Amino acid dipepetide frequency for Streptococcus satellite phage Javan398

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.608AlaAla: 0.608 ± 0.418
0.912AlaCys: 0.912 ± 0.445
3.951AlaAsp: 3.951 ± 1.09
7.295AlaGlu: 7.295 ± 3.534
2.128AlaPhe: 2.128 ± 0.669
1.824AlaGly: 1.824 ± 0.885
0.304AlaHis: 0.304 ± 0.327
4.559AlaIle: 4.559 ± 1.565
11.246AlaLys: 11.246 ± 5.859
6.079AlaLeu: 6.079 ± 1.044
3.04AlaMet: 3.04 ± 0.83
1.52AlaAsn: 1.52 ± 0.663
0.608AlaPro: 0.608 ± 0.416
2.128AlaGln: 2.128 ± 1.108
2.128AlaArg: 2.128 ± 0.979
3.343AlaSer: 3.343 ± 0.955
3.647AlaThr: 3.647 ± 1.013
2.736AlaVal: 2.736 ± 1.297
0.304AlaTrp: 0.304 ± 0.291
1.52AlaTyr: 1.52 ± 0.541
0.0AlaXaa: 0.0 ± 0.0
Cys
0.608CysAla: 0.608 ± 0.598
0.0CysCys: 0.0 ± 0.0
0.304CysAsp: 0.304 ± 0.297
0.304CysGlu: 0.304 ± 0.297
0.304CysPhe: 0.304 ± 0.242
0.608CysGly: 0.608 ± 0.4
0.608CysHis: 0.608 ± 0.417
1.216CysIle: 1.216 ± 0.704
0.304CysLys: 0.304 ± 0.304
0.912CysLeu: 0.912 ± 0.758
0.0CysMet: 0.0 ± 0.0
0.608CysAsn: 0.608 ± 0.313
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.304CysSer: 0.304 ± 0.299
0.0CysThr: 0.0 ± 0.0
0.912CysVal: 0.912 ± 0.493
0.0CysTrp: 0.0 ± 0.0
0.304CysTyr: 0.304 ± 0.242
0.0CysXaa: 0.0 ± 0.0
Asp
2.432AspAla: 2.432 ± 1.019
0.912AspCys: 0.912 ± 0.537
4.863AspAsp: 4.863 ± 1.547
6.079AspGlu: 6.079 ± 1.58
3.04AspPhe: 3.04 ± 1.048
2.128AspGly: 2.128 ± 0.752
1.52AspHis: 1.52 ± 0.572
5.775AspIle: 5.775 ± 1.712
4.559AspLys: 4.559 ± 1.582
4.255AspLeu: 4.255 ± 1.117
2.432AspMet: 2.432 ± 0.828
4.863AspAsn: 4.863 ± 0.958
0.608AspPro: 0.608 ± 0.418
2.736AspGln: 2.736 ± 0.853
1.216AspArg: 1.216 ± 0.548
3.04AspSer: 3.04 ± 1.02
3.04AspThr: 3.04 ± 1.04
3.04AspVal: 3.04 ± 1.108
0.0AspTrp: 0.0 ± 0.0
4.255AspTyr: 4.255 ± 0.905
0.0AspXaa: 0.0 ± 0.0
Glu
10.942GluAla: 10.942 ± 5.642
0.608GluCys: 0.608 ± 0.313
4.559GluAsp: 4.559 ± 1.324
6.991GluGlu: 6.991 ± 2.194
3.647GluPhe: 3.647 ± 1.448
0.608GluGly: 0.608 ± 0.447
0.912GluHis: 0.912 ± 0.535
6.991GluIle: 6.991 ± 1.685
7.599GluLys: 7.599 ± 1.891
12.462GluLeu: 12.462 ± 1.912
2.736GluMet: 2.736 ± 0.779
6.079GluAsn: 6.079 ± 1.208
1.824GluPro: 1.824 ± 0.842
3.343GluGln: 3.343 ± 1.038
3.951GluArg: 3.951 ± 1.21
3.647GluSer: 3.647 ± 1.127
2.736GluThr: 2.736 ± 0.935
2.128GluVal: 2.128 ± 0.781
0.304GluTrp: 0.304 ± 0.299
3.647GluTyr: 3.647 ± 0.883
0.0GluXaa: 0.0 ± 0.0
Phe
1.824PheAla: 1.824 ± 0.852
0.0PheCys: 0.0 ± 0.0
3.04PheAsp: 3.04 ± 0.969
4.255PheGlu: 4.255 ± 1.113
3.647PhePhe: 3.647 ± 1.04
2.128PheGly: 2.128 ± 0.533
0.608PheHis: 0.608 ± 0.364
3.343PheIle: 3.343 ± 0.978
3.343PheLys: 3.343 ± 0.792
5.471PheLeu: 5.471 ± 1.438
0.912PheMet: 0.912 ± 0.653
2.432PheAsn: 2.432 ± 0.872
0.912PhePro: 0.912 ± 0.497
0.912PheGln: 0.912 ± 0.458
1.216PheArg: 1.216 ± 0.772
2.736PheSer: 2.736 ± 0.8
2.432PheThr: 2.432 ± 0.745
3.343PheVal: 3.343 ± 1.087
0.304PheTrp: 0.304 ± 0.242
1.824PheTyr: 1.824 ± 0.878
0.0PheXaa: 0.0 ± 0.0
Gly
1.52GlyAla: 1.52 ± 0.671
0.608GlyCys: 0.608 ± 0.484
2.432GlyAsp: 2.432 ± 1.115
3.647GlyGlu: 3.647 ± 0.949
0.608GlyPhe: 0.608 ± 0.349
2.736GlyGly: 2.736 ± 0.935
0.608GlyHis: 0.608 ± 0.598
4.863GlyIle: 4.863 ± 1.045
3.343GlyLys: 3.343 ± 0.778
5.775GlyLeu: 5.775 ± 1.369
0.608GlyMet: 0.608 ± 0.486
1.216GlyAsn: 1.216 ± 0.772
0.0GlyPro: 0.0 ± 0.0
1.216GlyGln: 1.216 ± 0.641
1.216GlyArg: 1.216 ± 0.477
3.04GlySer: 3.04 ± 0.922
2.128GlyThr: 2.128 ± 0.776
4.863GlyVal: 4.863 ± 1.053
0.608GlyTrp: 0.608 ± 0.381
1.824GlyTyr: 1.824 ± 0.693
0.0GlyXaa: 0.0 ± 0.0
His
1.216HisAla: 1.216 ± 0.918
0.0HisCys: 0.0 ± 0.0
0.912HisAsp: 0.912 ± 0.406
0.304HisGlu: 0.304 ± 0.328
0.304HisPhe: 0.304 ± 0.285
0.304HisGly: 0.304 ± 0.374
0.304HisHis: 0.304 ± 0.297
1.216HisIle: 1.216 ± 0.659
0.0HisLys: 0.0 ± 0.0
2.128HisLeu: 2.128 ± 0.707
1.216HisMet: 1.216 ± 0.526
0.912HisAsn: 0.912 ± 0.6
0.304HisPro: 0.304 ± 0.242
0.304HisGln: 0.304 ± 0.297
0.0HisArg: 0.0 ± 0.0
0.304HisSer: 0.304 ± 0.297
0.304HisThr: 0.304 ± 0.299
0.608HisVal: 0.608 ± 0.349
0.304HisTrp: 0.304 ± 0.353
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
6.383IleAla: 6.383 ± 1.521
0.608IleCys: 0.608 ± 0.461
6.079IleAsp: 6.079 ± 1.24
5.471IleGlu: 5.471 ± 1.584
3.951IlePhe: 3.951 ± 1.861
5.775IleGly: 5.775 ± 1.223
0.608IleHis: 0.608 ± 0.349
8.207IleIle: 8.207 ± 1.113
4.559IleLys: 4.559 ± 1.378
6.687IleLeu: 6.687 ± 1.485
0.912IleMet: 0.912 ± 0.503
4.863IleAsn: 4.863 ± 1.343
1.824IlePro: 1.824 ± 0.739
4.559IleGln: 4.559 ± 0.877
2.736IleArg: 2.736 ± 0.977
7.295IleSer: 7.295 ± 1.414
4.559IleThr: 4.559 ± 1.284
4.559IleVal: 4.559 ± 1.506
0.304IleTrp: 0.304 ± 0.297
2.432IleTyr: 2.432 ± 0.64
0.0IleXaa: 0.0 ± 0.0
Lys
7.903LysAla: 7.903 ± 3.06
0.304LysCys: 0.304 ± 0.323
5.167LysAsp: 5.167 ± 1.371
13.374LysGlu: 13.374 ± 2.557
3.647LysPhe: 3.647 ± 1.293
2.128LysGly: 2.128 ± 0.748
0.304LysHis: 0.304 ± 0.328
6.687LysIle: 6.687 ± 1.541
13.678LysLys: 13.678 ± 3.839
8.511LysLeu: 8.511 ± 1.464
2.128LysMet: 2.128 ± 0.844
6.687LysAsn: 6.687 ± 1.585
2.128LysPro: 2.128 ± 0.924
4.559LysGln: 4.559 ± 1.162
3.04LysArg: 3.04 ± 0.957
6.383LysSer: 6.383 ± 1.477
6.383LysThr: 6.383 ± 1.412
6.991LysVal: 6.991 ± 1.18
0.304LysTrp: 0.304 ± 0.323
2.432LysTyr: 2.432 ± 0.784
0.0LysXaa: 0.0 ± 0.0
Leu
5.167LeuAla: 5.167 ± 1.289
0.912LeuCys: 0.912 ± 0.455
7.295LeuAsp: 7.295 ± 1.268
6.383LeuGlu: 6.383 ± 1.899
5.775LeuPhe: 5.775 ± 1.223
6.687LeuGly: 6.687 ± 2.283
0.608LeuHis: 0.608 ± 0.471
9.119LeuIle: 9.119 ± 1.655
9.422LeuLys: 9.422 ± 1.317
10.334LeuLeu: 10.334 ± 1.977
2.432LeuMet: 2.432 ± 0.681
5.775LeuAsn: 5.775 ± 1.235
2.432LeuPro: 2.432 ± 0.777
5.471LeuGln: 5.471 ± 1.445
3.343LeuArg: 3.343 ± 1.121
4.255LeuSer: 4.255 ± 0.98
6.383LeuThr: 6.383 ± 1.695
4.255LeuVal: 4.255 ± 1.392
1.52LeuTrp: 1.52 ± 0.615
2.432LeuTyr: 2.432 ± 0.843
0.0LeuXaa: 0.0 ± 0.0
Met
1.824MetAla: 1.824 ± 0.769
0.304MetCys: 0.304 ± 0.299
1.52MetAsp: 1.52 ± 0.685
3.04MetGlu: 3.04 ± 1.043
0.304MetPhe: 0.304 ± 0.323
1.52MetGly: 1.52 ± 0.903
0.608MetHis: 0.608 ± 0.64
3.647MetIle: 3.647 ± 1.479
3.04MetLys: 3.04 ± 0.995
1.216MetLeu: 1.216 ± 0.881
1.216MetMet: 1.216 ± 0.647
2.432MetAsn: 2.432 ± 0.663
0.304MetPro: 0.304 ± 0.323
1.824MetGln: 1.824 ± 0.635
0.0MetArg: 0.0 ± 0.0
0.912MetSer: 0.912 ± 0.659
0.608MetThr: 0.608 ± 0.4
1.824MetVal: 1.824 ± 0.684
0.0MetTrp: 0.0 ± 0.0
1.216MetTyr: 1.216 ± 0.573
0.0MetXaa: 0.0 ± 0.0
Asn
5.471AsnAla: 5.471 ± 1.73
0.0AsnCys: 0.0 ± 0.0
2.432AsnAsp: 2.432 ± 0.683
6.079AsnGlu: 6.079 ± 1.697
2.432AsnPhe: 2.432 ± 0.896
3.04AsnGly: 3.04 ± 1.089
1.216AsnHis: 1.216 ± 0.756
5.167AsnIle: 5.167 ± 1.418
6.383AsnLys: 6.383 ± 1.023
5.167AsnLeu: 5.167 ± 1.35
0.608AsnMet: 0.608 ± 0.636
3.647AsnAsn: 3.647 ± 1.349
1.216AsnPro: 1.216 ± 0.671
1.824AsnGln: 1.824 ± 0.787
2.128AsnArg: 2.128 ± 0.674
3.951AsnSer: 3.951 ± 0.883
2.432AsnThr: 2.432 ± 0.664
2.432AsnVal: 2.432 ± 0.722
0.912AsnTrp: 0.912 ± 0.599
3.951AsnTyr: 3.951 ± 0.977
0.0AsnXaa: 0.0 ± 0.0
Pro
0.912ProAla: 0.912 ± 0.522
0.0ProCys: 0.0 ± 0.0
0.912ProAsp: 0.912 ± 0.449
1.52ProGlu: 1.52 ± 0.772
0.912ProPhe: 0.912 ± 0.532
0.304ProGly: 0.304 ± 0.291
0.0ProHis: 0.0 ± 0.0
1.52ProIle: 1.52 ± 0.538
2.128ProLys: 2.128 ± 0.878
1.52ProLeu: 1.52 ± 0.697
0.304ProMet: 0.304 ± 0.291
2.432ProAsn: 2.432 ± 1.151
1.216ProPro: 1.216 ± 0.527
0.304ProGln: 0.304 ± 0.299
2.128ProArg: 2.128 ± 1.005
1.216ProSer: 1.216 ± 0.47
1.824ProThr: 1.824 ± 0.66
1.52ProVal: 1.52 ± 0.741
0.0ProTrp: 0.0 ± 0.0
0.608ProTyr: 0.608 ± 0.357
0.0ProXaa: 0.0 ± 0.0
Gln
3.04GlnAla: 3.04 ± 0.884
0.608GlnCys: 0.608 ± 0.427
3.04GlnAsp: 3.04 ± 0.995
2.432GlnGlu: 2.432 ± 0.85
1.52GlnPhe: 1.52 ± 0.65
2.432GlnGly: 2.432 ± 0.812
0.0GlnHis: 0.0 ± 0.0
2.736GlnIle: 2.736 ± 1.459
4.863GlnLys: 4.863 ± 1.109
5.471GlnLeu: 5.471 ± 1.299
1.824GlnMet: 1.824 ± 0.613
2.128GlnAsn: 2.128 ± 0.872
1.216GlnPro: 1.216 ± 0.469
2.432GlnGln: 2.432 ± 0.846
1.216GlnArg: 1.216 ± 0.481
0.912GlnSer: 0.912 ± 0.628
0.912GlnThr: 0.912 ± 0.501
1.824GlnVal: 1.824 ± 0.648
0.608GlnTrp: 0.608 ± 0.455
2.736GlnTyr: 2.736 ± 0.925
0.0GlnXaa: 0.0 ± 0.0
Arg
0.912ArgAla: 0.912 ± 0.668
0.0ArgCys: 0.0 ± 0.0
1.52ArgAsp: 1.52 ± 0.575
2.432ArgGlu: 2.432 ± 0.785
1.824ArgPhe: 1.824 ± 0.677
0.304ArgGly: 0.304 ± 0.242
0.608ArgHis: 0.608 ± 0.375
2.736ArgIle: 2.736 ± 1.007
3.343ArgLys: 3.343 ± 0.838
2.128ArgLeu: 2.128 ± 0.736
0.912ArgMet: 0.912 ± 0.535
1.824ArgAsn: 1.824 ± 0.751
1.216ArgPro: 1.216 ± 0.578
3.343ArgGln: 3.343 ± 0.886
1.52ArgArg: 1.52 ± 0.699
2.736ArgSer: 2.736 ± 0.8
2.128ArgThr: 2.128 ± 0.601
3.04ArgVal: 3.04 ± 0.743
0.912ArgTrp: 0.912 ± 0.447
1.824ArgTyr: 1.824 ± 0.78
0.0ArgXaa: 0.0 ± 0.0
Ser
3.343SerAla: 3.343 ± 1.339
0.608SerCys: 0.608 ± 0.349
4.255SerAsp: 4.255 ± 0.681
3.647SerGlu: 3.647 ± 1.044
1.216SerPhe: 1.216 ± 0.434
3.04SerGly: 3.04 ± 0.823
1.216SerHis: 1.216 ± 0.612
4.255SerIle: 4.255 ± 0.767
6.383SerLys: 6.383 ± 1.553
5.471SerLeu: 5.471 ± 1.576
2.432SerMet: 2.432 ± 0.917
2.432SerAsn: 2.432 ± 0.805
1.52SerPro: 1.52 ± 0.589
2.432SerGln: 2.432 ± 0.714
2.128SerArg: 2.128 ± 0.727
3.647SerSer: 3.647 ± 1.534
3.04SerThr: 3.04 ± 0.864
2.432SerVal: 2.432 ± 0.865
0.0SerTrp: 0.0 ± 0.0
5.775SerTyr: 5.775 ± 1.378
0.0SerXaa: 0.0 ± 0.0
Thr
1.824ThrAla: 1.824 ± 0.801
