Amino acid dipepetide frequency for Flavobacteriaceae bacterium UJ101

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.19AlaAla: 3.19 ± 0.088	0.509AlaCys: 0.509 ± 0.027	2.794AlaAsp: 2.794 ± 0.06	3.462AlaGlu: 3.462 ± 0.074	2.956AlaPhe: 2.956 ± 0.064	3.68AlaGly: 3.68 ± 0.085	1.026AlaHis: 1.026 ± 0.035	4.768AlaIle: 4.768 ± 0.093	4.3AlaLys: 4.3 ± 0.078	5.42AlaLeu: 5.42 ± 0.091	1.219AlaMet: 1.219 ± 0.041	2.982AlaAsn: 2.982 ± 0.068	1.73AlaPro: 1.73 ± 0.04	2.47AlaGln: 2.47 ± 0.065	1.734AlaArg: 1.734 ± 0.044	3.775AlaSer: 3.775 ± 0.071	3.328AlaThr: 3.328 ± 0.076	3.326AlaVal: 3.326 ± 0.075	0.541AlaTrp: 0.541 ± 0.027	2.295AlaTyr: 2.295 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.432CysAla: 0.432 ± 0.022	0.108CysCys: 0.108 ± 0.013	0.414CysAsp: 0.414 ± 0.026	0.412CysGlu: 0.412 ± 0.022	0.405CysPhe: 0.405 ± 0.023	0.576CysGly: 0.576 ± 0.024	0.229CysHis: 0.229 ± 0.02	0.586CysIle: 0.586 ± 0.027	0.438CysLys: 0.438 ± 0.023	0.614CysLeu: 0.614 ± 0.027	0.14CysMet: 0.14 ± 0.014	0.434CysAsn: 0.434 ± 0.023	0.323CysPro: 0.323 ± 0.026	0.199CysGln: 0.199 ± 0.015	0.175CysArg: 0.175 ± 0.014	0.614CysSer: 0.614 ± 0.033	0.393CysThr: 0.393 ± 0.026	0.41CysVal: 0.41 ± 0.023	0.057CysTrp: 0.057 ± 0.008	0.284CysTyr: 0.284 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.16AspAla: 3.16 ± 0.074	0.383AspCys: 0.383 ± 0.02	3.091AspAsp: 3.091 ± 0.101	3.78AspGlu: 3.78 ± 0.072	3.608AspPhe: 3.608 ± 0.073	4.201AspGly: 4.201 ± 0.253	1.137AspHis: 1.137 ± 0.039	4.378AspIle: 4.378 ± 0.067	3.619AspLys: 3.619 ± 0.068	5.661AspLeu: 5.661 ± 0.11	0.96AspMet: 0.96 ± 0.039	3.073AspAsn: 3.073 ± 0.12	1.892AspPro: 1.892 ± 0.058	2.3AspGln: 2.3 ± 0.056	1.966AspArg: 1.966 ± 0.052	3.567AspSer: 3.567 ± 0.097	3.124AspThr: 3.124 ± 0.15	3.391AspVal: 3.391 ± 0.07	0.69AspTrp: 0.69 ± 0.031	3.09AspTyr: 3.09 ± 0.082	0.0AspXaa: 0.0 ± 0.0
Glu	4.027GluAla: 4.027 ± 0.074	0.365GluCys: 0.365 ± 0.026	3.841GluAsp: 3.841 ± 0.077	5.716GluGlu: 5.716 ± 0.106	2.983GluPhe: 2.983 ± 0.06	4.353GluGly: 4.353 ± 0.078	1.163GluHis: 1.163 ± 0.035	5.996GluIle: 5.996 ± 0.102	6.891GluLys: 6.891 ± 0.118	6.159GluLeu: 6.159 ± 0.093	1.556GluMet: 1.556 ± 0.04	4.965GluAsn: 4.965 ± 0.081	1.487GluPro: 1.487 ± 0.042	2.321GluGln: 2.321 ± 0.044	2.371GluArg: 2.371 ± 0.048	3.507GluSer: 3.507 ± 0.058	3.658GluThr: 3.658 ± 0.062	4.416GluVal: 4.416 ± 0.078	0.702GluTrp: 0.702 ± 0.031	2.715GluTyr: 2.715 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	2.512PheAla: 2.512 ± 0.06	0.388PheCys: 0.388 ± 0.021	3.14PheAsp: 3.14 ± 0.064	3.399PheGlu: 3.399 ± 0.077	2.78PhePhe: 2.78 ± 0.073	3.252PheGly: 3.252 ± 0.07	0.836PheHis: 0.836 ± 0.032	4.41PheIle: 4.41 ± 0.105	3.829PheLys: 3.829 ± 0.067	4.724PheLeu: 4.724 ± 0.103	1.123PheMet: 1.123 ± 0.039	3.219PheAsn: 3.219 ± 0.075	1.573PhePro: 1.573 ± 0.042	1.561PheGln: 1.561 ± 0.044	1.539PheArg: 1.539 ± 0.047	3.978PheSer: 3.978 ± 0.071	2.955PheThr: 2.955 ± 0.06	2.75PheVal: 2.75 ± 0.064	0.57PheTrp: 0.57 ± 0.025	2.287PheTyr: 2.287 ± 0.06	0.0PheXaa: 0.0 ± 0.0
Gly	3.864GlyAla: 3.864 ± 0.076	0.584GlyCys: 0.584 ± 0.03	3.636GlyAsp: 3.636 ± 0.121	3.862GlyGlu: 3.862 ± 0.072	3.468GlyPhe: 3.468 ± 0.068	4.646GlyGly: 4.646 ± 0.112	1.09GlyHis: 1.09 ± 0.041	5.95GlyIle: 5.95 ± 0.098	5.055GlyLys: 5.055 ± 0.084	5.622GlyLeu: 5.622 ± 0.096	1.576GlyMet: 1.576 ± 0.047	3.767GlyAsn: 3.767 ± 0.098	1.247GlyPro: 1.247 ± 0.038	1.896GlyGln: 1.896 ± 0.048	2.027GlyArg: 2.027 ± 0.052	4.039GlySer: 4.039 ± 0.08	4.345GlyThr: 4.345 ± 0.117	4.313GlyVal: 4.313 ± 0.081	0.733GlyTrp: 0.733 ± 0.027	2.931GlyTyr: 2.931 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	0.91HisAla: 0.91 ± 0.033	0.177HisCys: 0.177 ± 0.014	1.079HisAsp: 1.079 ± 0.034	1.069HisGlu: 1.069 ± 0.036	1.156HisPhe: 1.156 ± 0.035	0.969HisGly: 0.969 ± 0.034	0.586HisHis: 0.586 ± 0.028	1.51HisIle: 1.51 ± 0.041	1.213HisLys: 1.213 ± 0.043	1.805HisLeu: 1.805 ± 0.041	0.307HisMet: 0.307 ± 0.017	1.102HisAsn: 1.102 ± 0.032	0.893HisPro: 0.893 ± 0.03	0.747HisGln: 0.747 ± 0.032	0.6HisArg: 0.6 ± 0.026	1.162HisSer: 1.162 ± 0.033	1.084HisThr: 1.084 ± 0.034	0.967HisVal: 0.967 ± 0.037	0.233HisTrp: 0.233 ± 0.015	1.055HisTyr: 1.055 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.117IleAla: 5.117 ± 0.088	0.592IleCys: 0.592 ± 0.025	5.106IleAsp: 5.106 ± 0.089	6.423IleGlu: 6.423 ± 0.09	3.819IlePhe: 3.819 ± 0.091	5.448IleGly: 5.448 ± 0.103	1.653IleHis: 1.653 ± 0.047	7.125IleIle: 7.125 ± 0.139	6.494IleLys: 6.494 ± 0.094	7.668IleLeu: 7.668 ± 0.136	1.533IleMet: 1.533 ± 0.045	4.863IleAsn: 4.863 ± 0.081	3.44IlePro: 3.44 ± 0.075	3.419IleGln: 3.419 ± 0.068	2.554IleArg: 2.554 ± 0.056	5.784IleSer: 5.784 ± 0.09	4.99IleThr: 4.99 ± 0.09	4.986IleVal: 4.986 ± 0.088	0.669IleTrp: 0.669 ± 0.033	3.06IleTyr: 3.06 ± 0.067	0.0IleXaa: 0.0 ± 0.0
Lys	4.578LysAla: 4.578 ± 0.082	0.343LysCys: 0.343 ± 0.024	4.33LysAsp: 4.33 ± 0.075	7.532LysGlu: 7.532 ± 0.108	2.616LysPhe: 2.616 ± 0.061	5.075LysGly: 5.075 ± 0.079	1.348LysHis: 1.348 ± 0.035	7.01LysIle: 7.01 ± 0.096	8.082LysLys: 8.082 ± 0.123	6.271LysLeu: 6.271 ± 0.095	2.059LysMet: 2.059 ± 0.047	5.616LysAsn: 5.616 ± 0.096	2.327LysPro: 2.327 ± 0.061	2.848LysGln: 2.848 ± 0.064	2.919LysArg: 2.919 ± 0.06	4.269LysSer: 4.269 ± 0.076	4.696LysThr: 4.696 ± 0.081	4.888LysVal: 4.888 ± 0.078	0.844LysTrp: 0.844 ± 0.031	2.993LysTyr: 2.993 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	5.087LeuAla: 5.087 ± 0.094	0.61LeuCys: 0.61 ± 0.027	5.363LeuAsp: 5.363 ± 0.101	6.103LeuGlu: 6.103 ± 0.1	4.88LeuPhe: 4.88 ± 0.107	5.898LeuGly: 5.898 ± 0.113	1.54LeuHis: 1.54 ± 0.039	7.459LeuIle: 7.459 ± 0.126	7.856LeuLys: 7.856 ± 0.111	7.94LeuLeu: 7.94 ± 0.134	1.957LeuMet: 1.957 ± 0.052	5.868LeuAsn: 5.868 ± 0.087	3.378LeuPro: 3.378 ± 0.076	2.985LeuGln: 2.985 ± 0.063	2.761LeuArg: 2.761 ± 0.066	6.435LeuSer: 6.435 ± 0.144	5.259LeuThr: 5.259 ± 0.085	4.788LeuVal: 4.788 ± 0.075	0.75LeuTrp: 0.75 ± 0.033	3.543LeuTyr: 3.543 ± 0.078	0.0LeuXaa: 0.0 ± 0.0
Met	1.301MetAla: 1.301 ± 0.041	0.137MetCys: 0.137 ± 0.012	1.049MetAsp: 1.049 ± 0.04	1.396MetGlu: 1.396 ± 0.037	0.787MetPhe: 0.787 ± 0.033	1.337MetGly: 1.337 ± 0.039	0.381MetHis: 0.381 ± 0.021	1.797MetIle: 1.797 ± 0.052	2.291MetLys: 2.291 ± 0.054	1.819MetLeu: 1.819 ± 0.054	0.623MetMet: 0.623 ± 0.028	1.426MetAsn: 1.426 ± 0.045	0.703MetPro: 0.703 ± 0.026	0.651MetGln: 0.651 ± 0.027	0.816MetArg: 0.816 ± 0.027	1.295MetSer: 1.295 ± 0.04	1.105MetThr: 1.105 ± 0.034	1.283MetVal: 1.283 ± 0.037	0.16MetTrp: 0.16 ± 0.013	0.723MetTyr: 0.723 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.283AsnAla: 3.283 ± 0.07	0.469AsnCys: 0.469 ± 0.027	3.501AsnAsp: 3.501 ± 0.107	3.892AsnGlu: 3.892 ± 0.079	2.916AsnPhe: 2.916 ± 0.059	3.991AsnGly: 3.991 ± 0.105	1.391AsnHis: 1.391 ± 0.044	5.185AsnIle: 5.185 ± 0.085	4.507AsnLys: 4.507 ± 0.09	5.439AsnLeu: 5.439 ± 0.094	1.223AsnMet: 1.223 ± 0.036	3.907AsnAsn: 3.907 ± 0.076	2.795AsnPro: 2.795 ± 0.062	2.786AsnGln: 2.786 ± 0.079	2.199AsnArg: 2.199 ± 0.047	3.976AsnSer: 3.976 ± 0.104	4.046AsnThr: 4.046 ± 0.092	3.479AsnVal: 3.479 ± 0.072	0.816AsnTrp: 0.816 ± 0.029	2.958AsnTyr: 2.958 ± 0.065	0.0AsnXaa: 0.0 ± 0.0
Pro	1.578ProAla: 1.578 ± 0.047	0.23ProCys: 0.23 ± 0.017	2.137ProAsp: 2.137 ± 0.126	2.631ProGlu: 2.631 ± 0.056	1.782ProPhe: 1.782 ± 0.038	1.694ProGly: 1.694 ± 0.047	0.698ProHis: 0.698 ± 0.034	2.847ProIle: 2.847 ± 0.056	2.486ProLys: 2.486 ± 0.054	2.764ProLeu: 2.764 ± 0.056	0.717ProMet: 0.717 ± 0.025	2.231ProAsn: 2.231 ± 0.056	0.769ProPro: 0.769 ± 0.036	1.139ProGln: 1.139 ± 0.048	0.902ProArg: 0.902 ± 0.032	2.232ProSer: 2.232 ± 0.056	2.085ProThr: 2.085 ± 0.05	2.16ProVal: 2.16 ± 0.049	0.337ProTrp: 0.337 ± 0.021	1.489ProTyr: 1.489 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.886GlnAla: 1.886 ± 0.048	0.191GlnCys: 0.191 ± 0.017	1.784GlnAsp: 1.784 ± 0.046	2.71GlnGlu: 2.71 ± 0.056	1.87GlnPhe: 1.87 ± 0.052	1.868GlnGly: 1.868 ± 0.048	0.67GlnHis: 0.67 ± 0.028	2.963GlnIle: 2.963 ± 0.052	3.276GlnLys: 3.276 ± 0.063	3.458GlnLeu: 3.458 ± 0.076	0.762GlnMet: 0.762 ± 0.025	2.723GlnAsn: 2.723 ± 0.058	1.07GlnPro: 1.07 ± 0.036	1.379GlnGln: 1.379 ± 0.055	1.152GlnArg: 1.152 ± 0.038	2.128GlnSer: 2.128 ± 0.054	1.984GlnThr: 1.984 ± 0.044	2.055GlnVal: 2.055 ± 0.046	0.36GlnTrp: 0.36 ± 0.018	1.814GlnTyr: 1.814 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	1.771ArgAla: 1.771 ± 0.047	0.167ArgCys: 0.167 ± 0.014	1.709ArgAsp: 1.709 ± 0.047	2.09ArgGlu: 2.09 ± 0.057	1.86ArgPhe: 1.86 ± 0.047	1.921ArgGly: 1.921 ± 0.046	0.539ArgHis: 0.539 ± 0.024	2.82ArgIle: 2.82 ± 0.058	2.79ArgLys: 2.79 ± 0.067	2.911ArgLeu: 2.911 ± 0.061	0.829ArgMet: 0.829 ± 0.032	2.018ArgAsn: 2.018 ± 0.051	1.008ArgPro: 1.008 ± 0.035	0.963ArgGln: 0.963 ± 0.038	1.192ArgArg: 1.192 ± 0.04	1.842ArgSer: 1.842 ± 0.047	1.843ArgThr: 1.843 ± 0.048	1.905ArgVal: 1.905 ± 0.049	0.334ArgTrp: 0.334 ± 0.021	1.613ArgTyr: 1.613 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	3.182SerAla: 3.182 ± 0.063	0.701SerCys: 0.701 ± 0.031	3.493SerAsp: 3.493 ± 0.074	3.961SerGlu: 3.961 ± 0.078	3.902SerPhe: 3.902 ± 0.064	4.517SerGly: 4.517 ± 0.101	1.096SerHis: 1.096 ± 0.037	5.933SerIle: 5.933 ± 0.1	5.156SerLys: 5.156 ± 0.079	5.989SerLeu: 5.989 ± 0.124	1.253SerMet: 1.253 ± 0.038	4.107SerAsn: 4.107 ± 0.089	1.991SerPro: 1.991 ± 0.049	2.223SerGln: 2.223 ± 0.051	1.848SerArg: 1.848 ± 0.049	4.786SerSer: 4.786 ± 0.104	3.775SerThr: 3.775 ± 0.082	3.52SerVal: 3.52 ± 0.068	0.678SerTrp: 0.678 ± 0.028	2.849SerTyr: 2.849 ± 0.068	0.0SerXaa: 0.0 ± 0.0
Thr	3.336ThrAla: 3.336 ± 0.088	0.387ThrCys: 0.387 ± 0.021	3.617ThrAsp: 3.617 ± 0.175	3.283ThrGlu: 3.283 ± 0.061	3.076ThrPhe: 3.076 ± 0.066	4.051ThrGly: 4.051 ± 0.083	1.137ThrHis: 1.137 ± 0.033	5.375ThrIle: 5.375 ± 0.09	3.779ThrLys: 3.779 ± 0.074	5.855ThrLeu: 5.855 ± 0.087	0.947ThrMet: 0.947 ± 0.035	3.365ThrAsn: 3.365 ± 0.074	2.588ThrPro: 2.588 ± 0.062	2.173ThrGln: 2.173 ± 0.055	1.551ThrArg: 1.551 ± 0.044	4.124ThrSer: 4.124 ± 0.094	3.69ThrThr: 3.69 ± 0.087	3.52ThrVal: 3.52 ± 0.076	0.563ThrTrp: 0.563 ± 0.025	2.529ThrTyr: 2.529 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	3.414ValAla: 3.414 ± 0.08	0.474ValCys: 0.474 ± 0.027	3.648ValAsp: 3.648 ± 0.105	4.243ValGlu: 4.243 ± 0.087	2.953ValPhe: 2.953 ± 0.059	3.781ValGly: 3.781 ± 0.075	0.977ValHis: 0.977 ± 0.036	4.699ValIle: 4.699 ± 0.068	4.511ValLys: 4.511 ± 0.079	5.504ValLeu: 5.504 ± 0.098	1.247ValMet: 1.247 ± 0.043	3.448ValAsn: 3.448 ± 0.076	2.012ValPro: 2.012 ± 0.05	1.903ValGln: 1.903 ± 0.047	1.922ValArg: 1.922 ± 0.044	4.048ValSer: 4.048 ± 0.069	3.295ValThr: 3.295 ± 0.074	3.661ValVal: 3.661 ± 0.079	0.582ValTrp: 0.582 ± 0.028	2.362ValTyr: 2.362 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.572TrpAla: 0.572 ± 0.026	0.092TrpCys: 0.092 ± 0.011	0.623TrpAsp: 0.623 ± 0.029	0.697TrpGlu: 0.697 ± 0.028	0.518TrpPhe: 0.518 ± 0.027	0.723TrpGly: 0.723 ± 0.026	0.197TrpHis: 0.197 ± 0.016	0.863TrpIle: 0.863 ± 0.035	0.878TrpLys: 0.878 ± 0.036	0.888TrpLeu: 0.888 ± 0.037	0.3TrpMet: 0.3 ± 0.019	0.707TrpAsn: 0.707 ± 0.031	0.199TrpPro: 0.199 ± 0.014	0.305TrpGln: 0.305 ± 0.018	0.36TrpArg: 0.36 ± 0.025	0.617TrpSer: 0.617 ± 0.029	0.516TrpThr: 0.516 ± 0.024	0.629TrpVal: 0.629 ± 0.027	0.149TrpTrp: 0.149 ± 0.014	0.454TrpTyr: 0.454 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.303TyrAla: 2.303 ± 0.059	0.335TyrCys: 0.335 ± 0.021	2.714TyrAsp: 2.714 ± 0.075	2.531TyrGlu: 2.531 ± 0.06	2.488TyrPhe: 2.488 ± 0.056	2.673TyrGly: 2.673 ± 0.062	0.929TyrHis: 0.929 ± 0.031	3.071TyrIle: 3.071 ± 0.062	3.193TyrLys: 3.193 ± 0.068	3.951TyrLeu: 3.951 ± 0.078	0.747TyrMet: 0.747 ± 0.024	2.937TyrAsn: 2.937 ± 0.063	1.484TyrPro: 1.484 ± 0.04	1.833TyrGln: 1.833 ± 0.054	1.538TyrArg: 1.538 ± 0.047	2.783TyrSer: 2.783 ± 0.065	2.774TyrThr: 2.774 ± 0.07	2.24TyrVal: 2.24 ± 0.058	0.518TyrTrp: 0.518 ± 0.029	2.153TyrTyr: 2.153 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2681 proteins (933936 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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