.56HisCys: 0.56 ± 0.016	1.179HisAsp: 1.179 ± 0.021	1.408HisGlu: 1.408 ± 0.027	1.2HisPhe: 1.2 ± 0.021	1.375HisGly: 1.375 ± 0.025	0.756HisHis: 0.756 ± 0.021	1.311HisIle: 1.311 ± 0.02	1.132HisLys: 1.132 ± 0.022	2.345HisLeu: 2.345 ± 0.029	0.642HisMet: 0.642 ± 0.015	0.863HisAsn: 0.863 ± 0.019	1.319HisPro: 1.319 ± 0.024	0.895HisGln: 0.895 ± 0.02	1.474HisArg: 1.474 ± 0.021	1.727HisSer: 1.727 ± 0.027	1.158HisThr: 1.158 ± 0.021	1.555HisVal: 1.555 ± 0.027	0.299HisTrp: 0.299 ± 0.011	0.892HisTyr: 0.892 ± 0.02	0.007HisXaa: 0.007 ± 0.002
Ile	4.083IleAla: 4.083 ± 0.042	1.234IleCys: 1.234 ± 0.021	3.067IleAsp: 3.067 ± 0.038	3.406IleGlu: 3.406 ± 0.036	2.44IlePhe: 2.44 ± 0.035	2.999IleGly: 2.999 ± 0.04	1.232IleHis: 1.232 ± 0.024	2.978IleIle: 2.978 ± 0.038	2.716IleLys: 2.716 ± 0.036	4.887IleLeu: 4.887 ± 0.049	1.334IleMet: 1.334 ± 0.02	2.027IleAsn: 2.027 ± 0.03	2.859IlePro: 2.859 ± 0.037	1.961IleGln: 1.961 ± 0.029	3.17IleArg: 3.17 ± 0.039	4.195IleSer: 4.195 ± 0.04	3.06IleThr: 3.06 ± 0.04	3.827IleVal: 3.827 ± 0.044	0.618IleTrp: 0.618 ± 0.019	1.776IleTyr: 1.776 ± 0.027	0.019IleXaa: 0.019 ± 0.003
Lys	3.96LysAla: 3.96 ± 0.044	1.125LysCys: 1.125 ± 0.024	3.041LysAsp: 3.041 ± 0.039	4.747LysGlu: 4.747 ± 0.065	2.131LysPhe: 2.131 ± 0.03	2.853LysGly: 2.853 ± 0.044	1.313LysHis: 1.313 ± 0.023	3.176LysIle: 3.176 ± 0.04	4.871LysLys: 4.871 ± 0.082	5.011LysLeu: 5.011 ± 0.045	1.712LysMet: 1.712 ± 0.028	2.566LysAsn: 2.566 ± 0.032	2.606LysPro: 2.606 ± 0.039	2.249LysGln: 2.249 ± 0.03	3.761LysArg: 3.761 ± 0.044	3.767LysSer: 3.767 ± 0.037	3.157LysThr: 3.157 ± 0.041	3.77LysVal: 3.77 ± 0.042	0.654LysTrp: 0.654 ± 0.016	1.774LysTyr: 1.774 ± 0.029	0.013LysXaa: 0.013 ± 0.002
Leu	6.643LeuAla: 6.643 ± 0.056	2.0LeuCys: 2.0 ± 0.03	4.688LeuAsp: 4.688 ± 0.046	5.787LeuGlu: 5.787 ± 0.058	4.016LeuPhe: 4.016 ± 0.043	4.429LeuGly: 4.429 ± 0.046	2.305LeuHis: 2.305 ± 0.036	4.713LeuIle: 4.713 ± 0.044	5.106LeuLys: 5.106 ± 0.048	9.05LeuLeu: 9.05 ± 0.064	2.379LeuMet: 2.379 ± 0.029	3.687LeuAsn: 3.687 ± 0.034	4.964LeuPro: 4.964 ± 0.049	3.801LeuGln: 3.801 ± 0.043	5.745LeuArg: 5.745 ± 0.046	7.17LeuSer: 7.17 ± 0.06	4.786LeuThr: 4.786 ± 0.047	5.485LeuVal: 5.485 ± 0.05	1.018LeuTrp: 1.018 ± 0.022	2.694LeuTyr: 2.694 ± 0.035	0.036LeuXaa: 0.036 ± 0.004
Met	1.962MetAla: 1.962 ± 0.027	0.54MetCys: 0.54 ± 0.015	1.52MetAsp: 1.52 ± 0.025	1.887MetGlu: 1.887 ± 0.031	1.164MetPhe: 1.164 ± 0.019	1.492MetGly: 1.492 ± 0.026	0.616MetHis: 0.616 ± 0.017	1.411MetIle: 1.411 ± 0.026	1.686MetLys: 1.686 ± 0.025	2.571MetLeu: 2.571 ± 0.031	0.884MetMet: 0.884 ± 0.02	1.162MetAsn: 1.162 ± 0.023	1.35MetPro: 1.35 ± 0.025	1.123MetGln: 1.123 ± 0.026	1.687MetArg: 1.687 ± 0.028	2.0MetSer: 2.0 ± 0.031	1.507MetThr: 1.507 ± 0.026	1.685MetVal: 1.685 ± 0.029	0.303MetTrp: 0.303 ± 0.011	0.781MetTyr: 0.781 ± 0.019	0.005MetXaa: 0.005 ± 0.001
Asn	2.865AsnAla: 2.865 ± 0.04	0.861AsnCys: 0.861 ± 0.021	2.134AsnAsp: 2.134 ± 0.032	2.69AsnGlu: 2.69 ± 0.031	1.829AsnPhe: 1.829 ± 0.03	2.834AsnGly: 2.834 ± 0.04	0.918AsnHis: 0.918 ± 0.018	2.362AsnIle: 2.362 ± 0.033	2.022AsnLys: 2.022 ± 0.03	3.643AsnLeu: 3.643 ± 0.038	1.078AsnMet: 1.078 ± 0.019	1.718AsnAsn: 1.718 ± 0.028	2.077AsnPro: 2.077 ± 0.031	1.417AsnGln: 1.417 ± 0.025	2.216AsnArg: 2.216 ± 0.033	2.826AsnSer: 2.826 ± 0.033	2.046AsnThr: 2.046 ± 0.03	2.908AsnVal: 2.908 ± 0.04	0.428AsnTrp: 0.428 ± 0.015	1.404AsnTyr: 1.404 ± 0.022	0.011AsnXaa: 0.011 ± 0.002
Pro	3.555ProAla: 3.555 ± 0.046	0.772ProCys: 0.772 ± 0.024	2.502ProAsp: 2.502 ± 0.031	3.238ProGlu: 3.238 ± 0.046	2.019ProPhe: 2.019 ± 0.027	3.307ProGly: 3.307 ± 0.083	1.154ProHis: 1.154 ± 0.021	2.49ProIle: 2.49 ± 0.036	2.762ProLys: 2.762 ± 0.037	4.217ProLeu: 4.217 ± 0.045	1.219ProMet: 1.219 ± 0.023	1.994ProAsn: 1.994 ± 0.032	4.492ProPro: 4.492 ± 0.102	2.118ProGln: 2.118 ± 0.034	2.622ProArg: 2.622 ± 0.04	4.377ProSer: 4.377 ± 0.052	3.097ProThr: 3.097 ± 0.043	3.385ProVal: 3.385 ± 0.048	0.466ProTrp: 0.466 ± 0.016	1.507ProTyr: 1.507 ± 0.03	0.017ProXaa: 0.017 ± 0.003
Gln	2.603GlnAla: 2.603 ± 0.032	0.845GlnCys: 0.845 ± 0.025	1.545GlnAsp: 1.545 ± 0.025	2.441GlnGlu: 2.441 ± 0.033	1.631GlnPhe: 1.631 ± 0.029	1.797GlnGly: 1.797 ± 0.032	0.946GlnHis: 0.946 ± 0.02	2.125GlnIle: 2.125 ± 0.032	2.421GlnLys: 2.421 ± 0.038	3.916GlnLeu: 3.916 ± 0.04	1.237GlnMet: 1.237 ± 0.025	1.67GlnAsn: 1.67 ± 0.03	2.05GlnPro: 2.05 ± 0.035	2.299GlnGln: 2.299 ± 0.064	2.488GlnArg: 2.488 ± 0.032	2.606GlnSer: 2.606 ± 0.037	1.92GlnThr: 1.92 ± 0.03	2.563GlnVal: 2.563 ± 0.03	0.468GlnTrp: 0.468 ± 0.014	1.204GlnTyr: 1.204 ± 0.024	0.008GlnXaa: 0.008 ± 0.002
Arg	3.837ArgAla: 3.837 ± 0.047	1.196ArgCys: 1.196 ± 0.023	2.942ArgAsp: 2.942 ± 0.042	3.922ArgGlu: 3.922 ± 0.056	2.502ArgPhe: 2.502 ± 0.035	3.096ArgGly: 3.096 ± 0.044	1.452ArgHis: 1.452 ± 0.024	3.362ArgIle: 3.362 ± 0.035	4.058ArgLys: 4.058 ± 0.043	5.574ArgLeu: 5.574 ± 0.05	1.847ArgMet: 1.847 ± 0.029	2.542ArgAsn: 2.542 ± 0.032	2.664ArgPro: 2.664 ± 0.039	2.422ArgGln: 2.422 ± 0.031	4.644ArgArg: 4.644 ± 0.06	4.296ArgSer: 4.296 ± 0.038	3.074ArgThr: 3.074 ± 0.033	3.517ArgVal: 3.517 ± 0.04	0.691ArgTrp: 0.691 ± 0.019	1.848ArgTyr: 1.848 ± 0.026	0.021ArgXaa: 0.021 ± 0.003
Ser	5.409SerAla: 5.409 ± 0.055	1.517SerCys: 1.517 ± 0.029	3.979SerAsp: 3.979 ± 0.046	4.565SerGlu: 4.565 ± 0.048	3.331SerPhe: 3.331 ± 0.038	4.422SerGly: 4.422 ± 0.055	1.708SerHis: 1.708 ± 0.028	3.964SerIle: 3.964 ± 0.046	3.932SerLys: 3.932 ± 0.043	6.788SerLeu: 6.788 ± 0.064	1.974SerMet: 1.974 ± 0.028	2.907SerAsn: 2.907 ± 0.036	3.944SerPro: 3.944 ± 0.056	2.771SerGln: 2.771 ± 0.04	4.255SerArg: 4.255 ± 0.045	7.349SerSer: 7.349 ± 0.086	4.776SerThr: 4.776 ± 0.056	4.852SerVal: 4.852 ± 0.055	0.78SerTrp: 0.78 ± 0.019	2.214SerTyr: 2.214 ± 0.034	0.023SerXaa: 0.023 ± 0.003
Thr	4.231ThrAla: 4.231 ± 0.043	1.139ThrCys: 1.139 ± 0.026	2.693ThrAsp: 2.693 ± 0.039	3.328ThrGlu: 3.328 ± 0.042	2.277ThrPhe: 2.277 ± 0.031	3.072ThrGly: 3.072 ± 0.039	1.164ThrHis: 1.164 ± 0.022	3.159ThrIle: 3.159 ± 0.035	2.929ThrLys: 2.929 ± 0.044	4.819ThrLeu: 4.819 ± 0.046	1.451ThrMet: 1.451 ± 0.024	2.134ThrAsn: 2.134 ± 0.029	3.231ThrPro: 3.231 ± 0.047	1.891ThrGln: 1.891 ± 0.029	2.773ThrArg: 2.773 ± 0.033	4.589ThrSer: 4.589 ± 0.051	3.96ThrThr: 3.96 ± 0.09	4.118ThrVal: 4.118 ± 0.045	0.588ThrTrp: 0.588 ± 0.015	1.574ThrTyr: 1.574 ± 0.023	0.025ThrXaa: 0.025 ± 0.003
Val	4.943ValAla: 4.943 ± 0.055	1.573ValCys: 1.573 ± 0.029	3.843ValAsp: 3.843 ± 0.042	4.415ValGlu: 4.415 ± 0.045	2.863ValPhe: 2.863 ± 0.039	3.679ValGly: 3.679 ± 0.043	1.598ValHis: 1.598 ± 0.024	3.729ValIle: 3.729 ± 0.041	3.589ValLys: 3.589 ± 0.038	5.983ValLeu: 5.983 ± 0.053	1.743ValMet: 1.743 ± 0.028	2.607ValAsn: 2.607 ± 0.034	3.426ValPro: 3.426 ± 0.043	2.499ValGln: 2.499 ± 0.037	3.79ValArg: 3.79 ± 0.043	5.163ValSer: 5.163 ± 0.051	3.765ValThr: 3.765 ± 0.048	5.023ValVal: 5.023 ± 0.076	0.711ValTrp: 0.711 ± 0.017	1.886ValTyr: 1.886 ± 0.028	0.026ValXaa: 0.026 ± 0.003
Trp	0.697TrpAla: 0.697 ± 0.017	0.226TrpCys: 0.226 ± 0.01	0.597TrpAsp: 0.597 ± 0.014	0.63TrpGlu: 0.63 ± 0.015	0.472TrpPhe: 0.472 ± 0.014	0.532TrpGly: 0.532 ± 0.016	0.274TrpHis: 0.274 ± 0.011	0.656TrpIle: 0.656 ± 0.017	0.779TrpLys: 0.779 ± 0.018	1.083TrpLeu: 1.083 ± 0.024	0.392TrpMet: 0.392 ± 0.013	0.568TrpAsn: 0.568 ± 0.016	0.461TrpPro: 0.461 ± 0.015	0.441TrpGln: 0.441 ± 0.015	0.716TrpArg: 0.716 ± 0.017	0.817TrpSer: 0.817 ± 0.022	0.688TrpThr: 0.688 ± 0.017	0.595TrpVal: 0.595 ± 0.016	0.19TrpTrp: 0.19 ± 0.008	0.353TrpTyr: 0.353 ± 0.011	0.005TrpXaa: 0.005 ± 0.002
Tyr	2.067TyrAla: 2.067 ± 0.032	0.776TyrCys: 0.776 ± 0.019	1.796TyrAsp: 1.796 ± 0.031	1.896TyrGlu: 1.896 ± 0.028	1.504TyrPhe: 1.504 ± 0.025	2.066TyrGly: 2.066 ± 0.036	0.85TyrHis: 0.85 ± 0.019	1.612TyrIle: 1.612 ± 0.029	1.599TyrLys: 1.599 ± 0.026	2.855TyrLeu: 2.855 ± 0.034	0.825TyrMet: 0.825 ± 0.019	1.258TyrAsn: 1.258 ± 0.025	1.456TyrPro: 1.456 ± 0.029	1.084TyrGln: 1.084 ± 0.023	1.879TyrArg: 1.879 ± 0.031	2.189TyrSer: 2.189 ± 0.029	1.6TyrThr: 1.6 ± 0.028	2.067TyrVal: 2.067 ± 0.027	0.376TyrTrp: 0.376 ± 0.013	1.191TyrTyr: 1.191 ± 0.025	0.006TyrXaa: 0.006 ± 0.002
Xaa	0.018XaaAla: 0.018 ± 0.003	0.008XaaCys: 0.008 ± 0.002	0.015XaaAsp: 0.015 ± 0.003	0.016XaaGlu: 0.016 ± 0.003	0.011XaaPhe: 0.011 ± 0.002	0.019XaaGly: 0.019 ± 0.003	0.006XaaHis: 0.006 ± 0.002	0.016XaaIle: 0.016 ± 0.002	0.019XaaLys: 0.019 ± 0.003	0.034XaaLeu: 0.034 ± 0.003	0.013XaaMet: 0.013 ± 0.003	0.012XaaAsn: 0.012 ± 0.003	0.014XaaPro: 0.014 ± 0.002	0.014XaaGln: 0.014 ± 0.002	0.018XaaArg: 0.018 ± 0.003	0.028XaaSer: 0.028 ± 0.003	0.014XaaThr: 0.014 ± 0.002	0.024XaaVal: 0.024 ± 0.003	0.006XaaTrp: 0.006 ± 0.001	0.011XaaTyr: 0.011 ± 0.002	2.484XaaXaa: 2.484 ± 0.153

Statistics based on 13786 proteins (2470701 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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