Amino acid dipepetide frequency for Propionibacteriaceae bacterium NML 030167

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.707AlaAla: 18.707 ± 0.203
0.903AlaCys: 0.903 ± 0.027
8.532AlaAsp: 8.532 ± 0.095
9.399AlaGlu: 9.399 ± 0.107
3.175AlaPhe: 3.175 ± 0.055
12.526AlaGly: 12.526 ± 0.112
2.168AlaHis: 2.168 ± 0.04
5.166AlaIle: 5.166 ± 0.071
2.594AlaLys: 2.594 ± 0.058
12.645AlaLeu: 12.645 ± 0.142
2.808AlaMet: 2.808 ± 0.047
2.48AlaAsn: 2.48 ± 0.054
6.093AlaPro: 6.093 ± 0.084
3.808AlaGln: 3.808 ± 0.055
8.867AlaArg: 8.867 ± 0.111
5.598AlaSer: 5.598 ± 0.068
7.152AlaThr: 7.152 ± 0.096
10.296AlaVal: 10.296 ± 0.102
1.789AlaTrp: 1.789 ± 0.034
2.782AlaTyr: 2.782 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.895CysAla: 0.895 ± 0.027
0.105CysCys: 0.105 ± 0.009
0.452CysAsp: 0.452 ± 0.019
0.345CysGlu: 0.345 ± 0.017
0.264CysPhe: 0.264 ± 0.017
0.899CysGly: 0.899 ± 0.031
0.161CysHis: 0.161 ± 0.011
0.253CysIle: 0.253 ± 0.013
0.087CysLys: 0.087 ± 0.007
0.692CysLeu: 0.692 ± 0.023
0.108CysMet: 0.108 ± 0.009
0.147CysAsn: 0.147 ± 0.01
0.46CysPro: 0.46 ± 0.021
0.186CysGln: 0.186 ± 0.012
0.54CysArg: 0.54 ± 0.019
0.427CysSer: 0.427 ± 0.02
0.497CysThr: 0.497 ± 0.025
0.555CysVal: 0.555 ± 0.023
0.154CysTrp: 0.154 ± 0.01
0.167CysTyr: 0.167 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.865AspAla: 6.865 ± 0.075
0.387AspCys: 0.387 ± 0.016
3.632AspAsp: 3.632 ± 0.067
4.113AspGlu: 4.113 ± 0.056
1.748AspPhe: 1.748 ± 0.042
5.44AspGly: 5.44 ± 0.074
1.331AspHis: 1.331 ± 0.034
1.866AspIle: 1.866 ± 0.042
1.192AspLys: 1.192 ± 0.032
6.395AspLeu: 6.395 ± 0.076
0.718AspMet: 0.718 ± 0.02
1.124AspAsn: 1.124 ± 0.032
4.964AspPro: 4.964 ± 0.067
2.385AspGln: 2.385 ± 0.045
5.353AspArg: 5.353 ± 0.071
2.685AspSer: 2.685 ± 0.051
2.935AspThr: 2.935 ± 0.045
3.897AspVal: 3.897 ± 0.054
1.156AspTrp: 1.156 ± 0.029
1.238AspTyr: 1.238 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
6.501GluAla: 6.501 ± 0.078
0.307GluCys: 0.307 ± 0.015
2.392GluAsp: 2.392 ± 0.043
2.914GluGlu: 2.914 ± 0.06
1.799GluPhe: 1.799 ± 0.042
3.722GluGly: 3.722 ± 0.057
1.415GluHis: 1.415 ± 0.032
2.515GluIle: 2.515 ± 0.045
1.332GluLys: 1.332 ± 0.031
7.862GluLeu: 7.862 ± 0.095
0.972GluMet: 0.972 ± 0.028
1.155GluAsn: 1.155 ± 0.032
3.319GluPro: 3.319 ± 0.053
3.019GluGln: 3.019 ± 0.046
5.177GluArg: 5.177 ± 0.073
2.697GluSer: 2.697 ± 0.046
2.867GluThr: 2.867 ± 0.047
5.336GluVal: 5.336 ± 0.066
0.768GluTrp: 0.768 ± 0.025
0.959GluTyr: 0.959 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
3.793PheAla: 3.793 ± 0.059
0.306PheCys: 0.306 ± 0.015
2.218PheAsp: 2.218 ± 0.043
1.438PheGlu: 1.438 ± 0.036
1.025PhePhe: 1.025 ± 0.031
3.345PheGly: 3.345 ± 0.052
0.555PheHis: 0.555 ± 0.019
1.004PheIle: 1.004 ± 0.03
0.526PheLys: 0.526 ± 0.024
2.766PheLeu: 2.766 ± 0.048
0.411PheMet: 0.411 ± 0.02
0.671PheAsn: 0.671 ± 0.022
1.364PhePro: 1.364 ± 0.029
0.745PheGln: 0.745 ± 0.027
1.724PheArg: 1.724 ± 0.037
1.556PheSer: 1.556 ± 0.037
2.07PheThr: 2.07 ± 0.038
2.406PheVal: 2.406 ± 0.043
0.542PheTrp: 0.542 ± 0.024
0.528PheTyr: 0.528 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
10.17GlyAla: 10.17 ± 0.118
0.87GlyCys: 0.87 ± 0.031
4.837GlyAsp: 4.837 ± 0.058
5.148GlyGlu: 5.148 ± 0.07
3.069GlyPhe: 3.069 ± 0.054
7.956GlyGly: 7.956 ± 0.104
1.835GlyHis: 1.835 ± 0.04
4.36GlyIle: 4.36 ± 0.067
2.182GlyLys: 2.182 ± 0.047
9.624GlyLeu: 9.624 ± 0.094
2.283GlyMet: 2.283 ± 0.038
1.942GlyAsn: 1.942 ± 0.044
4.613GlyPro: 4.613 ± 0.067
3.254GlyGln: 3.254 ± 0.078
7.016GlyArg: 7.016 ± 0.081
5.359GlySer: 5.359 ± 0.063
5.625GlyThr: 5.625 ± 0.08
7.886GlyVal: 7.886 ± 0.08
1.993GlyTrp: 1.993 ± 0.041
2.342GlyTyr: 2.342 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.004HisAla: 2.004 ± 0.044
0.175HisCys: 0.175 ± 0.011
1.215HisAsp: 1.215 ± 0.031
0.986HisGlu: 0.986 ± 0.027
0.569HisPhe: 0.569 ± 0.023
1.937HisGly: 1.937 ± 0.039
0.561HisHis: 0.561 ± 0.023
0.583HisIle: 0.583 ± 0.02
0.267HisLys: 0.267 ± 0.016
2.158HisLeu: 2.158 ± 0.041
0.257HisMet: 0.257 ± 0.013
0.375HisAsn: 0.375 ± 0.017
1.612HisPro: 1.612 ± 0.033
0.71HisGln: 0.71 ± 0.022
1.95HisArg: 1.95 ± 0.047
0.876HisSer: 0.876 ± 0.025
1.077HisThr: 1.077 ± 0.031
1.312HisVal: 1.312 ± 0.032
0.36HisTrp: 0.36 ± 0.016
0.441HisTyr: 0.441 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
5.844IleAla: 5.844 ± 0.078
0.424IleCys: 0.424 ± 0.018
3.012IleAsp: 3.012 ± 0.049
2.466IleGlu: 2.466 ± 0.047
1.152IlePhe: 1.152 ± 0.033
4.84IleGly: 4.84 ± 0.065
0.616IleHis: 0.616 ± 0.022
1.459IleIle: 1.459 ± 0.039
0.785IleLys: 0.785 ± 0.026
3.182IleLeu: 3.182 ± 0.054
0.577IleMet: 0.577 ± 0.021
0.986IleAsn: 0.986 ± 0.027
2.245IlePro: 2.245 ± 0.044
0.943IleGln: 0.943 ± 0.028
2.661IleArg: 2.661 ± 0.047
2.246IleSer: 2.246 ± 0.043
2.812IleThr: 2.812 ± 0.059
3.363IleVal: 3.363 ± 0.048
0.57IleTrp: 0.57 ± 0.021
0.735IleTyr: 0.735 ± 0.022
0.0IleXaa: 0.0 ± 0.0
Lys
2.407LysAla: 2.407 ± 0.056
0.095LysCys: 0.095 ± 0.009
1.104LysAsp: 1.104 ± 0.03
1.074LysGlu: 1.074 ± 0.031
0.523LysPhe: 0.523 ± 0.02
1.489LysGly: 1.489 ± 0.039
0.403LysHis: 0.403 ± 0.018
0.862LysIle: 0.862 ± 0.031
0.825LysLys: 0.825 ± 0.038
1.971LysLeu: 1.971 ± 0.041
0.411LysMet: 0.411 ± 0.018
0.536LysAsn: 0.536 ± 0.019
1.328LysPro: 1.328 ± 0.043
0.909LysGln: 0.909 ± 0.031
1.344LysArg: 1.344 ± 0.039
1.105LysSer: 1.105 ± 0.032
1.193LysThr: 1.193 ± 0.044
1.919LysVal: 1.919 ± 0.046
0.264LysTrp: 0.264 ± 0.015
0.456LysTyr: 0.456 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
15.411LeuAla: 15.411 ± 0.16
0.737LeuCys: 0.737 ± 0.025
6.445LeuAsp: 6.445 ± 0.092
4.867LeuGlu: 4.867 ± 0.069
2.722LeuPhe: 2.722 ± 0.053
10.084LeuGly: 10.084 ± 0.11
1.906LeuHis: 1.906 ± 0.038
4.51LeuIle: 4.51 ± 0.069
1.834LeuLys: 1.834 ± 0.038
11.503LeuLeu: 11.503 ± 0.154
1.802LeuMet: 1.802 ± 0.042
2.041LeuAsn: 2.041 ± 0.041
6.076LeuPro: 6.076 ± 0.074
2.986LeuGln: 2.986 ± 0.046
7.808LeuArg: 7.808 ± 0.085
5.42LeuSer: 5.42 ± 0.063
6.789LeuThr: 6.789 ± 0.071
9.412LeuVal: 9.412 ± 0.115
1.296LeuTrp: 1.296 ± 0.034
1.534LeuTyr: 1.534 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
2.394MetAla: 2.394 ± 0.041
0.125MetCys: 0.125 ± 0.008
0.842MetAsp: 0.842 ± 0.025
0.737MetGlu: 0.737 ± 0.024
0.582MetPhe: 0.582 ± 0.023
1.48MetGly: 1.48 ± 0.032
0.335MetHis: 0.335 ± 0.015
0.938MetIle: 0.938 ± 0.028
0.472MetLys: 0.472 ± 0.019
2.049MetLeu: 2.049 ± 0.042
0.4MetMet: 0.4 ± 0.017
0.494MetAsn: 0.494 ± 0.02
1.175MetPro: 1.175 ± 0.031
0.576MetGln: 0.576 ± 0.022
1.345MetArg: 1.345 ± 0.03
1.458MetSer: 1.458 ± 0.036
1.589MetThr: 1.589 ± 0.03
1.627MetVal: 1.627 ± 0.035
0.225MetTrp: 0.225 ± 0.012
0.311MetTyr: 0.311 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.404AsnAla: 2.404 ± 0.048
0.163AsnCys: 0.163 ± 0.013
1.166AsnAsp: 1.166 ± 0.033
1.031AsnGlu: 1.031 ± 0.027
0.635AsnPhe: 0.635 ± 0.023
1.987AsnGly: 1.987 ± 0.056
0.421AsnHis: 0.421 ± 0.02
0.701AsnIle: 0.701 ± 0.024
0.518AsnLys: 0.518 ± 0.021
2.105AsnLeu: 2.105 ± 0.039
0.346AsnMet: 0.346 ± 0.017
0.587AsnAsn: 0.587 ± 0.039
1.823AsnPro: 1.823 ± 0.043
0.795AsnGln: 0.795 ± 0.027
1.659AsnArg: 1.659 ± 0.039
1.102AsnSer: 1.102 ± 0.035
1.28AsnThr: 1.28 ± 0.043
1.486AsnVal: 1.486 ± 0.037
0.343AsnTrp: 0.343 ± 0.018
0.476AsnTyr: 0.476 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
7.739ProAla: 7.739 ± 0.092
0.269ProCys: 0.269 ± 0.015
4.241ProAsp: 4.241 ± 0.052
4.373ProGlu: 4.373 ± 0.066
1.489ProPhe: 1.489 ± 0.038
6.095ProGly: 6.095 ± 0.069
1.058ProHis: 1.058 ± 0.031
2.168ProIle: 2.168 ± 0.044
1.239ProLys: 1.239 ± 0.033
4.962ProLeu: 4.962 ± 0.073
1.125ProMet: 1.125 ± 0.026
1.21ProAsn: 1.21 ± 0.035
3.041ProPro: 3.041 ± 0.075
1.986ProGln: 1.986 ± 0.041
3.749ProArg: 3.749 ± 0.058
2.92ProSer: 2.92 ± 0.058
3.901ProThr: 3.901 ± 0.079
5.258ProVal: 5.258 ± 0.06
0.872ProTrp: 0.872 ± 0.027
1.037ProTyr: 1.037 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.339GlnAla: 4.339 ± 0.067
0.178GlnCys: 0.178 ± 0.011
1.267GlnAsp: 1.267 ± 0.031
1.315GlnGlu: 1.315 ± 0.034
0.856GlnPhe: 0.856 ± 0.025
2.574GlnGly: 2.574 ± 0.061
0.72GlnHis: 0.72 ± 0.022
1.465GlnIle: 1.465 ± 0.036
0.667GlnLys: 0.667 ± 0.026
4.229GlnLeu: 4.229 ± 0.059
0.566GlnMet: 0.566 ± 0.021
0.726GlnAsn: 0.726 ± 0.028
2.307GlnPro: 2.307 ± 0.045
2.133GlnGln: 2.133 ± 0.061
3.055GlnArg: 3.055 ± 0.059
1.47GlnSer: 1.47 ± 0.037
1.756GlnThr: 1.756 ± 0.042
3.379GlnVal: 3.379 ± 0.05
0.564GlnTrp: 0.564 ± 0.021
0.609GlnTyr: 0.609 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
8.736ArgAla: 8.736 ± 0.098
0.579ArgCys: 0.579 ± 0.021
4.173ArgAsp: 4.173 ± 0.058
4.331ArgGlu: 4.331 ± 0.07
2.412ArgPhe: 2.412 ± 0.045
5.791ArgGly: 5.791 ± 0.073
1.676ArgHis: 1.676 ± 0.039
3.666ArgIle: 3.666 ± 0.054
1.384ArgLys: 1.384 ± 0.038
8.305ArgLeu: 8.305 ± 0.103
1.895ArgMet: 1.895 ± 0.042
1.626ArgAsn: 1.626 ± 0.035
4.444ArgPro: 4.444 ± 0.07
2.57ArgGln: 2.57 ± 0.045
7.323ArgArg: 7.323 ± 0.102
4.212ArgSer: 4.212 ± 0.062
4.761ArgThr: 4.761 ± 0.056
5.992ArgVal: 5.992 ± 0.072
1.433ArgTrp: 1.433 ± 0.032
1.664ArgTyr: 1.664 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.251SerAla: 6.251 ± 0.079
0.404SerCys: 0.404 ± 0.022
2.912SerAsp: 2.912 ± 0.048
2.633SerGlu: 2.633 ± 0.045
1.649SerPhe: 1.649 ± 0.039
5.654SerGly: 5.654 ± 0.067
0.948SerHis: 0.948 ± 0.027
2.061SerIle: 2.061 ± 0.04
1.056SerLys: 1.056 ± 0.03
4.862SerLeu: 4.862 ± 0.061
1.292SerMet: 1.292 ± 0.029
1.125SerAsn: 1.125 ± 0.03
2.893SerPro: 2.893 ± 0.043
1.568SerGln: 1.568 ± 0.036
3.633SerArg: 3.633 ± 0.055
2.784SerSer: 2.784 ± 0.051
3.287SerThr: 3.287 ± 0.067
4.169SerVal: 4.169 ± 0.057
0.985SerTrp: 0.985 ± 0.026
1.146SerTyr: 1.146 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
7.678ThrAla: 7.678 ± 0.108
0.401ThrCys: 0.401 ± 0.022
3.978ThrAsp: 3.978 ± 0.061
3.755ThrGlu: 3.755 ± 0.049
1.657ThrPhe: 1.657 ± 0.035
6.35ThrGly: 6.35 ± 0.092
1.049ThrHis: 1.049 ± 0.03
2.521ThrIle: 2.521 ± 0.046
1.164ThrLys: 1.164 ± 0.044
5.666ThrLeu: 5.666 ± 0.071
1.157ThrMet: 1.157 ± 0.031
1.217ThrAsn: 1.217 ± 0.041
4.291ThrPro: 4.291 ± 0.066
1.593ThrGln: 1.593 ± 0.033
4.172ThrArg: 4.172 ± 0.063
3.126ThrSer: 3.126 ± 0.065
3.637ThrThr: 3.637 ± 0.086
5.346ThrVal: 5.346 ± 0.117
0.879ThrTrp: 0.879 ± 0.028
1.03ThrTyr: 1.03 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
10.652ValAla: 10.652 ± 0.093
0.666ValCys: 0.666 ± 0.022
5.09ValAsp: 5.09 ± 0.061
4.532ValGlu: 4.532 ± 0.063
2.425ValPhe: 2.425 ± 0.05
7.198ValGly: 7.198 ± 0.082
1.613ValHis: 1.613 ± 0.037
3.664ValIle: 3.664 ± 0.052
1.478ValLys: 1.478 ± 0.044
9.826ValLeu: 9.826 ± 0.119
1.51ValMet: 1.51 ± 0.03
1.786ValAsn: 1.786 ± 0.036
4.682ValPro: 4.682 ± 0.062
2.396ValGln: 2.396 ± 0.043
6.541ValArg: 6.541 ± 0.078
4.293ValSer: 4.293 ± 0.055
5.517ValThr: 5.517 ± 0.11
7.754ValVal: 7.754 ± 0.098
1.114ValTrp: 1.114 ± 0.028
1.272ValTyr: 1.272 ± 0.026
0.0ValXaa: 0.0 ± 0.0
Trp
1.643TrpAla: 1.643 ± 0.037
0.154TrpCys: 0.154 ± 0.009
0.753TrpAsp: 0.753 ± 0.023
0.673TrpGlu: 0.673 ± 0.026
0.582TrpPhe: 0.582 ± 0.02
1.167TrpGly: 1.167 ± 0.035
0.336TrpHis: 0.336 ± 0.017
0.654TrpIle: 0.654 ± 0.02
0.298TrpLys: 0.298 ± 0.016
2.139TrpLeu: 2.139 ± 0.048
0.294TrpMet: 0.294 ± 0.018
0.387TrpAsn: 0.387 ± 0.018
0.829TrpPro: 0.829 ± 0.022
0.819TrpGln: 0.819 ± 0.028
1.432TrpArg: 1.432 ± 0.032
1.017TrpSer: 1.017 ± 0.028
0.874TrpThr: 0.874 ± 0.025
1.245TrpVal: 1.245 ± 0.031
0.373TrpTrp: 0.373 ± 0.017
0.348TrpTyr: 0.348 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.058TyrAla: 3.058 ± 0.047
0.146TyrCys: 0.146 ± 0.01
1.165TyrAsp: 1.165 ± 0.034
0.899TyrGlu: 0.899 ± 0.026
0.664TyrPhe: 0.664 ± 0.025
1.831TyrGly: 1.831 ± 0.039
0.32TyrHis: 0.32 ± 0.017
0.502TyrIle: 0.502 ± 0.021
0.316TyrLys: 0.316 ± 0.015
2.241TyrLeu: 2.241 ± 0.042
0.221TyrMet: 0.221 ± 0.013
0.412TyrAsn: 0.412 ± 0.018
1.171TyrPro: 1.171 ± 0.033
0.792TyrGln: 0.792 ± 0.026
1.625TyrArg: 1.625 ± 0.037
0.962TyrSer: 0.962 ± 0.026
1.047TyrThr: 1.047 ± 0.03
1.369TyrVal: 1.369 ± 0.031
0.335TyrTrp: 0.335 ± 0.018
0.416TyrTyr: 0.416 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4158 proteins (1373801 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski