Amino acid dipepetide frequency for Mycobacterium virus Halo

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.78AlaAla: 19.78 ± 1.666
0.863AlaCys: 0.863 ± 0.286
8.272AlaAsp: 8.272 ± 0.89
8.487AlaGlu: 8.487 ± 1.204
4.028AlaPhe: 4.028 ± 0.758
14.673AlaGly: 14.673 ± 1.426
2.446AlaHis: 2.446 ± 0.6
6.258AlaIle: 6.258 ± 0.734
5.179AlaLys: 5.179 ± 0.815
9.71AlaLeu: 9.71 ± 0.925
3.452AlaMet: 3.452 ± 0.453
3.668AlaAsn: 3.668 ± 0.552
6.617AlaPro: 6.617 ± 1.104
4.819AlaGln: 4.819 ± 0.519
7.912AlaArg: 7.912 ± 1.113
5.395AlaSer: 5.395 ± 1.0
6.977AlaThr: 6.977 ± 0.742
8.631AlaVal: 8.631 ± 0.877
2.589AlaTrp: 2.589 ± 0.321
2.23AlaTyr: 2.23 ± 0.435
0.0AlaXaa: 0.0 ± 0.0
Cys
1.079CysAla: 1.079 ± 0.33
0.072CysCys: 0.072 ± 0.08
0.36CysAsp: 0.36 ± 0.161
0.432CysGlu: 0.432 ± 0.164
0.288CysPhe: 0.288 ± 0.14
1.582CysGly: 1.582 ± 0.392
0.072CysHis: 0.072 ± 0.063
0.288CysIle: 0.288 ± 0.14
0.216CysLys: 0.216 ± 0.129
0.36CysLeu: 0.36 ± 0.167
0.072CysMet: 0.072 ± 0.071
0.36CysAsn: 0.36 ± 0.172
0.719CysPro: 0.719 ± 0.298
0.575CysGln: 0.575 ± 0.194
1.007CysArg: 1.007 ± 0.251
0.647CysSer: 0.647 ± 0.272
0.647CysThr: 0.647 ± 0.314
0.575CysVal: 0.575 ± 0.221
0.288CysTrp: 0.288 ± 0.153
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
8.559AspAla: 8.559 ± 0.794
0.36AspCys: 0.36 ± 0.206
6.33AspAsp: 6.33 ± 0.763
5.323AspGlu: 5.323 ± 0.697
2.086AspPhe: 2.086 ± 0.398
7.768AspGly: 7.768 ± 0.873
1.223AspHis: 1.223 ± 0.316
1.582AspIle: 1.582 ± 0.352
1.798AspLys: 1.798 ± 0.438
5.035AspLeu: 5.035 ± 0.64
0.935AspMet: 0.935 ± 0.227
1.223AspAsn: 1.223 ± 0.324
4.675AspPro: 4.675 ± 0.707
3.093AspGln: 3.093 ± 0.516
4.172AspArg: 4.172 ± 0.713
2.517AspSer: 2.517 ± 0.378
3.381AspThr: 3.381 ± 0.396
5.251AspVal: 5.251 ± 0.708
1.439AspTrp: 1.439 ± 0.369
2.589AspTyr: 2.589 ± 0.479
0.0AspXaa: 0.0 ± 0.0
Glu
5.826GluAla: 5.826 ± 0.867
0.432GluCys: 0.432 ± 0.23
4.172GluAsp: 4.172 ± 0.599
3.237GluGlu: 3.237 ± 0.629
1.654GluPhe: 1.654 ± 0.37
4.172GluGly: 4.172 ± 0.46
2.589GluHis: 2.589 ± 0.509
2.158GluIle: 2.158 ± 0.412
1.223GluLys: 1.223 ± 0.255
6.258GluLeu: 6.258 ± 0.797
1.079GluMet: 1.079 ± 0.243
2.23GluAsn: 2.23 ± 0.494
4.028GluPro: 4.028 ± 0.785
2.23GluGln: 2.23 ± 0.429
4.316GluArg: 4.316 ± 0.903
2.158GluSer: 2.158 ± 0.432
3.093GluThr: 3.093 ± 0.425
3.812GluVal: 3.812 ± 0.408
1.151GluTrp: 1.151 ± 0.319
0.575GluTyr: 0.575 ± 0.2
0.0GluXaa: 0.0 ± 0.0
Phe
3.237PheAla: 3.237 ± 0.394
0.503PheCys: 0.503 ± 0.215
2.805PheAsp: 2.805 ± 0.385
2.374PheGlu: 2.374 ± 0.447
0.791PhePhe: 0.791 ± 0.224
3.812PheGly: 3.812 ± 0.635
0.432PheHis: 0.432 ± 0.181
0.647PheIle: 0.647 ± 0.23
0.719PheLys: 0.719 ± 0.193
2.086PheLeu: 2.086 ± 0.512
0.647PheMet: 0.647 ± 0.195
1.079PheAsn: 1.079 ± 0.298
1.439PhePro: 1.439 ± 0.309
0.719PheGln: 0.719 ± 0.217
1.367PheArg: 1.367 ± 0.333
2.302PheSer: 2.302 ± 0.418
1.439PheThr: 1.439 ± 0.244
2.014PheVal: 2.014 ± 0.364
0.432PheTrp: 0.432 ± 0.196
0.432PheTyr: 0.432 ± 0.155
0.0PheXaa: 0.0 ± 0.0
Gly
11.58GlyAla: 11.58 ± 1.015
0.791GlyCys: 0.791 ± 0.22
6.33GlyAsp: 6.33 ± 0.629
4.459GlyGlu: 4.459 ± 0.492
2.877GlyPhe: 2.877 ± 0.351
7.48GlyGly: 7.48 ± 1.349
2.446GlyHis: 2.446 ± 0.508
4.747GlyIle: 4.747 ± 0.646
4.388GlyLys: 4.388 ± 0.782
7.48GlyLeu: 7.48 ± 0.98
1.295GlyMet: 1.295 ± 0.255
3.021GlyAsn: 3.021 ± 0.584
4.1GlyPro: 4.1 ± 0.616
2.517GlyGln: 2.517 ± 0.532
5.97GlyArg: 5.97 ± 0.626
5.251GlySer: 5.251 ± 0.641
5.035GlyThr: 5.035 ± 0.775
6.042GlyVal: 6.042 ± 0.709
2.158GlyTrp: 2.158 ± 0.34
2.517GlyTyr: 2.517 ± 0.415
0.0GlyXaa: 0.0 ± 0.0
His
2.733HisAla: 2.733 ± 0.709
0.288HisCys: 0.288 ± 0.162
1.51HisAsp: 1.51 ± 0.369
1.079HisGlu: 1.079 ± 0.3
0.36HisPhe: 0.36 ± 0.167
1.726HisGly: 1.726 ± 0.305
0.503HisHis: 0.503 ± 0.227
1.079HisIle: 1.079 ± 0.283
0.791HisLys: 0.791 ± 0.229
1.295HisLeu: 1.295 ± 0.353
0.719HisMet: 0.719 ± 0.191
0.863HisAsn: 0.863 ± 0.232
2.086HisPro: 2.086 ± 0.481
0.863HisGln: 0.863 ± 0.253
2.733HisArg: 2.733 ± 0.548
0.863HisSer: 0.863 ± 0.209
0.863HisThr: 0.863 ± 0.267
1.798HisVal: 1.798 ± 0.342
0.575HisTrp: 0.575 ± 0.183
0.216HisTyr: 0.216 ± 0.118
0.0HisXaa: 0.0 ± 0.0
Ile
5.682IleAla: 5.682 ± 0.674
0.503IleCys: 0.503 ± 0.186
3.381IleAsp: 3.381 ± 0.536
3.165IleGlu: 3.165 ± 0.521
1.151IlePhe: 1.151 ± 0.218
4.244IleGly: 4.244 ± 0.772
0.935IleHis: 0.935 ± 0.23
1.007IleIle: 1.007 ± 0.283
1.295IleLys: 1.295 ± 0.464
2.805IleLeu: 2.805 ± 0.445
0.647IleMet: 0.647 ± 0.247
0.719IleAsn: 0.719 ± 0.247
4.531IlePro: 4.531 ± 0.761
1.51IleGln: 1.51 ± 0.262
3.884IleArg: 3.884 ± 0.557
1.582IleSer: 1.582 ± 0.315
2.014IleThr: 2.014 ± 0.563
3.021IleVal: 3.021 ± 0.43
1.079IleTrp: 1.079 ± 0.326
1.007IleTyr: 1.007 ± 0.262
0.0IleXaa: 0.0 ± 0.0
Lys
5.61LysAla: 5.61 ± 0.79
0.216LysCys: 0.216 ± 0.124
1.151LysAsp: 1.151 ± 0.347
0.719LysGlu: 0.719 ± 0.259
0.935LysPhe: 0.935 ± 0.257
1.942LysGly: 1.942 ± 0.464
0.719LysHis: 0.719 ± 0.235
2.158LysIle: 2.158 ± 0.487
1.51LysLys: 1.51 ± 0.32
2.589LysLeu: 2.589 ± 0.666
0.935LysMet: 0.935 ± 0.234
1.582LysAsn: 1.582 ± 0.305
2.661LysPro: 2.661 ± 0.463
1.007LysGln: 1.007 ± 0.32
2.589LysArg: 2.589 ± 0.473
1.87LysSer: 1.87 ± 0.342
2.877LysThr: 2.877 ± 0.485
2.086LysVal: 2.086 ± 0.355
0.36LysTrp: 0.36 ± 0.143
0.719LysTyr: 0.719 ± 0.235
0.0LysXaa: 0.0 ± 0.0
Leu
9.207LeuAla: 9.207 ± 0.77
0.647LeuCys: 0.647 ± 0.223
6.258LeuAsp: 6.258 ± 0.737
3.165LeuGlu: 3.165 ± 0.418
2.302LeuPhe: 2.302 ± 0.416
7.121LeuGly: 7.121 ± 0.842
1.51LeuHis: 1.51 ± 0.32
4.388LeuIle: 4.388 ± 0.632
2.877LeuLys: 2.877 ± 0.56
4.603LeuLeu: 4.603 ± 0.563
1.367LeuMet: 1.367 ± 0.304
1.942LeuAsn: 1.942 ± 0.457
4.819LeuPro: 4.819 ± 0.493
1.726LeuGln: 1.726 ± 0.372
5.323LeuArg: 5.323 ± 0.639
4.1LeuSer: 4.1 ± 0.612
5.251LeuThr: 5.251 ± 0.729
5.754LeuVal: 5.754 ± 0.797
1.079LeuTrp: 1.079 ± 0.368
1.439LeuTyr: 1.439 ± 0.349
0.0LeuXaa: 0.0 ± 0.0
Met
2.302MetAla: 2.302 ± 0.454
0.144MetCys: 0.144 ± 0.089
0.935MetAsp: 0.935 ± 0.256
0.791MetGlu: 0.791 ± 0.222
0.935MetPhe: 0.935 ± 0.234
1.223MetGly: 1.223 ± 0.296
0.935MetHis: 0.935 ± 0.361
1.007MetIle: 1.007 ± 0.264
0.647MetLys: 0.647 ± 0.2
2.086MetLeu: 2.086 ± 0.326
0.575MetMet: 0.575 ± 0.184
0.503MetAsn: 0.503 ± 0.176
0.575MetPro: 0.575 ± 0.213
0.863MetGln: 0.863 ± 0.21
1.223MetArg: 1.223 ± 0.25
1.654MetSer: 1.654 ± 0.323
2.302MetThr: 2.302 ± 0.365
1.367MetVal: 1.367 ± 0.261
0.288MetTrp: 0.288 ± 0.132
0.216MetTyr: 0.216 ± 0.123
0.0MetXaa: 0.0 ± 0.0
Asn
4.675AsnAla: 4.675 ± 0.743
0.575AsnCys: 0.575 ± 0.235
1.007AsnAsp: 1.007 ± 0.289
1.654AsnGlu: 1.654 ± 0.355
0.935AsnPhe: 0.935 ± 0.302
3.021AsnGly: 3.021 ± 0.473
0.647AsnHis: 0.647 ± 0.177
1.439AsnIle: 1.439 ± 0.392
0.647AsnLys: 0.647 ± 0.229
2.086AsnLeu: 2.086 ± 0.364
0.36AsnMet: 0.36 ± 0.168
0.647AsnAsn: 0.647 ± 0.273
2.877AsnPro: 2.877 ± 0.49
1.295AsnGln: 1.295 ± 0.308
2.589AsnArg: 2.589 ± 0.335
0.791AsnSer: 0.791 ± 0.221
1.798AsnThr: 1.798 ± 0.378
1.798AsnVal: 1.798 ± 0.572
0.288AsnTrp: 0.288 ± 0.107
0.719AsnTyr: 0.719 ± 0.217
0.0AsnXaa: 0.0 ± 0.0
Pro
11.724ProAla: 11.724 ± 1.303
0.503ProCys: 0.503 ± 0.279
4.891ProAsp: 4.891 ± 0.757
4.244ProGlu: 4.244 ± 0.592
1.295ProPhe: 1.295 ± 0.245
4.963ProGly: 4.963 ± 0.766
1.439ProHis: 1.439 ± 0.358
2.661ProIle: 2.661 ± 0.405
2.086ProLys: 2.086 ± 0.344
4.028ProLeu: 4.028 ± 0.564
0.791ProMet: 0.791 ± 0.274
1.654ProAsn: 1.654 ± 0.35
3.668ProPro: 3.668 ± 0.597
2.086ProGln: 2.086 ± 0.407
3.668ProArg: 3.668 ± 0.657
3.093ProSer: 3.093 ± 0.356
3.74ProThr: 3.74 ± 0.531
3.596ProVal: 3.596 ± 0.625
0.935ProTrp: 0.935 ± 0.28
1.007ProTyr: 1.007 ± 0.246
0.0ProXaa: 0.0 ± 0.0
Gln
4.603GlnAla: 4.603 ± 0.644
0.36GlnCys: 0.36 ± 0.138
2.446GlnAsp: 2.446 ± 0.334
1.295GlnGlu: 1.295 ± 0.277
1.439GlnPhe: 1.439 ± 0.308
2.661GlnGly: 2.661 ± 0.424
1.223GlnHis: 1.223 ± 0.384
1.87GlnIle: 1.87 ± 0.352
1.223GlnLys: 1.223 ± 0.278
3.165GlnLeu: 3.165 ± 0.507
0.863GlnMet: 0.863 ± 0.193
1.439GlnAsn: 1.439 ± 0.438
1.726GlnPro: 1.726 ± 0.299
1.87GlnGln: 1.87 ± 0.415
2.446GlnArg: 2.446 ± 0.47
1.582GlnSer: 1.582 ± 0.44
1.582GlnThr: 1.582 ± 0.259
1.798GlnVal: 1.798 ± 0.464
0.575GlnTrp: 0.575 ± 0.176
0.719GlnTyr: 0.719 ± 0.241
0.0GlnXaa: 0.0 ± 0.0
Arg
9.207ArgAla: 9.207 ± 1.219
1.151ArgCys: 1.151 ± 0.337
4.316ArgAsp: 4.316 ± 0.491
3.524ArgGlu: 3.524 ± 0.538
1.726ArgPhe: 1.726 ± 0.409
4.603ArgGly: 4.603 ± 0.591
1.223ArgHis: 1.223 ± 0.338
3.237ArgIle: 3.237 ± 0.453
2.517ArgLys: 2.517 ± 0.427
4.891ArgLeu: 4.891 ± 0.542
2.302ArgMet: 2.302 ± 0.373
2.877ArgAsn: 2.877 ± 0.52
4.459ArgPro: 4.459 ± 0.579
2.877ArgGln: 2.877 ± 0.425
7.337ArgArg: 7.337 ± 1.214
2.877ArgSer: 2.877 ± 0.479
4.531ArgThr: 4.531 ± 0.475
3.884ArgVal: 3.884 ± 0.702
1.51ArgTrp: 1.51 ± 0.341
1.582ArgTyr: 1.582 ± 0.292
0.0ArgXaa: 0.0 ± 0.0
Ser
5.682SerAla: 5.682 ± 0.959
0.575SerCys: 0.575 ± 0.248
4.172SerAsp: 4.172 ± 0.533
3.093SerGlu: 3.093 ± 0.591
1.582SerPhe: 1.582 ± 0.306
4.531SerGly: 4.531 ± 1.104
0.503SerHis: 0.503 ± 0.171
2.374SerIle: 2.374 ± 0.413
2.374SerLys: 2.374 ± 0.434
3.093SerLeu: 3.093 ± 0.538
1.295SerMet: 1.295 ± 0.285
1.51SerAsn: 1.51 ± 0.394
2.805SerPro: 2.805 ± 0.475
1.079SerGln: 1.079 ± 0.268
3.237SerArg: 3.237 ± 0.418
3.524SerSer: 3.524 ± 0.585
3.812SerThr: 3.812 ± 0.522
3.165SerVal: 3.165 ± 0.563
1.223SerTrp: 1.223 ± 0.346
1.079SerTyr: 1.079 ± 0.277
0.0SerXaa: 0.0 ± 0.0
Thr
8.272ThrAla: 8.272 ± 0.859
0.432ThrCys: 0.432 ± 0.193
3.812ThrAsp: 3.812 ± 0.425
2.949ThrGlu: 2.949 ± 0.387
1.942ThrPhe: 1.942 ± 0.397
5.538ThrGly: 5.538 ± 0.757
1.367ThrHis: 1.367 ± 0.286
2.733ThrIle: 2.733 ± 0.478
1.654ThrLys: 1.654 ± 0.357
3.884ThrLeu: 3.884 ± 0.625
1.582ThrMet: 1.582 ± 0.345
1.582ThrAsn: 1.582 ± 0.309
4.244ThrPro: 4.244 ± 0.634
1.367ThrGln: 1.367 ± 0.285
3.524ThrArg: 3.524 ± 0.48
4.316ThrSer: 4.316 ± 0.647
4.244ThrThr: 4.244 ± 0.62
5.107ThrVal: 5.107 ± 0.456
0.719ThrTrp: 0.719 ± 0.252
0.935ThrTyr: 0.935 ± 0.323
0.0ThrXaa: 0.0 ± 0.0
Val
8.056ValAla: 8.056 ± 0.794
0.935ValCys: 0.935 ± 0.327
5.323ValAsp: 5.323 ± 0.7
4.747ValGlu: 4.747 ± 0.441
2.158ValPhe: 2.158 ± 0.364
5.323ValGly: 5.323 ± 0.591
1.439ValHis: 1.439 ± 0.246
2.589ValIle: 2.589 ± 0.482
1.798ValLys: 1.798 ± 0.329
5.107ValLeu: 5.107 ± 0.487
0.863ValMet: 0.863 ± 0.249
2.086ValAsn: 2.086 ± 0.394
3.956ValPro: 3.956 ± 0.467
2.23ValGln: 2.23 ± 0.462
4.459ValArg: 4.459 ± 0.721
3.524ValSer: 3.524 ± 0.74
4.388ValThr: 4.388 ± 0.57
5.179ValVal: 5.179 ± 0.75
2.158ValTrp: 2.158 ± 0.52
1.439ValTyr: 1.439 ± 0.257
0.0ValXaa: 0.0 ± 0.0
Trp
2.086TrpAla: 2.086 ± 0.324
0.144TrpCys: 0.144 ± 0.097
1.007TrpAsp: 1.007 ± 0.278
0.647TrpGlu: 0.647 ± 0.203
0.432TrpPhe: 0.432 ± 0.141
1.726TrpGly: 1.726 ± 0.417
0.575TrpHis: 0.575 ± 0.19
1.223TrpIle: 1.223 ± 0.294
0.791TrpLys: 0.791 ± 0.261
2.302TrpLeu: 2.302 ± 0.565
0.503TrpMet: 0.503 ± 0.191
0.575TrpAsn: 0.575 ± 0.208
1.007TrpPro: 1.007 ± 0.228
0.935TrpGln: 0.935 ± 0.229
1.439TrpArg: 1.439 ± 0.278
1.654TrpSer: 1.654 ± 0.384
0.935TrpThr: 0.935 ± 0.25
0.935TrpVal: 0.935 ± 0.236
0.216TrpTrp: 0.216 ± 0.114
0.503TrpTyr: 0.503 ± 0.203
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.086TyrAla: 2.086 ± 0.433
0.144TyrCys: 0.144 ± 0.111
0.863TyrAsp: 0.863 ± 0.274
1.007TyrGlu: 1.007 ± 0.28
0.36TyrPhe: 0.36 ± 0.185
2.374TyrGly: 2.374 ± 0.39
0.719TyrHis: 0.719 ± 0.248
0.791TyrIle: 0.791 ± 0.204
0.503TyrLys: 0.503 ± 0.165
2.014TyrLeu: 2.014 ± 0.364
0.216TyrMet: 0.216 ± 0.148
0.288TyrAsn: 0.288 ± 0.13
1.079TyrPro: 1.079 ± 0.275
1.223TyrGln: 1.223 ± 0.274
1.439TyrArg: 1.439 ± 0.3
1.007TyrSer: 1.007 ± 0.316
1.295TyrThr: 1.295 ± 0.307
1.942TyrVal: 1.942 ± 0.396
0.575TyrTrp: 0.575 ± 0.163
0.432TyrTyr: 0.432 ± 0.18
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 64 proteins (13904 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski