Amino acid dipepetide frequency for Eubacterium sp. CAG:274

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.898AlaAla: 3.898 ± 0.122
0.899AlaCys: 0.899 ± 0.044
4.109AlaAsp: 4.109 ± 0.104
4.605AlaGlu: 4.605 ± 0.105
2.894AlaPhe: 2.894 ± 0.079
4.72AlaGly: 4.72 ± 0.088
0.917AlaHis: 0.917 ± 0.037
5.891AlaIle: 5.891 ± 0.119
5.436AlaLys: 5.436 ± 0.108
5.93AlaLeu: 5.93 ± 0.104
2.058AlaMet: 2.058 ± 0.068
3.222AlaAsn: 3.222 ± 0.078
1.657AlaPro: 1.657 ± 0.059
1.887AlaGln: 1.887 ± 0.062
2.138AlaArg: 2.138 ± 0.06
3.636AlaSer: 3.636 ± 0.079
3.937AlaThr: 3.937 ± 0.108
5.827AlaVal: 5.827 ± 0.108
0.372AlaTrp: 0.372 ± 0.024
2.432AlaTyr: 2.432 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.862CysAla: 0.862 ± 0.034
0.297CysCys: 0.297 ± 0.023
0.906CysAsp: 0.906 ± 0.04
0.857CysGlu: 0.857 ± 0.036
0.619CysPhe: 0.619 ± 0.034
1.515CysGly: 1.515 ± 0.059
0.248CysHis: 0.248 ± 0.021
1.141CysIle: 1.141 ± 0.043
1.128CysLys: 1.128 ± 0.044
1.04CysLeu: 1.04 ± 0.042
0.323CysMet: 0.323 ± 0.024
0.795CysAsn: 0.795 ± 0.036
0.576CysPro: 0.576 ± 0.037
0.342CysGln: 0.342 ± 0.022
0.454CysArg: 0.454 ± 0.028
0.977CysSer: 0.977 ± 0.042
0.789CysThr: 0.789 ± 0.036
1.032CysVal: 1.032 ± 0.043
0.101CysTrp: 0.101 ± 0.013
0.573CysTyr: 0.573 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
3.62AspAla: 3.62 ± 0.104
0.887AspCys: 0.887 ± 0.039
3.322AspAsp: 3.322 ± 0.091
4.442AspGlu: 4.442 ± 0.092
2.9AspPhe: 2.9 ± 0.063
4.333AspGly: 4.333 ± 0.101
0.576AspHis: 0.576 ± 0.033
5.625AspIle: 5.625 ± 0.116
5.037AspLys: 5.037 ± 0.082
4.412AspLeu: 4.412 ± 0.086
1.722AspMet: 1.722 ± 0.052
3.612AspAsn: 3.612 ± 0.081
1.362AspPro: 1.362 ± 0.058
0.827AspGln: 0.827 ± 0.038
1.955AspArg: 1.955 ± 0.057
3.442AspSer: 3.442 ± 0.087
3.391AspThr: 3.391 ± 0.08
4.212AspVal: 4.212 ± 0.094
0.45AspTrp: 0.45 ± 0.029
2.984AspTyr: 2.984 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
4.136GluAla: 4.136 ± 0.1
0.715GluCys: 0.715 ± 0.035
3.898GluAsp: 3.898 ± 0.108
5.417GluGlu: 5.417 ± 0.163
2.67GluPhe: 2.67 ± 0.06
3.533GluGly: 3.533 ± 0.079
0.988GluHis: 0.988 ± 0.043
6.132GluIle: 6.132 ± 0.115
7.077GluLys: 7.077 ± 0.118
5.635GluLeu: 5.635 ± 0.106
2.051GluMet: 2.051 ± 0.058
6.104GluAsn: 6.104 ± 0.103
1.658GluPro: 1.658 ± 0.052
2.075GluGln: 2.075 ± 0.057
2.34GluArg: 2.34 ± 0.066
3.214GluSer: 3.214 ± 0.077
3.655GluThr: 3.655 ± 0.101
4.475GluVal: 4.475 ± 0.1
0.376GluTrp: 0.376 ± 0.025
3.047GluTyr: 3.047 ± 0.083
0.0GluXaa: 0.0 ± 0.0
Phe
2.791PheAla: 2.791 ± 0.074
0.675PheCys: 0.675 ± 0.03
2.801PheAsp: 2.801 ± 0.076
2.708PheGlu: 2.708 ± 0.069
1.703PhePhe: 1.703 ± 0.064
3.123PheGly: 3.123 ± 0.07
0.499PheHis: 0.499 ± 0.027
3.38PheIle: 3.38 ± 0.084
3.028PheLys: 3.028 ± 0.072
3.173PheLeu: 3.173 ± 0.091
1.261PheMet: 1.261 ± 0.046
2.597PheAsn: 2.597 ± 0.064
1.15PhePro: 1.15 ± 0.039
0.825PheGln: 0.825 ± 0.034
1.376PheArg: 1.376 ± 0.049
2.903PheSer: 2.903 ± 0.07
2.518PheThr: 2.518 ± 0.056
3.221PheVal: 3.221 ± 0.081
0.257PheTrp: 0.257 ± 0.021
1.709PheTyr: 1.709 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
4.737GlyAla: 4.737 ± 0.099
1.288GlyCys: 1.288 ± 0.05
3.669GlyAsp: 3.669 ± 0.084
4.259GlyGlu: 4.259 ± 0.086
3.027GlyPhe: 3.027 ± 0.062
4.907GlyGly: 4.907 ± 0.115
1.117GlyHis: 1.117 ± 0.044
6.121GlyIle: 6.121 ± 0.102
5.797GlyLys: 5.797 ± 0.11
5.447GlyLeu: 5.447 ± 0.1
1.946GlyMet: 1.946 ± 0.051
3.853GlyAsn: 3.853 ± 0.098
1.092GlyPro: 1.092 ± 0.043
1.673GlyGln: 1.673 ± 0.051
2.258GlyArg: 2.258 ± 0.074
4.141GlySer: 4.141 ± 0.099
4.13GlyThr: 4.13 ± 0.09
5.256GlyVal: 5.256 ± 0.097
0.478GlyTrp: 0.478 ± 0.027
3.187GlyTyr: 3.187 ± 0.083
0.0GlyXaa: 0.0 ± 0.0
His
0.641HisAla: 0.641 ± 0.037
0.257HisCys: 0.257 ± 0.021
0.655HisAsp: 0.655 ± 0.035
0.655HisGlu: 0.655 ± 0.028
0.663HisPhe: 0.663 ± 0.034
0.926HisGly: 0.926 ± 0.045
0.295HisHis: 0.295 ± 0.03
1.411HisIle: 1.411 ± 0.05
0.981HisLys: 0.981 ± 0.041
0.985HisLeu: 0.985 ± 0.039
0.301HisMet: 0.301 ± 0.02
0.986HisAsn: 0.986 ± 0.034
0.587HisPro: 0.587 ± 0.033
0.39HisGln: 0.39 ± 0.025
0.581HisArg: 0.581 ± 0.032
0.997HisSer: 0.997 ± 0.04
0.819HisThr: 0.819 ± 0.039
0.579HisVal: 0.579 ± 0.032
0.09HisTrp: 0.09 ± 0.012
0.582HisTyr: 0.582 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.831IleAla: 5.831 ± 0.108
1.393IleCys: 1.393 ± 0.043
5.414IleAsp: 5.414 ± 0.098
5.813IleGlu: 5.813 ± 0.124
3.481IlePhe: 3.481 ± 0.08
5.611IleGly: 5.611 ± 0.115
1.092IleHis: 1.092 ± 0.048
6.938IleIle: 6.938 ± 0.131
6.364IleLys: 6.364 ± 0.122
6.962IleLeu: 6.962 ± 0.145
2.203IleMet: 2.203 ± 0.063
5.141IleAsn: 5.141 ± 0.093
3.003IlePro: 3.003 ± 0.079
1.889IleGln: 1.889 ± 0.058
2.605IleArg: 2.605 ± 0.062
5.9IleSer: 5.9 ± 0.1
5.086IleThr: 5.086 ± 0.093
6.246IleVal: 6.246 ± 0.108
0.406IleTrp: 0.406 ± 0.026
3.17IleTyr: 3.17 ± 0.077
0.0IleXaa: 0.0 ± 0.0
Lys
5.804LysAla: 5.804 ± 0.114
0.955LysCys: 0.955 ± 0.044
4.866LysAsp: 4.866 ± 0.09
6.591LysGlu: 6.591 ± 0.115
2.826LysPhe: 2.826 ± 0.067
4.892LysGly: 4.892 ± 0.09
0.934LysHis: 0.934 ± 0.04
6.918LysIle: 6.918 ± 0.12
6.964LysLys: 6.964 ± 0.134
6.253LysLeu: 6.253 ± 0.105
2.589LysMet: 2.589 ± 0.072
5.872LysAsn: 5.872 ± 0.104
2.298LysPro: 2.298 ± 0.068
2.036LysGln: 2.036 ± 0.058
2.665LysArg: 2.665 ± 0.061
4.391LysSer: 4.391 ± 0.092
4.575LysThr: 4.575 ± 0.085
5.43LysVal: 5.43 ± 0.089
0.612LysTrp: 0.612 ± 0.03
3.928LysTyr: 3.928 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
5.501LeuAla: 5.501 ± 0.103
1.286LeuCys: 1.286 ± 0.047
4.713LeuAsp: 4.713 ± 0.09
5.177LeuGlu: 5.177 ± 0.098
3.541LeuPhe: 3.541 ± 0.087
5.816LeuGly: 5.816 ± 0.107
1.122LeuHis: 1.122 ± 0.048
5.98LeuIle: 5.98 ± 0.118
6.896LeuLys: 6.896 ± 0.105
6.781LeuLeu: 6.781 ± 0.121
2.245LeuMet: 2.245 ± 0.066
4.762LeuAsn: 4.762 ± 0.106
2.825LeuPro: 2.825 ± 0.076
2.059LeuGln: 2.059 ± 0.054
2.832LeuArg: 2.832 ± 0.069
5.837LeuSer: 5.837 ± 0.105
4.605LeuThr: 4.605 ± 0.106
5.25LeuVal: 5.25 ± 0.1
0.551LeuTrp: 0.551 ± 0.033
3.068LeuTyr: 3.068 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
2.391MetAla: 2.391 ± 0.062
0.372MetCys: 0.372 ± 0.026
1.701MetAsp: 1.701 ± 0.053
2.072MetGlu: 2.072 ± 0.063
1.087MetPhe: 1.087 ± 0.035
2.007MetGly: 2.007 ± 0.055
0.328MetHis: 0.328 ± 0.022
1.799MetIle: 1.799 ± 0.061
2.357MetLys: 2.357 ± 0.059
2.495MetLeu: 2.495 ± 0.063
0.653MetMet: 0.653 ± 0.032
1.562MetAsn: 1.562 ± 0.048
1.081MetPro: 1.081 ± 0.043
0.693MetGln: 0.693 ± 0.036
0.907MetArg: 0.907 ± 0.039
1.698MetSer: 1.698 ± 0.05
1.58MetThr: 1.58 ± 0.049
1.84MetVal: 1.84 ± 0.059
0.193MetTrp: 0.193 ± 0.019
1.032MetTyr: 1.032 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
3.688AsnAla: 3.688 ± 0.08
0.986AsnCys: 0.986 ± 0.048
3.224AsnAsp: 3.224 ± 0.08
3.718AsnGlu: 3.718 ± 0.082
2.286AsnPhe: 2.286 ± 0.059
4.633AsnGly: 4.633 ± 0.1
0.773AsnHis: 0.773 ± 0.037
6.16AsnIle: 6.16 ± 0.112
5.15AsnLys: 5.15 ± 0.104
4.496AsnLeu: 4.496 ± 0.093
1.75AsnMet: 1.75 ± 0.056
3.992AsnAsn: 3.992 ± 0.123
2.239AsnPro: 2.239 ± 0.057
1.39AsnGln: 1.39 ± 0.048
2.069AsnArg: 2.069 ± 0.067
4.152AsnSer: 4.152 ± 0.095
3.639AsnThr: 3.639 ± 0.086
4.186AsnVal: 4.186 ± 0.084
0.445AsnTrp: 0.445 ± 0.025
2.619AsnTyr: 2.619 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
1.826ProAla: 1.826 ± 0.06
0.418ProCys: 0.418 ± 0.027
1.864ProAsp: 1.864 ± 0.057
2.683ProGlu: 2.683 ± 0.076
1.403ProPhe: 1.403 ± 0.046
1.382ProGly: 1.382 ± 0.049
0.453ProHis: 0.453 ± 0.026
2.394ProIle: 2.394 ± 0.074
2.222ProLys: 2.222 ± 0.063
2.309ProLeu: 2.309 ± 0.063
0.895ProMet: 0.895 ± 0.036
1.613ProAsn: 1.613 ± 0.059
0.666ProPro: 0.666 ± 0.036
0.94ProGln: 0.94 ± 0.043
0.827ProArg: 0.827 ± 0.035
1.69ProSer: 1.69 ± 0.061
1.87ProThr: 1.87 ± 0.058
2.812ProVal: 2.812 ± 0.067
0.219ProTrp: 0.219 ± 0.023
1.236ProTyr: 1.236 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
1.748GlnAla: 1.748 ± 0.052
0.341GlnCys: 0.341 ± 0.022
1.127GlnAsp: 1.127 ± 0.04
1.565GlnGlu: 1.565 ± 0.051
0.953GlnPhe: 0.953 ± 0.04
1.505GlnGly: 1.505 ± 0.049
0.338GlnHis: 0.338 ± 0.025
1.995GlnIle: 1.995 ± 0.06
2.19GlnLys: 2.19 ± 0.068
2.312GlnLeu: 2.312 ± 0.062
0.772GlnMet: 0.772 ± 0.039
1.52GlnAsn: 1.52 ± 0.047
0.765GlnPro: 0.765 ± 0.034
0.862GlnGln: 0.862 ± 0.044
0.933GlnArg: 0.933 ± 0.041
1.36GlnSer: 1.36 ± 0.045
1.324GlnThr: 1.324 ± 0.052
1.63GlnVal: 1.63 ± 0.048
0.278GlnTrp: 0.278 ± 0.022
1.116GlnTyr: 1.116 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.119ArgAla: 2.119 ± 0.056
0.453ArgCys: 0.453 ± 0.027
1.846ArgAsp: 1.846 ± 0.056
2.553ArgGlu: 2.553 ± 0.08
1.389ArgPhe: 1.389 ± 0.048
2.073ArgGly: 2.073 ± 0.062
0.549ArgHis: 0.549 ± 0.029
2.812ArgIle: 2.812 ± 0.075
2.908ArgLys: 2.908 ± 0.077
2.806ArgLeu: 2.806 ± 0.075
0.972ArgMet: 0.972 ± 0.036
1.849ArgAsn: 1.849 ± 0.063
0.985ArgPro: 0.985 ± 0.046
1.018ArgGln: 1.018 ± 0.047
1.291ArgArg: 1.291 ± 0.054
1.548ArgSer: 1.548 ± 0.048
1.742ArgThr: 1.742 ± 0.054
2.302ArgVal: 2.302 ± 0.058
0.234ArgTrp: 0.234 ± 0.019
1.313ArgTyr: 1.313 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
4.294SerAla: 4.294 ± 0.094
0.792SerCys: 0.792 ± 0.037
3.661SerAsp: 3.661 ± 0.089
3.896SerGlu: 3.896 ± 0.067
2.656SerPhe: 2.656 ± 0.068
4.63SerGly: 4.63 ± 0.1
0.825SerHis: 0.825 ± 0.038
5.089SerIle: 5.089 ± 0.096
4.764SerLys: 4.764 ± 0.087
5.053SerLeu: 5.053 ± 0.104
1.665SerMet: 1.665 ± 0.057
3.519SerAsn: 3.519 ± 0.073
1.75SerPro: 1.75 ± 0.054
1.807SerGln: 1.807 ± 0.061
1.988SerArg: 1.988 ± 0.062
4.407SerSer: 4.407 ± 0.142
3.573SerThr: 3.573 ± 0.088
4.786SerVal: 4.786 ± 0.085
0.429SerTrp: 0.429 ± 0.025
2.528SerTyr: 2.528 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
4.33ThrAla: 4.33 ± 0.107
0.593ThrCys: 0.593 ± 0.032
3.579ThrAsp: 3.579 ± 0.088
4.103ThrGlu: 4.103 ± 0.129
2.356ThrPhe: 2.356 ± 0.062
4.668ThrGly: 4.668 ± 0.087
0.767ThrHis: 0.767 ± 0.038
4.728ThrIle: 4.728 ± 0.086
3.839ThrLys: 3.839 ± 0.081
4.811ThrLeu: 4.811 ± 0.088
1.352ThrMet: 1.352 ± 0.049
2.873ThrAsn: 2.873 ± 0.076
2.189ThrPro: 2.189 ± 0.065
1.307ThrGln: 1.307 ± 0.046
1.734ThrArg: 1.734 ± 0.055
3.541ThrSer: 3.541 ± 0.089
4.601ThrThr: 4.601 ± 0.234
5.319ThrVal: 5.319 ± 0.094
0.355ThrTrp: 0.355 ± 0.021
2.231ThrTyr: 2.231 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
5.381ValAla: 5.381 ± 0.112
1.152ValCys: 1.152 ± 0.048
4.466ValAsp: 4.466 ± 0.085
5.064ValGlu: 5.064 ± 0.099
3.12ValPhe: 3.12 ± 0.082
4.593ValGly: 4.593 ± 0.096
0.933ValHis: 0.933 ± 0.04
5.788ValIle: 5.788 ± 0.104
5.504ValLys: 5.504 ± 0.091
6.282ValLeu: 6.282 ± 0.108
1.93ValMet: 1.93 ± 0.057
4.303ValAsn: 4.303 ± 0.08
2.477ValPro: 2.477 ± 0.071
1.635ValGln: 1.635 ± 0.05
2.193ValArg: 2.193 ± 0.063
4.98ValSer: 4.98 ± 0.092
4.598ValThr: 4.598 ± 0.1
6.1ValVal: 6.1 ± 0.107
0.467ValTrp: 0.467 ± 0.031
2.891ValTyr: 2.891 ± 0.068
0.0ValXaa: 0.0 ± 0.0
Trp
0.48TrpAla: 0.48 ± 0.033
0.085TrpCys: 0.085 ± 0.014
0.484TrpAsp: 0.484 ± 0.029
0.42TrpGlu: 0.42 ± 0.026
0.323TrpPhe: 0.323 ± 0.02
0.533TrpGly: 0.533 ± 0.033
0.103TrpHis: 0.103 ± 0.013
0.464TrpIle: 0.464 ± 0.029
0.451TrpLys: 0.451 ± 0.025
0.634TrpLeu: 0.634 ± 0.033
0.158TrpMet: 0.158 ± 0.016
0.466TrpAsn: 0.466 ± 0.029
0.14TrpPro: 0.14 ± 0.018
0.194TrpGln: 0.194 ± 0.02
0.238TrpArg: 0.238 ± 0.019
0.366TrpSer: 0.366 ± 0.024
0.305TrpThr: 0.305 ± 0.025
0.417TrpVal: 0.417 ± 0.028
0.08TrpTrp: 0.08 ± 0.01
0.323TrpTyr: 0.323 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.389TyrAla: 2.389 ± 0.072
0.729TyrCys: 0.729 ± 0.037
2.806TyrAsp: 2.806 ± 0.071
2.599TyrGlu: 2.599 ± 0.057
1.804TyrPhe: 1.804 ± 0.052
2.981TyrGly: 2.981 ± 0.066
0.525TyrHis: 0.525 ± 0.025
3.782TyrIle: 3.782 ± 0.088
3.304TyrLys: 3.304 ± 0.079
3.033TyrLeu: 3.033 ± 0.064
1.0TyrMet: 1.0 ± 0.039
2.954TyrAsn: 2.954 ± 0.083
1.22TyrPro: 1.22 ± 0.047
0.784TyrGln: 0.784 ± 0.033
1.376TyrArg: 1.376 ± 0.053
2.93TyrSer: 2.93 ± 0.069
2.542TyrThr: 2.542 ± 0.076
2.937TyrVal: 2.937 ± 0.082
0.273TyrTrp: 0.273 ± 0.022
1.968TyrTyr: 1.968 ± 0.068
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2006 proteins (633728 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski