Amino acid dipepetide frequency for Salmonella phage vB_SenS_PVP-SE2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.786AlaAla: 11.786 ± 1.486
0.847AlaCys: 0.847 ± 0.251
6.163AlaAsp: 6.163 ± 0.797
6.317AlaGlu: 6.317 ± 1.028
3.852AlaPhe: 3.852 ± 0.493
7.241AlaGly: 7.241 ± 0.616
2.157AlaHis: 2.157 ± 0.47
4.237AlaIle: 4.237 ± 0.58
5.855AlaLys: 5.855 ± 0.792
7.935AlaLeu: 7.935 ± 1.018
2.234AlaMet: 2.234 ± 0.496
3.004AlaAsn: 3.004 ± 0.474
3.313AlaPro: 3.313 ± 0.446
3.698AlaGln: 3.698 ± 0.799
4.314AlaArg: 4.314 ± 0.562
6.24AlaSer: 6.24 ± 0.948
5.778AlaThr: 5.778 ± 0.877
6.933AlaVal: 6.933 ± 0.917
1.156AlaTrp: 1.156 ± 0.223
3.544AlaTyr: 3.544 ± 0.468
0.0AlaXaa: 0.0 ± 0.0
Cys
0.924CysAla: 0.924 ± 0.278
0.077CysCys: 0.077 ± 0.077
0.847CysAsp: 0.847 ± 0.226
0.924CysGlu: 0.924 ± 0.325
0.308CysPhe: 0.308 ± 0.158
0.77CysGly: 0.77 ± 0.198
0.077CysHis: 0.077 ± 0.069
0.154CysIle: 0.154 ± 0.089
0.77CysLys: 0.77 ± 0.243
0.924CysLeu: 0.924 ± 0.312
0.308CysMet: 0.308 ± 0.138
0.385CysAsn: 0.385 ± 0.175
0.308CysPro: 0.308 ± 0.149
0.231CysGln: 0.231 ± 0.136
0.616CysArg: 0.616 ± 0.229
0.385CysSer: 0.385 ± 0.198
0.462CysThr: 0.462 ± 0.137
0.693CysVal: 0.693 ± 0.224
0.231CysTrp: 0.231 ± 0.108
0.308CysTyr: 0.308 ± 0.149
0.0CysXaa: 0.0 ± 0.0
Asp
6.933AspAla: 6.933 ± 0.813
0.616AspCys: 0.616 ± 0.179
3.544AspAsp: 3.544 ± 0.469
3.698AspGlu: 3.698 ± 0.62
3.158AspPhe: 3.158 ± 0.45
6.163AspGly: 6.163 ± 0.856
0.693AspHis: 0.693 ± 0.188
3.621AspIle: 3.621 ± 0.357
3.39AspLys: 3.39 ± 0.481
4.468AspLeu: 4.468 ± 0.531
1.541AspMet: 1.541 ± 0.271
3.081AspAsn: 3.081 ± 0.483
1.772AspPro: 1.772 ± 0.408
0.693AspGln: 0.693 ± 0.208
2.773AspArg: 2.773 ± 0.418
3.621AspSer: 3.621 ± 0.404
4.237AspThr: 4.237 ± 0.505
4.083AspVal: 4.083 ± 0.397
0.924AspTrp: 0.924 ± 0.333
1.772AspTyr: 1.772 ± 0.392
0.0AspXaa: 0.0 ± 0.0
Glu
6.163GluAla: 6.163 ± 0.702
0.231GluCys: 0.231 ± 0.132
3.544GluAsp: 3.544 ± 0.462
4.776GluGlu: 4.776 ± 0.848
3.158GluPhe: 3.158 ± 0.734
4.853GluGly: 4.853 ± 0.751
1.001GluHis: 1.001 ± 0.267
3.467GluIle: 3.467 ± 0.461
4.237GluLys: 4.237 ± 0.54
5.932GluLeu: 5.932 ± 0.638
2.311GluMet: 2.311 ± 0.38
2.465GluAsn: 2.465 ± 0.372
1.849GluPro: 1.849 ± 0.579
3.313GluGln: 3.313 ± 0.596
3.929GluArg: 3.929 ± 0.621
3.775GluSer: 3.775 ± 0.672
3.852GluThr: 3.852 ± 0.629
4.468GluVal: 4.468 ± 0.549
0.924GluTrp: 0.924 ± 0.291
1.772GluTyr: 1.772 ± 0.362
0.0GluXaa: 0.0 ± 0.0
Phe
2.85PheAla: 2.85 ± 0.469
0.462PheCys: 0.462 ± 0.166
3.313PheAsp: 3.313 ± 0.468
2.927PheGlu: 2.927 ± 0.478
0.847PhePhe: 0.847 ± 0.25
2.927PheGly: 2.927 ± 0.374
0.616PheHis: 0.616 ± 0.197
2.465PheIle: 2.465 ± 0.407
1.464PheLys: 1.464 ± 0.343
2.234PheLeu: 2.234 ± 0.372
0.385PheMet: 0.385 ± 0.175
1.618PheAsn: 1.618 ± 0.414
1.772PhePro: 1.772 ± 0.45
1.541PheGln: 1.541 ± 0.386
2.311PheArg: 2.311 ± 0.343
2.388PheSer: 2.388 ± 0.544
3.467PheThr: 3.467 ± 0.633
2.773PheVal: 2.773 ± 0.498
0.77PheTrp: 0.77 ± 0.24
0.847PheTyr: 0.847 ± 0.257
0.0PheXaa: 0.0 ± 0.0
Gly
7.164GlyAla: 7.164 ± 0.768
0.77GlyCys: 0.77 ± 0.205
4.16GlyAsp: 4.16 ± 0.728
5.778GlyGlu: 5.778 ± 0.82
3.004GlyPhe: 3.004 ± 0.494
6.548GlyGly: 6.548 ± 0.891
1.618GlyHis: 1.618 ± 0.507
3.698GlyIle: 3.698 ± 0.422
5.084GlyLys: 5.084 ± 0.494
5.392GlyLeu: 5.392 ± 0.534
2.465GlyMet: 2.465 ± 0.611
3.544GlyAsn: 3.544 ± 0.549
2.157GlyPro: 2.157 ± 0.389
2.619GlyGln: 2.619 ± 0.438
5.007GlyArg: 5.007 ± 0.579
5.007GlySer: 5.007 ± 0.811
4.006GlyThr: 4.006 ± 0.584
5.932GlyVal: 5.932 ± 0.741
1.233GlyTrp: 1.233 ± 0.265
2.773GlyTyr: 2.773 ± 0.436
0.0GlyXaa: 0.0 ± 0.0
His
1.31HisAla: 1.31 ± 0.307
0.385HisCys: 0.385 ± 0.14
0.847HisAsp: 0.847 ± 0.179
0.924HisGlu: 0.924 ± 0.27
0.693HisPhe: 0.693 ± 0.232
1.001HisGly: 1.001 ± 0.34
0.693HisHis: 0.693 ± 0.255
1.078HisIle: 1.078 ± 0.279
1.078HisLys: 1.078 ± 0.278
1.31HisLeu: 1.31 ± 0.332
0.539HisMet: 0.539 ± 0.209
0.462HisAsn: 0.462 ± 0.201
1.001HisPro: 1.001 ± 0.305
0.847HisGln: 0.847 ± 0.243
0.924HisArg: 0.924 ± 0.226
1.001HisSer: 1.001 ± 0.254
0.616HisThr: 0.616 ± 0.289
0.77HisVal: 0.77 ± 0.248
0.077HisTrp: 0.077 ± 0.076
0.847HisTyr: 0.847 ± 0.317
0.0HisXaa: 0.0 ± 0.0
Ile
4.622IleAla: 4.622 ± 0.707
0.616IleCys: 0.616 ± 0.237
4.237IleAsp: 4.237 ± 0.563
3.004IleGlu: 3.004 ± 0.494
1.31IlePhe: 1.31 ± 0.353
3.004IleGly: 3.004 ± 0.376
0.539IleHis: 0.539 ± 0.138
2.08IleIle: 2.08 ± 0.396
2.619IleLys: 2.619 ± 0.536
3.313IleLeu: 3.313 ± 0.508
1.233IleMet: 1.233 ± 0.321
2.08IleAsn: 2.08 ± 0.345
2.465IlePro: 2.465 ± 0.414
1.849IleGln: 1.849 ± 0.494
2.542IleArg: 2.542 ± 0.328
3.235IleSer: 3.235 ± 0.595
4.237IleThr: 4.237 ± 0.565
3.39IleVal: 3.39 ± 0.477
0.847IleTrp: 0.847 ± 0.208
1.31IleTyr: 1.31 ± 0.395
0.0IleXaa: 0.0 ± 0.0
Lys
5.547LysAla: 5.547 ± 0.775
0.77LysCys: 0.77 ± 0.294
3.698LysAsp: 3.698 ± 0.556
3.929LysGlu: 3.929 ± 0.553
2.08LysPhe: 2.08 ± 0.317
3.852LysGly: 3.852 ± 0.507
1.156LysHis: 1.156 ± 0.307
1.926LysIle: 1.926 ± 0.396
3.544LysLys: 3.544 ± 0.587
5.315LysLeu: 5.315 ± 0.531
2.696LysMet: 2.696 ± 0.433
2.388LysAsn: 2.388 ± 0.326
2.619LysPro: 2.619 ± 0.579
2.311LysGln: 2.311 ± 0.345
3.621LysArg: 3.621 ± 0.606
2.773LysSer: 2.773 ± 0.497
4.083LysThr: 4.083 ± 0.473
3.852LysVal: 3.852 ± 0.712
0.693LysTrp: 0.693 ± 0.241
2.542LysTyr: 2.542 ± 0.386
0.0LysXaa: 0.0 ± 0.0
Leu
7.087LeuAla: 7.087 ± 0.681
0.847LeuCys: 0.847 ± 0.246
4.237LeuAsp: 4.237 ± 0.62
4.93LeuGlu: 4.93 ± 0.667
2.003LeuPhe: 2.003 ± 0.489
4.853LeuGly: 4.853 ± 0.516
1.001LeuHis: 1.001 ± 0.261
4.237LeuIle: 4.237 ± 0.542
5.778LeuLys: 5.778 ± 0.76
5.778LeuLeu: 5.778 ± 0.59
2.311LeuMet: 2.311 ± 0.384
4.853LeuAsn: 4.853 ± 0.757
3.544LeuPro: 3.544 ± 0.532
2.542LeuGln: 2.542 ± 0.414
5.161LeuArg: 5.161 ± 0.514
4.083LeuSer: 4.083 ± 0.504
5.392LeuThr: 5.392 ± 0.482
5.238LeuVal: 5.238 ± 0.57
1.001LeuTrp: 1.001 ± 0.321
2.388LeuTyr: 2.388 ± 0.329
0.0LeuXaa: 0.0 ± 0.0
Met
2.388MetAla: 2.388 ± 0.415
0.462MetCys: 0.462 ± 0.187
1.078MetAsp: 1.078 ± 0.351
1.233MetGlu: 1.233 ± 0.27
1.156MetPhe: 1.156 ± 0.268
2.157MetGly: 2.157 ± 0.405
0.231MetHis: 0.231 ± 0.117
1.001MetIle: 1.001 ± 0.329
1.387MetLys: 1.387 ± 0.302
1.772MetLeu: 1.772 ± 0.335
0.77MetMet: 0.77 ± 0.24
1.31MetAsn: 1.31 ± 0.277
1.387MetPro: 1.387 ± 0.397
0.924MetGln: 0.924 ± 0.23
1.387MetArg: 1.387 ± 0.288
2.234MetSer: 2.234 ± 0.377
2.003MetThr: 2.003 ± 0.376
2.234MetVal: 2.234 ± 0.412
0.693MetTrp: 0.693 ± 0.227
0.539MetTyr: 0.539 ± 0.187
0.0MetXaa: 0.0 ± 0.0
Asn
4.083AsnAla: 4.083 ± 0.492
0.385AsnCys: 0.385 ± 0.139
2.773AsnAsp: 2.773 ± 0.438
2.465AsnGlu: 2.465 ± 0.462
1.695AsnPhe: 1.695 ± 0.323
4.314AsnGly: 4.314 ± 0.633
0.462AsnHis: 0.462 ± 0.189
2.927AsnIle: 2.927 ± 0.39
2.003AsnLys: 2.003 ± 0.402
4.083AsnLeu: 4.083 ± 0.424
0.616AsnMet: 0.616 ± 0.287
2.234AsnAsn: 2.234 ± 0.468
1.464AsnPro: 1.464 ± 0.368
1.387AsnGln: 1.387 ± 0.338
2.465AsnArg: 2.465 ± 0.338
2.003AsnSer: 2.003 ± 0.282
2.388AsnThr: 2.388 ± 0.355
3.775AsnVal: 3.775 ± 0.432
0.77AsnTrp: 0.77 ± 0.223
1.464AsnTyr: 1.464 ± 0.341
0.0AsnXaa: 0.0 ± 0.0
Pro
2.85ProAla: 2.85 ± 0.486
0.308ProCys: 0.308 ± 0.141
3.158ProAsp: 3.158 ± 0.524
3.467ProGlu: 3.467 ± 0.498
1.541ProPhe: 1.541 ± 0.32
3.004ProGly: 3.004 ± 0.453
0.539ProHis: 0.539 ± 0.171
1.541ProIle: 1.541 ± 0.324
2.85ProLys: 2.85 ± 0.412
3.467ProLeu: 3.467 ± 0.419
0.693ProMet: 0.693 ± 0.204
1.464ProAsn: 1.464 ± 0.483
1.31ProPro: 1.31 ± 0.306
1.156ProGln: 1.156 ± 0.286
2.08ProArg: 2.08 ± 0.424
2.311ProSer: 2.311 ± 0.407
1.541ProThr: 1.541 ± 0.36
3.852ProVal: 3.852 ± 0.49
0.308ProTrp: 0.308 ± 0.169
1.541ProTyr: 1.541 ± 0.402
0.0ProXaa: 0.0 ± 0.0
Gln
4.468GlnAla: 4.468 ± 0.641
0.231GlnCys: 0.231 ± 0.128
1.541GlnAsp: 1.541 ± 0.295
2.388GlnGlu: 2.388 ± 0.569
1.387GlnPhe: 1.387 ± 0.386
2.234GlnGly: 2.234 ± 0.455
0.616GlnHis: 0.616 ± 0.225
1.695GlnIle: 1.695 ± 0.364
2.08GlnLys: 2.08 ± 0.396
2.773GlnLeu: 2.773 ± 0.447
1.078GlnMet: 1.078 ± 0.3
1.849GlnAsn: 1.849 ± 0.362
2.157GlnPro: 2.157 ± 0.342
2.08GlnGln: 2.08 ± 0.519
1.849GlnArg: 1.849 ± 0.379
1.772GlnSer: 1.772 ± 0.349
1.772GlnThr: 1.772 ± 0.315
2.85GlnVal: 2.85 ± 0.436
0.616GlnTrp: 0.616 ± 0.175
1.387GlnTyr: 1.387 ± 0.287
0.0GlnXaa: 0.0 ± 0.0
Arg
5.084ArgAla: 5.084 ± 0.503
0.462ArgCys: 0.462 ± 0.181
3.39ArgAsp: 3.39 ± 0.441
3.39ArgGlu: 3.39 ± 0.562
2.234ArgPhe: 2.234 ± 0.378
4.16ArgGly: 4.16 ± 0.45
1.156ArgHis: 1.156 ± 0.301
2.773ArgIle: 2.773 ± 0.384
3.698ArgLys: 3.698 ± 0.56
3.775ArgLeu: 3.775 ± 0.551
2.157ArgMet: 2.157 ± 0.418
3.235ArgAsn: 3.235 ± 0.521
2.08ArgPro: 2.08 ± 0.307
3.081ArgGln: 3.081 ± 0.528
4.468ArgArg: 4.468 ± 0.63
2.234ArgSer: 2.234 ± 0.354
2.696ArgThr: 2.696 ± 0.403
4.391ArgVal: 4.391 ± 0.549
1.156ArgTrp: 1.156 ± 0.259
1.541ArgTyr: 1.541 ± 0.413
0.0ArgXaa: 0.0 ± 0.0
Ser
6.086SerAla: 6.086 ± 1.08
0.385SerCys: 0.385 ± 0.207
3.081SerAsp: 3.081 ± 0.467
3.158SerGlu: 3.158 ± 0.523
2.465SerPhe: 2.465 ± 0.374
6.856SerGly: 6.856 ± 0.696
0.924SerHis: 0.924 ± 0.216
2.465SerIle: 2.465 ± 0.376
2.696SerLys: 2.696 ± 0.472
5.084SerLeu: 5.084 ± 0.607
1.156SerMet: 1.156 ± 0.259
2.311SerAsn: 2.311 ± 0.36
1.464SerPro: 1.464 ± 0.366
2.08SerGln: 2.08 ± 0.329
3.235SerArg: 3.235 ± 0.532
3.39SerSer: 3.39 ± 0.502
4.391SerThr: 4.391 ± 0.665
5.701SerVal: 5.701 ± 0.733
0.847SerTrp: 0.847 ± 0.197
2.003SerTyr: 2.003 ± 0.354
0.0SerXaa: 0.0 ± 0.0
Thr
6.702ThrAla: 6.702 ± 0.919
0.539ThrCys: 0.539 ± 0.174
4.468ThrAsp: 4.468 ± 0.463
3.235ThrGlu: 3.235 ± 0.463
2.85ThrPhe: 2.85 ± 0.501
6.24ThrGly: 6.24 ± 0.858
0.847ThrHis: 0.847 ± 0.273
2.773ThrIle: 2.773 ± 0.424
2.927ThrLys: 2.927 ± 0.389
5.084ThrLeu: 5.084 ± 0.586
1.233ThrMet: 1.233 ± 0.308
2.003ThrAsn: 2.003 ± 0.362
4.16ThrPro: 4.16 ± 0.477
1.926ThrGln: 1.926 ± 0.369
3.235ThrArg: 3.235 ± 0.424
4.853ThrSer: 4.853 ± 0.464
3.698ThrThr: 3.698 ± 0.382
4.699ThrVal: 4.699 ± 0.73
1.078ThrTrp: 1.078 ± 0.278
2.157ThrTyr: 2.157 ± 0.405
0.0ThrXaa: 0.0 ± 0.0
Val
6.548ValAla: 6.548 ± 0.889
0.616ValCys: 0.616 ± 0.199
3.698ValAsp: 3.698 ± 0.395
6.625ValGlu: 6.625 ± 0.619
2.234ValPhe: 2.234 ± 0.465
4.16ValGly: 4.16 ± 0.61
1.078ValHis: 1.078 ± 0.274
4.006ValIle: 4.006 ± 0.583
5.084ValLys: 5.084 ± 0.746
4.776ValLeu: 4.776 ± 0.656
1.233ValMet: 1.233 ± 0.331
3.313ValAsn: 3.313 ± 0.518
2.465ValPro: 2.465 ± 0.589
2.388ValGln: 2.388 ± 0.356
3.544ValArg: 3.544 ± 0.413
5.855ValSer: 5.855 ± 0.767
7.01ValThr: 7.01 ± 0.925
5.701ValVal: 5.701 ± 0.74
1.001ValTrp: 1.001 ± 0.215
2.773ValTyr: 2.773 ± 0.418
0.0ValXaa: 0.0 ± 0.0
Trp
1.233TrpAla: 1.233 ± 0.384
0.154TrpCys: 0.154 ± 0.114
0.924TrpAsp: 0.924 ± 0.257
0.539TrpGlu: 0.539 ± 0.196
0.693TrpPhe: 0.693 ± 0.332
0.847TrpGly: 0.847 ± 0.208
0.385TrpHis: 0.385 ± 0.181
0.77TrpIle: 0.77 ± 0.208
0.693TrpLys: 0.693 ± 0.271
1.695TrpLeu: 1.695 ± 0.313
0.462TrpMet: 0.462 ± 0.205
0.616TrpAsn: 0.616 ± 0.283
0.462TrpPro: 0.462 ± 0.277
0.616TrpGln: 0.616 ± 0.207
1.31TrpArg: 1.31 ± 0.32
0.693TrpSer: 0.693 ± 0.194
0.77TrpThr: 0.77 ± 0.215
1.156TrpVal: 1.156 ± 0.227
0.154TrpTrp: 0.154 ± 0.091
0.308TrpTyr: 0.308 ± 0.144
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.773TyrAla: 2.773 ± 0.41
0.539TyrCys: 0.539 ± 0.177
2.08TyrAsp: 2.08 ± 0.492
2.388TyrGlu: 2.388 ± 0.457
1.31TyrPhe: 1.31 ± 0.327
2.773TyrGly: 2.773 ± 0.384
0.616TyrHis: 0.616 ± 0.207
1.618TyrIle: 1.618 ± 0.282
2.157TyrLys: 2.157 ± 0.41
2.157TyrLeu: 2.157 ± 0.39
0.847TyrMet: 0.847 ± 0.193
1.541TyrAsn: 1.541 ± 0.386
1.233TyrPro: 1.233 ± 0.345
1.541TyrGln: 1.541 ± 0.3
2.388TyrArg: 2.388 ± 0.505
1.926TyrSer: 1.926 ± 0.366
2.311TyrThr: 2.311 ± 0.34
1.618TyrVal: 1.618 ± 0.296
0.0TyrTrp: 0.0 ± 0.0
1.387TyrTyr: 1.387 ± 0.289
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 60 proteins (12982 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski