Amino acid dipepetide frequency for Mycobacterium virus Gumbie

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.669AlaAla: 13.669 ± 1.935
1.139AlaCys: 1.139 ± 0.26
6.563AlaAsp: 6.563 ± 0.54
7.431AlaGlu: 7.431 ± 0.76
2.712AlaPhe: 2.712 ± 0.404
9.872AlaGly: 9.872 ± 1.296
2.549AlaHis: 2.549 ± 0.407
4.177AlaIle: 4.177 ± 0.59
4.285AlaLys: 4.285 ± 0.452
7.594AlaLeu: 7.594 ± 0.797
2.278AlaMet: 2.278 ± 0.336
2.604AlaAsn: 2.604 ± 0.405
4.719AlaPro: 4.719 ± 0.561
3.309AlaGln: 3.309 ± 0.421
7.106AlaArg: 7.106 ± 0.677
5.153AlaSer: 5.153 ± 0.572
6.509AlaThr: 6.509 ± 0.55
6.997AlaVal: 6.997 ± 0.634
2.549AlaTrp: 2.549 ± 0.404
2.332AlaTyr: 2.332 ± 0.353
0.0AlaXaa: 0.0 ± 0.0
Cys
1.031CysAla: 1.031 ± 0.304
0.108CysCys: 0.108 ± 0.077
1.356CysAsp: 1.356 ± 0.362
1.085CysGlu: 1.085 ± 0.254
0.217CysPhe: 0.217 ± 0.106
2.007CysGly: 2.007 ± 0.349
0.217CysHis: 0.217 ± 0.098
0.163CysIle: 0.163 ± 0.1
0.488CysLys: 0.488 ± 0.14
0.705CysLeu: 0.705 ± 0.232
0.217CysMet: 0.217 ± 0.127
0.271CysAsn: 0.271 ± 0.118
1.302CysPro: 1.302 ± 0.272
0.325CysGln: 0.325 ± 0.121
0.814CysArg: 0.814 ± 0.219
0.814CysSer: 0.814 ± 0.226
0.922CysThr: 0.922 ± 0.22
0.922CysVal: 0.922 ± 0.195
0.325CysTrp: 0.325 ± 0.127
0.163CysTyr: 0.163 ± 0.098
0.0CysXaa: 0.0 ± 0.0
Asp
6.726AspAla: 6.726 ± 0.664
0.976AspCys: 0.976 ± 0.198
4.502AspAsp: 4.502 ± 0.476
3.58AspGlu: 3.58 ± 0.492
1.465AspPhe: 1.465 ± 0.224
6.292AspGly: 6.292 ± 0.525
1.465AspHis: 1.465 ± 0.316
2.17AspIle: 2.17 ± 0.347
1.573AspLys: 1.573 ± 0.255
5.858AspLeu: 5.858 ± 0.559
1.356AspMet: 1.356 ± 0.283
1.79AspAsn: 1.79 ± 0.346
4.882AspPro: 4.882 ± 0.577
2.278AspGln: 2.278 ± 0.376
4.611AspArg: 4.611 ± 0.557
3.092AspSer: 3.092 ± 0.442
4.611AspThr: 4.611 ± 0.522
4.394AspVal: 4.394 ± 0.583
1.627AspTrp: 1.627 ± 0.251
2.115AspTyr: 2.115 ± 0.328
0.0AspXaa: 0.0 ± 0.0
Glu
6.563GluAla: 6.563 ± 0.67
1.302GluCys: 1.302 ± 0.354
2.549GluAsp: 2.549 ± 0.327
2.983GluGlu: 2.983 ± 0.616
2.278GluPhe: 2.278 ± 0.368
3.471GluGly: 3.471 ± 0.379
2.061GluHis: 2.061 ± 0.391
1.953GluIle: 1.953 ± 0.265
1.898GluLys: 1.898 ± 0.306
5.75GluLeu: 5.75 ± 0.623
1.356GluMet: 1.356 ± 0.294
1.844GluAsn: 1.844 ± 0.265
3.255GluPro: 3.255 ± 0.481
2.875GluGln: 2.875 ± 0.405
5.044GluArg: 5.044 ± 0.61
3.255GluSer: 3.255 ± 0.414
3.96GluThr: 3.96 ± 0.565
3.797GluVal: 3.797 ± 0.457
1.248GluTrp: 1.248 ± 0.238
2.224GluTyr: 2.224 ± 0.429
0.0GluXaa: 0.0 ± 0.0
Phe
2.875PheAla: 2.875 ± 0.417
0.325PheCys: 0.325 ± 0.122
2.821PheAsp: 2.821 ± 0.464
1.519PheGlu: 1.519 ± 0.272
0.922PhePhe: 0.922 ± 0.249
2.712PheGly: 2.712 ± 0.54
0.542PheHis: 0.542 ± 0.223
1.302PheIle: 1.302 ± 0.342
1.031PheLys: 1.031 ± 0.237
1.627PheLeu: 1.627 ± 0.258
0.705PheMet: 0.705 ± 0.213
1.248PheAsn: 1.248 ± 0.286
1.41PhePro: 1.41 ± 0.294
1.139PheGln: 1.139 ± 0.289
1.627PheArg: 1.627 ± 0.33
1.79PheSer: 1.79 ± 0.334
2.17PheThr: 2.17 ± 0.374
2.115PheVal: 2.115 ± 0.346
0.814PheTrp: 0.814 ± 0.215
0.814PheTyr: 0.814 ± 0.256
0.0PheXaa: 0.0 ± 0.0
Gly
8.679GlyAla: 8.679 ± 1.252
1.085GlyCys: 1.085 ± 0.236
5.316GlyAsp: 5.316 ± 0.488
4.339GlyGlu: 4.339 ± 0.469
2.441GlyPhe: 2.441 ± 0.38
10.414GlyGly: 10.414 ± 2.144
2.224GlyHis: 2.224 ± 0.342
4.068GlyIle: 4.068 ± 0.453
2.604GlyLys: 2.604 ± 0.381
5.967GlyLeu: 5.967 ± 0.463
2.495GlyMet: 2.495 ± 0.404
3.363GlyAsn: 3.363 ± 0.388
4.122GlyPro: 4.122 ± 0.614
2.495GlyGln: 2.495 ± 0.514
5.533GlyArg: 5.533 ± 0.681
5.858GlySer: 5.858 ± 0.824
5.804GlyThr: 5.804 ± 0.746
5.75GlyVal: 5.75 ± 0.567
2.495GlyTrp: 2.495 ± 0.38
2.278GlyTyr: 2.278 ± 0.468
0.0GlyXaa: 0.0 ± 0.0
His
2.115HisAla: 2.115 ± 0.359
0.38HisCys: 0.38 ± 0.16
1.085HisAsp: 1.085 ± 0.221
1.302HisGlu: 1.302 ± 0.294
0.488HisPhe: 0.488 ± 0.122
2.007HisGly: 2.007 ± 0.292
1.085HisHis: 1.085 ± 0.292
1.465HisIle: 1.465 ± 0.287
1.085HisLys: 1.085 ± 0.228
1.681HisLeu: 1.681 ± 0.315
0.434HisMet: 0.434 ± 0.119
0.868HisAsn: 0.868 ± 0.225
1.736HisPro: 1.736 ± 0.278
0.922HisGln: 0.922 ± 0.225
2.17HisArg: 2.17 ± 0.368
1.139HisSer: 1.139 ± 0.26
1.681HisThr: 1.681 ± 0.352
1.41HisVal: 1.41 ± 0.386
0.597HisTrp: 0.597 ± 0.177
0.976HisTyr: 0.976 ± 0.216
0.0HisXaa: 0.0 ± 0.0
Ile
5.261IleAla: 5.261 ± 0.616
0.651IleCys: 0.651 ± 0.211
3.797IleAsp: 3.797 ± 0.441
3.526IleGlu: 3.526 ± 0.35
0.759IlePhe: 0.759 ± 0.206
3.797IleGly: 3.797 ± 0.446
1.627IleHis: 1.627 ± 0.341
1.573IleIle: 1.573 ± 0.302
1.085IleLys: 1.085 ± 0.233
2.441IleLeu: 2.441 ± 0.392
0.217IleMet: 0.217 ± 0.104
1.953IleAsn: 1.953 ± 0.34
2.495IlePro: 2.495 ± 0.395
1.573IleGln: 1.573 ± 0.22
2.115IleArg: 2.115 ± 0.283
2.061IleSer: 2.061 ± 0.395
3.417IleThr: 3.417 ± 0.383
3.417IleVal: 3.417 ± 0.424
1.031IleTrp: 1.031 ± 0.254
0.868IleTyr: 0.868 ± 0.206
0.0IleXaa: 0.0 ± 0.0
Lys
4.231LysAla: 4.231 ± 0.504
0.434LysCys: 0.434 ± 0.151
2.061LysAsp: 2.061 ± 0.344
1.41LysGlu: 1.41 ± 0.239
1.139LysPhe: 1.139 ± 0.187
2.278LysGly: 2.278 ± 0.327
1.248LysHis: 1.248 ± 0.288
1.031LysIle: 1.031 ± 0.286
1.465LysLys: 1.465 ± 0.371
2.604LysLeu: 2.604 ± 0.454
0.542LysMet: 0.542 ± 0.142
0.976LysAsn: 0.976 ± 0.24
2.441LysPro: 2.441 ± 0.344
1.41LysGln: 1.41 ± 0.237
2.441LysArg: 2.441 ± 0.393
1.953LysSer: 1.953 ± 0.316
2.224LysThr: 2.224 ± 0.339
2.495LysVal: 2.495 ± 0.412
0.976LysTrp: 0.976 ± 0.262
0.976LysTyr: 0.976 ± 0.241
0.0LysXaa: 0.0 ± 0.0
Leu
7.648LeuAla: 7.648 ± 0.876
0.651LeuCys: 0.651 ± 0.197
4.502LeuAsp: 4.502 ± 0.507
3.96LeuGlu: 3.96 ± 0.468
2.604LeuPhe: 2.604 ± 0.303
4.99LeuGly: 4.99 ± 0.533
1.031LeuHis: 1.031 ± 0.245
3.309LeuIle: 3.309 ± 0.504
2.061LeuLys: 2.061 ± 0.289
4.719LeuLeu: 4.719 ± 0.457
1.573LeuMet: 1.573 ± 0.286
2.604LeuAsn: 2.604 ± 0.331
5.153LeuPro: 5.153 ± 0.655
2.983LeuGln: 2.983 ± 0.386
4.936LeuArg: 4.936 ± 0.56
4.828LeuSer: 4.828 ± 0.515
5.641LeuThr: 5.641 ± 0.49
5.044LeuVal: 5.044 ± 0.473
1.085LeuTrp: 1.085 ± 0.233
2.332LeuTyr: 2.332 ± 0.355
0.0LeuXaa: 0.0 ± 0.0
Met
2.441MetAla: 2.441 ± 0.347
0.163MetCys: 0.163 ± 0.113
1.193MetAsp: 1.193 ± 0.257
0.976MetGlu: 0.976 ± 0.232
0.759MetPhe: 0.759 ± 0.202
2.061MetGly: 2.061 ± 0.267
0.108MetHis: 0.108 ± 0.077
0.922MetIle: 0.922 ± 0.222
1.139MetLys: 1.139 ± 0.253
1.898MetLeu: 1.898 ± 0.287
0.434MetMet: 0.434 ± 0.215
1.031MetAsn: 1.031 ± 0.185
1.41MetPro: 1.41 ± 0.266
0.597MetGln: 0.597 ± 0.14
1.41MetArg: 1.41 ± 0.289
2.766MetSer: 2.766 ± 0.388
1.953MetThr: 1.953 ± 0.29
1.248MetVal: 1.248 ± 0.293
0.271MetTrp: 0.271 ± 0.111
0.325MetTyr: 0.325 ± 0.128
0.0MetXaa: 0.0 ± 0.0
Asn
3.2AsnAla: 3.2 ± 0.377
0.271AsnCys: 0.271 ± 0.134
2.115AsnAsp: 2.115 ± 0.327
1.79AsnGlu: 1.79 ± 0.294
0.814AsnPhe: 0.814 ± 0.23
4.014AsnGly: 4.014 ± 0.654
0.868AsnHis: 0.868 ± 0.167
1.627AsnIle: 1.627 ± 0.446
1.085AsnLys: 1.085 ± 0.238
2.061AsnLeu: 2.061 ± 0.368
0.705AsnMet: 0.705 ± 0.154
1.844AsnAsn: 1.844 ± 0.377
2.983AsnPro: 2.983 ± 0.331
1.085AsnGln: 1.085 ± 0.381
2.332AsnArg: 2.332 ± 0.374
1.519AsnSer: 1.519 ± 0.329
2.278AsnThr: 2.278 ± 0.307
1.79AsnVal: 1.79 ± 0.309
0.759AsnTrp: 0.759 ± 0.19
0.651AsnTyr: 0.651 ± 0.18
0.0AsnXaa: 0.0 ± 0.0
Pro
4.719ProAla: 4.719 ± 0.414
0.814ProCys: 0.814 ± 0.222
4.611ProAsp: 4.611 ± 0.532
4.882ProGlu: 4.882 ± 0.43
1.79ProPhe: 1.79 ± 0.293
6.238ProGly: 6.238 ± 0.556
1.627ProHis: 1.627 ± 0.28
1.898ProIle: 1.898 ± 0.326
2.224ProLys: 2.224 ± 0.341
4.177ProLeu: 4.177 ± 0.516
1.519ProMet: 1.519 ± 0.317
2.115ProAsn: 2.115 ± 0.316
4.068ProPro: 4.068 ± 0.507
2.061ProGln: 2.061 ± 0.291
3.146ProArg: 3.146 ± 0.481
3.255ProSer: 3.255 ± 0.487
3.58ProThr: 3.58 ± 0.426
4.719ProVal: 4.719 ± 0.553
1.193ProTrp: 1.193 ± 0.228
1.627ProTyr: 1.627 ± 0.273
0.0ProXaa: 0.0 ± 0.0
Gln
4.014GlnAla: 4.014 ± 0.589
0.542GlnCys: 0.542 ± 0.246
1.465GlnAsp: 1.465 ± 0.26
1.844GlnGlu: 1.844 ± 0.343
1.248GlnPhe: 1.248 ± 0.215
2.387GlnGly: 2.387 ± 0.439
1.085GlnHis: 1.085 ± 0.254
1.519GlnIle: 1.519 ± 0.239
1.356GlnLys: 1.356 ± 0.225
2.821GlnLeu: 2.821 ± 0.332
0.922GlnMet: 0.922 ± 0.223
0.651GlnAsn: 0.651 ± 0.254
2.821GlnPro: 2.821 ± 0.417
1.248GlnGln: 1.248 ± 0.29
2.983GlnArg: 2.983 ± 0.348
2.332GlnSer: 2.332 ± 0.369
1.736GlnThr: 1.736 ± 0.313
2.278GlnVal: 2.278 ± 0.304
0.759GlnTrp: 0.759 ± 0.189
0.814GlnTyr: 0.814 ± 0.253
0.0GlnXaa: 0.0 ± 0.0
Arg
7.051ArgAla: 7.051 ± 0.695
0.922ArgCys: 0.922 ± 0.281
5.099ArgAsp: 5.099 ± 0.568
4.665ArgGlu: 4.665 ± 0.551
2.115ArgPhe: 2.115 ± 0.348
4.068ArgGly: 4.068 ± 0.385
1.248ArgHis: 1.248 ± 0.236
4.556ArgIle: 4.556 ± 0.566
2.549ArgLys: 2.549 ± 0.396
4.122ArgLeu: 4.122 ± 0.553
2.766ArgMet: 2.766 ± 0.385
2.332ArgAsn: 2.332 ± 0.379
3.363ArgPro: 3.363 ± 0.414
1.79ArgGln: 1.79 ± 0.335
5.587ArgArg: 5.587 ± 0.613
3.634ArgSer: 3.634 ± 0.37
3.797ArgThr: 3.797 ± 0.458
5.153ArgVal: 5.153 ± 0.539
1.898ArgTrp: 1.898 ± 0.323
1.844ArgTyr: 1.844 ± 0.261
0.0ArgXaa: 0.0 ± 0.0
Ser
4.936SerAla: 4.936 ± 0.702
0.651SerCys: 0.651 ± 0.177
4.122SerAsp: 4.122 ± 0.51
3.092SerGlu: 3.092 ± 0.395
2.115SerPhe: 2.115 ± 0.458
6.455SerGly: 6.455 ± 0.81
1.356SerHis: 1.356 ± 0.259
2.875SerIle: 2.875 ± 0.404
2.549SerLys: 2.549 ± 0.392
3.851SerLeu: 3.851 ± 0.459
1.302SerMet: 1.302 ± 0.245
2.387SerAsn: 2.387 ± 0.503
3.2SerPro: 3.2 ± 0.407
1.681SerGln: 1.681 ± 0.335
3.2SerArg: 3.2 ± 0.411
3.797SerSer: 3.797 ± 0.608
3.309SerThr: 3.309 ± 0.371
4.014SerVal: 4.014 ± 0.462
1.302SerTrp: 1.302 ± 0.269
1.41SerTyr: 1.41 ± 0.198
0.0SerXaa: 0.0 ± 0.0
Thr
6.401ThrAla: 6.401 ± 0.602
0.814ThrCys: 0.814 ± 0.213
4.014ThrAsp: 4.014 ± 0.641
3.905ThrGlu: 3.905 ± 0.36
1.898ThrPhe: 1.898 ± 0.364
6.021ThrGly: 6.021 ± 0.679
1.681ThrHis: 1.681 ± 0.304
3.851ThrIle: 3.851 ± 0.577
1.736ThrLys: 1.736 ± 0.275
4.339ThrLeu: 4.339 ± 0.545
1.573ThrMet: 1.573 ± 0.229
2.278ThrAsn: 2.278 ± 0.365
4.936ThrPro: 4.936 ± 0.652
1.844ThrGln: 1.844 ± 0.322
4.177ThrArg: 4.177 ± 0.499
3.743ThrSer: 3.743 ± 0.399
4.448ThrThr: 4.448 ± 0.655
5.858ThrVal: 5.858 ± 0.599
0.922ThrTrp: 0.922 ± 0.243
2.224ThrTyr: 2.224 ± 0.312
0.0ThrXaa: 0.0 ± 0.0
Val
7.16ValAla: 7.16 ± 0.622
1.627ValCys: 1.627 ± 0.297
5.099ValAsp: 5.099 ± 0.564
4.394ValGlu: 4.394 ± 0.574
2.441ValPhe: 2.441 ± 0.403
5.044ValGly: 5.044 ± 0.622
1.465ValHis: 1.465 ± 0.281
2.875ValIle: 2.875 ± 0.428
2.712ValLys: 2.712 ± 0.392
5.207ValLeu: 5.207 ± 0.537
1.519ValMet: 1.519 ± 0.283
2.224ValAsn: 2.224 ± 0.292
3.688ValPro: 3.688 ± 0.367
2.983ValGln: 2.983 ± 0.354
4.611ValArg: 4.611 ± 0.602
4.339ValSer: 4.339 ± 0.551
5.153ValThr: 5.153 ± 0.519
6.292ValVal: 6.292 ± 0.747
1.844ValTrp: 1.844 ± 0.351
1.465ValTyr: 1.465 ± 0.272
0.0ValXaa: 0.0 ± 0.0
Trp
2.115TrpAla: 2.115 ± 0.302
0.163TrpCys: 0.163 ± 0.084
1.356TrpAsp: 1.356 ± 0.292
1.193TrpGlu: 1.193 ± 0.275
0.542TrpPhe: 0.542 ± 0.134
1.085TrpGly: 1.085 ± 0.289
0.868TrpHis: 0.868 ± 0.193
1.193TrpIle: 1.193 ± 0.267
0.705TrpLys: 0.705 ± 0.168
1.898TrpLeu: 1.898 ± 0.358
0.922TrpMet: 0.922 ± 0.239
0.705TrpAsn: 0.705 ± 0.229
1.031TrpPro: 1.031 ± 0.263
1.302TrpGln: 1.302 ± 0.236
2.17TrpArg: 2.17 ± 0.412
1.356TrpSer: 1.356 ± 0.255
1.356TrpThr: 1.356 ± 0.248
1.953TrpVal: 1.953 ± 0.416
0.976TrpTrp: 0.976 ± 0.185
0.434TrpTyr: 0.434 ± 0.157
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.766TyrAla: 2.766 ± 0.382
0.434TyrCys: 0.434 ± 0.233
1.736TyrAsp: 1.736 ± 0.367
1.79TyrGlu: 1.79 ± 0.301
0.759TyrPhe: 0.759 ± 0.195
2.115TyrGly: 2.115 ± 0.344
0.271TyrHis: 0.271 ± 0.11
1.139TyrIle: 1.139 ± 0.262
0.705TyrLys: 0.705 ± 0.183
2.332TyrLeu: 2.332 ± 0.291
0.217TyrMet: 0.217 ± 0.097
0.705TyrAsn: 0.705 ± 0.162
1.248TyrPro: 1.248 ± 0.2
0.922TyrGln: 0.922 ± 0.208
2.549TyrArg: 2.549 ± 0.417
0.922TyrSer: 0.922 ± 0.251
2.115TyrThr: 2.115 ± 0.4
2.495TyrVal: 2.495 ± 0.298
0.651TyrTrp: 0.651 ± 0.18
0.705TyrTyr: 0.705 ± 0.156
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 104 proteins (18437 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski