Amino acid dipepetide frequency for Actinophytocola sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.325AlaAla: 19.325 ± 0.204	1.1AlaCys: 1.1 ± 0.029	8.775AlaAsp: 8.775 ± 0.091	9.623AlaGlu: 9.623 ± 0.091	3.257AlaPhe: 3.257 ± 0.048	12.359AlaGly: 12.359 ± 0.124	2.534AlaHis: 2.534 ± 0.039	4.743AlaIle: 4.743 ± 0.059	2.978AlaLys: 2.978 ± 0.052	13.193AlaLeu: 13.193 ± 0.114	2.753AlaMet: 2.753 ± 0.05	2.33AlaAsn: 2.33 ± 0.039	5.734AlaPro: 5.734 ± 0.071	3.334AlaGln: 3.334 ± 0.049	9.727AlaArg: 9.727 ± 0.106	6.097AlaSer: 6.097 ± 0.068	7.536AlaThr: 7.536 ± 0.075	11.434AlaVal: 11.434 ± 0.105	1.677AlaTrp: 1.677 ± 0.039	2.27AlaTyr: 2.27 ± 0.045	0.001AlaXaa: 0.001 ± 0.001
Cys	1.091CysAla: 1.091 ± 0.028	0.121CysCys: 0.121 ± 0.01	0.562CysAsp: 0.562 ± 0.021	0.478CysGlu: 0.478 ± 0.019	0.23CysPhe: 0.23 ± 0.012	0.983CysGly: 0.983 ± 0.03	0.218CysHis: 0.218 ± 0.013	0.207CysIle: 0.207 ± 0.013	0.124CysLys: 0.124 ± 0.01	0.72CysLeu: 0.72 ± 0.023	0.121CysMet: 0.121 ± 0.009	0.125CysAsn: 0.125 ± 0.01	0.544CysPro: 0.544 ± 0.022	0.207CysGln: 0.207 ± 0.012	0.603CysArg: 0.603 ± 0.024	0.461CysSer: 0.461 ± 0.018	0.467CysThr: 0.467 ± 0.016	0.705CysVal: 0.705 ± 0.024	0.123CysTrp: 0.123 ± 0.01	0.201CysTyr: 0.201 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.611AspAla: 8.611 ± 0.089	0.417AspCys: 0.417 ± 0.021	4.427AspAsp: 4.427 ± 0.065	4.498AspGlu: 4.498 ± 0.062	1.596AspPhe: 1.596 ± 0.039	6.307AspGly: 6.307 ± 0.076	1.394AspHis: 1.394 ± 0.033	2.355AspIle: 2.355 ± 0.046	1.24AspLys: 1.24 ± 0.032	5.951AspLeu: 5.951 ± 0.078	0.939AspMet: 0.939 ± 0.029	1.096AspAsn: 1.096 ± 0.03	4.201AspPro: 4.201 ± 0.058	1.575AspGln: 1.575 ± 0.031	4.692AspArg: 4.692 ± 0.06	2.511AspSer: 2.511 ± 0.039	3.525AspThr: 3.525 ± 0.047	6.362AspVal: 6.362 ± 0.077	0.932AspTrp: 0.932 ± 0.027	1.334AspTyr: 1.334 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.419GluAla: 6.419 ± 0.072	0.404GluCys: 0.404 ± 0.017	2.755GluAsp: 2.755 ± 0.049	2.862GluGlu: 2.862 ± 0.058	1.732GluPhe: 1.732 ± 0.036	3.599GluGly: 3.599 ± 0.062	1.942GluHis: 1.942 ± 0.041	2.559GluIle: 2.559 ± 0.044	1.265GluLys: 1.265 ± 0.035	7.788GluLeu: 7.788 ± 0.096	1.014GluMet: 1.014 ± 0.029	1.043GluAsn: 1.043 ± 0.027	3.694GluPro: 3.694 ± 0.054	2.723GluGln: 2.723 ± 0.052	5.991GluArg: 5.991 ± 0.073	2.752GluSer: 2.752 ± 0.048	2.95GluThr: 2.95 ± 0.046	4.986GluVal: 4.986 ± 0.066	0.824GluTrp: 0.824 ± 0.026	1.139GluTyr: 1.139 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.905PheAla: 3.905 ± 0.057	0.315PheCys: 0.315 ± 0.014	2.182PheAsp: 2.182 ± 0.037	1.519PheGlu: 1.519 ± 0.034	0.872PhePhe: 0.872 ± 0.027	3.3PheGly: 3.3 ± 0.051	0.641PheHis: 0.641 ± 0.023	0.828PheIle: 0.828 ± 0.025	0.411PheLys: 0.411 ± 0.017	2.535PheLeu: 2.535 ± 0.044	0.363PheMet: 0.363 ± 0.017	0.566PheAsn: 0.566 ± 0.022	1.265PhePro: 1.265 ± 0.034	0.644PheGln: 0.644 ± 0.023	1.698PheArg: 1.698 ± 0.033	1.454PheSer: 1.454 ± 0.037	1.873PheThr: 1.873 ± 0.039	2.338PheVal: 2.338 ± 0.041	0.375PheTrp: 0.375 ± 0.017	0.611PheTyr: 0.611 ± 0.024	0.001PheXaa: 0.001 ± 0.001
Gly	10.004GlyAla: 10.004 ± 0.095	0.914GlyCys: 0.914 ± 0.028	5.249GlyAsp: 5.249 ± 0.064	5.551GlyGlu: 5.551 ± 0.065	2.98GlyPhe: 2.98 ± 0.05	8.159GlyGly: 8.159 ± 0.106	2.133GlyHis: 2.133 ± 0.04	3.896GlyIle: 3.896 ± 0.066	2.652GlyLys: 2.652 ± 0.051	8.867GlyLeu: 8.867 ± 0.085	2.232GlyMet: 2.232 ± 0.041	1.768GlyAsn: 1.768 ± 0.039	4.192GlyPro: 4.192 ± 0.058	2.706GlyGln: 2.706 ± 0.05	6.49GlyArg: 6.49 ± 0.075	5.013GlySer: 5.013 ± 0.065	5.722GlyThr: 5.722 ± 0.083	8.159GlyVal: 8.159 ± 0.078	1.717GlyTrp: 1.717 ± 0.043	2.399GlyTyr: 2.399 ± 0.04	0.001GlyXaa: 0.001 ± 0.001
His	2.822HisAla: 2.822 ± 0.045	0.233HisCys: 0.233 ± 0.013	1.553HisAsp: 1.553 ± 0.033	1.242HisGlu: 1.242 ± 0.027	0.609HisPhe: 0.609 ± 0.02	2.435HisGly: 2.435 ± 0.051	0.729HisHis: 0.729 ± 0.023	0.775HisIle: 0.775 ± 0.025	0.404HisLys: 0.404 ± 0.015	2.144HisLeu: 2.144 ± 0.036	0.335HisMet: 0.335 ± 0.015	0.472HisAsn: 0.472 ± 0.021	1.68HisPro: 1.68 ± 0.035	0.666HisGln: 0.666 ± 0.021	2.041HisArg: 2.041 ± 0.04	0.974HisSer: 0.974 ± 0.025	1.26HisThr: 1.26 ± 0.03	1.876HisVal: 1.876 ± 0.036	0.352HisTrp: 0.352 ± 0.018	0.56HisTyr: 0.56 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.879IleAla: 5.879 ± 0.075	0.299IleCys: 0.299 ± 0.013	3.095IleAsp: 3.095 ± 0.051	2.57IleGlu: 2.57 ± 0.047	0.806IlePhe: 0.806 ± 0.029	4.34IleGly: 4.34 ± 0.069	0.663IleHis: 0.663 ± 0.023	1.162IleIle: 1.162 ± 0.034	0.849IleLys: 0.849 ± 0.029	2.369IleLeu: 2.369 ± 0.048	0.56IleMet: 0.56 ± 0.021	0.9IleAsn: 0.9 ± 0.028	1.899IlePro: 1.899 ± 0.038	0.751IleGln: 0.751 ± 0.026	2.341IleArg: 2.341 ± 0.046	2.016IleSer: 2.016 ± 0.042	2.564IleThr: 2.564 ± 0.041	3.383IleVal: 3.383 ± 0.055	0.385IleTrp: 0.385 ± 0.017	0.657IleTyr: 0.657 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.629LysAla: 2.629 ± 0.05	0.112LysCys: 0.112 ± 0.009	1.115LysAsp: 1.115 ± 0.035	1.015LysGlu: 1.015 ± 0.033	0.479LysPhe: 0.479 ± 0.019	1.552LysGly: 1.552 ± 0.041	0.536LysHis: 0.536 ± 0.02	0.992LysIle: 0.992 ± 0.029	0.592LysLys: 0.592 ± 0.027	2.244LysLeu: 2.244 ± 0.054	0.378LysMet: 0.378 ± 0.017	0.421LysAsn: 0.421 ± 0.02	1.47LysPro: 1.47 ± 0.036	0.842LysGln: 0.842 ± 0.026	1.769LysArg: 1.769 ± 0.04	1.095LysSer: 1.095 ± 0.034	1.272LysThr: 1.272 ± 0.029	1.867LysVal: 1.867 ± 0.04	0.232LysTrp: 0.232 ± 0.013	0.435LysTyr: 0.435 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.714LeuAla: 15.714 ± 0.128	0.828LeuCys: 0.828 ± 0.027	7.148LeuAsp: 7.148 ± 0.081	4.298LeuGlu: 4.298 ± 0.061	2.603LeuPhe: 2.603 ± 0.05	9.187LeuGly: 9.187 ± 0.091	2.27LeuHis: 2.27 ± 0.048	3.507LeuIle: 3.507 ± 0.06	1.585LeuLys: 1.585 ± 0.038	10.892LeuLeu: 10.892 ± 0.122	1.448LeuMet: 1.448 ± 0.032	1.698LeuAsn: 1.698 ± 0.038	6.08LeuPro: 6.08 ± 0.081	1.836LeuGln: 1.836 ± 0.043	9.25LeuArg: 9.25 ± 0.11	5.384LeuSer: 5.384 ± 0.065	6.49LeuThr: 6.49 ± 0.07	8.681LeuVal: 8.681 ± 0.084	1.144LeuTrp: 1.144 ± 0.032	1.726LeuTyr: 1.726 ± 0.039	0.001LeuXaa: 0.001 ± 0.001
Met	2.461MetAla: 2.461 ± 0.047	0.15MetCys: 0.15 ± 0.008	0.869MetAsp: 0.869 ± 0.026	0.67MetGlu: 0.67 ± 0.022	0.521MetPhe: 0.521 ± 0.019	1.252MetGly: 1.252 ± 0.039	0.373MetHis: 0.373 ± 0.017	0.812MetIle: 0.812 ± 0.027	0.362MetLys: 0.362 ± 0.015	1.985MetLeu: 1.985 ± 0.037	0.329MetMet: 0.329 ± 0.018	0.387MetAsn: 0.387 ± 0.016	1.252MetPro: 1.252 ± 0.029	0.464MetGln: 0.464 ± 0.018	1.692MetArg: 1.692 ± 0.037	1.378MetSer: 1.378 ± 0.034	1.743MetThr: 1.743 ± 0.035	1.417MetVal: 1.417 ± 0.034	0.213MetTrp: 0.213 ± 0.013	0.286MetTyr: 0.286 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.341AsnAla: 2.341 ± 0.044	0.172AsnCys: 0.172 ± 0.013	1.126AsnAsp: 1.126 ± 0.03	0.948AsnGlu: 0.948 ± 0.028	0.484AsnPhe: 0.484 ± 0.019	1.897AsnGly: 1.897 ± 0.042	0.468AsnHis: 0.468 ± 0.018	0.721AsnIle: 0.721 ± 0.023	0.395AsnLys: 0.395 ± 0.017	1.807AsnLeu: 1.807 ± 0.043	0.305AsnMet: 0.305 ± 0.014	0.432AsnAsn: 0.432 ± 0.02	1.479AsnPro: 1.479 ± 0.036	0.579AsnGln: 0.579 ± 0.021	1.352AsnArg: 1.352 ± 0.035	0.889AsnSer: 0.889 ± 0.024	1.141AsnThr: 1.141 ± 0.034	1.581AsnVal: 1.581 ± 0.032	0.284AsnTrp: 0.284 ± 0.017	0.441AsnTyr: 0.441 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.178ProAla: 7.178 ± 0.079	0.332ProCys: 0.332 ± 0.016	4.487ProAsp: 4.487 ± 0.063	4.153ProGlu: 4.153 ± 0.048	1.55ProPhe: 1.55 ± 0.034	5.712ProGly: 5.712 ± 0.071	1.277ProHis: 1.277 ± 0.031	1.872ProIle: 1.872 ± 0.036	1.226ProLys: 1.226 ± 0.034	4.85ProLeu: 4.85 ± 0.067	1.136ProMet: 1.136 ± 0.029	1.037ProAsn: 1.037 ± 0.032	3.36ProPro: 3.36 ± 0.079	1.553ProGln: 1.553 ± 0.037	3.648ProArg: 3.648 ± 0.051	3.043ProSer: 3.043 ± 0.054	3.076ProThr: 3.076 ± 0.054	5.003ProVal: 5.003 ± 0.065	0.833ProTrp: 0.833 ± 0.024	1.149ProTyr: 1.149 ± 0.03	0.001ProXaa: 0.001 ± 0.001
Gln	3.539GlnAla: 3.539 ± 0.058	0.185GlnCys: 0.185 ± 0.012	1.244GlnAsp: 1.244 ± 0.033	1.232GlnGlu: 1.232 ± 0.039	0.692GlnPhe: 0.692 ± 0.024	2.024GlnGly: 2.024 ± 0.043	0.763GlnHis: 0.763 ± 0.024	1.119GlnIle: 1.119 ± 0.03	0.447GlnLys: 0.447 ± 0.023	3.517GlnLeu: 3.517 ± 0.051	0.449GlnMet: 0.449 ± 0.019	0.489GlnAsn: 0.489 ± 0.019	1.915GlnPro: 1.915 ± 0.047	1.446GlnGln: 1.446 ± 0.043	3.122GlnArg: 3.122 ± 0.052	1.249GlnSer: 1.249 ± 0.03	1.275GlnThr: 1.275 ± 0.032	2.498GlnVal: 2.498 ± 0.044	0.407GlnTrp: 0.407 ± 0.017	0.571GlnTyr: 0.571 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.366ArgAla: 9.366 ± 0.099	0.689ArgCys: 0.689 ± 0.023	4.689ArgAsp: 4.689 ± 0.056	4.752ArgGlu: 4.752 ± 0.066	2.417ArgPhe: 2.417 ± 0.047	5.679ArgGly: 5.679 ± 0.069	2.094ArgHis: 2.094 ± 0.045	3.334ArgIle: 3.334 ± 0.049	1.984ArgLys: 1.984 ± 0.043	8.47ArgLeu: 8.47 ± 0.094	1.882ArgMet: 1.882 ± 0.03	1.537ArgAsn: 1.537 ± 0.035	4.371ArgPro: 4.371 ± 0.06	2.644ArgGln: 2.644 ± 0.049	7.583ArgArg: 7.583 ± 0.103	4.183ArgSer: 4.183 ± 0.061	4.574ArgThr: 4.574 ± 0.059	6.144ArgVal: 6.144 ± 0.073	1.428ArgTrp: 1.428 ± 0.033	1.982ArgTyr: 1.982 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.28SerAla: 6.28 ± 0.071	0.461SerCys: 0.461 ± 0.021	3.081SerAsp: 3.081 ± 0.054	2.773SerGlu: 2.773 ± 0.054	1.597SerPhe: 1.597 ± 0.037	5.735SerGly: 5.735 ± 0.059	1.106SerHis: 1.106 ± 0.027	1.744SerIle: 1.744 ± 0.039	1.069SerLys: 1.069 ± 0.03	4.782SerLeu: 4.782 ± 0.059	1.254SerMet: 1.254 ± 0.03	0.983SerAsn: 0.983 ± 0.029	2.786SerPro: 2.786 ± 0.049	1.402SerGln: 1.402 ± 0.035	3.837SerArg: 3.837 ± 0.05	2.731SerSer: 2.731 ± 0.053	3.1SerThr: 3.1 ± 0.056	4.258SerVal: 4.258 ± 0.058	0.917SerTrp: 0.917 ± 0.026	1.292SerTyr: 1.292 ± 0.031	0.001SerXaa: 0.001 ± 0.001
Thr	7.738ThrAla: 7.738 ± 0.084	0.423ThrCys: 0.423 ± 0.017	3.683ThrAsp: 3.683 ± 0.052	3.728ThrGlu: 3.728 ± 0.058	1.674ThrPhe: 1.674 ± 0.039	6.439ThrGly: 6.439 ± 0.074	1.169ThrHis: 1.169 ± 0.028	2.156ThrIle: 2.156 ± 0.046	1.278ThrLys: 1.278 ± 0.032	5.777ThrLeu: 5.777 ± 0.057	1.152ThrMet: 1.152 ± 0.031	1.038ThrAsn: 1.038 ± 0.033	3.677ThrPro: 3.677 ± 0.051	1.437ThrGln: 1.437 ± 0.03	3.735ThrArg: 3.735 ± 0.06	3.416ThrSer: 3.416 ± 0.052	4.125ThrThr: 4.125 ± 0.079	5.881ThrVal: 5.881 ± 0.072	0.834ThrTrp: 0.834 ± 0.026	1.157ThrTyr: 1.157 ± 0.034	0.001ThrXaa: 0.001 ± 0.001
Val	11.589ValAla: 11.589 ± 0.116	0.765ValCys: 0.765 ± 0.023	5.755ValAsp: 5.755 ± 0.077	4.781ValGlu: 4.781 ± 0.066	2.438ValPhe: 2.438 ± 0.048	6.855ValGly: 6.855 ± 0.076	1.96ValHis: 1.96 ± 0.037	3.62ValIle: 3.62 ± 0.064	1.628ValLys: 1.628 ± 0.043	9.668ValLeu: 9.668 ± 0.1	1.498ValMet: 1.498 ± 0.036	1.797ValAsn: 1.797 ± 0.039	4.927ValPro: 4.927 ± 0.065	1.914ValGln: 1.914 ± 0.039	6.898ValArg: 6.898 ± 0.066	4.738ValSer: 4.738 ± 0.054	5.862ValThr: 5.862 ± 0.07	8.742ValVal: 8.742 ± 0.096	1.052ValTrp: 1.052 ± 0.028	1.511ValTyr: 1.511 ± 0.035	0.001ValXaa: 0.001 ± 0.001
Trp	1.424TrpAla: 1.424 ± 0.031	0.167TrpCys: 0.167 ± 0.013	0.703TrpAsp: 0.703 ± 0.022	0.614TrpGlu: 0.614 ± 0.024	0.529TrpPhe: 0.529 ± 0.021	0.923TrpGly: 0.923 ± 0.026	0.417TrpHis: 0.417 ± 0.019	0.516TrpIle: 0.516 ± 0.019	0.239TrpLys: 0.239 ± 0.013	1.932TrpLeu: 1.932 ± 0.04	0.252TrpMet: 0.252 ± 0.013	0.302TrpAsn: 0.302 ± 0.015	0.81TrpPro: 0.81 ± 0.025	0.752TrpGln: 0.752 ± 0.023	1.44TrpArg: 1.44 ± 0.039	0.838TrpSer: 0.838 ± 0.025	0.858TrpThr: 0.858 ± 0.028	1.062TrpVal: 1.062 ± 0.032	0.341TrpTrp: 0.341 ± 0.019	0.287TrpTyr: 0.287 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.461TyrAla: 2.461 ± 0.044	0.203TyrCys: 0.203 ± 0.013	1.465TyrAsp: 1.465 ± 0.038	1.134TyrGlu: 1.134 ± 0.034	0.632TyrPhe: 0.632 ± 0.022	2.068TyrGly: 2.068 ± 0.044	0.472TyrHis: 0.472 ± 0.021	0.569TyrIle: 0.569 ± 0.022	0.319TyrLys: 0.319 ± 0.015	2.278TyrLeu: 2.278 ± 0.04	0.215TyrMet: 0.215 ± 0.013	0.421TyrAsn: 0.421 ± 0.016	1.14TyrPro: 1.14 ± 0.031	0.709TyrGln: 0.709 ± 0.025	1.89TyrArg: 1.89 ± 0.042	0.969TyrSer: 0.969 ± 0.028	1.102TyrThr: 1.102 ± 0.028	1.62TyrVal: 1.62 ± 0.034	0.338TyrTrp: 0.338 ± 0.013	0.483TyrTyr: 0.483 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.019XaaXaa: 0.019 ± 0.005

Statistics based on 4585 proteins (1350462 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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