Amino acid dipepetide frequency for Acinetobacter qingfengensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.278AlaAla: 7.278 ± 0.121
0.925AlaCys: 0.925 ± 0.034
4.221AlaAsp: 4.221 ± 0.086
4.986AlaGlu: 4.986 ± 0.08
3.307AlaPhe: 3.307 ± 0.064
5.69AlaGly: 5.69 ± 0.102
1.803AlaHis: 1.803 ± 0.046
6.418AlaIle: 6.418 ± 0.101
4.927AlaLys: 4.927 ± 0.09
9.609AlaLeu: 9.609 ± 0.126
2.326AlaMet: 2.326 ± 0.057
3.427AlaAsn: 3.427 ± 0.065
2.707AlaPro: 2.707 ± 0.052
5.033AlaGln: 5.033 ± 0.092
3.436AlaArg: 3.436 ± 0.067
4.638AlaSer: 4.638 ± 0.075
4.525AlaThr: 4.525 ± 0.073
5.536AlaVal: 5.536 ± 0.089
1.149AlaTrp: 1.149 ± 0.036
2.708AlaTyr: 2.708 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.71CysAla: 0.71 ± 0.03
0.157CysCys: 0.157 ± 0.014
0.483CysAsp: 0.483 ± 0.02
0.496CysGlu: 0.496 ± 0.023
0.438CysPhe: 0.438 ± 0.023
0.781CysGly: 0.781 ± 0.029
0.293CysHis: 0.293 ± 0.019
0.74CysIle: 0.74 ± 0.027
0.388CysLys: 0.388 ± 0.023
1.046CysLeu: 1.046 ± 0.038
0.247CysMet: 0.247 ± 0.017
0.345CysAsn: 0.345 ± 0.02
0.404CysPro: 0.404 ± 0.023
0.52CysGln: 0.52 ± 0.027
0.439CysArg: 0.439 ± 0.024
0.64CysSer: 0.64 ± 0.026
0.453CysThr: 0.453 ± 0.021
0.614CysVal: 0.614 ± 0.028
0.12CysTrp: 0.12 ± 0.012
0.332CysTyr: 0.332 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.345AspAla: 4.345 ± 0.086
0.48AspCys: 0.48 ± 0.026
2.776AspAsp: 2.776 ± 0.069
3.056AspGlu: 3.056 ± 0.064
2.397AspPhe: 2.397 ± 0.056
3.064AspGly: 3.064 ± 0.062
1.481AspHis: 1.481 ± 0.043
4.012AspIle: 4.012 ± 0.068
2.409AspLys: 2.409 ± 0.06
5.71AspLeu: 5.71 ± 0.084
1.196AspMet: 1.196 ± 0.04
1.927AspAsn: 1.927 ± 0.052
2.064AspPro: 2.064 ± 0.047
3.397AspGln: 3.397 ± 0.06
2.355AspArg: 2.355 ± 0.053
2.598AspSer: 2.598 ± 0.064
2.434AspThr: 2.434 ± 0.053
3.623AspVal: 3.623 ± 0.081
0.837AspTrp: 0.837 ± 0.029
2.117AspTyr: 2.117 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
4.156GluAla: 4.156 ± 0.079
0.362GluCys: 0.362 ± 0.019
2.567GluAsp: 2.567 ± 0.06
2.665GluGlu: 2.665 ± 0.074
2.126GluPhe: 2.126 ± 0.046
2.838GluGly: 2.838 ± 0.064
1.626GluHis: 1.626 ± 0.044
4.341GluIle: 4.341 ± 0.077
3.739GluLys: 3.739 ± 0.069
5.526GluLeu: 5.526 ± 0.099
1.321GluMet: 1.321 ± 0.038
2.925GluAsn: 2.925 ± 0.062
1.571GluPro: 1.571 ± 0.045
4.465GluGln: 4.465 ± 0.08
2.657GluArg: 2.657 ± 0.068
2.634GluSer: 2.634 ± 0.056
2.717GluThr: 2.717 ± 0.056
3.247GluVal: 3.247 ± 0.064
0.69GluTrp: 0.69 ± 0.028
1.75GluTyr: 1.75 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
3.813PheAla: 3.813 ± 0.074
0.493PheCys: 0.493 ± 0.023
2.642PheAsp: 2.642 ± 0.058
2.277PheGlu: 2.277 ± 0.055
1.882PhePhe: 1.882 ± 0.057
2.942PheGly: 2.942 ± 0.061
0.875PheHis: 0.875 ± 0.036
3.233PheIle: 3.233 ± 0.073
2.303PheLys: 2.303 ± 0.051
3.848PheLeu: 3.848 ± 0.075
1.058PheMet: 1.058 ± 0.032
2.245PheAsn: 2.245 ± 0.052
1.396PhePro: 1.396 ± 0.041
1.636PheGln: 1.636 ± 0.044
1.492PheArg: 1.492 ± 0.035
3.139PheSer: 3.139 ± 0.069
2.116PheThr: 2.116 ± 0.056
2.416PheVal: 2.416 ± 0.046
0.599PheTrp: 0.599 ± 0.028
1.574PheTyr: 1.574 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
4.926GlyAla: 4.926 ± 0.092
0.782GlyCys: 0.782 ± 0.028
2.879GlyAsp: 2.879 ± 0.066
3.426GlyGlu: 3.426 ± 0.068
3.13GlyPhe: 3.13 ± 0.065
4.411GlyGly: 4.411 ± 0.092
1.582GlyHis: 1.582 ± 0.046
5.05GlyIle: 5.05 ± 0.073
3.605GlyLys: 3.605 ± 0.072
6.996GlyLeu: 6.996 ± 0.093
1.671GlyMet: 1.671 ± 0.049
2.473GlyAsn: 2.473 ± 0.058
1.304GlyPro: 1.304 ± 0.04
3.278GlyGln: 3.278 ± 0.072
2.85GlyArg: 2.85 ± 0.059
3.676GlySer: 3.676 ± 0.069
3.459GlyThr: 3.459 ± 0.066
4.503GlyVal: 4.503 ± 0.067
0.982GlyTrp: 0.982 ± 0.032
2.483GlyTyr: 2.483 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
2.134HisAla: 2.134 ± 0.05
0.304HisCys: 0.304 ± 0.018
1.371HisAsp: 1.371 ± 0.041
1.222HisGlu: 1.222 ± 0.037
1.206HisPhe: 1.206 ± 0.037
1.575HisGly: 1.575 ± 0.047
0.945HisHis: 0.945 ± 0.034
1.936HisIle: 1.936 ± 0.048
0.935HisLys: 0.935 ± 0.032
2.767HisLeu: 2.767 ± 0.048
0.47HisMet: 0.47 ± 0.023
0.909HisAsn: 0.909 ± 0.031
1.375HisPro: 1.375 ± 0.04
1.764HisGln: 1.764 ± 0.041
1.166HisArg: 1.166 ± 0.031
1.361HisSer: 1.361 ± 0.042
1.17HisThr: 1.17 ± 0.04
1.488HisVal: 1.488 ± 0.045
0.406HisTrp: 0.406 ± 0.019
1.07HisTyr: 1.07 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
7.057IleAla: 7.057 ± 0.089
0.852IleCys: 0.852 ± 0.033
4.458IleAsp: 4.458 ± 0.073
4.679IleGlu: 4.679 ± 0.081
3.037IlePhe: 3.037 ± 0.07
4.936IleGly: 4.936 ± 0.101
1.728IleHis: 1.728 ± 0.049
4.679IleIle: 4.679 ± 0.083
3.586IleLys: 3.586 ± 0.063
7.266IleLeu: 7.266 ± 0.113
1.528IleMet: 1.528 ± 0.049
3.327IleAsn: 3.327 ± 0.072
2.997IlePro: 2.997 ± 0.068
3.969IleGln: 3.969 ± 0.068
3.178IleArg: 3.178 ± 0.053
4.644IleSer: 4.644 ± 0.08
3.856IleThr: 3.856 ± 0.068
4.455IleVal: 4.455 ± 0.068
0.828IleTrp: 0.828 ± 0.036
2.363IleTyr: 2.363 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
4.361LysAla: 4.361 ± 0.089
0.303LysCys: 0.303 ± 0.017
2.833LysAsp: 2.833 ± 0.069
2.537LysGlu: 2.537 ± 0.055
1.947LysPhe: 1.947 ± 0.05
2.797LysGly: 2.797 ± 0.053
1.323LysHis: 1.323 ± 0.033
4.315LysIle: 4.315 ± 0.074
3.315LysLys: 3.315 ± 0.069
5.114LysLeu: 5.114 ± 0.073
1.255LysMet: 1.255 ± 0.039
3.042LysAsn: 3.042 ± 0.057
2.098LysPro: 2.098 ± 0.044
3.668LysGln: 3.668 ± 0.071
2.435LysArg: 2.435 ± 0.052
2.968LysSer: 2.968 ± 0.054
3.277LysThr: 3.277 ± 0.071
3.323LysVal: 3.323 ± 0.064
0.574LysTrp: 0.574 ± 0.027
1.778LysTyr: 1.778 ± 0.041
0.001LysXaa: 0.001 ± 0.001
Leu
9.365LeuAla: 9.365 ± 0.113
1.123LeuCys: 1.123 ± 0.041
5.863LeuAsp: 5.863 ± 0.089
5.41LeuGlu: 5.41 ± 0.092
4.2LeuPhe: 4.2 ± 0.079
6.94LeuGly: 6.94 ± 0.103
2.31LeuHis: 2.31 ± 0.056
7.324LeuIle: 7.324 ± 0.118
6.294LeuLys: 6.294 ± 0.074
10.247LeuLeu: 10.247 ± 0.16
2.506LeuMet: 2.506 ± 0.058
5.501LeuAsn: 5.501 ± 0.085
4.65LeuPro: 4.65 ± 0.076
5.758LeuGln: 5.758 ± 0.101
4.38LeuArg: 4.38 ± 0.072
7.509LeuSer: 7.509 ± 0.088
5.895LeuThr: 5.895 ± 0.078
5.81LeuVal: 5.81 ± 0.1
1.231LeuTrp: 1.231 ± 0.039
2.89LeuTyr: 2.89 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.066MetAla: 2.066 ± 0.051
0.208MetCys: 0.208 ± 0.015
1.014MetAsp: 1.014 ± 0.036
0.88MetGlu: 0.88 ± 0.031
0.801MetPhe: 0.801 ± 0.03
1.567MetGly: 1.567 ± 0.048
0.525MetHis: 0.525 ± 0.022
1.685MetIle: 1.685 ± 0.046
1.163MetLys: 1.163 ± 0.039
2.589MetLeu: 2.589 ± 0.061
0.683MetMet: 0.683 ± 0.03
1.157MetAsn: 1.157 ± 0.035
1.031MetPro: 1.031 ± 0.036
1.617MetGln: 1.617 ± 0.045
1.036MetArg: 1.036 ± 0.033
1.752MetSer: 1.752 ± 0.041
1.457MetThr: 1.457 ± 0.041
1.453MetVal: 1.453 ± 0.045
0.197MetTrp: 0.197 ± 0.015
0.613MetTyr: 0.613 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.709AsnAla: 3.709 ± 0.072
0.384AsnCys: 0.384 ± 0.021
2.258AsnAsp: 2.258 ± 0.059
2.189AsnGlu: 2.189 ± 0.049
1.982AsnPhe: 1.982 ± 0.047
2.758AsnGly: 2.758 ± 0.068
1.227AsnHis: 1.227 ± 0.044
3.596AsnIle: 3.596 ± 0.072
2.274AsnLys: 2.274 ± 0.055
4.722AsnLeu: 4.722 ± 0.083
0.968AsnMet: 0.968 ± 0.028
2.068AsnAsn: 2.068 ± 0.055
2.213AsnPro: 2.213 ± 0.048
2.705AsnGln: 2.705 ± 0.06
1.863AsnArg: 1.863 ± 0.044
2.556AsnSer: 2.556 ± 0.063
2.668AsnThr: 2.668 ± 0.059
2.68AsnVal: 2.68 ± 0.062
0.625AsnTrp: 0.625 ± 0.031
1.773AsnTyr: 1.773 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
3.031ProAla: 3.031 ± 0.067
0.244ProCys: 0.244 ± 0.015
2.31ProAsp: 2.31 ± 0.048
3.215ProGlu: 3.215 ± 0.058
1.707ProPhe: 1.707 ± 0.041
1.62ProGly: 1.62 ± 0.045
0.912ProHis: 0.912 ± 0.03
2.614ProIle: 2.614 ± 0.056
2.145ProLys: 2.145 ± 0.044
3.784ProLeu: 3.784 ± 0.07
0.925ProMet: 0.925 ± 0.032
1.803ProAsn: 1.803 ± 0.045
1.073ProPro: 1.073 ± 0.043
2.156ProGln: 2.156 ± 0.051
1.375ProArg: 1.375 ± 0.039
2.207ProSer: 2.207 ± 0.05
2.124ProThr: 2.124 ± 0.049
3.011ProVal: 3.011 ± 0.058
0.428ProTrp: 0.428 ± 0.022
1.382ProTyr: 1.382 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
5.442GlnAla: 5.442 ± 0.105
0.491GlnCys: 0.491 ± 0.024
2.862GlnAsp: 2.862 ± 0.061
2.613GlnGlu: 2.613 ± 0.057
2.28GlnPhe: 2.28 ± 0.043
3.424GlnGly: 3.424 ± 0.058
2.303GlnHis: 2.303 ± 0.059
4.171GlnIle: 4.171 ± 0.061
3.232GlnLys: 3.232 ± 0.06
6.731GlnLeu: 6.731 ± 0.105
1.182GlnMet: 1.182 ± 0.034
2.838GlnAsn: 2.838 ± 0.064
2.36GlnPro: 2.36 ± 0.053
6.294GlnGln: 6.294 ± 0.164
2.963GlnArg: 2.963 ± 0.062
3.513GlnSer: 3.513 ± 0.068
2.98GlnThr: 2.98 ± 0.06
3.509GlnVal: 3.509 ± 0.064
0.832GlnTrp: 0.832 ± 0.031
2.26GlnTyr: 2.26 ± 0.057
0.001GlnXaa: 0.001 ± 0.001
Arg
3.086ArgAla: 3.086 ± 0.064
0.357ArgCys: 0.357 ± 0.023
2.132ArgAsp: 2.132 ± 0.049
2.513ArgGlu: 2.513 ± 0.064
2.064ArgPhe: 2.064 ± 0.046
2.454ArgGly: 2.454 ± 0.06
1.225ArgHis: 1.225 ± 0.039
3.38ArgIle: 3.38 ± 0.065
2.29ArgLys: 2.29 ± 0.053
4.976ArgLeu: 4.976 ± 0.068
1.08ArgMet: 1.08 ± 0.034
1.781ArgAsn: 1.781 ± 0.046
1.702ArgPro: 1.702 ± 0.039
2.933ArgGln: 2.933 ± 0.063
1.999ArgArg: 1.999 ± 0.058
2.335ArgSer: 2.335 ± 0.053
2.012ArgThr: 2.012 ± 0.051
2.649ArgVal: 2.649 ± 0.054
0.556ArgTrp: 0.556 ± 0.025
1.942ArgTyr: 1.942 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
4.993SerAla: 4.993 ± 0.08
0.56SerCys: 0.56 ± 0.028
2.972SerAsp: 2.972 ± 0.073
3.136SerGlu: 3.136 ± 0.059
2.585SerPhe: 2.585 ± 0.052
4.453SerGly: 4.453 ± 0.074
1.523SerHis: 1.523 ± 0.042
4.528SerIle: 4.528 ± 0.074
3.022SerLys: 3.022 ± 0.069
6.112SerLeu: 6.112 ± 0.086
1.413SerMet: 1.413 ± 0.043
2.611SerAsn: 2.611 ± 0.061
2.257SerPro: 2.257 ± 0.047
3.174SerGln: 3.174 ± 0.07
2.683SerArg: 2.683 ± 0.056
4.071SerSer: 4.071 ± 0.083
3.527SerThr: 3.527 ± 0.068
3.647SerVal: 3.647 ± 0.063
0.77SerTrp: 0.77 ± 0.033
2.03SerTyr: 2.03 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
4.921ThrAla: 4.921 ± 0.086
0.424ThrCys: 0.424 ± 0.023
2.762ThrAsp: 2.762 ± 0.058
2.976ThrGlu: 2.976 ± 0.057
2.007ThrPhe: 2.007 ± 0.044
4.167ThrGly: 4.167 ± 0.073
1.331ThrHis: 1.331 ± 0.038
3.636ThrIle: 3.636 ± 0.07
2.182ThrLys: 2.182 ± 0.05
6.072ThrLeu: 6.072 ± 0.09
0.989ThrMet: 0.989 ± 0.034
1.947ThrAsn: 1.947 ± 0.054
2.713ThrPro: 2.713 ± 0.062
3.147ThrGln: 3.147 ± 0.057
2.185ThrArg: 2.185 ± 0.052
3.201ThrSer: 3.201 ± 0.072
3.422ThrThr: 3.422 ± 0.106
3.717ThrVal: 3.717 ± 0.067
0.622ThrTrp: 0.622 ± 0.028
1.587ThrTyr: 1.587 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
5.5ValAla: 5.5 ± 0.088
0.674ValCys: 0.674 ± 0.028
3.529ValAsp: 3.529 ± 0.066
3.655ValGlu: 3.655 ± 0.076
2.587ValPhe: 2.587 ± 0.058
4.048ValGly: 4.048 ± 0.064
1.267ValHis: 1.267 ± 0.038
4.778ValIle: 4.778 ± 0.079
3.294ValLys: 3.294 ± 0.065
6.525ValLeu: 6.525 ± 0.095
1.695ValMet: 1.695 ± 0.043
2.99ValAsn: 2.99 ± 0.06
2.353ValPro: 2.353 ± 0.063
3.045ValGln: 3.045 ± 0.068
2.565ValArg: 2.565 ± 0.056
3.769ValSer: 3.769 ± 0.066
3.55ValThr: 3.55 ± 0.069
4.322ValVal: 4.322 ± 0.071
0.814ValTrp: 0.814 ± 0.034
1.864ValTyr: 1.864 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.845TrpAla: 0.845 ± 0.028
0.173TrpCys: 0.173 ± 0.013
0.524TrpAsp: 0.524 ± 0.026
0.465TrpGlu: 0.465 ± 0.024
0.624TrpPhe: 0.624 ± 0.026
0.719TrpGly: 0.719 ± 0.03
0.387TrpHis: 0.387 ± 0.021
0.996TrpIle: 0.996 ± 0.036
0.662TrpLys: 0.662 ± 0.029
1.768TrpLeu: 1.768 ± 0.051
0.365TrpMet: 0.365 ± 0.019
0.583TrpAsn: 0.583 ± 0.025
0.342TrpPro: 0.342 ± 0.019
1.159TrpGln: 1.159 ± 0.044
0.606TrpArg: 0.606 ± 0.026
0.756TrpSer: 0.756 ± 0.03
0.586TrpThr: 0.586 ± 0.024
0.805TrpVal: 0.805 ± 0.031
0.191TrpTrp: 0.191 ± 0.015
0.42TrpTyr: 0.42 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.912TyrAla: 2.912 ± 0.057
0.351TyrCys: 0.351 ± 0.02
1.824TyrAsp: 1.824 ± 0.052
1.527TyrGlu: 1.527 ± 0.04
1.67TyrPhe: 1.67 ± 0.054
2.28TyrGly: 2.28 ± 0.058
0.908TyrHis: 0.908 ± 0.032
1.991TyrIle: 1.991 ± 0.05
1.499TyrLys: 1.499 ± 0.043
3.795TyrLeu: 3.795 ± 0.071
0.613TyrMet: 0.613 ± 0.024
1.318TyrAsn: 1.318 ± 0.045
1.46TyrPro: 1.46 ± 0.041
2.563TyrGln: 2.563 ± 0.063
1.803TyrArg: 1.803 ± 0.05
2.1TyrSer: 2.1 ± 0.056
1.78TyrThr: 1.78 ± 0.058
2.015TyrVal: 2.015 ± 0.049
0.525TyrTrp: 0.525 ± 0.022
1.245TyrTyr: 1.245 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.001XaaPhe: 0.001 ± 0.001
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.001XaaArg: 0.001 ± 0.001
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2825 proteins (906604 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski