Amino acid dipepetide frequency for Streptococcus phage Javan485

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.397AlaAla: 5.397 ± 0.937
0.095AlaCys: 0.095 ± 0.099
4.545AlaAsp: 4.545 ± 0.567
5.965AlaGlu: 5.965 ± 0.69
2.651AlaPhe: 2.651 ± 0.522
4.072AlaGly: 4.072 ± 1.101
1.326AlaHis: 1.326 ± 0.384
7.291AlaIle: 7.291 ± 1.172
8.048AlaLys: 8.048 ± 0.908
6.249AlaLeu: 6.249 ± 0.581
1.894AlaMet: 1.894 ± 0.4
4.64AlaAsn: 4.64 ± 0.768
1.515AlaPro: 1.515 ± 0.326
2.557AlaGln: 2.557 ± 0.471
2.273AlaArg: 2.273 ± 0.388
4.734AlaSer: 4.734 ± 0.682
3.598AlaThr: 3.598 ± 0.703
4.829AlaVal: 4.829 ± 0.566
0.852AlaTrp: 0.852 ± 0.359
2.083AlaTyr: 2.083 ± 0.399
0.0AlaXaa: 0.0 ± 0.0
Cys
0.284CysAla: 0.284 ± 0.151
0.189CysCys: 0.189 ± 0.133
0.284CysAsp: 0.284 ± 0.152
0.758CysGlu: 0.758 ± 0.261
0.379CysPhe: 0.379 ± 0.168
0.568CysGly: 0.568 ± 0.261
0.189CysHis: 0.189 ± 0.125
0.0CysIle: 0.0 ± 0.0
0.095CysLys: 0.095 ± 0.093
1.042CysLeu: 1.042 ± 0.25
0.095CysMet: 0.095 ± 0.075
0.284CysAsn: 0.284 ± 0.146
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.473CysArg: 0.473 ± 0.237
0.379CysSer: 0.379 ± 0.166
0.284CysThr: 0.284 ± 0.152
0.379CysVal: 0.379 ± 0.235
0.095CysTrp: 0.095 ± 0.093
0.379CysTyr: 0.379 ± 0.203
0.0CysXaa: 0.0 ± 0.0
Asp
4.261AspAla: 4.261 ± 0.604
0.663AspCys: 0.663 ± 0.256
3.977AspAsp: 3.977 ± 0.686
5.492AspGlu: 5.492 ± 0.95
2.651AspPhe: 2.651 ± 0.454
4.924AspGly: 4.924 ± 0.813
0.663AspHis: 0.663 ± 0.203
4.734AspIle: 4.734 ± 0.523
4.829AspLys: 4.829 ± 0.821
6.249AspLeu: 6.249 ± 0.743
1.42AspMet: 1.42 ± 0.314
4.166AspAsn: 4.166 ± 0.532
1.799AspPro: 1.799 ± 0.425
1.136AspGln: 1.136 ± 0.312
1.799AspArg: 1.799 ± 0.3
4.356AspSer: 4.356 ± 0.802
3.882AspThr: 3.882 ± 0.765
4.261AspVal: 4.261 ± 0.561
0.758AspTrp: 0.758 ± 0.32
2.462AspTyr: 2.462 ± 0.429
0.0AspXaa: 0.0 ± 0.0
Glu
6.533GluAla: 6.533 ± 0.714
0.284GluCys: 0.284 ± 0.174
3.882GluAsp: 3.882 ± 0.607
5.492GluGlu: 5.492 ± 0.859
3.314GluPhe: 3.314 ± 0.605
2.273GluGly: 2.273 ± 0.439
1.515GluHis: 1.515 ± 0.385
5.113GluIle: 5.113 ± 0.646
5.776GluLys: 5.776 ± 0.744
7.954GluLeu: 7.954 ± 1.016
1.894GluMet: 1.894 ± 0.426
4.072GluAsn: 4.072 ± 0.68
2.273GluPro: 2.273 ± 0.476
2.935GluGln: 2.935 ± 0.637
2.462GluArg: 2.462 ± 0.549
3.693GluSer: 3.693 ± 0.565
4.734GluThr: 4.734 ± 0.635
3.693GluVal: 3.693 ± 0.749
1.136GluTrp: 1.136 ± 0.299
2.178GluTyr: 2.178 ± 0.47
0.0GluXaa: 0.0 ± 0.0
Phe
3.693PheAla: 3.693 ± 0.666
0.095PheCys: 0.095 ± 0.091
3.219PheAsp: 3.219 ± 0.543
4.45PheGlu: 4.45 ± 0.689
1.326PhePhe: 1.326 ± 0.302
2.651PheGly: 2.651 ± 0.43
0.663PheHis: 0.663 ± 0.291
1.988PheIle: 1.988 ± 0.384
2.935PheLys: 2.935 ± 0.542
2.557PheLeu: 2.557 ± 0.489
1.042PheMet: 1.042 ± 0.37
2.746PheAsn: 2.746 ± 0.481
0.663PhePro: 0.663 ± 0.303
0.758PheGln: 0.758 ± 0.255
1.704PheArg: 1.704 ± 0.346
2.935PheSer: 2.935 ± 0.697
2.273PheThr: 2.273 ± 0.464
2.557PheVal: 2.557 ± 0.434
0.568PheTrp: 0.568 ± 0.217
0.663PheTyr: 0.663 ± 0.203
0.0PheXaa: 0.0 ± 0.0
Gly
3.598GlyAla: 3.598 ± 0.921
0.379GlyCys: 0.379 ± 0.188
3.598GlyAsp: 3.598 ± 0.47
4.261GlyGlu: 4.261 ± 0.672
2.746GlyPhe: 2.746 ± 0.586
4.261GlyGly: 4.261 ± 0.631
1.231GlyHis: 1.231 ± 0.239
6.344GlyIle: 6.344 ± 0.84
5.303GlyLys: 5.303 ± 0.682
5.587GlyLeu: 5.587 ± 0.9
2.083GlyMet: 2.083 ± 0.475
3.219GlyAsn: 3.219 ± 0.467
1.042GlyPro: 1.042 ± 0.303
2.178GlyGln: 2.178 ± 0.481
1.704GlyArg: 1.704 ± 0.487
3.693GlySer: 3.693 ± 0.618
3.503GlyThr: 3.503 ± 0.552
3.977GlyVal: 3.977 ± 0.769
1.136GlyTrp: 1.136 ± 0.543
4.166GlyTyr: 4.166 ± 0.566
0.0GlyXaa: 0.0 ± 0.0
His
0.852HisAla: 0.852 ± 0.373
0.095HisCys: 0.095 ± 0.106
0.663HisAsp: 0.663 ± 0.243
1.515HisGlu: 1.515 ± 0.388
0.379HisPhe: 0.379 ± 0.156
0.947HisGly: 0.947 ± 0.263
0.0HisHis: 0.0 ± 0.0
1.042HisIle: 1.042 ± 0.283
1.136HisLys: 1.136 ± 0.334
1.61HisLeu: 1.61 ± 0.397
0.379HisMet: 0.379 ± 0.188
0.852HisAsn: 0.852 ± 0.298
0.758HisPro: 0.758 ± 0.253
0.663HisGln: 0.663 ± 0.24
1.136HisArg: 1.136 ± 0.287
0.758HisSer: 0.758 ± 0.228
0.852HisThr: 0.852 ± 0.283
0.852HisVal: 0.852 ± 0.226
0.284HisTrp: 0.284 ± 0.141
0.189HisTyr: 0.189 ± 0.127
0.0HisXaa: 0.0 ± 0.0
Ile
4.829IleAla: 4.829 ± 0.69
0.284IleCys: 0.284 ± 0.163
6.628IleAsp: 6.628 ± 0.926
5.113IleGlu: 5.113 ± 0.819
2.841IlePhe: 2.841 ± 0.506
4.166IleGly: 4.166 ± 1.071
0.568IleHis: 0.568 ± 0.192
4.356IleIle: 4.356 ± 0.514
7.764IleLys: 7.764 ± 0.711
5.965IleLeu: 5.965 ± 0.707
1.988IleMet: 1.988 ± 0.502
4.45IleAsn: 4.45 ± 0.62
1.988IlePro: 1.988 ± 0.541
2.462IleGln: 2.462 ± 0.418
2.083IleArg: 2.083 ± 0.381
5.397IleSer: 5.397 ± 1.22
4.261IleThr: 4.261 ± 0.753
4.45IleVal: 4.45 ± 0.747
0.379IleTrp: 0.379 ± 0.194
1.988IleTyr: 1.988 ± 0.445
0.0IleXaa: 0.0 ± 0.0
Lys
6.249LysAla: 6.249 ± 0.692
0.095LysCys: 0.095 ± 0.092
6.439LysAsp: 6.439 ± 0.896
5.492LysGlu: 5.492 ± 0.688
2.746LysPhe: 2.746 ± 0.423
5.303LysGly: 5.303 ± 0.694
1.42LysHis: 1.42 ± 0.332
5.587LysIle: 5.587 ± 0.871
9.09LysLys: 9.09 ± 1.184
6.533LysLeu: 6.533 ± 0.702
2.462LysMet: 2.462 ± 0.515
4.261LysAsn: 4.261 ± 0.578
3.03LysPro: 3.03 ± 0.595
4.072LysGln: 4.072 ± 0.59
3.977LysArg: 3.977 ± 0.607
6.344LysSer: 6.344 ± 0.672
5.397LysThr: 5.397 ± 0.73
6.628LysVal: 6.628 ± 0.877
0.852LysTrp: 0.852 ± 0.286
3.598LysTyr: 3.598 ± 0.518
0.0LysXaa: 0.0 ± 0.0
Leu
7.007LeuAla: 7.007 ± 0.902
0.284LeuCys: 0.284 ± 0.174
7.007LeuAsp: 7.007 ± 0.789
5.776LeuGlu: 5.776 ± 0.918
3.03LeuPhe: 3.03 ± 0.454
4.829LeuGly: 4.829 ± 0.749
1.136LeuHis: 1.136 ± 0.346
5.492LeuIle: 5.492 ± 0.733
9.563LeuLys: 9.563 ± 1.104
7.291LeuLeu: 7.291 ± 0.89
1.515LeuMet: 1.515 ± 0.373
5.303LeuAsn: 5.303 ± 0.585
2.462LeuPro: 2.462 ± 0.425
3.882LeuGln: 3.882 ± 0.598
3.598LeuArg: 3.598 ± 0.528
6.723LeuSer: 6.723 ± 1.023
4.45LeuThr: 4.45 ± 0.616
4.924LeuVal: 4.924 ± 0.734
0.663LeuTrp: 0.663 ± 0.257
1.894LeuTyr: 1.894 ± 0.325
0.0LeuXaa: 0.0 ± 0.0
Met
2.746MetAla: 2.746 ± 0.708
0.189MetCys: 0.189 ± 0.118
1.515MetAsp: 1.515 ± 0.386
1.136MetGlu: 1.136 ± 0.355
0.473MetPhe: 0.473 ± 0.189
2.083MetGly: 2.083 ± 0.644
0.189MetHis: 0.189 ± 0.119
1.61MetIle: 1.61 ± 0.36
1.042MetLys: 1.042 ± 0.277
1.988MetLeu: 1.988 ± 0.38
0.379MetMet: 0.379 ± 0.204
1.326MetAsn: 1.326 ± 0.378
0.947MetPro: 0.947 ± 0.291
1.42MetGln: 1.42 ± 0.318
0.758MetArg: 0.758 ± 0.301
1.894MetSer: 1.894 ± 0.393
2.557MetThr: 2.557 ± 0.431
1.231MetVal: 1.231 ± 0.338
0.473MetTrp: 0.473 ± 0.172
0.663MetTyr: 0.663 ± 0.291
0.0MetXaa: 0.0 ± 0.0
Asn
4.072AsnAla: 4.072 ± 0.795
0.473AsnCys: 0.473 ± 0.165
2.178AsnAsp: 2.178 ± 0.423
3.125AsnGlu: 3.125 ± 0.477
2.367AsnPhe: 2.367 ± 0.444
4.45AsnGly: 4.45 ± 0.701
0.758AsnHis: 0.758 ± 0.267
4.166AsnIle: 4.166 ± 0.558
4.734AsnLys: 4.734 ± 0.822
5.018AsnLeu: 5.018 ± 0.646
1.42AsnMet: 1.42 ± 0.303
1.799AsnAsn: 1.799 ± 0.47
2.462AsnPro: 2.462 ± 0.507
3.219AsnGln: 3.219 ± 0.653
2.367AsnArg: 2.367 ± 0.468
3.125AsnSer: 3.125 ± 0.583
2.841AsnThr: 2.841 ± 0.448
3.314AsnVal: 3.314 ± 0.562
0.473AsnTrp: 0.473 ± 0.233
2.462AsnTyr: 2.462 ± 0.526
0.0AsnXaa: 0.0 ± 0.0
Pro
1.894ProAla: 1.894 ± 0.412
0.284ProCys: 0.284 ± 0.17
2.273ProAsp: 2.273 ± 0.535
1.326ProGlu: 1.326 ± 0.348
1.231ProPhe: 1.231 ± 0.354
1.136ProGly: 1.136 ± 0.343
0.379ProHis: 0.379 ± 0.195
2.273ProIle: 2.273 ± 0.47
3.788ProLys: 3.788 ± 0.556
2.273ProLeu: 2.273 ± 0.446
0.663ProMet: 0.663 ± 0.184
1.326ProAsn: 1.326 ± 0.399
0.568ProPro: 0.568 ± 0.201
1.326ProGln: 1.326 ± 0.383
0.852ProArg: 0.852 ± 0.229
2.462ProSer: 2.462 ± 0.418
1.515ProThr: 1.515 ± 0.394
1.326ProVal: 1.326 ± 0.4
0.189ProTrp: 0.189 ± 0.114
0.852ProTyr: 0.852 ± 0.326
0.0ProXaa: 0.0 ± 0.0
Gln
2.273GlnAla: 2.273 ± 0.455
0.473GlnCys: 0.473 ± 0.245
1.988GlnAsp: 1.988 ± 0.415
2.841GlnGlu: 2.841 ± 0.655
1.704GlnPhe: 1.704 ± 0.427
2.367GlnGly: 2.367 ± 0.392
0.568GlnHis: 0.568 ± 0.226
2.935GlnIle: 2.935 ± 0.662
2.935GlnLys: 2.935 ± 0.532
3.788GlnLeu: 3.788 ± 0.528
0.758GlnMet: 0.758 ± 0.285
2.841GlnAsn: 2.841 ± 0.587
0.947GlnPro: 0.947 ± 0.316
1.136GlnGln: 1.136 ± 0.37
1.894GlnArg: 1.894 ± 0.447
2.462GlnSer: 2.462 ± 0.52
2.178GlnThr: 2.178 ± 0.807
2.083GlnVal: 2.083 ± 0.451
0.852GlnTrp: 0.852 ± 0.314
1.042GlnTyr: 1.042 ± 0.337
0.0GlnXaa: 0.0 ± 0.0
Arg
2.651ArgAla: 2.651 ± 0.69
0.473ArgCys: 0.473 ± 0.251
1.799ArgAsp: 1.799 ± 0.484
2.935ArgGlu: 2.935 ± 0.602
1.326ArgPhe: 1.326 ± 0.353
1.894ArgGly: 1.894 ± 0.437
0.663ArgHis: 0.663 ± 0.295
2.746ArgIle: 2.746 ± 0.431
2.746ArgLys: 2.746 ± 0.545
4.072ArgLeu: 4.072 ± 0.626
1.231ArgMet: 1.231 ± 0.355
2.367ArgAsn: 2.367 ± 0.459
1.326ArgPro: 1.326 ± 0.291
1.42ArgGln: 1.42 ± 0.404
1.42ArgArg: 1.42 ± 0.342
1.515ArgSer: 1.515 ± 0.441
2.367ArgThr: 2.367 ± 0.481
2.083ArgVal: 2.083 ± 0.349
0.379ArgTrp: 0.379 ± 0.179
1.704ArgTyr: 1.704 ± 0.426
0.0ArgXaa: 0.0 ± 0.0
Ser
4.924SerAla: 4.924 ± 1.509
0.852SerCys: 0.852 ± 0.253
4.45SerAsp: 4.45 ± 0.587
4.166SerGlu: 4.166 ± 0.61
3.693SerPhe: 3.693 ± 0.653
5.871SerGly: 5.871 ± 0.818
0.568SerHis: 0.568 ± 0.21
3.977SerIle: 3.977 ± 0.529
5.587SerLys: 5.587 ± 0.777
5.965SerLeu: 5.965 ± 0.929
1.326SerMet: 1.326 ± 0.274
3.693SerAsn: 3.693 ± 0.601
1.136SerPro: 1.136 ± 0.287
2.651SerGln: 2.651 ± 0.595
2.462SerArg: 2.462 ± 0.703
4.545SerSer: 4.545 ± 0.878
4.356SerThr: 4.356 ± 0.531
3.693SerVal: 3.693 ± 0.44
0.663SerTrp: 0.663 ± 0.265
2.273SerTyr: 2.273 ± 0.395
0.0SerXaa: 0.0 ± 0.0
Thr
5.871ThrAla: 5.871 ± 0.744
0.189ThrCys: 0.189 ± 0.124
3.409ThrAsp: 3.409 ± 0.744
3.882ThrGlu: 3.882 ± 0.598
2.178ThrPhe: 2.178 ± 0.366
5.303ThrGly: 5.303 ± 0.775
1.136ThrHis: 1.136 ± 0.308
5.018ThrIle: 5.018 ± 0.629
5.018ThrLys: 5.018 ± 0.641
4.924ThrLeu: 4.924 ± 0.651
1.42ThrMet: 1.42 ± 0.303
2.367ThrAsn: 2.367 ± 0.353
1.515ThrPro: 1.515 ± 0.356
2.273ThrGln: 2.273 ± 0.465
1.799ThrArg: 1.799 ± 0.406
4.356ThrSer: 4.356 ± 0.619
3.693ThrThr: 3.693 ± 0.564
3.598ThrVal: 3.598 ± 0.585
0.758ThrTrp: 0.758 ± 0.308
1.988ThrTyr: 1.988 ± 0.365
0.0ThrXaa: 0.0 ± 0.0
Val
3.598ValAla: 3.598 ± 0.668
0.379ValCys: 0.379 ± 0.169
3.977ValAsp: 3.977 ± 0.585
5.018ValGlu: 5.018 ± 0.637
1.988ValPhe: 1.988 ± 0.416
3.977ValGly: 3.977 ± 0.568
1.042ValHis: 1.042 ± 0.3
4.356ValIle: 4.356 ± 0.633
4.356ValLys: 4.356 ± 0.625
4.64ValLeu: 4.64 ± 0.66
1.704ValMet: 1.704 ± 0.376
3.314ValAsn: 3.314 ± 0.472
1.988ValPro: 1.988 ± 0.455
2.083ValGln: 2.083 ± 0.452
1.799ValArg: 1.799 ± 0.473
5.018ValSer: 5.018 ± 0.526
5.587ValThr: 5.587 ± 0.741
4.829ValVal: 4.829 ± 0.648
0.189ValTrp: 0.189 ± 0.145
1.42ValTyr: 1.42 ± 0.303
0.0ValXaa: 0.0 ± 0.0
Trp
0.852TrpAla: 0.852 ± 0.325
0.095TrpCys: 0.095 ± 0.096
0.284TrpAsp: 0.284 ± 0.173
0.758TrpGlu: 0.758 ± 0.285
0.379TrpPhe: 0.379 ± 0.22
1.231TrpGly: 1.231 ± 0.425
0.284TrpHis: 0.284 ± 0.207
0.947TrpIle: 0.947 ± 0.314
1.042TrpLys: 1.042 ± 0.337
0.568TrpLeu: 0.568 ± 0.325
0.189TrpMet: 0.189 ± 0.12
0.473TrpAsn: 0.473 ± 0.21
0.284TrpPro: 0.284 ± 0.139
0.568TrpGln: 0.568 ± 0.219
0.852TrpArg: 0.852 ± 0.335
0.947TrpSer: 0.947 ± 0.267
0.758TrpThr: 0.758 ± 0.327
0.189TrpVal: 0.189 ± 0.116
0.095TrpTrp: 0.095 ± 0.086
0.473TrpTyr: 0.473 ± 0.187
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.03TyrAla: 3.03 ± 0.541
0.284TyrCys: 0.284 ± 0.162
2.462TyrAsp: 2.462 ± 0.475
1.704TyrGlu: 1.704 ± 0.418
2.083TyrPhe: 2.083 ± 0.472
1.704TyrGly: 1.704 ± 0.337
0.663TyrHis: 0.663 ± 0.244
1.988TyrIle: 1.988 ± 0.372
3.788TyrLys: 3.788 ± 0.589
2.557TyrLeu: 2.557 ± 0.486
0.663TyrMet: 0.663 ± 0.265
1.326TyrAsn: 1.326 ± 0.309
1.231TyrPro: 1.231 ± 0.282
1.326TyrGln: 1.326 ± 0.413
1.704TyrArg: 1.704 ± 0.512
1.515TyrSer: 1.515 ± 0.469
1.61TyrThr: 1.61 ± 0.352
2.367TyrVal: 2.367 ± 0.451
0.473TyrTrp: 0.473 ± 0.203
1.61TyrTyr: 1.61 ± 0.351
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (10562 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski