Amino acid dipepetide frequency for Microbacterium hydrocarbonoxydans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.806AlaAla: 20.806 ± 0.211	0.613AlaCys: 0.613 ± 0.023	8.954AlaAsp: 8.954 ± 0.108	8.696AlaGlu: 8.696 ± 0.109	4.054AlaPhe: 4.054 ± 0.062	12.08AlaGly: 12.08 ± 0.125	2.443AlaHis: 2.443 ± 0.043	6.1AlaIle: 6.1 ± 0.086	2.732AlaLys: 2.732 ± 0.057	14.078AlaLeu: 14.078 ± 0.13	2.654AlaMet: 2.654 ± 0.05	2.283AlaAsn: 2.283 ± 0.052	6.743AlaPro: 6.743 ± 0.119	4.024AlaGln: 4.024 ± 0.061	8.722AlaArg: 8.722 ± 0.103	7.892AlaSer: 7.892 ± 0.088	7.307AlaThr: 7.307 ± 0.09	11.395AlaVal: 11.395 ± 0.113	1.875AlaTrp: 1.875 ± 0.045	2.522AlaTyr: 2.522 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.635CysAla: 0.635 ± 0.024	0.041CysCys: 0.041 ± 0.006	0.312CysAsp: 0.312 ± 0.015	0.25CysGlu: 0.25 ± 0.014	0.172CysPhe: 0.172 ± 0.012	0.509CysGly: 0.509 ± 0.023	0.103CysHis: 0.103 ± 0.011	0.197CysIle: 0.197 ± 0.013	0.058CysLys: 0.058 ± 0.007	0.429CysLeu: 0.429 ± 0.022	0.082CysMet: 0.082 ± 0.009	0.105CysAsn: 0.105 ± 0.008	0.267CysPro: 0.267 ± 0.017	0.105CysGln: 0.105 ± 0.009	0.296CysArg: 0.296 ± 0.018	0.311CysSer: 0.311 ± 0.017	0.338CysThr: 0.338 ± 0.018	0.393CysVal: 0.393 ± 0.02	0.063CysTrp: 0.063 ± 0.007	0.095CysTyr: 0.095 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	9.936AspAla: 9.936 ± 0.124	0.239AspCys: 0.239 ± 0.015	4.583AspAsp: 4.583 ± 0.077	4.438AspGlu: 4.438 ± 0.069	1.827AspPhe: 1.827 ± 0.043	6.418AspGly: 6.418 ± 0.093	1.105AspHis: 1.105 ± 0.03	2.573AspIle: 2.573 ± 0.054	1.039AspLys: 1.039 ± 0.039	6.163AspLeu: 6.163 ± 0.08	0.863AspMet: 0.863 ± 0.028	0.973AspAsn: 0.973 ± 0.029	4.156AspPro: 4.156 ± 0.058	1.51AspGln: 1.51 ± 0.034	4.234AspArg: 4.234 ± 0.064	2.846AspSer: 2.846 ± 0.057	2.8AspThr: 2.8 ± 0.048	5.48AspVal: 5.48 ± 0.082	0.959AspTrp: 0.959 ± 0.033	1.315AspTyr: 1.315 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.046GluAla: 7.046 ± 0.09	0.237GluCys: 0.237 ± 0.014	2.724GluAsp: 2.724 ± 0.056	3.137GluGlu: 3.137 ± 0.063	1.728GluPhe: 1.728 ± 0.041	4.29GluGly: 4.29 ± 0.069	1.506GluHis: 1.506 ± 0.039	3.04GluIle: 3.04 ± 0.056	1.531GluLys: 1.531 ± 0.04	6.375GluLeu: 6.375 ± 0.083	0.988GluMet: 0.988 ± 0.03	1.356GluAsn: 1.356 ± 0.034	2.847GluPro: 2.847 ± 0.056	2.266GluGln: 2.266 ± 0.049	5.143GluArg: 5.143 ± 0.082	3.104GluSer: 3.104 ± 0.059	3.035GluThr: 3.035 ± 0.052	4.604GluVal: 4.604 ± 0.064	0.957GluTrp: 0.957 ± 0.032	1.258GluTyr: 1.258 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.375PheAla: 4.375 ± 0.069	0.172PheCys: 0.172 ± 0.012	2.464PheAsp: 2.464 ± 0.046	1.769PheGlu: 1.769 ± 0.043	1.125PhePhe: 1.125 ± 0.036	3.446PheGly: 3.446 ± 0.052	0.553PheHis: 0.553 ± 0.023	1.245PheIle: 1.245 ± 0.03	0.464PheLys: 0.464 ± 0.018	2.94PheLeu: 2.94 ± 0.051	0.484PheMet: 0.484 ± 0.023	0.716PheAsn: 0.716 ± 0.029	1.39PhePro: 1.39 ± 0.036	0.816PheGln: 0.816 ± 0.028	1.851PheArg: 1.851 ± 0.048	1.802PheSer: 1.802 ± 0.037	2.255PheThr: 2.255 ± 0.054	2.772PheVal: 2.772 ± 0.048	0.544PheTrp: 0.544 ± 0.022	0.663PheTyr: 0.663 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	11.183GlyAla: 11.183 ± 0.116	0.606GlyCys: 0.606 ± 0.025	5.215GlyAsp: 5.215 ± 0.081	5.133GlyGlu: 5.133 ± 0.072	3.292GlyPhe: 3.292 ± 0.053	7.697GlyGly: 7.697 ± 0.133	1.738GlyHis: 1.738 ± 0.045	5.091GlyIle: 5.091 ± 0.076	2.044GlyLys: 2.044 ± 0.049	8.585GlyLeu: 8.585 ± 0.126	1.99GlyMet: 1.99 ± 0.045	1.709GlyAsn: 1.709 ± 0.048	3.6GlyPro: 3.6 ± 0.049	2.441GlyGln: 2.441 ± 0.052	6.037GlyArg: 6.037 ± 0.071	5.481GlySer: 5.481 ± 0.077	5.612GlyThr: 5.612 ± 0.097	7.827GlyVal: 7.827 ± 0.094	1.773GlyTrp: 1.773 ± 0.042	2.246GlyTyr: 2.246 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.361HisAla: 2.361 ± 0.043	0.093HisCys: 0.093 ± 0.008	1.36HisAsp: 1.36 ± 0.036	1.195HisGlu: 1.195 ± 0.032	0.583HisPhe: 0.583 ± 0.023	1.98HisGly: 1.98 ± 0.045	0.552HisHis: 0.552 ± 0.022	0.753HisIle: 0.753 ± 0.023	0.255HisLys: 0.255 ± 0.016	1.877HisLeu: 1.877 ± 0.043	0.328HisMet: 0.328 ± 0.017	0.38HisAsn: 0.38 ± 0.017	1.461HisPro: 1.461 ± 0.038	0.498HisGln: 0.498 ± 0.023	1.507HisArg: 1.507 ± 0.042	0.957HisSer: 0.957 ± 0.03	0.93HisThr: 0.93 ± 0.029	1.683HisVal: 1.683 ± 0.039	0.282HisTrp: 0.282 ± 0.014	0.411HisTyr: 0.411 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.628IleAla: 7.628 ± 0.093	0.244IleCys: 0.244 ± 0.016	3.852IleAsp: 3.852 ± 0.051	2.936IleGlu: 2.936 ± 0.053	1.186IlePhe: 1.186 ± 0.037	4.962IleGly: 4.962 ± 0.076	0.714IleHis: 0.714 ± 0.026	2.018IleIle: 2.018 ± 0.048	0.771IleLys: 0.771 ± 0.027	3.756IleLeu: 3.756 ± 0.066	0.668IleMet: 0.668 ± 0.029	0.891IleAsn: 0.891 ± 0.027	2.519IlePro: 2.519 ± 0.05	1.044IleGln: 1.044 ± 0.029	3.093IleArg: 3.093 ± 0.053	2.547IleSer: 2.547 ± 0.044	3.002IleThr: 3.002 ± 0.051	4.829IleVal: 4.829 ± 0.075	0.575IleTrp: 0.575 ± 0.023	0.796IleTyr: 0.796 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.621LysAla: 2.621 ± 0.063	0.063LysCys: 0.063 ± 0.006	1.231LysAsp: 1.231 ± 0.036	0.956LysGlu: 0.956 ± 0.03	0.473LysPhe: 0.473 ± 0.02	1.585LysGly: 1.585 ± 0.046	0.439LysHis: 0.439 ± 0.022	0.99LysIle: 0.99 ± 0.03	0.836LysLys: 0.836 ± 0.032	1.792LysLeu: 1.792 ± 0.047	0.42LysMet: 0.42 ± 0.022	0.561LysAsn: 0.561 ± 0.022	1.145LysPro: 1.145 ± 0.036	0.658LysGln: 0.658 ± 0.026	1.37LysArg: 1.37 ± 0.034	1.168LysSer: 1.168 ± 0.034	1.43LysThr: 1.43 ± 0.036	1.68LysVal: 1.68 ± 0.044	0.25LysTrp: 0.25 ± 0.014	0.447LysTyr: 0.447 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.942LeuAla: 13.942 ± 0.131	0.478LeuCys: 0.478 ± 0.02	6.612LeuAsp: 6.612 ± 0.081	5.008LeuGlu: 5.008 ± 0.066	2.983LeuPhe: 2.983 ± 0.051	8.99LeuGly: 8.99 ± 0.095	1.878LeuHis: 1.878 ± 0.041	4.81LeuIle: 4.81 ± 0.073	1.777LeuLys: 1.777 ± 0.042	9.835LeuLeu: 9.835 ± 0.124	1.646LeuMet: 1.646 ± 0.041	1.841LeuAsn: 1.841 ± 0.042	5.522LeuPro: 5.522 ± 0.149	2.508LeuGln: 2.508 ± 0.046	7.348LeuArg: 7.348 ± 0.095	6.103LeuSer: 6.103 ± 0.084	6.223LeuThr: 6.223 ± 0.086	8.664LeuVal: 8.664 ± 0.092	1.369LeuTrp: 1.369 ± 0.036	1.642LeuTyr: 1.642 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.073MetAla: 2.073 ± 0.042	0.089MetCys: 0.089 ± 0.008	0.766MetAsp: 0.766 ± 0.026	0.628MetGlu: 0.628 ± 0.024	0.561MetPhe: 0.561 ± 0.024	1.248MetGly: 1.248 ± 0.033	0.353MetHis: 0.353 ± 0.018	0.929MetIle: 0.929 ± 0.025	0.455MetLys: 0.455 ± 0.02	2.184MetLeu: 2.184 ± 0.051	0.332MetMet: 0.332 ± 0.016	0.553MetAsn: 0.553 ± 0.021	1.238MetPro: 1.238 ± 0.035	0.557MetGln: 0.557 ± 0.022	1.399MetArg: 1.399 ± 0.032	1.503MetSer: 1.503 ± 0.033	1.726MetThr: 1.726 ± 0.041	1.282MetVal: 1.282 ± 0.035	0.22MetTrp: 0.22 ± 0.012	0.292MetTyr: 0.292 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.515AsnAla: 2.515 ± 0.051	0.09AsnCys: 0.09 ± 0.008	1.231AsnAsp: 1.231 ± 0.037	0.997AsnGlu: 0.997 ± 0.027	0.622AsnPhe: 0.622 ± 0.024	2.068AsnGly: 2.068 ± 0.052	0.379AsnHis: 0.379 ± 0.017	0.823AsnIle: 0.823 ± 0.029	0.421AsnLys: 0.421 ± 0.017	1.886AsnLeu: 1.886 ± 0.038	0.32AsnMet: 0.32 ± 0.015	0.457AsnAsn: 0.457 ± 0.025	1.575AsnPro: 1.575 ± 0.039	0.535AsnGln: 0.535 ± 0.021	1.245AsnArg: 1.245 ± 0.031	1.044AsnSer: 1.044 ± 0.035	1.18AsnThr: 1.18 ± 0.034	1.625AsnVal: 1.625 ± 0.042	0.346AsnTrp: 0.346 ± 0.016	0.506AsnTyr: 0.506 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.365ProAla: 7.365 ± 0.101	0.177ProCys: 0.177 ± 0.013	3.637ProAsp: 3.637 ± 0.067	3.896ProGlu: 3.896 ± 0.059	1.793ProPhe: 1.793 ± 0.04	4.958ProGly: 4.958 ± 0.153	1.047ProHis: 1.047 ± 0.032	2.085ProIle: 2.085 ± 0.045	1.007ProLys: 1.007 ± 0.032	4.973ProLeu: 4.973 ± 0.064	0.86ProMet: 0.86 ± 0.027	1.007ProAsn: 1.007 ± 0.028	2.114ProPro: 2.114 ± 0.053	1.641ProGln: 1.641 ± 0.037	3.18ProArg: 3.18 ± 0.056	3.122ProSer: 3.122 ± 0.06	3.184ProThr: 3.184 ± 0.062	4.82ProVal: 4.82 ± 0.086	0.85ProTrp: 0.85 ± 0.028	1.105ProTyr: 1.105 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.482GlnAla: 3.482 ± 0.065	0.111GlnCys: 0.111 ± 0.009	1.359GlnAsp: 1.359 ± 0.036	1.328GlnGlu: 1.328 ± 0.037	0.872GlnPhe: 0.872 ± 0.027	2.209GlnGly: 2.209 ± 0.047	0.671GlnHis: 0.671 ± 0.023	1.515GlnIle: 1.515 ± 0.036	0.693GlnLys: 0.693 ± 0.024	3.113GlnLeu: 3.113 ± 0.048	0.506GlnMet: 0.506 ± 0.017	0.714GlnAsn: 0.714 ± 0.028	1.521GlnPro: 1.521 ± 0.043	1.201GlnGln: 1.201 ± 0.039	2.367GlnArg: 2.367 ± 0.055	1.567GlnSer: 1.567 ± 0.036	1.663GlnThr: 1.663 ± 0.038	2.319GlnVal: 2.319 ± 0.044	0.46GlnTrp: 0.46 ± 0.021	0.645GlnTyr: 0.645 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.546ArgAla: 8.546 ± 0.105	0.289ArgCys: 0.289 ± 0.017	4.119ArgAsp: 4.119 ± 0.065	4.293ArgGlu: 4.293 ± 0.064	2.403ArgPhe: 2.403 ± 0.044	5.247ArgGly: 5.247 ± 0.077	1.48ArgHis: 1.48 ± 0.041	3.833ArgIle: 3.833 ± 0.057	1.288ArgLys: 1.288 ± 0.04	6.983ArgLeu: 6.983 ± 0.084	1.871ArgMet: 1.871 ± 0.042	1.285ArgAsn: 1.285 ± 0.029	3.43ArgPro: 3.43 ± 0.055	1.943ArgGln: 1.943 ± 0.042	6.232ArgArg: 6.232 ± 0.093	4.187ArgSer: 4.187 ± 0.068	4.208ArgThr: 4.208 ± 0.054	5.737ArgVal: 5.737 ± 0.078	1.204ArgTrp: 1.204 ± 0.034	1.419ArgTyr: 1.419 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	7.809SerAla: 7.809 ± 0.088	0.264SerCys: 0.264 ± 0.015	3.465SerAsp: 3.465 ± 0.058	2.966SerGlu: 2.966 ± 0.057	1.976SerPhe: 1.976 ± 0.042	6.005SerGly: 6.005 ± 0.083	1.001SerHis: 1.001 ± 0.03	2.852SerIle: 2.852 ± 0.054	1.146SerLys: 1.146 ± 0.037	5.453SerLeu: 5.453 ± 0.065	1.235SerMet: 1.235 ± 0.031	1.113SerAsn: 1.113 ± 0.031	3.041SerPro: 3.041 ± 0.048	1.383SerGln: 1.383 ± 0.033	3.77SerArg: 3.77 ± 0.07	3.668SerSer: 3.668 ± 0.062	3.892SerThr: 3.892 ± 0.067	4.796SerVal: 4.796 ± 0.067	1.082SerTrp: 1.082 ± 0.033	1.174SerTyr: 1.174 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	8.334ThrAla: 8.334 ± 0.11	0.287ThrCys: 0.287 ± 0.016	3.678ThrAsp: 3.678 ± 0.07	2.925ThrGlu: 2.925 ± 0.055	1.924ThrPhe: 1.924 ± 0.041	5.924ThrGly: 5.924 ± 0.083	1.094ThrHis: 1.094 ± 0.032	2.98ThrIle: 2.98 ± 0.05	1.227ThrLys: 1.227 ± 0.036	5.865ThrLeu: 5.865 ± 0.072	0.998ThrMet: 0.998 ± 0.033	1.139ThrAsn: 1.139 ± 0.037	3.833ThrPro: 3.833 ± 0.067	1.604ThrGln: 1.604 ± 0.043	3.563ThrArg: 3.563 ± 0.061	3.44ThrSer: 3.44 ± 0.066	3.935ThrThr: 3.935 ± 0.084	5.786ThrVal: 5.786 ± 0.092	0.97ThrTrp: 0.97 ± 0.033	1.189ThrTyr: 1.189 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	11.1ValAla: 11.1 ± 0.097	0.463ValCys: 0.463 ± 0.018	5.696ValAsp: 5.696 ± 0.068	4.786ValGlu: 4.786 ± 0.073	2.943ValPhe: 2.943 ± 0.057	6.612ValGly: 6.612 ± 0.099	1.764ValHis: 1.764 ± 0.04	4.632ValIle: 4.632 ± 0.07	1.641ValLys: 1.641 ± 0.04	9.119ValLeu: 9.119 ± 0.098	1.466ValMet: 1.466 ± 0.032	1.808ValAsn: 1.808 ± 0.041	4.669ValPro: 4.669 ± 0.067	2.371ValGln: 2.371 ± 0.044	5.822ValArg: 5.822 ± 0.086	5.155ValSer: 5.155 ± 0.068	5.71ValThr: 5.71 ± 0.097	8.434ValVal: 8.434 ± 0.108	1.175ValTrp: 1.175 ± 0.035	1.491ValTyr: 1.491 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.716TrpAla: 1.716 ± 0.037	0.1TrpCys: 0.1 ± 0.009	0.829TrpAsp: 0.829 ± 0.026	0.706TrpGlu: 0.706 ± 0.027	0.603TrpPhe: 0.603 ± 0.024	1.168TrpGly: 1.168 ± 0.036	0.354TrpHis: 0.354 ± 0.018	0.764TrpIle: 0.764 ± 0.028	0.352TrpLys: 0.352 ± 0.016	1.729TrpLeu: 1.729 ± 0.038	0.373TrpMet: 0.373 ± 0.018	0.495TrpAsn: 0.495 ± 0.02	0.718TrpPro: 0.718 ± 0.026	0.616TrpGln: 0.616 ± 0.023	1.246TrpArg: 1.246 ± 0.031	1.039TrpSer: 1.039 ± 0.034	1.012TrpThr: 1.012 ± 0.036	1.153TrpVal: 1.153 ± 0.031	0.397TrpTrp: 0.397 ± 0.021	0.307TrpTyr: 0.307 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.501TyrAla: 2.501 ± 0.046	0.108TyrCys: 0.108 ± 0.009	1.37TyrAsp: 1.37 ± 0.034	1.13TyrGlu: 1.13 ± 0.03	0.726TyrPhe: 0.726 ± 0.026	1.906TyrGly: 1.906 ± 0.043	0.271TyrHis: 0.271 ± 0.014	0.799TyrIle: 0.799 ± 0.03	0.378TyrLys: 0.378 ± 0.016	2.044TyrLeu: 2.044 ± 0.045	0.305TyrMet: 0.305 ± 0.016	0.477TyrAsn: 0.477 ± 0.022	1.033TyrPro: 1.033 ± 0.033	0.593TyrGln: 0.593 ± 0.026	1.57TyrArg: 1.57 ± 0.037	1.157TyrSer: 1.157 ± 0.032	1.252TyrThr: 1.252 ± 0.035	1.581TyrVal: 1.581 ± 0.037	0.326TyrTrp: 0.326 ± 0.018	0.493TyrTyr: 0.493 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3663 proteins (1217945 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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