Amino acid dipepetide frequency for Parvibaculum sedimenti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.156AlaAla: 16.156 ± 0.186	1.068AlaCys: 1.068 ± 0.029	6.654AlaAsp: 6.654 ± 0.086	7.948AlaGlu: 7.948 ± 0.096	4.368AlaPhe: 4.368 ± 0.062	10.019AlaGly: 10.019 ± 0.104	2.609AlaHis: 2.609 ± 0.048	6.13AlaIle: 6.13 ± 0.081	4.858AlaLys: 4.858 ± 0.094	13.046AlaLeu: 13.046 ± 0.144	3.238AlaMet: 3.238 ± 0.05	3.088AlaAsn: 3.088 ± 0.052	5.643AlaPro: 5.643 ± 0.079	3.721AlaGln: 3.721 ± 0.065	8.891AlaArg: 8.891 ± 0.115	6.261AlaSer: 6.261 ± 0.08	5.827AlaThr: 5.827 ± 0.08	7.877AlaVal: 7.877 ± 0.1	1.36AlaTrp: 1.36 ± 0.036	2.724AlaTyr: 2.724 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.953CysAla: 0.953 ± 0.031	0.118CysCys: 0.118 ± 0.011	0.551CysAsp: 0.551 ± 0.02	0.486CysGlu: 0.486 ± 0.019	0.374CysPhe: 0.374 ± 0.021	0.891CysGly: 0.891 ± 0.028	0.245CysHis: 0.245 ± 0.017	0.412CysIle: 0.412 ± 0.02	0.215CysLys: 0.215 ± 0.013	0.812CysLeu: 0.812 ± 0.026	0.156CysMet: 0.156 ± 0.013	0.222CysAsn: 0.222 ± 0.016	0.446CysPro: 0.446 ± 0.023	0.202CysGln: 0.202 ± 0.013	0.584CysArg: 0.584 ± 0.023	0.445CysSer: 0.445 ± 0.021	0.421CysThr: 0.421 ± 0.022	0.617CysVal: 0.617 ± 0.025	0.103CysTrp: 0.103 ± 0.01	0.188CysTyr: 0.188 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.881AspAla: 6.881 ± 0.086	0.436AspCys: 0.436 ± 0.019	2.935AspAsp: 2.935 ± 0.065	4.054AspGlu: 4.054 ± 0.078	2.278AspPhe: 2.278 ± 0.052	4.935AspGly: 4.935 ± 0.07	1.262AspHis: 1.262 ± 0.032	3.296AspIle: 3.296 ± 0.056	2.021AspLys: 2.021 ± 0.047	5.834AspLeu: 5.834 ± 0.086	1.494AspMet: 1.494 ± 0.038	1.289AspAsn: 1.289 ± 0.036	3.141AspPro: 3.141 ± 0.054	1.581AspGln: 1.581 ± 0.035	3.811AspArg: 3.811 ± 0.064	1.946AspSer: 1.946 ± 0.042	2.557AspThr: 2.557 ± 0.055	4.133AspVal: 4.133 ± 0.056	0.951AspTrp: 0.951 ± 0.031	1.608AspTyr: 1.608 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.243GluAla: 8.243 ± 0.105	0.403GluCys: 0.403 ± 0.021	2.945GluAsp: 2.945 ± 0.057	3.906GluGlu: 3.906 ± 0.086	1.882GluPhe: 1.882 ± 0.044	4.922GluGly: 4.922 ± 0.07	1.383GluHis: 1.383 ± 0.037	3.867GluIle: 3.867 ± 0.058	2.848GluLys: 2.848 ± 0.059	5.692GluLeu: 5.692 ± 0.082	1.728GluMet: 1.728 ± 0.045	1.711GluAsn: 1.711 ± 0.038	2.856GluPro: 2.856 ± 0.052	2.007GluGln: 2.007 ± 0.046	5.126GluArg: 5.126 ± 0.071	2.463GluSer: 2.463 ± 0.049	3.639GluThr: 3.639 ± 0.06	4.3GluVal: 4.3 ± 0.058	0.744GluTrp: 0.744 ± 0.026	1.169GluTyr: 1.169 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.558PheAla: 4.558 ± 0.074	0.432PheCys: 0.432 ± 0.022	2.693PheAsp: 2.693 ± 0.05	2.337PheGlu: 2.337 ± 0.049	1.56PhePhe: 1.56 ± 0.044	3.664PheGly: 3.664 ± 0.066	0.808PheHis: 0.808 ± 0.025	1.917PheIle: 1.917 ± 0.041	1.177PheLys: 1.177 ± 0.034	3.515PheLeu: 3.515 ± 0.061	0.869PheMet: 0.869 ± 0.029	1.1PheAsn: 1.1 ± 0.032	1.622PhePro: 1.622 ± 0.038	0.927PheGln: 0.927 ± 0.028	2.355PheArg: 2.355 ± 0.043	2.229PheSer: 2.229 ± 0.047	2.029PheThr: 2.029 ± 0.044	2.764PheVal: 2.764 ± 0.054	0.508PheTrp: 0.508 ± 0.022	1.039PheTyr: 1.039 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.218GlyAla: 9.218 ± 0.125	0.779GlyCys: 0.779 ± 0.032	4.422GlyAsp: 4.422 ± 0.068	5.203GlyGlu: 5.203 ± 0.059	3.734GlyPhe: 3.734 ± 0.061	7.437GlyGly: 7.437 ± 0.133	2.028GlyHis: 2.028 ± 0.038	4.71GlyIle: 4.71 ± 0.071	3.744GlyLys: 3.744 ± 0.063	8.703GlyLeu: 8.703 ± 0.1	2.163GlyMet: 2.163 ± 0.053	2.22GlyAsn: 2.22 ± 0.044	3.41GlyPro: 3.41 ± 0.058	2.529GlyGln: 2.529 ± 0.053	5.856GlyArg: 5.856 ± 0.078	4.554GlySer: 4.554 ± 0.076	4.614GlyThr: 4.614 ± 0.074	6.055GlyVal: 6.055 ± 0.083	1.289GlyTrp: 1.289 ± 0.034	2.364GlyTyr: 2.364 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.406HisAla: 2.406 ± 0.053	0.264HisCys: 0.264 ± 0.016	1.197HisAsp: 1.197 ± 0.039	1.302HisGlu: 1.302 ± 0.035	0.948HisPhe: 0.948 ± 0.029	2.003HisGly: 2.003 ± 0.049	0.621HisHis: 0.621 ± 0.025	1.146HisIle: 1.146 ± 0.033	0.605HisLys: 0.605 ± 0.02	2.078HisLeu: 2.078 ± 0.041	0.604HisMet: 0.604 ± 0.023	0.547HisAsn: 0.547 ± 0.023	1.386HisPro: 1.386 ± 0.031	0.546HisGln: 0.546 ± 0.025	1.39HisArg: 1.39 ± 0.039	0.983HisSer: 0.983 ± 0.028	0.846HisThr: 0.846 ± 0.028	1.773HisVal: 1.773 ± 0.042	0.352HisTrp: 0.352 ± 0.018	0.621HisTyr: 0.621 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.269IleAla: 7.269 ± 0.092	0.55IleCys: 0.55 ± 0.023	3.697IleAsp: 3.697 ± 0.059	4.007IleGlu: 4.007 ± 0.053	1.958IlePhe: 1.958 ± 0.043	4.939IleGly: 4.939 ± 0.087	1.03IleHis: 1.03 ± 0.033	2.487IleIle: 2.487 ± 0.052	1.649IleLys: 1.649 ± 0.042	4.376IleLeu: 4.376 ± 0.075	1.077IleMet: 1.077 ± 0.031	1.478IleAsn: 1.478 ± 0.036	2.313IlePro: 2.313 ± 0.044	1.193IleGln: 1.193 ± 0.032	3.285IleArg: 3.285 ± 0.057	3.013IleSer: 3.013 ± 0.056	2.548IleThr: 2.548 ± 0.047	4.48IleVal: 4.48 ± 0.074	0.644IleTrp: 0.644 ± 0.03	1.335IleTyr: 1.335 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.908LysAla: 4.908 ± 0.087	0.178LysCys: 0.178 ± 0.014	2.087LysAsp: 2.087 ± 0.05	2.026LysGlu: 2.026 ± 0.044	1.112LysPhe: 1.112 ± 0.032	3.284LysGly: 3.284 ± 0.065	0.777LysHis: 0.777 ± 0.03	2.104LysIle: 2.104 ± 0.052	1.778LysLys: 1.778 ± 0.058	4.008LysLeu: 4.008 ± 0.073	0.914LysMet: 0.914 ± 0.029	1.059LysAsn: 1.059 ± 0.033	2.509LysPro: 2.509 ± 0.056	1.09LysGln: 1.09 ± 0.033	2.815LysArg: 2.815 ± 0.057	2.058LysSer: 2.058 ± 0.047	2.219LysThr: 2.219 ± 0.05	2.783LysVal: 2.783 ± 0.055	0.442LysTrp: 0.442 ± 0.019	0.807LysTyr: 0.807 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	13.107LeuAla: 13.107 ± 0.148	0.895LeuCys: 0.895 ± 0.03	6.088LeuAsp: 6.088 ± 0.086	5.213LeuGlu: 5.213 ± 0.077	3.563LeuPhe: 3.563 ± 0.06	8.343LeuGly: 8.343 ± 0.099	1.9LeuHis: 1.9 ± 0.044	5.141LeuIle: 5.141 ± 0.072	4.289LeuLys: 4.289 ± 0.073	8.836LeuLeu: 8.836 ± 0.119	2.349LeuMet: 2.349 ± 0.043	2.665LeuAsn: 2.665 ± 0.051	5.398LeuPro: 5.398 ± 0.078	2.5LeuGln: 2.5 ± 0.057	6.684LeuArg: 6.684 ± 0.08	6.107LeuSer: 6.107 ± 0.088	5.498LeuThr: 5.498 ± 0.074	7.17LeuVal: 7.17 ± 0.093	1.156LeuTrp: 1.156 ± 0.036	2.193LeuTyr: 2.193 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.938MetAla: 2.938 ± 0.052	0.168MetCys: 0.168 ± 0.013	1.093MetAsp: 1.093 ± 0.033	1.266MetGlu: 1.266 ± 0.033	0.703MetPhe: 0.703 ± 0.025	1.905MetGly: 1.905 ± 0.04	0.456MetHis: 0.456 ± 0.02	1.298MetIle: 1.298 ± 0.033	1.139MetLys: 1.139 ± 0.033	2.466MetLeu: 2.466 ± 0.048	0.678MetMet: 0.678 ± 0.029	0.827MetAsn: 0.827 ± 0.027	1.596MetPro: 1.596 ± 0.039	0.769MetGln: 0.769 ± 0.024	1.921MetArg: 1.921 ± 0.041	1.792MetSer: 1.792 ± 0.035	1.747MetThr: 1.747 ± 0.042	1.586MetVal: 1.586 ± 0.043	0.224MetTrp: 0.224 ± 0.015	0.326MetTyr: 0.326 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.225AsnAla: 3.225 ± 0.06	0.237AsnCys: 0.237 ± 0.015	1.441AsnAsp: 1.441 ± 0.035	1.566AsnGlu: 1.566 ± 0.044	1.11AsnPhe: 1.11 ± 0.031	2.381AsnGly: 2.381 ± 0.055	0.494AsnHis: 0.494 ± 0.022	1.596AsnIle: 1.596 ± 0.04	0.805AsnLys: 0.805 ± 0.029	2.673AsnLeu: 2.673 ± 0.053	0.667AsnMet: 0.667 ± 0.023	0.736AsnAsn: 0.736 ± 0.032	1.804AsnPro: 1.804 ± 0.044	0.732AsnGln: 0.732 ± 0.026	1.839AsnArg: 1.839 ± 0.041	1.234AsnSer: 1.234 ± 0.033	1.226AsnThr: 1.226 ± 0.04	2.156AsnVal: 2.156 ± 0.04	0.467AsnTrp: 0.467 ± 0.02	0.754AsnTyr: 0.754 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.941ProAla: 5.941 ± 0.094	0.364ProCys: 0.364 ± 0.019	3.39ProAsp: 3.39 ± 0.058	3.938ProGlu: 3.938 ± 0.061	2.033ProPhe: 2.033 ± 0.044	4.297ProGly: 4.297 ± 0.072	1.114ProHis: 1.114 ± 0.032	2.287ProIle: 2.287 ± 0.049	2.066ProLys: 2.066 ± 0.05	4.765ProLeu: 4.765 ± 0.072	1.2ProMet: 1.2 ± 0.036	1.398ProAsn: 1.398 ± 0.038	2.175ProPro: 2.175 ± 0.053	1.568ProGln: 1.568 ± 0.041	2.979ProArg: 2.979 ± 0.063	2.648ProSer: 2.648 ± 0.045	2.423ProThr: 2.423 ± 0.046	4.158ProVal: 4.158 ± 0.068	0.69ProTrp: 0.69 ± 0.03	1.314ProTyr: 1.314 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.46GlnAla: 3.46 ± 0.056	0.205GlnCys: 0.205 ± 0.014	1.245GlnAsp: 1.245 ± 0.038	1.389GlnGlu: 1.389 ± 0.035	1.024GlnPhe: 1.024 ± 0.031	2.364GlnGly: 2.364 ± 0.047	0.618GlnHis: 0.618 ± 0.021	1.722GlnIle: 1.722 ± 0.046	1.314GlnLys: 1.314 ± 0.033	2.62GlnLeu: 2.62 ± 0.051	0.81GlnMet: 0.81 ± 0.026	0.827GlnAsn: 0.827 ± 0.028	1.403GlnPro: 1.403 ± 0.04	0.977GlnGln: 0.977 ± 0.036	2.104GlnArg: 2.104 ± 0.042	1.662GlnSer: 1.662 ± 0.038	1.628GlnThr: 1.628 ± 0.042	1.999GlnVal: 1.999 ± 0.039	0.37GlnTrp: 0.37 ± 0.021	0.634GlnTyr: 0.634 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.836ArgAla: 7.836 ± 0.107	0.485ArgCys: 0.485 ± 0.023	3.933ArgAsp: 3.933 ± 0.068	4.513ArgGlu: 4.513 ± 0.07	2.919ArgPhe: 2.919 ± 0.051	4.819ArgGly: 4.819 ± 0.069	1.762ArgHis: 1.762 ± 0.045	3.994ArgIle: 3.994 ± 0.055	2.693ArgLys: 2.693 ± 0.05	7.617ArgLeu: 7.617 ± 0.099	1.851ArgMet: 1.851 ± 0.042	1.99ArgAsn: 1.99 ± 0.041	3.33ArgPro: 3.33 ± 0.06	2.156ArgGln: 2.156 ± 0.044	5.516ArgArg: 5.516 ± 0.096	3.51ArgSer: 3.51 ± 0.057	3.128ArgThr: 3.128 ± 0.053	4.819ArgVal: 4.819 ± 0.065	0.969ArgTrp: 0.969 ± 0.028	1.726ArgTyr: 1.726 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.88SerAla: 5.88 ± 0.095	0.44SerCys: 0.44 ± 0.02	2.966SerAsp: 2.966 ± 0.051	3.027SerGlu: 3.027 ± 0.061	2.377SerPhe: 2.377 ± 0.04	5.243SerGly: 5.243 ± 0.082	1.083SerHis: 1.083 ± 0.033	2.828SerIle: 2.828 ± 0.058	1.825SerLys: 1.825 ± 0.041	5.446SerLeu: 5.446 ± 0.076	1.29SerMet: 1.29 ± 0.036	1.426SerAsn: 1.426 ± 0.041	2.697SerPro: 2.697 ± 0.046	1.385SerGln: 1.385 ± 0.04	3.449SerArg: 3.449 ± 0.061	3.028SerSer: 3.028 ± 0.062	2.671SerThr: 2.671 ± 0.051	3.913SerVal: 3.913 ± 0.071	0.72SerTrp: 0.72 ± 0.026	1.388SerTyr: 1.388 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.555ThrAla: 5.555 ± 0.081	0.411ThrCys: 0.411 ± 0.017	2.71ThrAsp: 2.71 ± 0.049	2.803ThrGlu: 2.803 ± 0.044	1.881ThrPhe: 1.881 ± 0.049	5.043ThrGly: 5.043 ± 0.072	1.151ThrHis: 1.151 ± 0.03	2.781ThrIle: 2.781 ± 0.052	1.779ThrLys: 1.779 ± 0.045	5.655ThrLeu: 5.655 ± 0.08	1.117ThrMet: 1.117 ± 0.034	1.362ThrAsn: 1.362 ± 0.038	3.311ThrPro: 3.311 ± 0.062	1.434ThrGln: 1.434 ± 0.04	3.353ThrArg: 3.353 ± 0.053	2.879ThrSer: 2.879 ± 0.053	2.763ThrThr: 2.763 ± 0.053	3.952ThrVal: 3.952 ± 0.061	0.618ThrTrp: 0.618 ± 0.027	1.303ThrTyr: 1.303 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.958ValAla: 8.958 ± 0.099	0.614ValCys: 0.614 ± 0.021	4.253ValAsp: 4.253 ± 0.065	4.789ValGlu: 4.789 ± 0.077	2.659ValPhe: 2.659 ± 0.05	5.444ValGly: 5.444 ± 0.083	1.407ValHis: 1.407 ± 0.041	3.9ValIle: 3.9 ± 0.065	2.794ValLys: 2.794 ± 0.056	6.966ValLeu: 6.966 ± 0.089	1.807ValMet: 1.807 ± 0.04	2.094ValAsn: 2.094 ± 0.041	3.943ValPro: 3.943 ± 0.066	1.842ValGln: 1.842 ± 0.045	4.653ValArg: 4.653 ± 0.065	4.226ValSer: 4.226 ± 0.065	4.195ValThr: 4.195 ± 0.067	5.629ValVal: 5.629 ± 0.083	0.915ValTrp: 0.915 ± 0.031	1.609ValTyr: 1.609 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.298TrpAla: 1.298 ± 0.041	0.13TrpCys: 0.13 ± 0.01	0.612TrpAsp: 0.612 ± 0.024	0.598TrpGlu: 0.598 ± 0.024	0.54TrpPhe: 0.54 ± 0.023	0.932TrpGly: 0.932 ± 0.029	0.34TrpHis: 0.34 ± 0.019	0.658TrpIle: 0.658 ± 0.026	0.512TrpLys: 0.512 ± 0.023	1.523TrpLeu: 1.523 ± 0.04	0.352TrpMet: 0.352 ± 0.019	0.462TrpAsn: 0.462 ± 0.02	0.683TrpPro: 0.683 ± 0.024	0.493TrpGln: 0.493 ± 0.025	1.144TrpArg: 1.144 ± 0.036	0.783TrpSer: 0.783 ± 0.027	0.761TrpThr: 0.761 ± 0.027	0.798TrpVal: 0.798 ± 0.029	0.208TrpTrp: 0.208 ± 0.013	0.327TrpTyr: 0.327 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.697TyrAla: 2.697 ± 0.051	0.266TyrCys: 0.266 ± 0.016	1.532TyrAsp: 1.532 ± 0.044	1.463TyrGlu: 1.463 ± 0.04	1.079TyrPhe: 1.079 ± 0.03	2.168TyrGly: 2.168 ± 0.049	0.531TyrHis: 0.531 ± 0.025	1.052TyrIle: 1.052 ± 0.032	0.846TyrLys: 0.846 ± 0.031	2.464TyrLeu: 2.464 ± 0.046	0.534TyrMet: 0.534 ± 0.025	0.64TyrAsn: 0.64 ± 0.026	1.086TyrPro: 1.086 ± 0.034	0.724TyrGln: 0.724 ± 0.024	1.809TyrArg: 1.809 ± 0.043	1.261TyrSer: 1.261 ± 0.034	1.121TyrThr: 1.121 ± 0.034	1.735TyrVal: 1.735 ± 0.045	0.421TyrTrp: 0.421 ± 0.019	0.711TyrTyr: 0.711 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3429 proteins (1103409 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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