Amino acid dipepetide frequency for Barnesiella viscericola DSM 18177

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.473AlaAla: 6.473 ± 0.093	1.051AlaCys: 1.051 ± 0.031	4.652AlaAsp: 4.652 ± 0.08	4.991AlaGlu: 4.991 ± 0.098	3.277AlaPhe: 3.277 ± 0.075	5.42AlaGly: 5.42 ± 0.099	1.427AlaHis: 1.427 ± 0.039	5.054AlaIle: 5.054 ± 0.081	3.434AlaLys: 3.434 ± 0.069	7.407AlaLeu: 7.407 ± 0.111	1.899AlaMet: 1.899 ± 0.046	2.798AlaAsn: 2.798 ± 0.058	2.761AlaPro: 2.761 ± 0.059	3.075AlaGln: 3.075 ± 0.07	4.333AlaArg: 4.333 ± 0.09	4.439AlaSer: 4.439 ± 0.081	4.251AlaThr: 4.251 ± 0.092	5.418AlaVal: 5.418 ± 0.088	0.859AlaTrp: 0.859 ± 0.033	2.967AlaTyr: 2.967 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.821CysAla: 0.821 ± 0.032	0.193CysCys: 0.193 ± 0.017	0.718CysAsp: 0.718 ± 0.032	0.746CysGlu: 0.746 ± 0.027	0.588CysPhe: 0.588 ± 0.028	1.059CysGly: 1.059 ± 0.04	0.321CysHis: 0.321 ± 0.021	0.829CysIle: 0.829 ± 0.028	0.62CysLys: 0.62 ± 0.029	0.979CysLeu: 0.979 ± 0.034	0.288CysMet: 0.288 ± 0.02	0.586CysAsn: 0.586 ± 0.027	0.509CysPro: 0.509 ± 0.029	0.353CysGln: 0.353 ± 0.024	0.794CysArg: 0.794 ± 0.034	0.744CysSer: 0.744 ± 0.03	0.703CysThr: 0.703 ± 0.033	0.753CysVal: 0.753 ± 0.031	0.158CysTrp: 0.158 ± 0.015	0.526CysTyr: 0.526 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	3.833AspAla: 3.833 ± 0.069	0.673AspCys: 0.673 ± 0.027	3.263AspAsp: 3.263 ± 0.07	4.29AspGlu: 4.29 ± 0.072	2.919AspPhe: 2.919 ± 0.061	4.016AspGly: 4.016 ± 0.076	0.969AspHis: 0.969 ± 0.031	3.987AspIle: 3.987 ± 0.075	3.488AspLys: 3.488 ± 0.074	4.975AspLeu: 4.975 ± 0.082	1.575AspMet: 1.575 ± 0.042	2.769AspAsn: 2.769 ± 0.059	2.185AspPro: 2.185 ± 0.057	1.407AspGln: 1.407 ± 0.039	3.241AspArg: 3.241 ± 0.069	3.386AspSer: 3.386 ± 0.07	2.935AspThr: 2.935 ± 0.059	3.266AspVal: 3.266 ± 0.062	0.842AspTrp: 0.842 ± 0.032	3.036AspTyr: 3.036 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	5.468GluAla: 5.468 ± 0.094	0.644GluCys: 0.644 ± 0.028	2.584GluAsp: 2.584 ± 0.064	4.683GluGlu: 4.683 ± 0.092	2.408GluPhe: 2.408 ± 0.058	4.202GluGly: 4.202 ± 0.082	1.252GluHis: 1.252 ± 0.04	4.636GluIle: 4.636 ± 0.078	4.571GluLys: 4.571 ± 0.086	6.076GluLeu: 6.076 ± 0.087	1.969GluMet: 1.969 ± 0.049	3.223GluAsn: 3.223 ± 0.058	2.128GluPro: 2.128 ± 0.049	2.749GluGln: 2.749 ± 0.068	3.671GluArg: 3.671 ± 0.073	3.695GluSer: 3.695 ± 0.067	3.504GluThr: 3.504 ± 0.069	4.375GluVal: 4.375 ± 0.077	0.909GluTrp: 0.909 ± 0.034	2.55GluTyr: 2.55 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.272PheAla: 3.272 ± 0.064	0.637PheCys: 0.637 ± 0.025	3.091PheAsp: 3.091 ± 0.064	2.577PheGlu: 2.577 ± 0.057	2.101PhePhe: 2.101 ± 0.058	3.155PheGly: 3.155 ± 0.065	0.843PheHis: 0.843 ± 0.031	2.891PheIle: 2.891 ± 0.066	2.234PheLys: 2.234 ± 0.058	3.876PheLeu: 3.876 ± 0.074	1.117PheMet: 1.117 ± 0.037	2.133PheAsn: 2.133 ± 0.045	1.681PhePro: 1.681 ± 0.047	1.108PheGln: 1.108 ± 0.035	2.1PheArg: 2.1 ± 0.045	3.19PheSer: 3.19 ± 0.064	2.708PheThr: 2.708 ± 0.06	3.118PheVal: 3.118 ± 0.065	0.534PheTrp: 0.534 ± 0.024	1.846PheTyr: 1.846 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.728GlyAla: 4.728 ± 0.082	0.949GlyCys: 0.949 ± 0.04	3.712GlyAsp: 3.712 ± 0.067	4.524GlyGlu: 4.524 ± 0.07	3.049GlyPhe: 3.049 ± 0.066	4.886GlyGly: 4.886 ± 0.098	1.377GlyHis: 1.377 ± 0.044	5.153GlyIle: 5.153 ± 0.074	4.537GlyLys: 4.537 ± 0.07	5.898GlyLeu: 5.898 ± 0.08	1.901GlyMet: 1.901 ± 0.053	3.428GlyAsn: 3.428 ± 0.07	1.338GlyPro: 1.338 ± 0.038	2.139GlyGln: 2.139 ± 0.049	3.47GlyArg: 3.47 ± 0.06	4.062GlySer: 4.062 ± 0.075	4.043GlyThr: 4.043 ± 0.068	5.02GlyVal: 5.02 ± 0.082	0.938GlyTrp: 0.938 ± 0.036	3.403GlyTyr: 3.403 ± 0.075	0.0GlyXaa: 0.0 ± 0.0
His	1.253HisAla: 1.253 ± 0.038	0.298HisCys: 0.298 ± 0.019	1.065HisAsp: 1.065 ± 0.036	1.203HisGlu: 1.203 ± 0.036	0.999HisPhe: 0.999 ± 0.034	1.208HisGly: 1.208 ± 0.04	0.536HisHis: 0.536 ± 0.025	1.66HisIle: 1.66 ± 0.043	0.971HisLys: 0.971 ± 0.037	1.94HisLeu: 1.94 ± 0.049	0.413HisMet: 0.413 ± 0.025	0.913HisAsn: 0.913 ± 0.033	0.956HisPro: 0.956 ± 0.035	0.594HisGln: 0.594 ± 0.027	1.163HisArg: 1.163 ± 0.04	1.06HisSer: 1.06 ± 0.036	1.211HisThr: 1.211 ± 0.038	1.057HisVal: 1.057 ± 0.039	0.242HisTrp: 0.242 ± 0.017	0.977HisTyr: 0.977 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.763IleAla: 5.763 ± 0.097	0.825IleCys: 0.825 ± 0.036	4.786IleAsp: 4.786 ± 0.072	4.773IleGlu: 4.773 ± 0.078	2.757IlePhe: 2.757 ± 0.068	4.603IleGly: 4.603 ± 0.092	1.269IleHis: 1.269 ± 0.04	4.068IleIle: 4.068 ± 0.084	3.498IleLys: 3.498 ± 0.072	5.749IleLeu: 5.749 ± 0.09	1.304IleMet: 1.304 ± 0.041	2.835IleAsn: 2.835 ± 0.059	3.215IlePro: 3.215 ± 0.061	1.997IleGln: 1.997 ± 0.041	3.307IleArg: 3.307 ± 0.069	4.036IleSer: 4.036 ± 0.073	3.902IleThr: 3.902 ± 0.072	4.665IleVal: 4.665 ± 0.077	0.612IleTrp: 0.612 ± 0.027	2.67IleTyr: 2.67 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.278LysAla: 4.278 ± 0.082	0.456LysCys: 0.456 ± 0.024	2.815LysAsp: 2.815 ± 0.081	4.483LysGlu: 4.483 ± 0.096	1.909LysPhe: 1.909 ± 0.047	3.779LysGly: 3.779 ± 0.075	1.053LysHis: 1.053 ± 0.039	3.817LysIle: 3.817 ± 0.074	3.776LysLys: 3.776 ± 0.092	4.603LysLeu: 4.603 ± 0.074	1.748LysMet: 1.748 ± 0.047	2.891LysAsn: 2.891 ± 0.064	2.117LysPro: 2.117 ± 0.051	2.212LysGln: 2.212 ± 0.042	3.209LysArg: 3.209 ± 0.065	3.314LysSer: 3.314 ± 0.065	2.979LysThr: 2.979 ± 0.056	3.549LysVal: 3.549 ± 0.075	0.644LysTrp: 0.644 ± 0.025	2.441LysTyr: 2.441 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	6.996LeuAla: 6.996 ± 0.098	1.398LeuCys: 1.398 ± 0.041	5.329LeuAsp: 5.329 ± 0.085	4.683LeuGlu: 4.683 ± 0.079	4.54LeuPhe: 4.54 ± 0.083	5.842LeuGly: 5.842 ± 0.104	2.023LeuHis: 2.023 ± 0.057	5.305LeuIle: 5.305 ± 0.092	5.413LeuLys: 5.413 ± 0.09	9.518LeuLeu: 9.518 ± 0.147	2.34LeuMet: 2.34 ± 0.059	4.347LeuAsn: 4.347 ± 0.079	4.474LeuPro: 4.474 ± 0.081	3.334LeuGln: 3.334 ± 0.067	4.57LeuArg: 4.57 ± 0.081	7.05LeuSer: 7.05 ± 0.11	5.364LeuThr: 5.364 ± 0.084	5.574LeuVal: 5.574 ± 0.098	1.012LeuTrp: 1.012 ± 0.044	3.993LeuTyr: 3.993 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.159MetAla: 2.159 ± 0.052	0.236MetCys: 0.236 ± 0.016	1.206MetAsp: 1.206 ± 0.04	1.622MetGlu: 1.622 ± 0.04	0.896MetPhe: 0.896 ± 0.032	1.796MetGly: 1.796 ± 0.044	0.469MetHis: 0.469 ± 0.024	1.463MetIle: 1.463 ± 0.037	2.068MetLys: 2.068 ± 0.05	2.292MetLeu: 2.292 ± 0.051	0.707MetMet: 0.707 ± 0.031	1.266MetAsn: 1.266 ± 0.038	1.166MetPro: 1.166 ± 0.038	1.009MetGln: 1.009 ± 0.035	1.377MetArg: 1.377 ± 0.038	1.485MetSer: 1.485 ± 0.042	1.499MetThr: 1.499 ± 0.042	1.552MetVal: 1.552 ± 0.048	0.27MetTrp: 0.27 ± 0.018	0.761MetTyr: 0.761 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.168AsnAla: 3.168 ± 0.065	0.505AsnCys: 0.505 ± 0.028	2.617AsnAsp: 2.617 ± 0.054	2.794AsnGlu: 2.794 ± 0.059	1.952AsnPhe: 1.952 ± 0.059	3.374AsnGly: 3.374 ± 0.074	0.901AsnHis: 0.901 ± 0.034	3.152AsnIle: 3.152 ± 0.071	2.39AsnLys: 2.39 ± 0.064	4.155AsnLeu: 4.155 ± 0.075	1.093AsnMet: 1.093 ± 0.035	2.337AsnAsn: 2.337 ± 0.072	2.585AsnPro: 2.585 ± 0.06	1.477AsnGln: 1.477 ± 0.038	2.859AsnArg: 2.859 ± 0.055	2.576AsnSer: 2.576 ± 0.062	2.445AsnThr: 2.445 ± 0.057	2.739AsnVal: 2.739 ± 0.06	0.569AsnTrp: 0.569 ± 0.024	2.072AsnTyr: 2.072 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	3.44ProAla: 3.44 ± 0.069	0.397ProCys: 0.397 ± 0.023	2.996ProAsp: 2.996 ± 0.062	3.463ProGlu: 3.463 ± 0.055	1.921ProPhe: 1.921 ± 0.048	2.699ProGly: 2.699 ± 0.062	0.886ProHis: 0.886 ± 0.037	2.317ProIle: 2.317 ± 0.053	1.714ProLys: 1.714 ± 0.048	3.598ProLeu: 3.598 ± 0.073	0.907ProMet: 0.907 ± 0.037	1.603ProAsn: 1.603 ± 0.047	1.023ProPro: 1.023 ± 0.039	1.747ProGln: 1.747 ± 0.047	1.842ProArg: 1.842 ± 0.051	2.364ProSer: 2.364 ± 0.053	2.125ProThr: 2.125 ± 0.053	3.381ProVal: 3.381 ± 0.062	0.432ProTrp: 0.432 ± 0.023	1.811ProTyr: 1.811 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.87GlnAla: 2.87 ± 0.072	0.315GlnCys: 0.315 ± 0.018	1.312GlnAsp: 1.312 ± 0.04	2.34GlnGlu: 2.34 ± 0.057	1.387GlnPhe: 1.387 ± 0.031	2.145GlnGly: 2.145 ± 0.048	0.628GlnHis: 0.628 ± 0.026	2.503GlnIle: 2.503 ± 0.055	2.089GlnLys: 2.089 ± 0.056	3.389GlnLeu: 3.389 ± 0.071	1.036GlnMet: 1.036 ± 0.038	1.601GlnAsn: 1.601 ± 0.045	1.407GlnPro: 1.407 ± 0.045	1.679GlnGln: 1.679 ± 0.054	1.817GlnArg: 1.817 ± 0.05	2.072GlnSer: 2.072 ± 0.055	2.031GlnThr: 2.031 ± 0.053	2.329GlnVal: 2.329 ± 0.055	0.464GlnTrp: 0.464 ± 0.024	1.523GlnTyr: 1.523 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	3.35ArgAla: 3.35 ± 0.063	0.572ArgCys: 0.572 ± 0.025	2.553ArgAsp: 2.553 ± 0.056	3.779ArgGlu: 3.779 ± 0.072	2.67ArgPhe: 2.67 ± 0.055	2.827ArgGly: 2.827 ± 0.065	1.208ArgHis: 1.208 ± 0.035	4.07ArgIle: 4.07 ± 0.072	3.151ArgLys: 3.151 ± 0.072	5.33ArgLeu: 5.33 ± 0.094	1.515ArgMet: 1.515 ± 0.043	2.551ArgAsn: 2.551 ± 0.053	2.101ArgPro: 2.101 ± 0.058	2.223ArgGln: 2.223 ± 0.058	3.073ArgArg: 3.073 ± 0.075	2.706ArgSer: 2.706 ± 0.066	2.647ArgThr: 2.647 ± 0.055	3.527ArgVal: 3.527 ± 0.063	0.702ArgTrp: 0.702 ± 0.03	2.83ArgTyr: 2.83 ± 0.061	0.0ArgXaa: 0.0 ± 0.0
Ser	4.547SerAla: 4.547 ± 0.078	0.817SerCys: 0.817 ± 0.033	3.323SerAsp: 3.323 ± 0.062	3.365SerGlu: 3.365 ± 0.061	3.075SerPhe: 3.075 ± 0.055	4.787SerGly: 4.787 ± 0.085	1.255SerHis: 1.255 ± 0.039	4.095SerIle: 4.095 ± 0.072	2.892SerLys: 2.892 ± 0.075	6.236SerLeu: 6.236 ± 0.095	1.483SerMet: 1.483 ± 0.041	2.515SerAsn: 2.515 ± 0.062	2.662SerPro: 2.662 ± 0.063	2.061SerGln: 2.061 ± 0.047	3.09SerArg: 3.09 ± 0.06	3.836SerSer: 3.836 ± 0.085	3.46SerThr: 3.46 ± 0.064	4.248SerVal: 4.248 ± 0.075	0.796SerTrp: 0.796 ± 0.037	2.682SerTyr: 2.682 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	4.38ThrAla: 4.38 ± 0.084	0.627ThrCys: 0.627 ± 0.027	3.687ThrAsp: 3.687 ± 0.072	3.227ThrGlu: 3.227 ± 0.064	2.588ThrPhe: 2.588 ± 0.062	4.35ThrGly: 4.35 ± 0.085	1.102ThrHis: 1.102 ± 0.036	3.757ThrIle: 3.757 ± 0.07	2.15ThrLys: 2.15 ± 0.057	5.921ThrLeu: 5.921 ± 0.098	1.126ThrMet: 1.126 ± 0.033	2.01ThrAsn: 2.01 ± 0.051	3.299ThrPro: 3.299 ± 0.071	1.95ThrGln: 1.95 ± 0.051	2.729ThrArg: 2.729 ± 0.062	3.224ThrSer: 3.224 ± 0.068	3.32ThrThr: 3.32 ± 0.086	4.245ThrVal: 4.245 ± 0.075	0.638ThrTrp: 0.638 ± 0.031	2.249ThrTyr: 2.249 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	5.375ValAla: 5.375 ± 0.106	0.943ValCys: 0.943 ± 0.032	3.986ValAsp: 3.986 ± 0.069	4.48ValGlu: 4.48 ± 0.088	2.62ValPhe: 2.62 ± 0.054	4.449ValGly: 4.449 ± 0.087	1.05ValHis: 1.05 ± 0.034	4.219ValIle: 4.219 ± 0.071	4.124ValLys: 4.124 ± 0.077	5.912ValLeu: 5.912 ± 0.087	1.648ValMet: 1.648 ± 0.048	2.957ValAsn: 2.957 ± 0.059	2.76ValPro: 2.76 ± 0.052	1.989ValGln: 1.989 ± 0.045	3.336ValArg: 3.336 ± 0.066	4.72ValSer: 4.72 ± 0.081	4.006ValThr: 4.006 ± 0.078	5.221ValVal: 5.221 ± 0.088	0.877ValTrp: 0.877 ± 0.039	2.681ValTyr: 2.681 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.805TrpAla: 0.805 ± 0.035	0.189TrpCys: 0.189 ± 0.015	0.669TrpAsp: 0.669 ± 0.029	0.746TrpGlu: 0.746 ± 0.032	0.517TrpPhe: 0.517 ± 0.026	1.004TrpGly: 1.004 ± 0.039	0.269TrpHis: 0.269 ± 0.02	0.832TrpIle: 0.832 ± 0.032	0.666TrpLys: 0.666 ± 0.029	1.226TrpLeu: 1.226 ± 0.038	0.248TrpMet: 0.248 ± 0.018	0.729TrpAsn: 0.729 ± 0.032	0.297TrpPro: 0.297 ± 0.02	0.493TrpGln: 0.493 ± 0.027	0.644TrpArg: 0.644 ± 0.031	0.719TrpSer: 0.719 ± 0.026	0.686TrpThr: 0.686 ± 0.031	0.796TrpVal: 0.796 ± 0.033	0.208TrpTrp: 0.208 ± 0.015	0.497TrpTyr: 0.497 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.01TyrAla: 3.01 ± 0.069	0.563TyrCys: 0.563 ± 0.025	2.693TyrAsp: 2.693 ± 0.06	2.527TyrGlu: 2.527 ± 0.053	2.038TyrPhe: 2.038 ± 0.046	2.954TyrGly: 2.954 ± 0.067	0.881TyrHis: 0.881 ± 0.037	2.826TyrIle: 2.826 ± 0.061	2.284TyrLys: 2.284 ± 0.061	4.025TyrLeu: 4.025 ± 0.078	0.981TyrMet: 0.981 ± 0.033	2.268TyrAsn: 2.268 ± 0.065	2.002TyrPro: 2.002 ± 0.056	1.34TyrGln: 1.34 ± 0.043	2.761TyrArg: 2.761 ± 0.064	2.55TyrSer: 2.55 ± 0.059	2.756TyrThr: 2.756 ± 0.07	2.521TyrVal: 2.521 ± 0.054	0.535TyrTrp: 0.535 ± 0.027	2.116TyrTyr: 2.116 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2487 proteins (885770 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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