0.0ThrCys: 0.0 ± 0.0
2.432ThrAsp: 2.432 ± 0.642
5.167ThrGlu: 5.167 ± 1.19
2.432ThrPhe: 2.432 ± 0.849
3.04ThrGly: 3.04 ± 0.79
0.304ThrHis: 0.304 ± 0.299
4.255ThrIle: 4.255 ± 1.104
5.167ThrLys: 5.167 ± 1.602
4.559ThrLeu: 4.559 ± 1.44
1.52ThrMet: 1.52 ± 0.808
3.04ThrAsn: 3.04 ± 1.018
1.216ThrPro: 1.216 ± 0.563
1.52ThrGln: 1.52 ± 0.584
2.128ThrArg: 2.128 ± 0.762
2.128ThrSer: 2.128 ± 0.805
3.343ThrThr: 3.343 ± 0.893
3.04ThrVal: 3.04 ± 1.216
0.608ThrTrp: 0.608 ± 0.425
2.736ThrTyr: 2.736 ± 0.765
0.0ThrXaa: 0.0 ± 0.0
Val
2.128ValAla: 2.128 ± 0.972
0.608ValCys: 0.608 ± 0.379
3.04ValAsp: 3.04 ± 0.965
3.04ValGlu: 3.04 ± 0.867
2.128ValPhe: 2.128 ± 0.929
1.216ValGly: 1.216 ± 0.558
0.0ValHis: 0.0 ± 0.0
2.432ValIle: 2.432 ± 1.147
4.863ValLys: 4.863 ± 1.197
7.903ValLeu: 7.903 ± 1.342
0.608ValMet: 0.608 ± 0.357
3.647ValAsn: 3.647 ± 0.655
2.432ValPro: 2.432 ± 1.073
1.216ValGln: 1.216 ± 0.762
1.52ValArg: 1.52 ± 0.62
6.687ValSer: 6.687 ± 1.248
3.647ValThr: 3.647 ± 0.875
2.736ValVal: 2.736 ± 0.887
0.304ValTrp: 0.304 ± 0.242
3.647ValTyr: 3.647 ± 0.993
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.52TrpGlu: 1.52 ± 0.616
1.216TrpPhe: 1.216 ± 0.514
0.608TrpGly: 0.608 ± 0.349
0.0TrpHis: 0.0 ± 0.0
0.912TrpIle: 0.912 ± 0.63
0.608TrpLys: 0.608 ± 0.46
0.912TrpLeu: 0.912 ± 0.494
0.0TrpMet: 0.0 ± 0.0
0.912TrpAsn: 0.912 ± 0.525
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.304TrpArg: 0.304 ± 0.242
0.608TrpSer: 0.608 ± 0.375
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.304TrpTrp: 0.304 ± 0.297
0.304TrpTyr: 0.304 ± 0.242
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.824TyrAla: 1.824 ± 1.62
0.304TyrCys: 0.304 ± 0.273
3.04TyrAsp: 3.04 ± 0.834
2.736TyrGlu: 2.736 ± 0.863
3.647TyrPhe: 3.647 ± 1.214
2.432TyrGly: 2.432 ± 0.791
0.608TyrHis: 0.608 ± 0.515
2.736TyrIle: 2.736 ± 0.843
8.207TyrLys: 8.207 ± 1.434
3.04TyrLeu: 3.04 ± 0.773
1.216TyrMet: 1.216 ± 0.607
3.04TyrAsn: 3.04 ± 0.799
0.304TyrPro: 0.304 ± 0.374
1.824TyrGln: 1.824 ± 0.705
3.343TyrArg: 3.343 ± 1.223
2.128TyrSer: 2.128 ± 0.965
0.912TyrThr: 0.912 ± 0.671
1.52TyrVal: 1.52 ± 0.507
0.608TyrTrp: 0.608 ± 0.46
1.216TyrTyr: 1.216 ± 0.571
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (3291 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski