Amino acid dipepetide frequency for Pseudobutyrivibrio sp. OR37

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.437AlaAla: 6.437 ± 0.111	1.064AlaCys: 1.064 ± 0.032	5.074AlaAsp: 5.074 ± 0.082	5.034AlaGlu: 5.034 ± 0.089	3.191AlaPhe: 3.191 ± 0.068	5.529AlaGly: 5.529 ± 0.086	1.117AlaHis: 1.117 ± 0.032	5.72AlaIle: 5.72 ± 0.073	5.514AlaLys: 5.514 ± 0.078	6.347AlaLeu: 6.347 ± 0.089	2.285AlaMet: 2.285 ± 0.043	3.5AlaAsn: 3.5 ± 0.062	2.021AlaPro: 2.021 ± 0.046	1.961AlaGln: 1.961 ± 0.042	2.506AlaArg: 2.506 ± 0.052	4.384AlaSer: 4.384 ± 0.075	4.253AlaThr: 4.253 ± 0.104	5.442AlaVal: 5.442 ± 0.081	0.587AlaTrp: 0.587 ± 0.027	2.959AlaTyr: 2.959 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.87CysAla: 0.87 ± 0.029	0.211CysCys: 0.211 ± 0.017	0.953CysAsp: 0.953 ± 0.032	0.822CysGlu: 0.822 ± 0.029	0.592CysPhe: 0.592 ± 0.027	1.24CysGly: 1.24 ± 0.039	0.276CysHis: 0.276 ± 0.016	1.02CysIle: 1.02 ± 0.036	0.826CysLys: 0.826 ± 0.03	1.026CysLeu: 1.026 ± 0.036	0.414CysMet: 0.414 ± 0.021	0.579CysAsn: 0.579 ± 0.024	0.536CysPro: 0.536 ± 0.026	0.382CysGln: 0.382 ± 0.017	0.458CysArg: 0.458 ± 0.022	0.82CysSer: 0.82 ± 0.027	0.693CysThr: 0.693 ± 0.027	0.918CysVal: 0.918 ± 0.03	0.096CysTrp: 0.096 ± 0.009	0.595CysTyr: 0.595 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	4.766AspAla: 4.766 ± 0.08	0.825AspCys: 0.825 ± 0.03	4.182AspAsp: 4.182 ± 0.088	5.739AspGlu: 5.739 ± 0.087	3.141AspPhe: 3.141 ± 0.06	4.928AspGly: 4.928 ± 0.094	0.756AspHis: 0.756 ± 0.031	5.316AspIle: 5.316 ± 0.073	4.564AspLys: 4.564 ± 0.073	4.798AspLeu: 4.798 ± 0.058	2.02AspMet: 2.02 ± 0.041	3.215AspAsn: 3.215 ± 0.061	1.587AspPro: 1.587 ± 0.042	1.074AspGln: 1.074 ± 0.033	2.099AspArg: 2.099 ± 0.046	3.829AspSer: 3.829 ± 0.078	3.318AspThr: 3.318 ± 0.064	4.591AspVal: 4.591 ± 0.073	0.613AspTrp: 0.613 ± 0.025	3.738AspTyr: 3.738 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	5.823GluAla: 5.823 ± 0.092	0.759GluCys: 0.759 ± 0.024	4.834GluAsp: 4.834 ± 0.072	6.635GluGlu: 6.635 ± 0.123	2.68GluPhe: 2.68 ± 0.057	4.316GluGly: 4.316 ± 0.067	1.289GluHis: 1.289 ± 0.041	5.702GluIle: 5.702 ± 0.083	6.092GluLys: 6.092 ± 0.078	6.424GluLeu: 6.424 ± 0.102	2.143GluMet: 2.143 ± 0.048	4.359GluAsn: 4.359 ± 0.069	1.84GluPro: 1.84 ± 0.055	2.379GluGln: 2.379 ± 0.05	2.624GluArg: 2.624 ± 0.053	3.634GluSer: 3.634 ± 0.071	3.593GluThr: 3.593 ± 0.058	4.534GluVal: 4.534 ± 0.07	0.63GluTrp: 0.63 ± 0.025	3.351GluTyr: 3.351 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.12PheAla: 3.12 ± 0.061	0.609PheCys: 0.609 ± 0.025	3.074PheAsp: 3.074 ± 0.06	2.993PheGlu: 2.993 ± 0.054	1.925PhePhe: 1.925 ± 0.052	2.886PheGly: 2.886 ± 0.06	0.645PheHis: 0.645 ± 0.023	3.187PheIle: 3.187 ± 0.077	2.733PheLys: 2.733 ± 0.054	3.4PheLeu: 3.4 ± 0.071	1.251PheMet: 1.251 ± 0.038	2.152PheAsn: 2.152 ± 0.048	1.219PhePro: 1.219 ± 0.037	0.862PheGln: 0.862 ± 0.029	1.418PheArg: 1.418 ± 0.041	2.838PheSer: 2.838 ± 0.061	2.637PheThr: 2.637 ± 0.049	3.004PheVal: 3.004 ± 0.063	0.427PheTrp: 0.427 ± 0.022	1.892PheTyr: 1.892 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	4.802GlyAla: 4.802 ± 0.082	1.076GlyCys: 1.076 ± 0.032	3.998GlyAsp: 3.998 ± 0.079	4.396GlyGlu: 4.396 ± 0.066	3.186GlyPhe: 3.186 ± 0.06	4.457GlyGly: 4.457 ± 0.071	1.245GlyHis: 1.245 ± 0.036	5.61GlyIle: 5.61 ± 0.078	5.312GlyLys: 5.312 ± 0.084	5.426GlyLeu: 5.426 ± 0.073	2.197GlyMet: 2.197 ± 0.043	3.422GlyAsn: 3.422 ± 0.067	1.262GlyPro: 1.262 ± 0.04	1.979GlyGln: 1.979 ± 0.038	2.51GlyArg: 2.51 ± 0.057	3.905GlySer: 3.905 ± 0.067	4.211GlyThr: 4.211 ± 0.097	4.863GlyVal: 4.863 ± 0.07	0.758GlyTrp: 0.758 ± 0.037	3.296GlyTyr: 3.296 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.979HisAla: 0.979 ± 0.033	0.24HisCys: 0.24 ± 0.015	0.968HisAsp: 0.968 ± 0.031	1.087HisGlu: 1.087 ± 0.034	0.847HisPhe: 0.847 ± 0.026	1.141HisGly: 1.141 ± 0.035	0.377HisHis: 0.377 ± 0.026	1.296HisIle: 1.296 ± 0.033	0.922HisLys: 0.922 ± 0.031	1.262HisLeu: 1.262 ± 0.038	0.462HisMet: 0.462 ± 0.022	0.756HisAsn: 0.756 ± 0.026	0.721HisPro: 0.721 ± 0.024	0.413HisGln: 0.413 ± 0.017	0.661HisArg: 0.661 ± 0.026	0.949HisSer: 0.949 ± 0.027	0.84HisThr: 0.84 ± 0.033	1.088HisVal: 1.088 ± 0.037	0.137HisTrp: 0.137 ± 0.012	0.77HisTyr: 0.77 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.998IleAla: 5.998 ± 0.085	1.189IleCys: 1.189 ± 0.035	5.151IleAsp: 5.151 ± 0.07	5.365IleGlu: 5.365 ± 0.082	3.044IlePhe: 3.044 ± 0.06	5.067IleGly: 5.067 ± 0.086	1.207IleHis: 1.207 ± 0.037	6.192IleIle: 6.192 ± 0.115	5.333IleLys: 5.333 ± 0.073	6.176IleLeu: 6.176 ± 0.102	2.03IleMet: 2.03 ± 0.045	4.104IleAsn: 4.104 ± 0.064	2.826IlePro: 2.826 ± 0.05	1.866IleGln: 1.866 ± 0.047	2.726IleArg: 2.726 ± 0.051	5.415IleSer: 5.415 ± 0.086	4.677IleThr: 4.677 ± 0.086	5.379IleVal: 5.379 ± 0.085	0.59IleTrp: 0.59 ± 0.024	3.154IleTyr: 3.154 ± 0.065	0.0IleXaa: 0.0 ± 0.0
Lys	5.694LysAla: 5.694 ± 0.075	0.818LysCys: 0.818 ± 0.027	4.897LysAsp: 4.897 ± 0.082	6.265LysGlu: 6.265 ± 0.076	2.218LysPhe: 2.218 ± 0.047	4.143LysGly: 4.143 ± 0.063	1.101LysHis: 1.101 ± 0.036	4.97LysIle: 4.97 ± 0.072	6.122LysLys: 6.122 ± 0.097	6.1LysLeu: 6.1 ± 0.08	1.981LysMet: 1.981 ± 0.046	4.231LysAsn: 4.231 ± 0.068	2.046LysPro: 2.046 ± 0.049	2.189LysGln: 2.189 ± 0.051	2.68LysArg: 2.68 ± 0.058	3.977LysSer: 3.977 ± 0.07	3.807LysThr: 3.807 ± 0.066	4.66LysVal: 4.66 ± 0.077	0.663LysTrp: 0.663 ± 0.027	3.553LysTyr: 3.553 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	6.311LeuAla: 6.311 ± 0.08	1.183LeuCys: 1.183 ± 0.036	5.319LeuAsp: 5.319 ± 0.076	5.638LeuGlu: 5.638 ± 0.082	3.487LeuPhe: 3.487 ± 0.071	5.529LeuGly: 5.529 ± 0.087	1.313LeuHis: 1.313 ± 0.035	6.029LeuIle: 6.029 ± 0.097	6.13LeuLys: 6.13 ± 0.091	7.227LeuLeu: 7.227 ± 0.111	2.403LeuMet: 2.403 ± 0.055	4.275LeuAsn: 4.275 ± 0.066	2.953LeuPro: 2.953 ± 0.058	2.31LeuGln: 2.31 ± 0.05	3.067LeuArg: 3.067 ± 0.059	5.841LeuSer: 5.841 ± 0.079	4.755LeuThr: 4.755 ± 0.071	5.425LeuVal: 5.425 ± 0.068	0.612LeuTrp: 0.612 ± 0.023	3.213LeuTyr: 3.213 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.383MetAla: 2.383 ± 0.048	0.356MetCys: 0.356 ± 0.017	1.948MetAsp: 1.948 ± 0.042	2.082MetGlu: 2.082 ± 0.052	1.088MetPhe: 1.088 ± 0.034	1.92MetGly: 1.92 ± 0.043	0.465MetHis: 0.465 ± 0.019	2.106MetIle: 2.106 ± 0.053	2.269MetLys: 2.269 ± 0.049	2.543MetLeu: 2.543 ± 0.053	0.844MetMet: 0.844 ± 0.028	1.555MetAsn: 1.555 ± 0.042	1.053MetPro: 1.053 ± 0.036	0.843MetGln: 0.843 ± 0.024	0.979MetArg: 0.979 ± 0.025	1.802MetSer: 1.802 ± 0.045	1.594MetThr: 1.594 ± 0.043	1.903MetVal: 1.903 ± 0.041	0.198MetTrp: 0.198 ± 0.012	1.033MetTyr: 1.033 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.533AsnAla: 3.533 ± 0.071	0.682AsnCys: 0.682 ± 0.027	3.0AsnAsp: 3.0 ± 0.05	3.496AsnGlu: 3.496 ± 0.059	1.843AsnPhe: 1.843 ± 0.043	3.891AsnGly: 3.891 ± 0.069	0.925AsnHis: 0.925 ± 0.032	4.17AsnIle: 4.17 ± 0.063	3.606AsnLys: 3.606 ± 0.064	4.146AsnLeu: 4.146 ± 0.068	1.544AsnMet: 1.544 ± 0.038	2.879AsnAsn: 2.879 ± 0.062	2.261AsnPro: 2.261 ± 0.05	1.64AsnGln: 1.64 ± 0.04	1.867AsnArg: 1.867 ± 0.053	3.027AsnSer: 3.027 ± 0.06	2.969AsnThr: 2.969 ± 0.06	3.408AsnVal: 3.408 ± 0.059	0.474AsnTrp: 0.474 ± 0.025	2.364AsnTyr: 2.364 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.228ProAla: 2.228 ± 0.048	0.341ProCys: 0.341 ± 0.019	2.086ProAsp: 2.086 ± 0.05	2.835ProGlu: 2.835 ± 0.05	1.388ProPhe: 1.388 ± 0.034	1.956ProGly: 1.956 ± 0.047	0.478ProHis: 0.478 ± 0.019	2.281ProIle: 2.281 ± 0.05	2.008ProLys: 2.008 ± 0.044	2.322ProLeu: 2.322 ± 0.05	0.797ProMet: 0.797 ± 0.026	1.499ProAsn: 1.499 ± 0.039	0.548ProPro: 0.548 ± 0.025	0.895ProGln: 0.895 ± 0.029	0.863ProArg: 0.863 ± 0.032	1.877ProSer: 1.877 ± 0.04	1.813ProThr: 1.813 ± 0.055	2.525ProVal: 2.525 ± 0.06	0.3ProTrp: 0.3 ± 0.02	1.355ProTyr: 1.355 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.127GlnAla: 2.127 ± 0.048	0.308GlnCys: 0.308 ± 0.018	1.463GlnAsp: 1.463 ± 0.042	1.92GlnGlu: 1.92 ± 0.049	1.16GlnPhe: 1.16 ± 0.035	1.631GlnGly: 1.631 ± 0.044	0.42GlnHis: 0.42 ± 0.018	2.315GlnIle: 2.315 ± 0.044	1.962GlnLys: 1.962 ± 0.047	2.556GlnLeu: 2.556 ± 0.053	0.967GlnMet: 0.967 ± 0.03	1.307GlnAsn: 1.307 ± 0.034	0.818GlnPro: 0.818 ± 0.03	0.934GlnGln: 0.934 ± 0.034	1.085GlnArg: 1.085 ± 0.038	1.474GlnSer: 1.474 ± 0.037	1.422GlnThr: 1.422 ± 0.037	1.871GlnVal: 1.871 ± 0.04	0.27GlnTrp: 0.27 ± 0.016	1.187GlnTyr: 1.187 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.429ArgAla: 2.429 ± 0.054	0.452ArgCys: 0.452 ± 0.022	2.156ArgAsp: 2.156 ± 0.05	2.627ArgGlu: 2.627 ± 0.055	1.627ArgPhe: 1.627 ± 0.042	2.126ArgGly: 2.126 ± 0.052	0.612ArgHis: 0.612 ± 0.027	3.071ArgIle: 3.071 ± 0.06	2.612ArgLys: 2.612 ± 0.054	3.091ArgLeu: 3.091 ± 0.068	1.183ArgMet: 1.183 ± 0.037	1.89ArgAsn: 1.89 ± 0.045	1.085ArgPro: 1.085 ± 0.035	1.148ArgGln: 1.148 ± 0.032	1.603ArgArg: 1.603 ± 0.044	1.691ArgSer: 1.691 ± 0.041	1.852ArgThr: 1.852 ± 0.041	2.316ArgVal: 2.316 ± 0.048	0.292ArgTrp: 0.292 ± 0.014	1.606ArgTyr: 1.606 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.23SerAla: 4.23 ± 0.071	0.729SerCys: 0.729 ± 0.025	3.899SerAsp: 3.899 ± 0.061	4.194SerGlu: 4.194 ± 0.086	2.989SerPhe: 2.989 ± 0.051	4.553SerGly: 4.553 ± 0.08	0.946SerHis: 0.946 ± 0.031	4.701SerIle: 4.701 ± 0.082	4.25SerLys: 4.25 ± 0.057	5.08SerLeu: 5.08 ± 0.072	1.785SerMet: 1.785 ± 0.045	3.039SerAsn: 3.039 ± 0.056	1.586SerPro: 1.586 ± 0.044	1.704SerGln: 1.704 ± 0.049	2.194SerArg: 2.194 ± 0.045	3.792SerSer: 3.792 ± 0.073	3.439SerThr: 3.439 ± 0.072	4.327SerVal: 4.327 ± 0.065	0.528SerTrp: 0.528 ± 0.021	2.756SerTyr: 2.756 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.288ThrAla: 4.288 ± 0.088	0.639ThrCys: 0.639 ± 0.024	3.598ThrAsp: 3.598 ± 0.077	3.718ThrGlu: 3.718 ± 0.069	2.447ThrPhe: 2.447 ± 0.054	4.497ThrGly: 4.497 ± 0.096	0.845ThrHis: 0.845 ± 0.026	4.674ThrIle: 4.674 ± 0.072	3.651ThrLys: 3.651 ± 0.067	4.721ThrLeu: 4.721 ± 0.071	1.383ThrMet: 1.383 ± 0.038	2.596ThrAsn: 2.596 ± 0.065	2.105ThrPro: 2.105 ± 0.056	1.355ThrGln: 1.355 ± 0.036	1.773ThrArg: 1.773 ± 0.044	3.348ThrSer: 3.348 ± 0.061	3.214ThrThr: 3.214 ± 0.076	4.534ThrVal: 4.534 ± 0.101	0.503ThrTrp: 0.503 ± 0.024	2.591ThrTyr: 2.591 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	5.442ValAla: 5.442 ± 0.082	1.085ValCys: 1.085 ± 0.034	4.709ValAsp: 4.709 ± 0.067	5.002ValGlu: 5.002 ± 0.067	2.97ValPhe: 2.97 ± 0.059	4.507ValGly: 4.507 ± 0.072	0.939ValHis: 0.939 ± 0.031	5.207ValIle: 5.207 ± 0.081	4.682ValLys: 4.682 ± 0.076	5.854ValLeu: 5.854 ± 0.089	1.815ValMet: 1.815 ± 0.043	3.442ValAsn: 3.442 ± 0.063	2.315ValPro: 2.315 ± 0.041	1.607ValGln: 1.607 ± 0.038	2.35ValArg: 2.35 ± 0.05	4.669ValSer: 4.669 ± 0.063	4.265ValThr: 4.265 ± 0.095	5.323ValVal: 5.323 ± 0.087	0.54ValTrp: 0.54 ± 0.024	2.856ValTyr: 2.856 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.581TrpAla: 0.581 ± 0.025	0.154TrpCys: 0.154 ± 0.012	0.588TrpAsp: 0.588 ± 0.026	0.557TrpGlu: 0.557 ± 0.025	0.422TrpPhe: 0.422 ± 0.021	0.626TrpGly: 0.626 ± 0.025	0.182TrpHis: 0.182 ± 0.012	0.649TrpIle: 0.649 ± 0.028	0.536TrpLys: 0.536 ± 0.023	0.811TrpLeu: 0.811 ± 0.032	0.282TrpMet: 0.282 ± 0.016	0.537TrpAsn: 0.537 ± 0.024	0.226TrpPro: 0.226 ± 0.015	0.326TrpGln: 0.326 ± 0.017	0.27TrpArg: 0.27 ± 0.017	0.479TrpSer: 0.479 ± 0.025	0.436TrpThr: 0.436 ± 0.023	0.506TrpVal: 0.506 ± 0.023	0.107TrpTrp: 0.107 ± 0.013	0.448TrpTyr: 0.448 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.885TyrAla: 2.885 ± 0.06	0.607TyrCys: 0.607 ± 0.023	3.2TyrAsp: 3.2 ± 0.059	3.237TyrGlu: 3.237 ± 0.067	2.027TyrPhe: 2.027 ± 0.046	2.97TyrGly: 2.97 ± 0.051	0.778TyrHis: 0.778 ± 0.024	3.277TyrIle: 3.277 ± 0.058	2.991TyrLys: 2.991 ± 0.052	3.713TyrLeu: 3.713 ± 0.068	1.178TyrMet: 1.178 ± 0.034	2.39TyrAsn: 2.39 ± 0.056	1.386TyrPro: 1.386 ± 0.032	1.328TyrGln: 1.328 ± 0.039	1.735TyrArg: 1.735 ± 0.044	2.97TyrSer: 2.97 ± 0.06	2.689TyrThr: 2.689 ± 0.082	2.961TyrVal: 2.961 ± 0.045	0.395TyrTrp: 0.395 ± 0.021	2.318TyrTyr: 2.318 ± 0.066	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3127 proteins (1072131 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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