Amino acid dipepetide frequency for Cohnella luojiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.117AlaAla: 8.117 ± 0.098
0.72AlaCys: 0.72 ± 0.021
4.296AlaAsp: 4.296 ± 0.065
5.531AlaGlu: 5.531 ± 0.074
3.363AlaPhe: 3.363 ± 0.054
6.645AlaGly: 6.645 ± 0.098
1.399AlaHis: 1.399 ± 0.034
5.766AlaIle: 5.766 ± 0.071
4.204AlaLys: 4.204 ± 0.06
8.359AlaLeu: 8.359 ± 0.089
2.399AlaMet: 2.399 ± 0.045
2.807AlaAsn: 2.807 ± 0.049
2.511AlaPro: 2.511 ± 0.042
2.574AlaGln: 2.574 ± 0.047
3.735AlaArg: 3.735 ± 0.054
5.176AlaSer: 5.176 ± 0.062
3.701AlaThr: 3.701 ± 0.054
6.282AlaVal: 6.282 ± 0.075
1.005AlaTrp: 1.005 ± 0.027
2.642AlaTyr: 2.642 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.523CysAla: 0.523 ± 0.019
0.115CysCys: 0.115 ± 0.009
0.387CysAsp: 0.387 ± 0.019
0.433CysGlu: 0.433 ± 0.016
0.277CysPhe: 0.277 ± 0.014
0.791CysGly: 0.791 ± 0.021
0.188CysHis: 0.188 ± 0.015
0.492CysIle: 0.492 ± 0.018
0.329CysLys: 0.329 ± 0.016
0.743CysLeu: 0.743 ± 0.024
0.195CysMet: 0.195 ± 0.012
0.279CysAsn: 0.279 ± 0.014
0.361CysPro: 0.361 ± 0.018
0.183CysGln: 0.183 ± 0.011
0.454CysArg: 0.454 ± 0.018
0.557CysSer: 0.557 ± 0.022
0.387CysThr: 0.387 ± 0.016
0.446CysVal: 0.446 ± 0.019
0.089CysTrp: 0.089 ± 0.007
0.252CysTyr: 0.252 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.967AspAla: 3.967 ± 0.061
0.38AspCys: 0.38 ± 0.016
2.617AspAsp: 2.617 ± 0.055
3.778AspGlu: 3.778 ± 0.052
2.24AspPhe: 2.24 ± 0.045
4.161AspGly: 4.161 ± 0.06
1.043AspHis: 1.043 ± 0.031
3.592AspIle: 3.592 ± 0.057
2.846AspLys: 2.846 ± 0.056
5.055AspLeu: 5.055 ± 0.06
1.321AspMet: 1.321 ± 0.031
1.994AspAsn: 1.994 ± 0.039
2.426AspPro: 2.426 ± 0.042
1.814AspGln: 1.814 ± 0.03
3.127AspArg: 3.127 ± 0.049
3.097AspSer: 3.097 ± 0.041
2.428AspThr: 2.428 ± 0.044
3.634AspVal: 3.634 ± 0.053
0.934AspTrp: 0.934 ± 0.028
2.052AspTyr: 2.052 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
5.863GluAla: 5.863 ± 0.072
0.401GluCys: 0.401 ± 0.016
3.206GluAsp: 3.206 ± 0.057
5.168GluGlu: 5.168 ± 0.066
2.287GluPhe: 2.287 ± 0.041
4.456GluGly: 4.456 ± 0.057
1.403GluHis: 1.403 ± 0.031
4.478GluIle: 4.478 ± 0.062
3.94GluLys: 3.94 ± 0.069
6.79GluLeu: 6.79 ± 0.079
2.027GluMet: 2.027 ± 0.036
2.487GluAsn: 2.487 ± 0.048
2.26GluPro: 2.26 ± 0.042
3.252GluGln: 3.252 ± 0.05
4.267GluArg: 4.267 ± 0.061
3.786GluSer: 3.786 ± 0.052
3.427GluThr: 3.427 ± 0.054
4.357GluVal: 4.357 ± 0.061
1.051GluTrp: 1.051 ± 0.033
1.983GluTyr: 1.983 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.357PheAla: 3.357 ± 0.057
0.349PheCys: 0.349 ± 0.018
2.384PheAsp: 2.384 ± 0.042
2.449PheGlu: 2.449 ± 0.047
1.821PhePhe: 1.821 ± 0.049
3.445PheGly: 3.445 ± 0.062
0.943PheHis: 0.943 ± 0.028
2.902PheIle: 2.902 ± 0.056
1.95PheLys: 1.95 ± 0.04
4.114PheLeu: 4.114 ± 0.073
1.123PheMet: 1.123 ± 0.028
1.622PheAsn: 1.622 ± 0.038
1.765PhePro: 1.765 ± 0.036
1.429PheGln: 1.429 ± 0.033
2.212PheArg: 2.212 ± 0.041
2.715PheSer: 2.715 ± 0.047
2.327PheThr: 2.327 ± 0.044
3.123PheVal: 3.123 ± 0.052
0.551PheTrp: 0.551 ± 0.022
1.459PheTyr: 1.459 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
5.618GlyAla: 5.618 ± 0.082
0.707GlyCys: 0.707 ± 0.025
3.66GlyAsp: 3.66 ± 0.055
4.589GlyGlu: 4.589 ± 0.059
3.41GlyPhe: 3.41 ± 0.056
5.642GlyGly: 5.642 ± 0.086
1.476GlyHis: 1.476 ± 0.034
5.859GlyIle: 5.859 ± 0.085
4.75GlyLys: 4.75 ± 0.067
7.396GlyLeu: 7.396 ± 0.08
2.42GlyMet: 2.42 ± 0.045
3.012GlyAsn: 3.012 ± 0.08
1.917GlyPro: 1.917 ± 0.036
2.583GlyGln: 2.583 ± 0.045
3.691GlyArg: 3.691 ± 0.065
4.764GlySer: 4.764 ± 0.073
4.296GlyThr: 4.296 ± 0.066
5.304GlyVal: 5.304 ± 0.073
1.176GlyTrp: 1.176 ± 0.028
2.908GlyTyr: 2.908 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.522HisAla: 1.522 ± 0.037
0.197HisCys: 0.197 ± 0.015
0.987HisAsp: 0.987 ± 0.03
1.239HisGlu: 1.239 ± 0.029
1.01HisPhe: 1.01 ± 0.027
1.524HisGly: 1.524 ± 0.035
0.611HisHis: 0.611 ± 0.025
1.2HisIle: 1.2 ± 0.028
0.759HisLys: 0.759 ± 0.024
2.104HisLeu: 2.104 ± 0.044
0.522HisMet: 0.522 ± 0.021
0.689HisAsn: 0.689 ± 0.023
1.308HisPro: 1.308 ± 0.03
0.727HisGln: 0.727 ± 0.023
1.205HisArg: 1.205 ± 0.029
1.247HisSer: 1.247 ± 0.027
0.956HisThr: 0.956 ± 0.025
1.395HisVal: 1.395 ± 0.031
0.317HisTrp: 0.317 ± 0.012
0.831HisTyr: 0.831 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.041IleAla: 6.041 ± 0.073
0.606IleCys: 0.606 ± 0.02
3.915IleAsp: 3.915 ± 0.059
4.293IleGlu: 4.293 ± 0.065
2.37IlePhe: 2.37 ± 0.053
5.645IleGly: 5.645 ± 0.074
1.404IleHis: 1.404 ± 0.03
4.303IleIle: 4.303 ± 0.065
3.094IleLys: 3.094 ± 0.042
5.957IleLeu: 5.957 ± 0.093
1.592IleMet: 1.592 ± 0.037
2.426IleAsn: 2.426 ± 0.042
3.307IlePro: 3.307 ± 0.051
2.391IleGln: 2.391 ± 0.044
4.106IleArg: 4.106 ± 0.056
4.524IleSer: 4.524 ± 0.062
3.684IleThr: 3.684 ± 0.059
5.526IleVal: 5.526 ± 0.059
0.734IleTrp: 0.734 ± 0.024
2.04IleTyr: 2.04 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
4.385LysAla: 4.385 ± 0.064
0.25LysCys: 0.25 ± 0.013
2.989LysAsp: 2.989 ± 0.047
4.258LysGlu: 4.258 ± 0.057
1.697LysPhe: 1.697 ± 0.035
3.688LysGly: 3.688 ± 0.06
1.073LysHis: 1.073 ± 0.026
3.238LysIle: 3.238 ± 0.053
3.109LysLys: 3.109 ± 0.062
5.556LysLeu: 5.556 ± 0.073
1.584LysMet: 1.584 ± 0.043
2.022LysAsn: 2.022 ± 0.041
2.478LysPro: 2.478 ± 0.046
2.168LysGln: 2.168 ± 0.046
2.943LysArg: 2.943 ± 0.046
3.139LysSer: 3.139 ± 0.048
2.765LysThr: 2.765 ± 0.044
3.655LysVal: 3.655 ± 0.055
0.763LysTrp: 0.763 ± 0.024
1.713LysTyr: 1.713 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
8.36LeuAla: 8.36 ± 0.104
0.783LeuCys: 0.783 ± 0.023
5.053LeuAsp: 5.053 ± 0.056
6.241LeuGlu: 6.241 ± 0.07
4.707LeuPhe: 4.707 ± 0.072
6.905LeuGly: 6.905 ± 0.097
2.068LeuHis: 2.068 ± 0.041
6.656LeuIle: 6.656 ± 0.076
5.44LeuLys: 5.44 ± 0.065
10.934LeuLeu: 10.934 ± 0.129
2.65LeuMet: 2.65 ± 0.047
3.956LeuAsn: 3.956 ± 0.055
4.535LeuPro: 4.535 ± 0.063
3.745LeuGln: 3.745 ± 0.049
5.298LeuArg: 5.298 ± 0.07
7.298LeuSer: 7.298 ± 0.074
5.71LeuThr: 5.71 ± 0.065
6.407LeuVal: 6.407 ± 0.077
1.129LeuTrp: 1.129 ± 0.031
3.016LeuTyr: 3.016 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.267MetAla: 2.267 ± 0.044
0.157MetCys: 0.157 ± 0.011
1.556MetAsp: 1.556 ± 0.031
1.933MetGlu: 1.933 ± 0.034
1.034MetPhe: 1.034 ± 0.03
1.837MetGly: 1.837 ± 0.038
0.454MetHis: 0.454 ± 0.018
1.848MetIle: 1.848 ± 0.039
1.95MetLys: 1.95 ± 0.035
2.787MetLeu: 2.787 ± 0.047
0.824MetMet: 0.824 ± 0.027
1.436MetAsn: 1.436 ± 0.029
1.174MetPro: 1.174 ± 0.027
0.978MetGln: 0.978 ± 0.029
1.39MetArg: 1.39 ± 0.033
1.867MetSer: 1.867 ± 0.038
1.696MetThr: 1.696 ± 0.037
1.707MetVal: 1.707 ± 0.036
0.242MetTrp: 0.242 ± 0.013
0.67MetTyr: 0.67 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.958AsnAla: 2.958 ± 0.052
0.242AsnCys: 0.242 ± 0.012
2.138AsnAsp: 2.138 ± 0.045
2.702AsnGlu: 2.702 ± 0.043
1.365AsnPhe: 1.365 ± 0.031
3.426AsnGly: 3.426 ± 0.088
0.834AsnHis: 0.834 ± 0.026
2.325AsnIle: 2.325 ± 0.044
2.1AsnLys: 2.1 ± 0.039
3.475AsnLeu: 3.475 ± 0.054
1.003AsnMet: 1.003 ± 0.027
1.653AsnAsn: 1.653 ± 0.044
2.146AsnPro: 2.146 ± 0.041
1.433AsnGln: 1.433 ± 0.031
2.371AsnArg: 2.371 ± 0.043
2.137AsnSer: 2.137 ± 0.043
1.859AsnThr: 1.859 ± 0.042
2.794AsnVal: 2.794 ± 0.048
0.548AsnTrp: 0.548 ± 0.016
1.31AsnTyr: 1.31 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
3.222ProAla: 3.222 ± 0.049
0.256ProCys: 0.256 ± 0.013
2.664ProAsp: 2.664 ± 0.048
3.402ProGlu: 3.402 ± 0.057
1.927ProPhe: 1.927 ± 0.038
2.937ProGly: 2.937 ± 0.044
0.933ProHis: 0.933 ± 0.026
2.747ProIle: 2.747 ± 0.05
1.861ProLys: 1.861 ± 0.036
4.049ProLeu: 4.049 ± 0.059
1.025ProMet: 1.025 ± 0.025
1.704ProAsn: 1.704 ± 0.039
1.335ProPro: 1.335 ± 0.031
1.353ProGln: 1.353 ± 0.032
1.642ProArg: 1.642 ± 0.037
2.849ProSer: 2.849 ± 0.052
2.048ProThr: 2.048 ± 0.049
3.103ProVal: 3.103 ± 0.047
0.565ProTrp: 0.565 ± 0.022
1.483ProTyr: 1.483 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.314GlnAla: 3.314 ± 0.05
0.196GlnCys: 0.196 ± 0.014
1.564GlnAsp: 1.564 ± 0.035
2.371GlnGlu: 2.371 ± 0.051
1.548GlnPhe: 1.548 ± 0.033
2.467GlnGly: 2.467 ± 0.05
0.678GlnHis: 0.678 ± 0.021
2.393GlnIle: 2.393 ± 0.044
1.799GlnLys: 1.799 ± 0.036
3.909GlnLeu: 3.909 ± 0.057
1.096GlnMet: 1.096 ± 0.029
1.203GlnAsn: 1.203 ± 0.035
1.486GlnPro: 1.486 ± 0.035
1.61GlnGln: 1.61 ± 0.042
1.861GlnArg: 1.861 ± 0.039
2.297GlnSer: 2.297 ± 0.047
1.885GlnThr: 1.885 ± 0.037
2.39GlnVal: 2.39 ± 0.041
0.577GlnTrp: 0.577 ± 0.02
1.227GlnTyr: 1.227 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
3.435ArgAla: 3.435 ± 0.051
0.349ArgCys: 0.349 ± 0.017
2.721ArgAsp: 2.721 ± 0.042
3.867ArgGlu: 3.867 ± 0.059
2.464ArgPhe: 2.464 ± 0.046
3.231ArgGly: 3.231 ± 0.042
1.157ArgHis: 1.157 ± 0.031
4.061ArgIle: 4.061 ± 0.061
3.423ArgLys: 3.423 ± 0.051
5.716ArgLeu: 5.716 ± 0.08
1.792ArgMet: 1.792 ± 0.037
2.312ArgAsn: 2.312 ± 0.04
1.791ArgPro: 1.791 ± 0.041
2.083ArgGln: 2.083 ± 0.042
3.166ArgArg: 3.166 ± 0.049
3.316ArgSer: 3.316 ± 0.053
2.758ArgThr: 2.758 ± 0.042
3.433ArgVal: 3.433 ± 0.05
0.718ArgTrp: 0.718 ± 0.023
1.956ArgTyr: 1.956 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.028SerAla: 5.028 ± 0.069
0.458SerCys: 0.458 ± 0.016
3.269SerAsp: 3.269 ± 0.05
3.962SerGlu: 3.962 ± 0.055
3.032SerPhe: 3.032 ± 0.049
5.517SerGly: 5.517 ± 0.07
1.296SerHis: 1.296 ± 0.029
4.41SerIle: 4.41 ± 0.069
3.261SerLys: 3.261 ± 0.047
6.525SerLeu: 6.525 ± 0.075
1.772SerMet: 1.772 ± 0.036
2.312SerAsn: 2.312 ± 0.046
2.718SerPro: 2.718 ± 0.049
1.987SerGln: 1.987 ± 0.038
3.435SerArg: 3.435 ± 0.053
4.477SerSer: 4.477 ± 0.069
3.106SerThr: 3.106 ± 0.049
4.782SerVal: 4.782 ± 0.076
0.871SerTrp: 0.871 ± 0.025
2.195SerTyr: 2.195 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
4.41ThrAla: 4.41 ± 0.06
0.311ThrCys: 0.311 ± 0.015
2.863ThrAsp: 2.863 ± 0.047
3.235ThrGlu: 3.235 ± 0.05
2.3ThrPhe: 2.3 ± 0.041
4.397ThrGly: 4.397 ± 0.05
0.995ThrHis: 0.995 ± 0.026
3.85ThrIle: 3.85 ± 0.06
2.418ThrLys: 2.418 ± 0.041
5.428ThrLeu: 5.428 ± 0.067
1.296ThrMet: 1.296 ± 0.028
1.942ThrAsn: 1.942 ± 0.044
2.528ThrPro: 2.528 ± 0.052
1.478ThrGln: 1.478 ± 0.032
2.337ThrArg: 2.337 ± 0.044
3.226ThrSer: 3.226 ± 0.053
2.729ThrThr: 2.729 ± 0.046
4.228ThrVal: 4.228 ± 0.057
0.653ThrTrp: 0.653 ± 0.023
1.785ThrTyr: 1.785 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
5.443ValAla: 5.443 ± 0.07
0.615ValCys: 0.615 ± 0.023
3.637ValAsp: 3.637 ± 0.056
4.382ValGlu: 4.382 ± 0.062
2.993ValPhe: 2.993 ± 0.051
4.79ValGly: 4.79 ± 0.076
1.436ValHis: 1.436 ± 0.032
4.941ValIle: 4.941 ± 0.065
3.872ValLys: 3.872 ± 0.061
7.169ValLeu: 7.169 ± 0.086
1.931ValMet: 1.931 ± 0.038
2.881ValAsn: 2.881 ± 0.047
3.11ValPro: 3.11 ± 0.046
2.448ValGln: 2.448 ± 0.041
3.668ValArg: 3.668 ± 0.051
4.907ValSer: 4.907 ± 0.053
4.31ValThr: 4.31 ± 0.072
5.118ValVal: 5.118 ± 0.072
0.875ValTrp: 0.875 ± 0.022
2.308ValTyr: 2.308 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.846TrpAla: 0.846 ± 0.026
0.112TrpCys: 0.112 ± 0.008
0.705TrpAsp: 0.705 ± 0.025
0.821TrpGlu: 0.821 ± 0.026
0.624TrpPhe: 0.624 ± 0.022
0.904TrpGly: 0.904 ± 0.024
0.252TrpHis: 0.252 ± 0.015
1.009TrpIle: 1.009 ± 0.025
0.815TrpLys: 0.815 ± 0.025
1.463TrpLeu: 1.463 ± 0.036
0.446TrpMet: 0.446 ± 0.018
0.763TrpAsn: 0.763 ± 0.025
0.423TrpPro: 0.423 ± 0.02
0.494TrpGln: 0.494 ± 0.019
0.664TrpArg: 0.664 ± 0.024
0.872TrpSer: 0.872 ± 0.025
0.725TrpThr: 0.725 ± 0.022
0.886TrpVal: 0.886 ± 0.026
0.213TrpTrp: 0.213 ± 0.013
0.435TrpTyr: 0.435 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.553TyrAla: 2.553 ± 0.042
0.277TyrCys: 0.277 ± 0.017
1.891TyrAsp: 1.891 ± 0.059
2.235TyrGlu: 2.235 ± 0.041
1.57TyrPhe: 1.57 ± 0.036
2.772TyrGly: 2.772 ± 0.044
0.709TyrHis: 0.709 ± 0.02
1.888TyrIle: 1.888 ± 0.038
1.554TyrLys: 1.554 ± 0.035
3.366TyrLeu: 3.366 ± 0.049
0.788TyrMet: 0.788 ± 0.026
1.319TyrAsn: 1.319 ± 0.035
1.524TyrPro: 1.524 ± 0.036
1.141TyrGln: 1.141 ± 0.03
2.178TyrArg: 2.178 ± 0.037
2.164TyrSer: 2.164 ± 0.04
1.611TyrThr: 1.611 ± 0.034
2.267TyrVal: 2.267 ± 0.037
0.46TyrTrp: 0.46 ± 0.018
1.252TyrTyr: 1.252 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4577 proteins (1446148 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski