Amino acid dipepetide frequency for Desulfosarcina alkanivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.025AlaAla: 11.025 ± 0.122	1.412AlaCys: 1.412 ± 0.033	6.08AlaAsp: 6.08 ± 0.066	5.127AlaGlu: 5.127 ± 0.056	3.981AlaPhe: 3.981 ± 0.05	9.025AlaGly: 9.025 ± 0.079	1.864AlaHis: 1.864 ± 0.027	5.76AlaIle: 5.76 ± 0.057	3.265AlaLys: 3.265 ± 0.046	9.287AlaLeu: 9.287 ± 0.09	3.129AlaMet: 3.129 ± 0.036	2.494AlaAsn: 2.494 ± 0.037	3.558AlaPro: 3.558 ± 0.048	2.572AlaGln: 2.572 ± 0.038	6.252AlaArg: 6.252 ± 0.068	4.917AlaSer: 4.917 ± 0.054	4.568AlaThr: 4.568 ± 0.048	7.788AlaVal: 7.788 ± 0.071	1.075AlaTrp: 1.075 ± 0.026	2.642AlaTyr: 2.642 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.998CysAla: 0.998 ± 0.023	0.251CysCys: 0.251 ± 0.01	0.691CysAsp: 0.691 ± 0.019	0.595CysGlu: 0.595 ± 0.017	0.537CysPhe: 0.537 ± 0.016	1.352CysGly: 1.352 ± 0.03	0.422CysHis: 0.422 ± 0.02	0.718CysIle: 0.718 ± 0.019	0.422CysLys: 0.422 ± 0.015	1.165CysLeu: 1.165 ± 0.026	0.344CysMet: 0.344 ± 0.013	0.405CysAsn: 0.405 ± 0.013	0.813CysPro: 0.813 ± 0.023	0.341CysGln: 0.341 ± 0.012	1.113CysArg: 1.113 ± 0.028	0.709CysSer: 0.709 ± 0.021	0.65CysThr: 0.65 ± 0.018	0.748CysVal: 0.748 ± 0.022	0.146CysTrp: 0.146 ± 0.008	0.352CysTyr: 0.352 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.798AspAla: 5.798 ± 0.065	0.66AspCys: 0.66 ± 0.02	3.471AspAsp: 3.471 ± 0.052	3.387AspGlu: 3.387 ± 0.043	2.546AspPhe: 2.546 ± 0.035	4.982AspGly: 4.982 ± 0.077	1.492AspHis: 1.492 ± 0.029	3.872AspIle: 3.872 ± 0.055	2.148AspLys: 2.148 ± 0.033	6.139AspLeu: 6.139 ± 0.06	1.524AspMet: 1.524 ± 0.028	1.79AspAsn: 1.79 ± 0.034	3.395AspPro: 3.395 ± 0.046	1.998AspGln: 1.998 ± 0.032	4.732AspArg: 4.732 ± 0.062	2.643AspSer: 2.643 ± 0.045	3.036AspThr: 3.036 ± 0.045	3.881AspVal: 3.881 ± 0.05	0.752AspTrp: 0.752 ± 0.022	1.792AspTyr: 1.792 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	5.762GluAla: 5.762 ± 0.064	0.477GluCys: 0.477 ± 0.016	2.914GluAsp: 2.914 ± 0.039	3.192GluGlu: 3.192 ± 0.046	1.707GluPhe: 1.707 ± 0.027	3.611GluGly: 3.611 ± 0.045	1.0GluHis: 1.0 ± 0.024	4.107GluIle: 4.107 ± 0.047	4.397GluLys: 4.397 ± 0.055	4.938GluLeu: 4.938 ± 0.047	1.892GluMet: 1.892 ± 0.03	2.511GluAsn: 2.511 ± 0.036	2.147GluPro: 2.147 ± 0.035	2.053GluGln: 2.053 ± 0.035	3.721GluArg: 3.721 ± 0.048	3.098GluSer: 3.098 ± 0.039	3.841GluThr: 3.841 ± 0.05	3.527GluVal: 3.527 ± 0.043	0.524GluTrp: 0.524 ± 0.018	1.325GluTyr: 1.325 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.245PheAla: 3.245 ± 0.045	0.576PheCys: 0.576 ± 0.017	2.707PheAsp: 2.707 ± 0.04	2.308PheGlu: 2.308 ± 0.037	2.164PhePhe: 2.164 ± 0.036	3.285PheGly: 3.285 ± 0.04	0.894PheHis: 0.894 ± 0.02	2.463PheIle: 2.463 ± 0.041	1.833PheLys: 1.833 ± 0.035	3.915PheLeu: 3.915 ± 0.06	1.085PheMet: 1.085 ± 0.024	1.59PheAsn: 1.59 ± 0.031	1.774PhePro: 1.774 ± 0.03	1.283PheGln: 1.283 ± 0.025	2.266PheArg: 2.266 ± 0.033	3.153PheSer: 3.153 ± 0.046	2.244PheThr: 2.244 ± 0.033	2.701PheVal: 2.701 ± 0.037	0.537PheTrp: 0.537 ± 0.017	1.278PheTyr: 1.278 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	6.782GlyAla: 6.782 ± 0.075	1.251GlyCys: 1.251 ± 0.026	4.267GlyAsp: 4.267 ± 0.059	4.133GlyGlu: 4.133 ± 0.046	3.535GlyPhe: 3.535 ± 0.048	6.293GlyGly: 6.293 ± 0.08	1.839GlyHis: 1.839 ± 0.03	5.722GlyIle: 5.722 ± 0.057	4.119GlyLys: 4.119 ± 0.048	7.765GlyLeu: 7.765 ± 0.071	2.62GlyMet: 2.62 ± 0.042	2.597GlyAsn: 2.597 ± 0.043	2.834GlyPro: 2.834 ± 0.042	2.739GlyGln: 2.739 ± 0.034	5.492GlyArg: 5.492 ± 0.063	4.496GlySer: 4.496 ± 0.06	4.518GlyThr: 4.518 ± 0.06	5.531GlyVal: 5.531 ± 0.051	1.072GlyTrp: 1.072 ± 0.025	2.64GlyTyr: 2.64 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	1.808HisAla: 1.808 ± 0.031	0.339HisCys: 0.339 ± 0.013	1.162HisAsp: 1.162 ± 0.025	1.044HisGlu: 1.044 ± 0.023	0.988HisPhe: 0.988 ± 0.021	1.72HisGly: 1.72 ± 0.03	0.685HisHis: 0.685 ± 0.023	1.233HisIle: 1.233 ± 0.024	0.697HisLys: 0.697 ± 0.018	2.32HisLeu: 2.32 ± 0.034	0.53HisMet: 0.53 ± 0.016	0.594HisAsn: 0.594 ± 0.016	1.465HisPro: 1.465 ± 0.028	0.86HisGln: 0.86 ± 0.023	1.683HisArg: 1.683 ± 0.03	1.025HisSer: 1.025 ± 0.024	1.12HisThr: 1.12 ± 0.026	1.407HisVal: 1.407 ± 0.023	0.297HisTrp: 0.297 ± 0.013	0.678HisTyr: 0.678 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.735IleAla: 5.735 ± 0.053	0.788IleCys: 0.788 ± 0.018	4.368IleAsp: 4.368 ± 0.055	3.867IleGlu: 3.867 ± 0.046	2.538IlePhe: 2.538 ± 0.038	4.911IleGly: 4.911 ± 0.06	1.482IleHis: 1.482 ± 0.026	3.518IleIle: 3.518 ± 0.05	2.765IleLys: 2.765 ± 0.041	5.662IleLeu: 5.662 ± 0.064	1.449IleMet: 1.449 ± 0.026	2.267IleAsn: 2.267 ± 0.036	3.072IlePro: 3.072 ± 0.041	2.005IleGln: 2.005 ± 0.034	4.218IleArg: 4.218 ± 0.058	3.866IleSer: 3.866 ± 0.047	3.294IleThr: 3.294 ± 0.05	4.411IleVal: 4.411 ± 0.049	0.553IleTrp: 0.553 ± 0.017	1.607IleTyr: 1.607 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.501LysAla: 4.501 ± 0.06	0.379LysCys: 0.379 ± 0.015	2.535LysAsp: 2.535 ± 0.04	2.887LysGlu: 2.887 ± 0.044	1.239LysPhe: 1.239 ± 0.029	3.671LysGly: 3.671 ± 0.044	0.821LysHis: 0.821 ± 0.021	3.107LysIle: 3.107 ± 0.044	3.648LysLys: 3.648 ± 0.059	3.505LysLeu: 3.505 ± 0.047	1.471LysMet: 1.471 ± 0.03	2.015LysAsn: 2.015 ± 0.03	2.158LysPro: 2.158 ± 0.037	1.551LysGln: 1.551 ± 0.032	3.018LysArg: 3.018 ± 0.043	2.405LysSer: 2.405 ± 0.034	3.066LysThr: 3.066 ± 0.038	2.808LysVal: 2.808 ± 0.045	0.495LysTrp: 0.495 ± 0.017	1.151LysTyr: 1.151 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	9.865LeuAla: 9.865 ± 0.089	1.226LeuCys: 1.226 ± 0.027	5.949LeuAsp: 5.949 ± 0.056	5.828LeuGlu: 5.828 ± 0.055	4.221LeuPhe: 4.221 ± 0.059	6.921LeuGly: 6.921 ± 0.069	1.717LeuHis: 1.717 ± 0.026	5.417LeuIle: 5.417 ± 0.07	5.482LeuLys: 5.482 ± 0.058	9.017LeuLeu: 9.017 ± 0.093	2.606LeuMet: 2.606 ± 0.038	3.363LeuAsn: 3.363 ± 0.039	4.689LeuPro: 4.689 ± 0.052	2.742LeuGln: 2.742 ± 0.035	4.904LeuArg: 4.904 ± 0.053	6.515LeuSer: 6.515 ± 0.056	5.355LeuThr: 5.355 ± 0.06	6.903LeuVal: 6.903 ± 0.066	0.959LeuTrp: 0.959 ± 0.022	2.352LeuTyr: 2.352 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.534MetAla: 3.534 ± 0.044	0.259MetCys: 0.259 ± 0.012	1.881MetAsp: 1.881 ± 0.036	1.695MetGlu: 1.695 ± 0.032	0.794MetPhe: 0.794 ± 0.021	2.444MetGly: 2.444 ± 0.039	0.471MetHis: 0.471 ± 0.017	1.725MetIle: 1.725 ± 0.031	1.594MetLys: 1.594 ± 0.03	2.464MetLeu: 2.464 ± 0.037	0.778MetMet: 0.778 ± 0.022	1.114MetAsn: 1.114 ± 0.023	1.399MetPro: 1.399 ± 0.025	0.81MetGln: 0.81 ± 0.017	1.415MetArg: 1.415 ± 0.03	1.396MetSer: 1.396 ± 0.03	1.749MetThr: 1.749 ± 0.03	2.387MetVal: 2.387 ± 0.037	0.195MetTrp: 0.195 ± 0.009	0.436MetTyr: 0.436 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.966AsnAla: 2.966 ± 0.036	0.479AsnCys: 0.479 ± 0.017	1.723AsnAsp: 1.723 ± 0.038	1.579AsnGlu: 1.579 ± 0.03	1.221AsnPhe: 1.221 ± 0.027	2.746AsnGly: 2.746 ± 0.051	0.818AsnHis: 0.818 ± 0.022	2.078AsnIle: 2.078 ± 0.038	1.204AsnLys: 1.204 ± 0.029	3.43AsnLeu: 3.43 ± 0.046	0.85AsnMet: 0.85 ± 0.021	1.028AsnAsn: 1.028 ± 0.028	2.091AsnPro: 2.091 ± 0.032	1.182AsnGln: 1.182 ± 0.027	2.724AsnArg: 2.724 ± 0.041	1.452AsnSer: 1.452 ± 0.034	1.67AsnThr: 1.67 ± 0.033	2.14AsnVal: 2.14 ± 0.037	0.417AsnTrp: 0.417 ± 0.015	0.915AsnTyr: 0.915 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	4.66ProAla: 4.66 ± 0.062	0.516ProCys: 0.516 ± 0.018	3.607ProAsp: 3.607 ± 0.049	3.592ProGlu: 3.592 ± 0.041	2.024ProPhe: 2.024 ± 0.034	4.189ProGly: 4.189 ± 0.051	1.0ProHis: 1.0 ± 0.023	2.289ProIle: 2.289 ± 0.037	1.651ProLys: 1.651 ± 0.032	4.183ProLeu: 4.183 ± 0.047	1.283ProMet: 1.283 ± 0.021	1.15ProAsn: 1.15 ± 0.029	2.284ProPro: 2.284 ± 0.041	1.346ProGln: 1.346 ± 0.024	2.275ProArg: 2.275 ± 0.039	2.453ProSer: 2.453 ± 0.039	2.078ProThr: 2.078 ± 0.029	4.32ProVal: 4.32 ± 0.046	0.592ProTrp: 0.592 ± 0.017	1.229ProTyr: 1.229 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.511GlnAla: 3.511 ± 0.049	0.373GlnCys: 0.373 ± 0.015	1.532GlnAsp: 1.532 ± 0.03	1.713GlnGlu: 1.713 ± 0.035	1.229GlnPhe: 1.229 ± 0.026	2.293GlnGly: 2.293 ± 0.037	0.598GlnHis: 0.598 ± 0.015	2.111GlnIle: 2.111 ± 0.031	1.704GlnLys: 1.704 ± 0.032	3.069GlnLeu: 3.069 ± 0.037	1.056GlnMet: 1.056 ± 0.027	1.005GlnAsn: 1.005 ± 0.022	1.448GlnPro: 1.448 ± 0.027	1.278GlnGln: 1.278 ± 0.028	2.206GlnArg: 2.206 ± 0.034	1.681GlnSer: 1.681 ± 0.033	1.892GlnThr: 1.892 ± 0.031	2.511GlnVal: 2.511 ± 0.04	0.45GlnTrp: 0.45 ± 0.015	0.809GlnTyr: 0.809 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	4.846ArgAla: 4.846 ± 0.058	0.885ArgCys: 0.885 ± 0.021	3.379ArgAsp: 3.379 ± 0.046	3.921ArgGlu: 3.921 ± 0.046	3.161ArgPhe: 3.161 ± 0.048	3.58ArgGly: 3.58 ± 0.045	1.718ArgHis: 1.718 ± 0.034	4.62ArgIle: 4.62 ± 0.058	3.292ArgLys: 3.292 ± 0.049	7.29ArgLeu: 7.29 ± 0.082	2.073ArgMet: 2.073 ± 0.028	1.938ArgAsn: 1.938 ± 0.033	2.852ArgPro: 2.852 ± 0.047	3.022ArgGln: 3.022 ± 0.045	4.801ArgArg: 4.801 ± 0.069	3.463ArgSer: 3.463 ± 0.04	3.182ArgThr: 3.182 ± 0.043	4.458ArgVal: 4.458 ± 0.055	0.9ArgTrp: 0.9 ± 0.024	2.06ArgTyr: 2.06 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.08SerAla: 5.08 ± 0.057	0.661SerCys: 0.661 ± 0.02	3.394SerAsp: 3.394 ± 0.05	2.995SerGlu: 2.995 ± 0.047	2.255SerPhe: 2.255 ± 0.036	5.593SerGly: 5.593 ± 0.065	1.237SerHis: 1.237 ± 0.025	3.405SerIle: 3.405 ± 0.05	1.951SerLys: 1.951 ± 0.033	5.501SerLeu: 5.501 ± 0.054	1.606SerMet: 1.606 ± 0.028	1.504SerAsn: 1.504 ± 0.034	2.82SerPro: 2.82 ± 0.039	1.712SerGln: 1.712 ± 0.032	3.933SerArg: 3.933 ± 0.047	3.051SerSer: 3.051 ± 0.046	2.701SerThr: 2.701 ± 0.042	3.892SerVal: 3.892 ± 0.05	0.658SerTrp: 0.658 ± 0.018	1.461SerTyr: 1.461 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	5.488ThrAla: 5.488 ± 0.062	0.679ThrCys: 0.679 ± 0.02	3.224ThrAsp: 3.224 ± 0.046	2.654ThrGlu: 2.654 ± 0.036	2.115ThrPhe: 2.115 ± 0.032	5.42ThrGly: 5.42 ± 0.062	1.12ThrHis: 1.12 ± 0.024	3.837ThrIle: 3.837 ± 0.049	1.471ThrLys: 1.471 ± 0.032	5.516ThrLeu: 5.516 ± 0.061	1.323ThrMet: 1.323 ± 0.024	1.412ThrAsn: 1.412 ± 0.028	2.876ThrPro: 2.876 ± 0.041	1.351ThrGln: 1.351 ± 0.028	3.378ThrArg: 3.378 ± 0.045	2.495ThrSer: 2.495 ± 0.04	2.837ThrThr: 2.837 ± 0.049	4.71ThrVal: 4.71 ± 0.063	0.573ThrTrp: 0.573 ± 0.018	1.46ThrTyr: 1.46 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.04ValAla: 7.04 ± 0.072	1.026ValCys: 1.026 ± 0.024	4.822ValAsp: 4.822 ± 0.049	4.15ValGlu: 4.15 ± 0.052	3.196ValPhe: 3.196 ± 0.041	5.125ValGly: 5.125 ± 0.054	1.471ValHis: 1.471 ± 0.027	4.258ValIle: 4.258 ± 0.047	3.251ValLys: 3.251 ± 0.048	6.758ValLeu: 6.758 ± 0.069	1.973ValMet: 1.973 ± 0.03	2.653ValAsn: 2.653 ± 0.044	3.165ValPro: 3.165 ± 0.04	2.052ValGln: 2.052 ± 0.034	4.279ValArg: 4.279 ± 0.051	4.54ValSer: 4.54 ± 0.053	4.025ValThr: 4.025 ± 0.057	5.954ValVal: 5.954 ± 0.069	0.766ValTrp: 0.766 ± 0.02	1.949ValTyr: 1.949 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.868TrpAla: 0.868 ± 0.02	0.145TrpCys: 0.145 ± 0.009	0.631TrpAsp: 0.631 ± 0.021	0.658TrpGlu: 0.658 ± 0.018	0.553TrpPhe: 0.553 ± 0.018	0.826TrpGly: 0.826 ± 0.023	0.282TrpHis: 0.282 ± 0.012	0.747TrpIle: 0.747 ± 0.018	0.56TrpLys: 0.56 ± 0.017	1.2TrpLeu: 1.2 ± 0.026	0.36TrpMet: 0.36 ± 0.013	0.412TrpAsn: 0.412 ± 0.015	0.515TrpPro: 0.515 ± 0.017	0.55TrpGln: 0.55 ± 0.017	0.724TrpArg: 0.724 ± 0.02	0.621TrpSer: 0.621 ± 0.021	0.625TrpThr: 0.625 ± 0.021	0.766TrpVal: 0.766 ± 0.019	0.175TrpTrp: 0.175 ± 0.01	0.312TrpTyr: 0.312 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.306TyrAla: 2.306 ± 0.034	0.389TyrCys: 0.389 ± 0.015	1.703TyrAsp: 1.703 ± 0.034	1.416TyrGlu: 1.416 ± 0.024	1.298TyrPhe: 1.298 ± 0.025	2.255TyrGly: 2.255 ± 0.037	0.725TyrHis: 0.725 ± 0.018	1.387TyrIle: 1.387 ± 0.028	0.975TyrLys: 0.975 ± 0.021	2.908TyrLeu: 2.908 ± 0.043	0.59TyrMet: 0.59 ± 0.017	0.872TyrAsn: 0.872 ± 0.028	1.368TyrPro: 1.368 ± 0.027	1.021TyrGln: 1.021 ± 0.025	2.308TyrArg: 2.308 ± 0.032	1.432TyrSer: 1.432 ± 0.032	1.488TyrThr: 1.488 ± 0.027	1.61TyrVal: 1.61 ± 0.029	0.394TyrTrp: 0.394 ± 0.017	0.923TyrTyr: 0.923 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6430 proteins (2052088 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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