Amino acid dipepetide frequency for Paraflavitalea soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.137AlaAla: 8.137 ± 0.072	0.748AlaCys: 0.748 ± 0.019	4.308AlaAsp: 4.308 ± 0.046	3.819AlaGlu: 3.819 ± 0.048	3.634AlaPhe: 3.634 ± 0.038	7.067AlaGly: 7.067 ± 0.062	1.341AlaHis: 1.341 ± 0.026	5.589AlaIle: 5.589 ± 0.045	3.932AlaLys: 3.932 ± 0.045	7.41AlaLeu: 7.41 ± 0.072	1.832AlaMet: 1.832 ± 0.031	3.936AlaAsn: 3.936 ± 0.057	2.985AlaPro: 2.985 ± 0.04	3.219AlaGln: 3.219 ± 0.033	3.431AlaArg: 3.431 ± 0.04	4.827AlaSer: 4.827 ± 0.053	5.112AlaThr: 5.112 ± 0.069	5.324AlaVal: 5.324 ± 0.046	1.177AlaTrp: 1.177 ± 0.022	3.039AlaTyr: 3.039 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.537CysAla: 0.537 ± 0.016	0.148CysCys: 0.148 ± 0.008	0.375CysAsp: 0.375 ± 0.013	0.35CysGlu: 0.35 ± 0.014	0.414CysPhe: 0.414 ± 0.013	0.57CysGly: 0.57 ± 0.017	0.197CysHis: 0.197 ± 0.01	0.614CysIle: 0.614 ± 0.014	0.447CysLys: 0.447 ± 0.014	0.875CysLeu: 0.875 ± 0.019	0.215CysMet: 0.215 ± 0.009	0.397CysAsn: 0.397 ± 0.017	0.333CysPro: 0.333 ± 0.013	0.245CysGln: 0.245 ± 0.01	0.379CysArg: 0.379 ± 0.012	0.525CysSer: 0.525 ± 0.015	0.523CysThr: 0.523 ± 0.015	0.443CysVal: 0.443 ± 0.016	0.13CysTrp: 0.13 ± 0.008	0.337CysTyr: 0.337 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.985AspAla: 3.985 ± 0.041	0.381AspCys: 0.381 ± 0.014	2.333AspAsp: 2.333 ± 0.035	2.797AspGlu: 2.797 ± 0.036	2.6AspPhe: 2.6 ± 0.034	3.998AspGly: 3.998 ± 0.059	1.059AspHis: 1.059 ± 0.024	3.604AspIle: 3.604 ± 0.037	3.506AspLys: 3.506 ± 0.04	4.569AspLeu: 4.569 ± 0.051	1.173AspMet: 1.173 ± 0.025	2.743AspAsn: 2.743 ± 0.04	2.365AspPro: 2.365 ± 0.035	1.889AspGln: 1.889 ± 0.025	2.237AspArg: 2.237 ± 0.037	3.053AspSer: 3.053 ± 0.04	2.818AspThr: 2.818 ± 0.042	3.056AspVal: 3.056 ± 0.04	0.865AspTrp: 0.865 ± 0.021	2.399AspTyr: 2.399 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	4.365GluAla: 4.365 ± 0.054	0.317GluCys: 0.317 ± 0.012	2.381GluAsp: 2.381 ± 0.034	3.33GluGlu: 3.33 ± 0.052	2.05GluPhe: 2.05 ± 0.033	3.448GluGly: 3.448 ± 0.042	0.987GluHis: 0.987 ± 0.025	3.286GluIle: 3.286 ± 0.041	4.236GluLys: 4.236 ± 0.048	5.09GluLeu: 5.09 ± 0.054	1.38GluMet: 1.38 ± 0.024	2.466GluAsn: 2.466 ± 0.034	1.653GluPro: 1.653 ± 0.025	2.607GluGln: 2.607 ± 0.04	2.376GluArg: 2.376 ± 0.035	2.412GluSer: 2.412 ± 0.03	2.565GluThr: 2.565 ± 0.037	3.604GluVal: 3.604 ± 0.042	0.723GluTrp: 0.723 ± 0.018	1.99GluTyr: 1.99 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.233PheAla: 3.233 ± 0.039	0.407PheCys: 0.407 ± 0.011	2.756PheAsp: 2.756 ± 0.034	2.306PheGlu: 2.306 ± 0.031	2.279PhePhe: 2.279 ± 0.037	3.128PheGly: 3.128 ± 0.033	0.881PheHis: 0.881 ± 0.02	3.086PheIle: 3.086 ± 0.038	2.544PheLys: 2.544 ± 0.037	4.205PheLeu: 4.205 ± 0.046	1.053PheMet: 1.053 ± 0.021	2.784PheAsn: 2.784 ± 0.042	1.815PhePro: 1.815 ± 0.026	1.468PheGln: 1.468 ± 0.025	2.236PheArg: 2.236 ± 0.037	3.398PheSer: 3.398 ± 0.038	3.435PheThr: 3.435 ± 0.042	2.722PheVal: 2.722 ± 0.033	0.63PheTrp: 0.63 ± 0.016	2.063PheTyr: 2.063 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	5.297GlyAla: 5.297 ± 0.055	0.678GlyCys: 0.678 ± 0.024	3.516GlyAsp: 3.516 ± 0.042	3.282GlyGlu: 3.282 ± 0.034	3.545GlyPhe: 3.545 ± 0.043	5.534GlyGly: 5.534 ± 0.069	1.336GlyHis: 1.336 ± 0.024	5.353GlyIle: 5.353 ± 0.048	5.249GlyLys: 5.249 ± 0.056	6.31GlyLeu: 6.31 ± 0.058	1.754GlyMet: 1.754 ± 0.028	4.189GlyAsn: 4.189 ± 0.067	1.924GlyPro: 1.924 ± 0.029	2.635GlyGln: 2.635 ± 0.037	3.079GlyArg: 3.079 ± 0.039	4.652GlySer: 4.652 ± 0.054	4.738GlyThr: 4.738 ± 0.067	4.693GlyVal: 4.693 ± 0.049	1.186GlyTrp: 1.186 ± 0.022	3.297GlyTyr: 3.297 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	1.295HisAla: 1.295 ± 0.027	0.222HisCys: 0.222 ± 0.01	0.868HisAsp: 0.868 ± 0.022	0.948HisGlu: 0.948 ± 0.02	1.193HisPhe: 1.193 ± 0.025	1.21HisGly: 1.21 ± 0.024	0.601HisHis: 0.601 ± 0.017	1.413HisIle: 1.413 ± 0.027	0.96HisLys: 0.96 ± 0.023	1.905HisLeu: 1.905 ± 0.035	0.387HisMet: 0.387 ± 0.012	0.911HisAsn: 0.911 ± 0.019	1.097HisPro: 1.097 ± 0.021	0.887HisGln: 0.887 ± 0.023	0.874HisArg: 0.874 ± 0.019	1.059HisSer: 1.059 ± 0.022	1.186HisThr: 1.186 ± 0.023	1.01HisVal: 1.01 ± 0.02	0.31HisTrp: 0.31 ± 0.012	0.946HisTyr: 0.946 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.614IleAla: 5.614 ± 0.054	0.618IleCys: 0.618 ± 0.017	3.757IleAsp: 3.757 ± 0.036	3.474IleGlu: 3.474 ± 0.045	2.587IlePhe: 2.587 ± 0.036	4.573IleGly: 4.573 ± 0.042	1.26IleHis: 1.26 ± 0.024	4.311IleIle: 4.311 ± 0.054	3.85IleLys: 3.85 ± 0.047	5.543IleLeu: 5.543 ± 0.053	1.268IleMet: 1.268 ± 0.024	3.743IleAsn: 3.743 ± 0.047	3.161IlePro: 3.161 ± 0.034	2.423IleGln: 2.423 ± 0.032	3.414IleArg: 3.414 ± 0.04	4.352IleSer: 4.352 ± 0.046	4.832IleThr: 4.832 ± 0.047	4.078IleVal: 4.078 ± 0.049	0.743IleTrp: 0.743 ± 0.019	2.422IleTyr: 2.422 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	5.054LysAla: 5.054 ± 0.053	0.301LysCys: 0.301 ± 0.013	3.829LysAsp: 3.829 ± 0.045	4.336LysGlu: 4.336 ± 0.057	1.977LysPhe: 1.977 ± 0.026	4.546LysGly: 4.546 ± 0.044	1.085LysHis: 1.085 ± 0.025	3.781LysIle: 3.781 ± 0.043	4.862LysLys: 4.862 ± 0.061	5.337LysLeu: 5.337 ± 0.05	1.638LysMet: 1.638 ± 0.029	3.169LysAsn: 3.169 ± 0.033	2.594LysPro: 2.594 ± 0.034	2.716LysGln: 2.716 ± 0.037	2.658LysArg: 2.658 ± 0.037	2.995LysSer: 2.995 ± 0.041	3.657LysThr: 3.657 ± 0.036	4.086LysVal: 4.086 ± 0.047	0.826LysTrp: 0.826 ± 0.018	2.437LysTyr: 2.437 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	7.286LeuAla: 7.286 ± 0.063	0.812LeuCys: 0.812 ± 0.019	4.439LeuAsp: 4.439 ± 0.047	4.583LeuGlu: 4.583 ± 0.057	4.577LeuPhe: 4.577 ± 0.051	5.636LeuGly: 5.636 ± 0.052	1.95LeuHis: 1.95 ± 0.031	5.624LeuIle: 5.624 ± 0.061	5.873LeuLys: 5.873 ± 0.051	10.412LeuLeu: 10.412 ± 0.094	2.058LeuMet: 2.058 ± 0.032	4.73LeuAsn: 4.73 ± 0.048	4.715LeuPro: 4.715 ± 0.055	4.762LeuGln: 4.762 ± 0.048	4.202LeuArg: 4.202 ± 0.048	6.428LeuSer: 6.428 ± 0.053	5.819LeuThr: 5.819 ± 0.058	5.945LeuVal: 5.945 ± 0.06	1.103LeuTrp: 1.103 ± 0.024	3.627LeuTyr: 3.627 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	1.992MetAla: 1.992 ± 0.031	0.127MetCys: 0.127 ± 0.006	1.204MetAsp: 1.204 ± 0.021	1.307MetGlu: 1.307 ± 0.024	0.73MetPhe: 0.73 ± 0.019	1.535MetGly: 1.535 ± 0.027	0.479MetHis: 0.479 ± 0.014	1.364MetIle: 1.364 ± 0.024	1.889MetLys: 1.889 ± 0.026	2.03MetLeu: 2.03 ± 0.028	0.597MetMet: 0.597 ± 0.016	1.21MetAsn: 1.21 ± 0.022	1.127MetPro: 1.127 ± 0.021	1.074MetGln: 1.074 ± 0.023	1.083MetArg: 1.083 ± 0.019	1.257MetSer: 1.257 ± 0.026	1.171MetThr: 1.171 ± 0.021	1.494MetVal: 1.494 ± 0.028	0.208MetTrp: 0.208 ± 0.01	0.72MetTyr: 0.72 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	4.017AsnAla: 4.017 ± 0.052	0.371AsnCys: 0.371 ± 0.013	2.673AsnAsp: 2.673 ± 0.036	2.532AsnGlu: 2.532 ± 0.035	2.296AsnPhe: 2.296 ± 0.031	4.295AsnGly: 4.295 ± 0.08	0.87AsnHis: 0.87 ± 0.02	3.75AsnIle: 3.75 ± 0.041	3.328AsnLys: 3.328 ± 0.038	4.423AsnLeu: 4.423 ± 0.058	1.136AsnMet: 1.136 ± 0.022	3.431AsnAsn: 3.431 ± 0.056	2.72AsnPro: 2.72 ± 0.037	1.925AsnGln: 1.925 ± 0.03	2.376AsnArg: 2.376 ± 0.031	3.021AsnSer: 3.021 ± 0.049	3.625AsnThr: 3.625 ± 0.049	2.963AsnVal: 2.963 ± 0.047	0.787AsnTrp: 0.787 ± 0.021	2.465AsnTyr: 2.465 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	4.678ProAla: 4.678 ± 0.061	0.256ProCys: 0.256 ± 0.01	2.703ProAsp: 2.703 ± 0.033	2.446ProGlu: 2.446 ± 0.032	2.029ProPhe: 2.029 ± 0.028	3.668ProGly: 3.668 ± 0.047	0.773ProHis: 0.773 ± 0.021	2.266ProIle: 2.266 ± 0.032	1.781ProLys: 1.781 ± 0.028	3.773ProLeu: 3.773 ± 0.04	0.856ProMet: 0.856 ± 0.019	1.898ProAsn: 1.898 ± 0.03	1.504ProPro: 1.504 ± 0.033	1.539ProGln: 1.539 ± 0.027	1.433ProArg: 1.433 ± 0.025	2.37ProSer: 2.37 ± 0.029	2.159ProThr: 2.159 ± 0.032	3.962ProVal: 3.962 ± 0.047	0.537ProTrp: 0.537 ± 0.015	1.631ProTyr: 1.631 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.338GlnAla: 3.338 ± 0.042	0.266GlnCys: 0.266 ± 0.01	1.699GlnAsp: 1.699 ± 0.028	2.353GlnGlu: 2.353 ± 0.04	1.915GlnPhe: 1.915 ± 0.03	2.459GlnGly: 2.459 ± 0.031	1.025GlnHis: 1.025 ± 0.023	1.933GlnIle: 1.933 ± 0.029	2.425GlnLys: 2.425 ± 0.031	4.67GlnLeu: 4.67 ± 0.051	0.88GlnMet: 0.88 ± 0.021	1.697GlnAsn: 1.697 ± 0.03	1.993GlnPro: 1.993 ± 0.029	2.906GlnGln: 2.906 ± 0.047	1.848GlnArg: 1.848 ± 0.033	2.34GlnSer: 2.34 ± 0.029	2.176GlnThr: 2.176 ± 0.03	3.006GlnVal: 3.006 ± 0.04	0.681GlnTrp: 0.681 ± 0.017	1.963GlnTyr: 1.963 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.739ArgAla: 2.739 ± 0.035	0.284ArgCys: 0.284 ± 0.012	2.088ArgAsp: 2.088 ± 0.029	2.415ArgGlu: 2.415 ± 0.036	2.41ArgPhe: 2.41 ± 0.033	2.389ArgGly: 2.389 ± 0.034	0.927ArgHis: 0.927 ± 0.022	3.307ArgIle: 3.307 ± 0.038	3.148ArgLys: 3.148 ± 0.038	4.445ArgLeu: 4.445 ± 0.042	1.196ArgMet: 1.196 ± 0.021	2.528ArgAsn: 2.528 ± 0.032	1.67ArgPro: 1.67 ± 0.028	2.115ArgGln: 2.115 ± 0.035	2.011ArgArg: 2.011 ± 0.035	2.709ArgSer: 2.709 ± 0.035	2.439ArgThr: 2.439 ± 0.034	2.629ArgVal: 2.629 ± 0.034	0.729ArgTrp: 0.729 ± 0.015	2.164ArgTyr: 2.164 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	4.53SerAla: 4.53 ± 0.048	0.575SerCys: 0.575 ± 0.016	2.674SerAsp: 2.674 ± 0.032	2.302SerGlu: 2.302 ± 0.036	3.574SerPhe: 3.574 ± 0.04	4.878SerGly: 4.878 ± 0.061	1.099SerHis: 1.099 ± 0.024	4.389SerIle: 4.389 ± 0.045	3.209SerLys: 3.209 ± 0.04	6.381SerLeu: 6.381 ± 0.054	1.33SerMet: 1.33 ± 0.021	3.16SerAsn: 3.16 ± 0.044	2.538SerPro: 2.538 ± 0.038	1.998SerGln: 1.998 ± 0.027	2.584SerArg: 2.584 ± 0.028	3.747SerSer: 3.747 ± 0.044	3.855SerThr: 3.855 ± 0.061	3.963SerVal: 3.963 ± 0.043	0.954SerTrp: 0.954 ± 0.022	2.704SerTyr: 2.704 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.639ThrAla: 5.639 ± 0.06	0.45ThrCys: 0.45 ± 0.014	3.454ThrAsp: 3.454 ± 0.041	2.712ThrGlu: 2.712 ± 0.033	2.704ThrPhe: 2.704 ± 0.042	5.653ThrGly: 5.653 ± 0.061	1.102ThrHis: 1.102 ± 0.025	4.579ThrIle: 4.579 ± 0.051	2.845ThrLys: 2.845 ± 0.04	5.681ThrLeu: 5.681 ± 0.062	1.14ThrMet: 1.14 ± 0.024	3.115ThrAsn: 3.115 ± 0.05	3.008ThrPro: 3.008 ± 0.038	2.042ThrGln: 2.042 ± 0.03	2.531ThrArg: 2.531 ± 0.037	3.605ThrSer: 3.605 ± 0.051	4.257ThrThr: 4.257 ± 0.065	4.477ThrVal: 4.477 ± 0.065	0.952ThrTrp: 0.952 ± 0.021	2.479ThrTyr: 2.479 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	5.151ValAla: 5.151 ± 0.052	0.571ValCys: 0.571 ± 0.018	3.247ValAsp: 3.247 ± 0.039	3.189ValGlu: 3.189 ± 0.044	3.016ValPhe: 3.016 ± 0.036	3.813ValGly: 3.813 ± 0.046	1.148ValHis: 1.148 ± 0.022	4.464ValIle: 4.464 ± 0.041	4.303ValLys: 4.303 ± 0.048	6.211ValLeu: 6.211 ± 0.064	1.485ValMet: 1.485 ± 0.024	3.674ValAsn: 3.674 ± 0.051	2.793ValPro: 2.793 ± 0.039	2.622ValGln: 2.622 ± 0.032	2.784ValArg: 2.784 ± 0.04	4.294ValSer: 4.294 ± 0.046	4.379ValThr: 4.379 ± 0.057	4.513ValVal: 4.513 ± 0.053	0.822ValTrp: 0.822 ± 0.02	2.591ValTyr: 2.591 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	0.922TrpAla: 0.922 ± 0.02	0.135TrpCys: 0.135 ± 0.007	0.746TrpAsp: 0.746 ± 0.018	0.718TrpGlu: 0.718 ± 0.016	0.661TrpPhe: 0.661 ± 0.018	0.983TrpGly: 0.983 ± 0.021	0.308TrpHis: 0.308 ± 0.011	0.881TrpIle: 0.881 ± 0.02	1.027TrpLys: 1.027 ± 0.021	1.489TrpLeu: 1.489 ± 0.027	0.429TrpMet: 0.429 ± 0.013	0.765TrpAsn: 0.765 ± 0.018	0.464TrpPro: 0.464 ± 0.015	0.759TrpGln: 0.759 ± 0.019	0.648TrpArg: 0.648 ± 0.019	0.806TrpSer: 0.806 ± 0.02	0.812TrpThr: 0.812 ± 0.021	0.835TrpVal: 0.835 ± 0.019	0.309TrpTrp: 0.309 ± 0.012	0.608TrpTyr: 0.608 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.058TyrAla: 3.058 ± 0.037	0.387TyrCys: 0.387 ± 0.013	2.382TyrAsp: 2.382 ± 0.042	2.065TyrGlu: 2.065 ± 0.031	2.24TyrPhe: 2.24 ± 0.031	2.863TyrGly: 2.863 ± 0.036	0.851TyrHis: 0.851 ± 0.021	2.431TyrIle: 2.431 ± 0.032	2.47TyrLys: 2.47 ± 0.035	3.825TyrLeu: 3.825 ± 0.042	0.792TyrMet: 0.792 ± 0.018	2.457TyrAsn: 2.457 ± 0.042	1.801TyrPro: 1.801 ± 0.028	1.741TyrGln: 1.741 ± 0.029	2.159TyrArg: 2.159 ± 0.032	2.593TyrSer: 2.593 ± 0.034	2.866TyrThr: 2.866 ± 0.044	2.266TyrVal: 2.266 ± 0.03	0.633TyrTrp: 0.633 ± 0.015	2.034TyrTyr: 2.034 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6406 proteins (2480089 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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