Amino acid dipepetide frequency for Marinomonas sp. HB171799

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.146AlaAla: 9.146 ± 0.117
0.955AlaCys: 0.955 ± 0.032
5.152AlaAsp: 5.152 ± 0.066
5.865AlaGlu: 5.865 ± 0.081
3.482AlaPhe: 3.482 ± 0.067
6.602AlaGly: 6.602 ± 0.112
1.866AlaHis: 1.866 ± 0.046
5.896AlaIle: 5.896 ± 0.073
4.726AlaLys: 4.726 ± 0.076
10.688AlaLeu: 10.688 ± 0.13
2.726AlaMet: 2.726 ± 0.053
3.683AlaAsn: 3.683 ± 0.069
3.54AlaPro: 3.54 ± 0.068
4.513AlaGln: 4.513 ± 0.078
4.33AlaArg: 4.33 ± 0.066
5.489AlaSer: 5.489 ± 0.08
5.146AlaThr: 5.146 ± 0.11
6.341AlaVal: 6.341 ± 0.085
1.108AlaTrp: 1.108 ± 0.035
2.489AlaTyr: 2.489 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.786CysAla: 0.786 ± 0.029
0.156CysCys: 0.156 ± 0.013
0.595CysAsp: 0.595 ± 0.024
0.619CysGlu: 0.619 ± 0.028
0.424CysPhe: 0.424 ± 0.021
0.876CysGly: 0.876 ± 0.033
0.368CysHis: 0.368 ± 0.022
0.538CysIle: 0.538 ± 0.024
0.303CysLys: 0.303 ± 0.018
1.062CysLeu: 1.062 ± 0.039
0.181CysMet: 0.181 ± 0.012
0.301CysAsn: 0.301 ± 0.017
0.447CysPro: 0.447 ± 0.024
0.495CysGln: 0.495 ± 0.021
0.511CysArg: 0.511 ± 0.026
0.65CysSer: 0.65 ± 0.025
0.462CysThr: 0.462 ± 0.022
0.66CysVal: 0.66 ± 0.023
0.127CysTrp: 0.127 ± 0.011
0.312CysTyr: 0.312 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.799AspAla: 4.799 ± 0.078
0.533AspCys: 0.533 ± 0.025
2.957AspAsp: 2.957 ± 0.068
3.874AspGlu: 3.874 ± 0.062
2.358AspPhe: 2.358 ± 0.052
3.95AspGly: 3.95 ± 0.112
1.314AspHis: 1.314 ± 0.036
3.727AspIle: 3.727 ± 0.059
2.577AspLys: 2.577 ± 0.053
5.68AspLeu: 5.68 ± 0.069
1.438AspMet: 1.438 ± 0.042
2.0AspAsn: 2.0 ± 0.052
2.185AspPro: 2.185 ± 0.048
2.441AspGln: 2.441 ± 0.052
2.712AspArg: 2.712 ± 0.05
3.15AspSer: 3.15 ± 0.083
2.808AspThr: 2.808 ± 0.107
4.039AspVal: 4.039 ± 0.065
0.945AspTrp: 0.945 ± 0.032
1.94AspTyr: 1.94 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.795GluAla: 5.795 ± 0.071
0.511GluCys: 0.511 ± 0.023
3.022GluAsp: 3.022 ± 0.066
4.005GluGlu: 4.005 ± 0.082
2.418GluPhe: 2.418 ± 0.053
3.661GluGly: 3.661 ± 0.075
1.593GluHis: 1.593 ± 0.045
3.637GluIle: 3.637 ± 0.06
2.981GluLys: 2.981 ± 0.054
6.985GluLeu: 6.985 ± 0.097
1.551GluMet: 1.551 ± 0.039
2.322GluAsn: 2.322 ± 0.052
2.145GluPro: 2.145 ± 0.054
4.341GluGln: 4.341 ± 0.081
3.905GluArg: 3.905 ± 0.069
3.425GluSer: 3.425 ± 0.065
3.052GluThr: 3.052 ± 0.062
4.446GluVal: 4.446 ± 0.064
0.782GluTrp: 0.782 ± 0.027
1.712GluTyr: 1.712 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.889PheAla: 3.889 ± 0.062
0.492PheCys: 0.492 ± 0.022
2.689PheAsp: 2.689 ± 0.053
2.324PheGlu: 2.324 ± 0.053
1.709PhePhe: 1.709 ± 0.046
3.18PheGly: 3.18 ± 0.067
0.877PheHis: 0.877 ± 0.034
2.374PheIle: 2.374 ± 0.051
1.65PheLys: 1.65 ± 0.039
3.513PheLeu: 3.513 ± 0.071
0.959PheMet: 0.959 ± 0.03
1.652PheAsn: 1.652 ± 0.042
1.515PhePro: 1.515 ± 0.04
1.375PheGln: 1.375 ± 0.036
1.715PheArg: 1.715 ± 0.046
2.941PheSer: 2.941 ± 0.052
2.281PheThr: 2.281 ± 0.061
2.877PheVal: 2.877 ± 0.062
0.512PheTrp: 0.512 ± 0.025
1.244PheTyr: 1.244 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
5.975GlyAla: 5.975 ± 0.094
0.823GlyCys: 0.823 ± 0.031
3.678GlyAsp: 3.678 ± 0.069
4.526GlyGlu: 4.526 ± 0.064
3.297GlyPhe: 3.297 ± 0.069
4.855GlyGly: 4.855 ± 0.097
1.606GlyHis: 1.606 ± 0.048
4.755GlyIle: 4.755 ± 0.069
3.795GlyLys: 3.795 ± 0.07
7.286GlyLeu: 7.286 ± 0.095
2.068GlyMet: 2.068 ± 0.051
2.562GlyAsn: 2.562 ± 0.122
1.794GlyPro: 1.794 ± 0.041
3.04GlyGln: 3.04 ± 0.058
3.579GlyArg: 3.579 ± 0.062
4.016GlySer: 4.016 ± 0.079
3.463GlyThr: 3.463 ± 0.105
5.659GlyVal: 5.659 ± 0.086
1.046GlyTrp: 1.046 ± 0.036
2.46GlyTyr: 2.46 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
1.746HisAla: 1.746 ± 0.047
0.294HisCys: 0.294 ± 0.016
1.181HisAsp: 1.181 ± 0.041
1.227HisGlu: 1.227 ± 0.041
1.097HisPhe: 1.097 ± 0.039
1.702HisGly: 1.702 ± 0.047
0.808HisHis: 0.808 ± 0.032
1.41HisIle: 1.41 ± 0.039
0.929HisLys: 0.929 ± 0.03
2.4HisLeu: 2.4 ± 0.053
0.537HisMet: 0.537 ± 0.025
0.833HisAsn: 0.833 ± 0.03
1.316HisPro: 1.316 ± 0.043
1.167HisGln: 1.167 ± 0.039
1.19HisArg: 1.19 ± 0.038
1.331HisSer: 1.331 ± 0.036
1.121HisThr: 1.121 ± 0.028
1.329HisVal: 1.329 ± 0.039
0.374HisTrp: 0.374 ± 0.019
0.85HisTyr: 0.85 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.34IleAla: 6.34 ± 0.074
0.638IleCys: 0.638 ± 0.024
3.865IleAsp: 3.865 ± 0.065
4.297IleGlu: 4.297 ± 0.065
2.033IlePhe: 2.033 ± 0.053
4.668IleGly: 4.668 ± 0.082
1.235IleHis: 1.235 ± 0.037
3.095IleIle: 3.095 ± 0.068
2.682IleLys: 2.682 ± 0.054
5.168IleLeu: 5.168 ± 0.086
1.237IleMet: 1.237 ± 0.035
2.514IleAsn: 2.514 ± 0.055
2.601IlePro: 2.601 ± 0.056
2.281IleGln: 2.281 ± 0.041
3.203IleArg: 3.203 ± 0.052
4.005IleSer: 4.005 ± 0.068
3.415IleThr: 3.415 ± 0.094
3.963IleVal: 3.963 ± 0.065
0.646IleTrp: 0.646 ± 0.024
1.557IleTyr: 1.557 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.571LysAla: 4.571 ± 0.073
0.307LysCys: 0.307 ± 0.015
2.501LysAsp: 2.501 ± 0.053
2.865LysGlu: 2.865 ± 0.065
1.299LysPhe: 1.299 ± 0.039
3.075LysGly: 3.075 ± 0.06
1.093LysHis: 1.093 ± 0.031
2.329LysIle: 2.329 ± 0.048
2.187LysLys: 2.187 ± 0.057
4.7LysLeu: 4.7 ± 0.081
1.193LysMet: 1.193 ± 0.033
1.57LysAsn: 1.57 ± 0.039
1.993LysPro: 1.993 ± 0.049
2.549LysGln: 2.549 ± 0.058
2.795LysArg: 2.795 ± 0.053
2.619LysSer: 2.619 ± 0.048
2.438LysThr: 2.438 ± 0.047
3.586LysVal: 3.586 ± 0.056
0.545LysTrp: 0.545 ± 0.023
1.084LysTyr: 1.084 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
11.148LeuAla: 11.148 ± 0.129
1.04LeuCys: 1.04 ± 0.035
6.11LeuAsp: 6.11 ± 0.093
6.526LeuGlu: 6.526 ± 0.092
4.124LeuPhe: 4.124 ± 0.076
7.38LeuGly: 7.38 ± 0.105
2.18LeuHis: 2.18 ± 0.051
5.979LeuIle: 5.979 ± 0.089
4.692LeuLys: 4.692 ± 0.08
11.149LeuLeu: 11.149 ± 0.182
2.713LeuMet: 2.713 ± 0.055
4.204LeuAsn: 4.204 ± 0.057
5.226LeuPro: 5.226 ± 0.075
4.193LeuGln: 4.193 ± 0.076
5.231LeuArg: 5.231 ± 0.095
7.564LeuSer: 7.564 ± 0.089
6.144LeuThr: 6.144 ± 0.109
7.566LeuVal: 7.566 ± 0.094
1.138LeuTrp: 1.138 ± 0.037
2.668LeuTyr: 2.668 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.715MetAla: 2.715 ± 0.057
0.184MetCys: 0.184 ± 0.013
1.333MetAsp: 1.333 ± 0.036
1.316MetGlu: 1.316 ± 0.038
0.809MetPhe: 0.809 ± 0.031
1.789MetGly: 1.789 ± 0.042
0.432MetHis: 0.432 ± 0.02
1.402MetIle: 1.402 ± 0.037
1.187MetLys: 1.187 ± 0.03
2.683MetLeu: 2.683 ± 0.057
0.733MetMet: 0.733 ± 0.025
0.947MetAsn: 0.947 ± 0.032
1.274MetPro: 1.274 ± 0.033
1.12MetGln: 1.12 ± 0.035
1.35MetArg: 1.35 ± 0.034
1.959MetSer: 1.959 ± 0.047
1.598MetThr: 1.598 ± 0.044
1.831MetVal: 1.831 ± 0.046
0.22MetTrp: 0.22 ± 0.013
0.496MetTyr: 0.496 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.287AsnAla: 3.287 ± 0.053
0.34AsnCys: 0.34 ± 0.018
2.094AsnAsp: 2.094 ± 0.059
2.156AsnGlu: 2.156 ± 0.053
1.307AsnPhe: 1.307 ± 0.037
2.973AsnGly: 2.973 ± 0.077
0.864AsnHis: 0.864 ± 0.033
2.319AsnIle: 2.319 ± 0.046
1.666AsnLys: 1.666 ± 0.037
3.828AsnLeu: 3.828 ± 0.063
0.929AsnMet: 0.929 ± 0.03
1.424AsnAsn: 1.424 ± 0.044
1.943AsnPro: 1.943 ± 0.046
1.904AsnGln: 1.904 ± 0.046
1.958AsnArg: 1.958 ± 0.047
2.181AsnSer: 2.181 ± 0.067
2.019AsnThr: 2.019 ± 0.053
2.416AsnVal: 2.416 ± 0.061
0.6AsnTrp: 0.6 ± 0.03
1.163AsnTyr: 1.163 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
3.652ProAla: 3.652 ± 0.065
0.325ProCys: 0.325 ± 0.019
2.428ProAsp: 2.428 ± 0.045
3.31ProGlu: 3.31 ± 0.065
1.752ProPhe: 1.752 ± 0.037
2.508ProGly: 2.508 ± 0.063
0.924ProHis: 0.924 ± 0.03
2.664ProIle: 2.664 ± 0.052
2.032ProLys: 2.032 ± 0.051
4.265ProLeu: 4.265 ± 0.075
1.101ProMet: 1.101 ± 0.039
1.758ProAsn: 1.758 ± 0.043
1.311ProPro: 1.311 ± 0.036
1.654ProGln: 1.654 ± 0.042
1.573ProArg: 1.573 ± 0.037
2.617ProSer: 2.617 ± 0.056
2.378ProThr: 2.378 ± 0.067
3.379ProVal: 3.379 ± 0.054
0.551ProTrp: 0.551 ± 0.024
1.258ProTyr: 1.258 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.977GlnAla: 4.977 ± 0.077
0.397GlnCys: 0.397 ± 0.02
2.142GlnAsp: 2.142 ± 0.051
2.713GlnGlu: 2.713 ± 0.058
1.738GlnPhe: 1.738 ± 0.038
3.176GlnGly: 3.176 ± 0.057
1.18GlnHis: 1.18 ± 0.037
2.621GlnIle: 2.621 ± 0.052
1.912GlnLys: 1.912 ± 0.048
5.378GlnLeu: 5.378 ± 0.088
1.09GlnMet: 1.09 ± 0.029
1.54GlnAsn: 1.54 ± 0.037
1.825GlnPro: 1.825 ± 0.051
3.434GlnGln: 3.434 ± 0.087
2.919GlnArg: 2.919 ± 0.065
2.754GlnSer: 2.754 ± 0.06
2.612GlnThr: 2.612 ± 0.057
3.592GlnVal: 3.592 ± 0.067
0.714GlnTrp: 0.714 ± 0.03
1.3GlnTyr: 1.3 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
4.152ArgAla: 4.152 ± 0.066
0.547ArgCys: 0.547 ± 0.026
2.659ArgAsp: 2.659 ± 0.053
3.234ArgGlu: 3.234 ± 0.066
2.456ArgPhe: 2.456 ± 0.046
2.975ArgGly: 2.975 ± 0.066
1.443ArgHis: 1.443 ± 0.038
3.397ArgIle: 3.397 ± 0.056
2.41ArgLys: 2.41 ± 0.052
5.949ArgLeu: 5.949 ± 0.095
1.327ArgMet: 1.327 ± 0.037
1.829ArgAsn: 1.829 ± 0.046
2.019ArgPro: 2.019 ± 0.053
2.813ArgGln: 2.813 ± 0.055
3.002ArgArg: 3.002 ± 0.063
2.908ArgSer: 2.908 ± 0.061
2.403ArgThr: 2.403 ± 0.05
3.511ArgVal: 3.511 ± 0.05
0.751ArgTrp: 0.751 ± 0.028
1.976ArgTyr: 1.976 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
5.544SerAla: 5.544 ± 0.086
0.579SerCys: 0.579 ± 0.027
3.5SerAsp: 3.5 ± 0.117
3.67SerGlu: 3.67 ± 0.067
2.637SerPhe: 2.637 ± 0.051
4.765SerGly: 4.765 ± 0.081
1.461SerHis: 1.461 ± 0.033
3.623SerIle: 3.623 ± 0.062
2.724SerLys: 2.724 ± 0.057
6.953SerLeu: 6.953 ± 0.084
1.553SerMet: 1.553 ± 0.041
2.32SerAsn: 2.32 ± 0.063
2.53SerPro: 2.53 ± 0.05
2.823SerGln: 2.823 ± 0.054
3.115SerArg: 3.115 ± 0.054
4.051SerSer: 4.051 ± 0.087
3.114SerThr: 3.114 ± 0.072
4.594SerVal: 4.594 ± 0.076
0.79SerTrp: 0.79 ± 0.029
1.921SerTyr: 1.921 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
4.566ThrAla: 4.566 ± 0.112
0.473ThrCys: 0.473 ± 0.024
2.882ThrAsp: 2.882 ± 0.104
3.021ThrGlu: 3.021 ± 0.056
2.085ThrPhe: 2.085 ± 0.047
4.309ThrGly: 4.309 ± 0.105
1.194ThrHis: 1.194 ± 0.034
3.148ThrIle: 3.148 ± 0.101
2.149ThrLys: 2.149 ± 0.054
6.54ThrLeu: 6.54 ± 0.098
1.177ThrMet: 1.177 ± 0.038
1.876ThrAsn: 1.876 ± 0.064
3.129ThrPro: 3.129 ± 0.071
2.529ThrGln: 2.529 ± 0.051
2.409ThrArg: 2.409 ± 0.047
3.161ThrSer: 3.161 ± 0.07
3.15ThrThr: 3.15 ± 0.132
3.806ThrVal: 3.806 ± 0.141
0.608ThrTrp: 0.608 ± 0.031
1.488ThrTyr: 1.488 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
7.447ValAla: 7.447 ± 0.089
0.772ValCys: 0.772 ± 0.028
4.356ValAsp: 4.356 ± 0.104
4.518ValGlu: 4.518 ± 0.068
2.806ValPhe: 2.806 ± 0.057
4.932ValGly: 4.932 ± 0.067
1.253ValHis: 1.253 ± 0.035
4.453ValIle: 4.453 ± 0.068
3.256ValLys: 3.256 ± 0.064
7.268ValLeu: 7.268 ± 0.099
1.926ValMet: 1.926 ± 0.044
2.722ValAsn: 2.722 ± 0.052
2.823ValPro: 2.823 ± 0.062
2.485ValGln: 2.485 ± 0.048
3.488ValArg: 3.488 ± 0.056
4.933ValSer: 4.933 ± 0.068
4.265ValThr: 4.265 ± 0.118
5.681ValVal: 5.681 ± 0.104
0.83ValTrp: 0.83 ± 0.027
1.861ValTyr: 1.861 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.893TrpAla: 0.893 ± 0.031
0.161TrpCys: 0.161 ± 0.012
0.612TrpAsp: 0.612 ± 0.023
0.587TrpGlu: 0.587 ± 0.023
0.598TrpPhe: 0.598 ± 0.025
0.821TrpGly: 0.821 ± 0.032
0.401TrpHis: 0.401 ± 0.023
0.653TrpIle: 0.653 ± 0.023
0.399TrpLys: 0.399 ± 0.02
1.986TrpLeu: 1.986 ± 0.056
0.35TrpMet: 0.35 ± 0.018
0.407TrpAsn: 0.407 ± 0.019
0.499TrpPro: 0.499 ± 0.021
1.057TrpGln: 1.057 ± 0.039
0.83TrpArg: 0.83 ± 0.029
0.767TrpSer: 0.767 ± 0.041
0.46TrpThr: 0.46 ± 0.031
0.938TrpVal: 0.938 ± 0.035
0.228TrpTrp: 0.228 ± 0.016
0.353TrpTyr: 0.353 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.314TyrAla: 2.314 ± 0.045
0.346TyrCys: 0.346 ± 0.018
1.671TyrAsp: 1.671 ± 0.039
1.636TyrGlu: 1.636 ± 0.039
1.34TyrPhe: 1.34 ± 0.04
2.086TyrGly: 2.086 ± 0.053
0.751TyrHis: 0.751 ± 0.029
1.421TyrIle: 1.421 ± 0.038
1.045TyrLys: 1.045 ± 0.03
3.492TyrLeu: 3.492 ± 0.066
0.589TyrMet: 0.589 ± 0.025
0.909TyrAsn: 0.909 ± 0.024
1.324TyrPro: 1.324 ± 0.032
1.801TyrGln: 1.801 ± 0.042
1.948TyrArg: 1.948 ± 0.048
1.746TyrSer: 1.746 ± 0.055
1.37TyrThr: 1.37 ± 0.069
1.861TyrVal: 1.861 ± 0.042
0.485TyrTrp: 0.485 ± 0.023
0.918TyrTyr: 0.918 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3326 proteins (1073541 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski