Amino acid dipepetide frequency for Rhodobacter veldkampii DSM 11550

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.379AlaAla: 22.379 ± 0.258	1.208AlaCys: 1.208 ± 0.036	7.735AlaAsp: 7.735 ± 0.1	9.526AlaGlu: 9.526 ± 0.129	4.403AlaPhe: 4.403 ± 0.085	12.676AlaGly: 12.676 ± 0.156	2.568AlaHis: 2.568 ± 0.055	5.648AlaIle: 5.648 ± 0.079	3.372AlaLys: 3.372 ± 0.072	16.344AlaLeu: 16.344 ± 0.186	3.949AlaMet: 3.949 ± 0.065	2.619AlaAsn: 2.619 ± 0.054	7.653AlaPro: 7.653 ± 0.112	4.977AlaGln: 4.977 ± 0.075	11.849AlaArg: 11.849 ± 0.151	5.393AlaSer: 5.393 ± 0.081	6.632AlaThr: 6.632 ± 0.087	9.598AlaVal: 9.598 ± 0.13	1.515AlaTrp: 1.515 ± 0.039	2.446AlaTyr: 2.446 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	1.148CysAla: 1.148 ± 0.038	0.112CysCys: 0.112 ± 0.012	0.562CysAsp: 0.562 ± 0.022	0.441CysGlu: 0.441 ± 0.021	0.269CysPhe: 0.269 ± 0.019	0.924CysGly: 0.924 ± 0.038	0.246CysHis: 0.246 ± 0.019	0.399CysIle: 0.399 ± 0.021	0.174CysLys: 0.174 ± 0.013	0.894CysLeu: 0.894 ± 0.032	0.159CysMet: 0.159 ± 0.013	0.191CysAsn: 0.191 ± 0.015	0.549CysPro: 0.549 ± 0.027	0.229CysGln: 0.229 ± 0.014	0.632CysArg: 0.632 ± 0.027	0.382CysSer: 0.382 ± 0.019	0.436CysThr: 0.436 ± 0.024	0.52CysVal: 0.52 ± 0.026	0.124CysTrp: 0.124 ± 0.011	0.175CysTyr: 0.175 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.11AspAla: 7.11 ± 0.088	0.514AspCys: 0.514 ± 0.028	3.042AspAsp: 3.042 ± 0.079	3.042AspGlu: 3.042 ± 0.071	2.178AspPhe: 2.178 ± 0.051	4.787AspGly: 4.787 ± 0.075	1.383AspHis: 1.383 ± 0.036	2.694AspIle: 2.694 ± 0.055	1.39AspLys: 1.39 ± 0.04	7.043AspLeu: 7.043 ± 0.103	1.496AspMet: 1.496 ± 0.036	1.033AspAsn: 1.033 ± 0.033	3.82AspPro: 3.82 ± 0.063	1.81AspGln: 1.81 ± 0.044	4.762AspArg: 4.762 ± 0.069	1.805AspSer: 1.805 ± 0.046	2.639AspThr: 2.639 ± 0.052	3.614AspVal: 3.614 ± 0.062	1.334AspTrp: 1.334 ± 0.038	1.469AspTyr: 1.469 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	9.223GluAla: 9.223 ± 0.123	0.365GluCys: 0.365 ± 0.018	2.958GluAsp: 2.958 ± 0.069	2.823GluGlu: 2.823 ± 0.071	1.745GluPhe: 1.745 ± 0.051	4.837GluGly: 4.837 ± 0.074	0.936GluHis: 0.936 ± 0.033	3.277GluIle: 3.277 ± 0.066	1.777GluLys: 1.777 ± 0.048	4.597GluLeu: 4.597 ± 0.074	1.666GluMet: 1.666 ± 0.043	1.35GluAsn: 1.35 ± 0.036	2.612GluPro: 2.612 ± 0.058	1.699GluGln: 1.699 ± 0.046	4.353GluArg: 4.353 ± 0.075	1.777GluSer: 1.777 ± 0.046	3.718GluThr: 3.718 ± 0.062	4.504GluVal: 4.504 ± 0.062	0.609GluTrp: 0.609 ± 0.025	0.889GluTyr: 0.889 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.79PheAla: 4.79 ± 0.077	0.416PheCys: 0.416 ± 0.022	2.695PheAsp: 2.695 ± 0.052	1.914PheGlu: 1.914 ± 0.052	1.264PhePhe: 1.264 ± 0.043	3.636PheGly: 3.636 ± 0.064	0.713PheHis: 0.713 ± 0.028	1.347PheIle: 1.347 ± 0.043	0.792PheLys: 0.792 ± 0.035	3.364PheLeu: 3.364 ± 0.071	0.728PheMet: 0.728 ± 0.025	0.911PheAsn: 0.911 ± 0.034	1.509PhePro: 1.509 ± 0.043	0.892PheGln: 0.892 ± 0.032	2.379PheArg: 2.379 ± 0.054	1.855PheSer: 1.855 ± 0.043	1.995PheThr: 1.995 ± 0.043	2.535PheVal: 2.535 ± 0.053	0.546PheTrp: 0.546 ± 0.024	0.811PheTyr: 0.811 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	11.566GlyAla: 11.566 ± 0.152	0.907GlyCys: 0.907 ± 0.035	4.368GlyAsp: 4.368 ± 0.077	4.292GlyGlu: 4.292 ± 0.072	3.664GlyPhe: 3.664 ± 0.063	7.527GlyGly: 7.527 ± 0.122	2.021GlyHis: 2.021 ± 0.046	4.148GlyIle: 4.148 ± 0.065	2.867GlyLys: 2.867 ± 0.06	10.132GlyLeu: 10.132 ± 0.131	2.547GlyMet: 2.547 ± 0.051	1.849GlyAsn: 1.849 ± 0.049	4.077GlyPro: 4.077 ± 0.066	3.346GlyGln: 3.346 ± 0.058	6.952GlyArg: 6.952 ± 0.096	3.836GlySer: 3.836 ± 0.057	4.331GlyThr: 4.331 ± 0.081	6.49GlyVal: 6.49 ± 0.085	1.734GlyTrp: 1.734 ± 0.043	2.12GlyTyr: 2.12 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.41HisAla: 2.41 ± 0.057	0.194HisCys: 0.194 ± 0.015	1.296HisAsp: 1.296 ± 0.038	0.961HisGlu: 0.961 ± 0.036	0.767HisPhe: 0.767 ± 0.028	1.866HisGly: 1.866 ± 0.048	0.53HisHis: 0.53 ± 0.025	0.885HisIle: 0.885 ± 0.026	0.446HisLys: 0.446 ± 0.023	2.221HisLeu: 2.221 ± 0.057	0.469HisMet: 0.469 ± 0.024	0.415HisAsn: 0.415 ± 0.02	1.446HisPro: 1.446 ± 0.038	0.581HisGln: 0.581 ± 0.029	1.471HisArg: 1.471 ± 0.041	0.853HisSer: 0.853 ± 0.031	0.748HisThr: 0.748 ± 0.03	1.493HisVal: 1.493 ± 0.041	0.387HisTrp: 0.387 ± 0.023	0.549HisTyr: 0.549 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.987IleAla: 6.987 ± 0.099	0.503IleCys: 0.503 ± 0.023	3.272IleAsp: 3.272 ± 0.061	3.253IleGlu: 3.253 ± 0.059	1.577IlePhe: 1.577 ± 0.044	4.571IleGly: 4.571 ± 0.078	0.867IleHis: 0.867 ± 0.029	1.824IleIle: 1.824 ± 0.046	1.092IleLys: 1.092 ± 0.039	4.406IleLeu: 4.406 ± 0.076	0.898IleMet: 0.898 ± 0.036	1.152IleAsn: 1.152 ± 0.038	2.122IlePro: 2.122 ± 0.052	0.907IleGln: 0.907 ± 0.028	3.403IleArg: 3.403 ± 0.061	2.569IleSer: 2.569 ± 0.055	2.714IleThr: 2.714 ± 0.058	3.565IleVal: 3.565 ± 0.056	0.727IleTrp: 0.727 ± 0.024	1.015IleTyr: 1.015 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.734LysAla: 3.734 ± 0.063	0.178LysCys: 0.178 ± 0.014	1.464LysAsp: 1.464 ± 0.047	1.19LysGlu: 1.19 ± 0.037	0.784LysPhe: 0.784 ± 0.034	2.459LysGly: 2.459 ± 0.059	0.504LysHis: 0.504 ± 0.024	1.414LysIle: 1.414 ± 0.039	1.047LysLys: 1.047 ± 0.04	2.636LysLeu: 2.636 ± 0.055	0.764LysMet: 0.764 ± 0.031	0.633LysAsn: 0.633 ± 0.028	1.68LysPro: 1.68 ± 0.052	0.727LysGln: 0.727 ± 0.03	2.009LysArg: 2.009 ± 0.047	1.513LysSer: 1.513 ± 0.04	1.722LysThr: 1.722 ± 0.049	2.094LysVal: 2.094 ± 0.053	0.326LysTrp: 0.326 ± 0.017	0.558LysTyr: 0.558 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	16.601LeuAla: 16.601 ± 0.202	0.903LeuCys: 0.903 ± 0.032	5.802LeuAsp: 5.802 ± 0.079	5.23LeuGlu: 5.23 ± 0.079	3.323LeuPhe: 3.323 ± 0.064	9.015LeuGly: 9.015 ± 0.128	1.996LeuHis: 1.996 ± 0.05	5.244LeuIle: 5.244 ± 0.076	2.923LeuLys: 2.923 ± 0.06	8.786LeuLeu: 8.786 ± 0.131	2.792LeuMet: 2.792 ± 0.055	2.393LeuAsn: 2.393 ± 0.047	6.355LeuPro: 6.355 ± 0.097	2.393LeuGln: 2.393 ± 0.053	8.322LeuArg: 8.322 ± 0.112	5.778LeuSer: 5.778 ± 0.082	6.195LeuThr: 6.195 ± 0.082	7.076LeuVal: 7.076 ± 0.093	1.446LeuTrp: 1.446 ± 0.047	1.896LeuTyr: 1.896 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.758MetAla: 3.758 ± 0.065	0.148MetCys: 0.148 ± 0.011	1.198MetAsp: 1.198 ± 0.034	1.209MetGlu: 1.209 ± 0.038	0.727MetPhe: 0.727 ± 0.032	2.213MetGly: 2.213 ± 0.046	0.404MetHis: 0.404 ± 0.02	1.445MetIle: 1.445 ± 0.04	0.908MetLys: 0.908 ± 0.029	2.51MetLeu: 2.51 ± 0.053	0.711MetMet: 0.711 ± 0.028	0.757MetAsn: 0.757 ± 0.025	1.517MetPro: 1.517 ± 0.042	0.909MetGln: 0.909 ± 0.031	1.957MetArg: 1.957 ± 0.047	1.389MetSer: 1.389 ± 0.038	2.043MetThr: 2.043 ± 0.046	1.802MetVal: 1.802 ± 0.043	0.214MetTrp: 0.214 ± 0.014	0.28MetTyr: 0.28 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.8AsnAla: 2.8 ± 0.052	0.237AsnCys: 0.237 ± 0.017	1.194AsnAsp: 1.194 ± 0.04	0.942AsnGlu: 0.942 ± 0.031	0.781AsnPhe: 0.781 ± 0.032	1.935AsnGly: 1.935 ± 0.048	0.436AsnHis: 0.436 ± 0.021	1.126AsnIle: 1.126 ± 0.032	0.559AsnLys: 0.559 ± 0.027	2.327AsnLeu: 2.327 ± 0.05	0.499AsnMet: 0.499 ± 0.025	0.51AsnAsn: 0.51 ± 0.024	1.76AsnPro: 1.76 ± 0.042	0.557AsnGln: 0.557 ± 0.026	1.752AsnArg: 1.752 ± 0.042	0.893AsnSer: 0.893 ± 0.036	1.146AsnThr: 1.146 ± 0.035	1.511AsnVal: 1.511 ± 0.04	0.386AsnTrp: 0.386 ± 0.023	0.491AsnTyr: 0.491 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.737ProAla: 7.737 ± 0.102	0.375ProCys: 0.375 ± 0.019	4.069ProAsp: 4.069 ± 0.068	4.559ProGlu: 4.559 ± 0.066	1.941ProPhe: 1.941 ± 0.04	5.38ProGly: 5.38 ± 0.088	1.025ProHis: 1.025 ± 0.035	2.124ProIle: 2.124 ± 0.047	1.554ProLys: 1.554 ± 0.042	4.798ProLeu: 4.798 ± 0.084	1.363ProMet: 1.363 ± 0.035	1.057ProAsn: 1.057 ± 0.034	2.724ProPro: 2.724 ± 0.068	1.723ProGln: 1.723 ± 0.049	3.422ProArg: 3.422 ± 0.062	2.172ProSer: 2.172 ± 0.046	2.37ProThr: 2.37 ± 0.053	4.717ProVal: 4.717 ± 0.075	0.741ProTrp: 0.741 ± 0.028	1.082ProTyr: 1.082 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.499GlnAla: 4.499 ± 0.076	0.174GlnCys: 0.174 ± 0.015	1.411GlnAsp: 1.411 ± 0.034	1.265GlnGlu: 1.265 ± 0.037	0.998GlnPhe: 0.998 ± 0.03	2.767GlnGly: 2.767 ± 0.062	0.536GlnHis: 0.536 ± 0.024	1.966GlnIle: 1.966 ± 0.05	0.89GlnLys: 0.89 ± 0.032	2.604GlnLeu: 2.604 ± 0.05	1.022GlnMet: 1.022 ± 0.031	0.705GlnAsn: 0.705 ± 0.031	1.765GlnPro: 1.765 ± 0.041	0.894GlnGln: 0.894 ± 0.036	2.291GlnArg: 2.291 ± 0.052	1.484GlnSer: 1.484 ± 0.042	1.651GlnThr: 1.651 ± 0.048	2.451GlnVal: 2.451 ± 0.054	0.365GlnTrp: 0.365 ± 0.022	0.475GlnTyr: 0.475 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	10.845ArgAla: 10.845 ± 0.118	0.503ArgCys: 0.503 ± 0.026	4.363ArgAsp: 4.363 ± 0.064	3.831ArgGlu: 3.831 ± 0.073	3.014ArgPhe: 3.014 ± 0.058	5.516ArgGly: 5.516 ± 0.079	1.769ArgHis: 1.769 ± 0.042	4.064ArgIle: 4.064 ± 0.077	2.192ArgLys: 2.192 ± 0.055	9.274ArgLeu: 9.274 ± 0.132	2.058ArgMet: 2.058 ± 0.051	1.627ArgAsn: 1.627 ± 0.045	4.247ArgPro: 4.247 ± 0.078	2.438ArgGln: 2.438 ± 0.049	6.131ArgArg: 6.131 ± 0.102	3.187ArgSer: 3.187 ± 0.056	2.999ArgThr: 2.999 ± 0.055	5.277ArgVal: 5.277 ± 0.079	1.115ArgTrp: 1.115 ± 0.036	1.552ArgTyr: 1.552 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.669SerAla: 5.669 ± 0.075	0.411SerCys: 0.411 ± 0.023	2.736SerAsp: 2.736 ± 0.053	2.285SerGlu: 2.285 ± 0.055	1.934SerPhe: 1.934 ± 0.051	4.829SerGly: 4.829 ± 0.074	0.952SerHis: 0.952 ± 0.033	1.936SerIle: 1.936 ± 0.047	1.156SerLys: 1.156 ± 0.034	4.646SerLeu: 4.646 ± 0.072	1.043SerMet: 1.043 ± 0.032	0.968SerAsn: 0.968 ± 0.034	2.375SerPro: 2.375 ± 0.046	1.278SerGln: 1.278 ± 0.037	3.083SerArg: 3.083 ± 0.067	2.034SerSer: 2.034 ± 0.05	2.097SerThr: 2.097 ± 0.051	3.353SerVal: 3.353 ± 0.058	0.598SerTrp: 0.598 ± 0.025	1.077SerTyr: 1.077 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.691ThrAla: 6.691 ± 0.082	0.475ThrCys: 0.475 ± 0.025	2.949ThrAsp: 2.949 ± 0.053	2.994ThrGlu: 2.994 ± 0.057	1.741ThrPhe: 1.741 ± 0.041	5.597ThrGly: 5.597 ± 0.082	1.046ThrHis: 1.046 ± 0.032	2.5ThrIle: 2.5 ± 0.052	1.292ThrLys: 1.292 ± 0.043	5.923ThrLeu: 5.923 ± 0.072	1.101ThrMet: 1.101 ± 0.04	1.104ThrAsn: 1.104 ± 0.039	3.384ThrPro: 3.384 ± 0.05	1.401ThrGln: 1.401 ± 0.04	3.738ThrArg: 3.738 ± 0.065	2.173ThrSer: 2.173 ± 0.054	2.694ThrThr: 2.694 ± 0.056	3.948ThrVal: 3.948 ± 0.072	0.64ThrTrp: 0.64 ± 0.026	1.033ThrTyr: 1.033 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	10.278ValAla: 10.278 ± 0.128	0.611ValCys: 0.611 ± 0.024	3.661ValAsp: 3.661 ± 0.072	4.294ValGlu: 4.294 ± 0.075	2.682ValPhe: 2.682 ± 0.057	5.213ValGly: 5.213 ± 0.079	1.256ValHis: 1.256 ± 0.039	3.955ValIle: 3.955 ± 0.076	2.043ValLys: 2.043 ± 0.056	7.973ValLeu: 7.973 ± 0.106	2.051ValMet: 2.051 ± 0.051	1.721ValAsn: 1.721 ± 0.046	3.639ValPro: 3.639 ± 0.064	2.228ValGln: 2.228 ± 0.051	4.606ValArg: 4.606 ± 0.084	3.664ValSer: 3.664 ± 0.073	4.646ValThr: 4.646 ± 0.074	5.776ValVal: 5.776 ± 0.093	1.013ValTrp: 1.013 ± 0.031	1.38ValTyr: 1.38 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.723TrpAla: 1.723 ± 0.044	0.135TrpCys: 0.135 ± 0.011	0.743TrpAsp: 0.743 ± 0.027	0.598TrpGlu: 0.598 ± 0.027	0.521TrpPhe: 0.521 ± 0.023	1.101TrpGly: 1.101 ± 0.036	0.355TrpHis: 0.355 ± 0.02	0.604TrpIle: 0.604 ± 0.031	0.421TrpLys: 0.421 ± 0.023	1.797TrpLeu: 1.797 ± 0.046	0.365TrpMet: 0.365 ± 0.021	0.328TrpAsn: 0.328 ± 0.018	0.749TrpPro: 0.749 ± 0.032	0.633TrpGln: 0.633 ± 0.026	1.327TrpArg: 1.327 ± 0.038	0.749TrpSer: 0.749 ± 0.028	0.667TrpThr: 0.667 ± 0.027	1.052TrpVal: 1.052 ± 0.028	0.241TrpTrp: 0.241 ± 0.018	0.266TrpTyr: 0.266 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.542TyrAla: 2.542 ± 0.056	0.197TyrCys: 0.197 ± 0.013	1.446TyrAsp: 1.446 ± 0.035	1.064TyrGlu: 1.064 ± 0.039	0.778TyrPhe: 0.778 ± 0.03	1.925TyrGly: 1.925 ± 0.044	0.444TyrHis: 0.444 ± 0.02	0.822TyrIle: 0.822 ± 0.033	0.541TyrLys: 0.541 ± 0.025	2.194TyrLeu: 2.194 ± 0.047	0.417TyrMet: 0.417 ± 0.02	0.518TyrAsn: 0.518 ± 0.023	0.954TyrPro: 0.954 ± 0.032	0.592TyrGln: 0.592 ± 0.028	1.564TyrArg: 1.564 ± 0.041	0.958TyrSer: 0.958 ± 0.036	0.983TyrThr: 0.983 ± 0.032	1.315TyrVal: 1.315 ± 0.04	0.313TyrTrp: 0.313 ± 0.022	0.483TyrTyr: 0.483 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3115 proteins (961833 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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