Amino acid dipepetide frequency for Bacteroides sp. CAG:927

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.612AlaAla: 7.612 ± 0.13
1.042AlaCys: 1.042 ± 0.04
4.974AlaAsp: 4.974 ± 0.081
4.943AlaGlu: 4.943 ± 0.098
3.013AlaPhe: 3.013 ± 0.069
5.57AlaGly: 5.57 ± 0.112
1.53AlaHis: 1.53 ± 0.045
5.533AlaIle: 5.533 ± 0.096
4.383AlaLys: 4.383 ± 0.086
7.809AlaLeu: 7.809 ± 0.129
2.644AlaMet: 2.644 ± 0.073
3.412AlaAsn: 3.412 ± 0.064
3.169AlaPro: 3.169 ± 0.075
2.971AlaGln: 2.971 ± 0.068
3.971AlaArg: 3.971 ± 0.075
5.162AlaSer: 5.162 ± 0.086
4.921AlaThr: 4.921 ± 0.099
5.999AlaVal: 5.999 ± 0.104
0.902AlaTrp: 0.902 ± 0.035
2.961AlaTyr: 2.961 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
1.072CysAla: 1.072 ± 0.038
0.208CysCys: 0.208 ± 0.018
0.754CysAsp: 0.754 ± 0.031
0.693CysGlu: 0.693 ± 0.033
0.524CysPhe: 0.524 ± 0.027
1.247CysGly: 1.247 ± 0.043
0.335CysHis: 0.335 ± 0.024
0.794CysIle: 0.794 ± 0.03
0.576CysLys: 0.576 ± 0.027
1.008CysLeu: 1.008 ± 0.037
0.358CysMet: 0.358 ± 0.021
0.603CysAsn: 0.603 ± 0.031
0.585CysPro: 0.585 ± 0.03
0.34CysGln: 0.34 ± 0.02
0.772CysArg: 0.772 ± 0.03
0.954CysSer: 0.954 ± 0.04
0.711CysThr: 0.711 ± 0.033
0.89CysVal: 0.89 ± 0.032
0.126CysTrp: 0.126 ± 0.014
0.52CysTyr: 0.52 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
4.785AspAla: 4.785 ± 0.082
0.699AspCys: 0.699 ± 0.031
2.883AspAsp: 2.883 ± 0.069
3.633AspGlu: 3.633 ± 0.085
2.805AspPhe: 2.805 ± 0.067
4.035AspGly: 4.035 ± 0.082
0.99AspHis: 0.99 ± 0.038
4.315AspIle: 4.315 ± 0.081
3.286AspLys: 3.286 ± 0.065
4.436AspLeu: 4.436 ± 0.072
1.881AspMet: 1.881 ± 0.048
2.853AspAsn: 2.853 ± 0.076
2.003AspPro: 2.003 ± 0.057
1.142AspGln: 1.142 ± 0.04
2.47AspArg: 2.47 ± 0.056
3.761AspSer: 3.761 ± 0.079
3.243AspThr: 3.243 ± 0.071
3.755AspVal: 3.755 ± 0.078
0.676AspTrp: 0.676 ± 0.031
2.723AspTyr: 2.723 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
4.739GluAla: 4.739 ± 0.09
0.724GluCys: 0.724 ± 0.031
2.734GluAsp: 2.734 ± 0.067
3.408GluGlu: 3.408 ± 0.069
2.49GluPhe: 2.49 ± 0.054
3.447GluGly: 3.447 ± 0.078
1.393GluHis: 1.393 ± 0.048
4.38GluIle: 4.38 ± 0.082
3.581GluLys: 3.581 ± 0.082
5.684GluLeu: 5.684 ± 0.092
1.784GluMet: 1.784 ± 0.044
2.913GluAsn: 2.913 ± 0.064
2.045GluPro: 2.045 ± 0.057
2.424GluGln: 2.424 ± 0.061
3.234GluArg: 3.234 ± 0.067
3.158GluSer: 3.158 ± 0.062
2.673GluThr: 2.673 ± 0.061
3.842GluVal: 3.842 ± 0.082
0.8GluTrp: 0.8 ± 0.034
2.464GluTyr: 2.464 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.389PheAla: 3.389 ± 0.073
0.592PheCys: 0.592 ± 0.027
2.523PheAsp: 2.523 ± 0.069
2.037PheGlu: 2.037 ± 0.051
1.806PhePhe: 1.806 ± 0.056
3.23PheGly: 3.23 ± 0.078
0.887PheHis: 0.887 ± 0.031
2.752PheIle: 2.752 ± 0.079
1.955PheLys: 1.955 ± 0.05
3.324PheLeu: 3.324 ± 0.082
1.273PheMet: 1.273 ± 0.041
2.295PheAsn: 2.295 ± 0.051
1.604PhePro: 1.604 ± 0.04
0.986PheGln: 0.986 ± 0.034
1.93PheArg: 1.93 ± 0.05
3.081PheSer: 3.081 ± 0.067
2.74PheThr: 2.74 ± 0.059
2.878PheVal: 2.878 ± 0.071
0.509PheTrp: 0.509 ± 0.031
1.688PheTyr: 1.688 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
5.535GlyAla: 5.535 ± 0.107
1.09GlyCys: 1.09 ± 0.043
3.594GlyAsp: 3.594 ± 0.071
3.974GlyGlu: 3.974 ± 0.081
3.038GlyPhe: 3.038 ± 0.064
4.703GlyGly: 4.703 ± 0.096
1.434GlyHis: 1.434 ± 0.048
5.16GlyIle: 5.16 ± 0.096
4.473GlyLys: 4.473 ± 0.086
5.505GlyLeu: 5.505 ± 0.089
2.23GlyMet: 2.23 ± 0.057
3.522GlyAsn: 3.522 ± 0.076
1.541GlyPro: 1.541 ± 0.044
1.866GlyGln: 1.866 ± 0.048
3.206GlyArg: 3.206 ± 0.067
4.367GlySer: 4.367 ± 0.095
4.371GlyThr: 4.371 ± 0.086
5.541GlyVal: 5.541 ± 0.101
0.96GlyTrp: 0.96 ± 0.043
3.227GlyTyr: 3.227 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.475HisAla: 1.475 ± 0.047
0.309HisCys: 0.309 ± 0.019
1.197HisAsp: 1.197 ± 0.049
1.131HisGlu: 1.131 ± 0.037
0.932HisPhe: 0.932 ± 0.034
1.557HisGly: 1.557 ± 0.044
0.52HisHis: 0.52 ± 0.03
1.632HisIle: 1.632 ± 0.046
1.144HisLys: 1.144 ± 0.044
1.841HisLeu: 1.841 ± 0.048
0.505HisMet: 0.505 ± 0.026
1.162HisAsn: 1.162 ± 0.04
1.2HisPro: 1.2 ± 0.043
0.571HisGln: 0.571 ± 0.026
1.146HisArg: 1.146 ± 0.041
1.329HisSer: 1.329 ± 0.048
1.279HisThr: 1.279 ± 0.041
1.229HisVal: 1.229 ± 0.043
0.245HisTrp: 0.245 ± 0.017
0.858HisTyr: 0.858 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.048IleAla: 6.048 ± 0.097
0.969IleCys: 0.969 ± 0.038
4.567IleAsp: 4.567 ± 0.076
3.996IleGlu: 3.996 ± 0.077
2.643IlePhe: 2.643 ± 0.073
4.777IleGly: 4.777 ± 0.083
1.318IleHis: 1.318 ± 0.041
4.759IleIle: 4.759 ± 0.095
3.634IleLys: 3.634 ± 0.066
5.4IleLeu: 5.4 ± 0.11
1.794IleMet: 1.794 ± 0.049
3.518IleAsn: 3.518 ± 0.069
3.101IlePro: 3.101 ± 0.066
1.636IleGln: 1.636 ± 0.051
2.993IleArg: 2.993 ± 0.068
4.824IleSer: 4.824 ± 0.091
4.338IleThr: 4.338 ± 0.074
4.807IleVal: 4.807 ± 0.088
0.619IleTrp: 0.619 ± 0.028
2.451IleTyr: 2.451 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
4.324LysAla: 4.324 ± 0.084
0.586LysCys: 0.586 ± 0.027
2.852LysAsp: 2.852 ± 0.069
3.771LysGlu: 3.771 ± 0.08
2.185LysPhe: 2.185 ± 0.054
3.62LysGly: 3.62 ± 0.068
1.146LysHis: 1.146 ± 0.036
3.77LysIle: 3.77 ± 0.082
3.364LysLys: 3.364 ± 0.085
4.691LysLeu: 4.691 ± 0.087
1.908LysMet: 1.908 ± 0.055
2.613LysAsn: 2.613 ± 0.063
2.186LysPro: 2.186 ± 0.062
1.916LysGln: 1.916 ± 0.055
2.849LysArg: 2.849 ± 0.071
3.299LysSer: 3.299 ± 0.072
2.645LysThr: 2.645 ± 0.064
3.821LysVal: 3.821 ± 0.074
0.737LysTrp: 0.737 ± 0.034
2.412LysTyr: 2.412 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
7.158LeuAla: 7.158 ± 0.118
1.395LeuCys: 1.395 ± 0.051
4.747LeuAsp: 4.747 ± 0.083
4.415LeuGlu: 4.415 ± 0.085
3.574LeuPhe: 3.574 ± 0.072
6.019LeuGly: 6.019 ± 0.091
1.991LeuHis: 1.991 ± 0.05
5.422LeuIle: 5.422 ± 0.087
4.983LeuLys: 4.983 ± 0.083
8.268LeuLeu: 8.268 ± 0.137
2.684LeuMet: 2.684 ± 0.068
4.367LeuAsn: 4.367 ± 0.087
4.446LeuPro: 4.446 ± 0.082
2.926LeuGln: 2.926 ± 0.062
4.82LeuArg: 4.82 ± 0.089
6.361LeuSer: 6.361 ± 0.097
5.734LeuThr: 5.734 ± 0.093
5.267LeuVal: 5.267 ± 0.084
1.087LeuTrp: 1.087 ± 0.045
3.319LeuTyr: 3.319 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.787MetAla: 2.787 ± 0.068
0.333MetCys: 0.333 ± 0.018
1.465MetAsp: 1.465 ± 0.046
1.689MetGlu: 1.689 ± 0.05
1.085MetPhe: 1.085 ± 0.036
1.932MetGly: 1.932 ± 0.054
0.68MetHis: 0.68 ± 0.032
1.742MetIle: 1.742 ± 0.05
1.847MetLys: 1.847 ± 0.048
3.11MetLeu: 3.11 ± 0.07
0.904MetMet: 0.904 ± 0.039
1.388MetAsn: 1.388 ± 0.042
1.546MetPro: 1.546 ± 0.048
1.096MetGln: 1.096 ± 0.042
1.655MetArg: 1.655 ± 0.048
1.945MetSer: 1.945 ± 0.056
1.676MetThr: 1.676 ± 0.047
1.744MetVal: 1.744 ± 0.049
0.335MetTrp: 0.335 ± 0.02
0.823MetTyr: 0.823 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.995AsnAla: 3.995 ± 0.078
0.558AsnCys: 0.558 ± 0.029
2.601AsnAsp: 2.601 ± 0.067
2.6AsnGlu: 2.6 ± 0.053
1.933AsnPhe: 1.933 ± 0.05
3.864AsnGly: 3.864 ± 0.099
1.022AsnHis: 1.022 ± 0.038
3.652AsnIle: 3.652 ± 0.077
2.508AsnLys: 2.508 ± 0.06
4.008AsnLeu: 4.008 ± 0.077
1.331AsnMet: 1.331 ± 0.037
2.553AsnAsn: 2.553 ± 0.07
2.765AsnPro: 2.765 ± 0.063
1.271AsnGln: 1.271 ± 0.045
2.453AsnArg: 2.453 ± 0.07
2.881AsnSer: 2.881 ± 0.069
2.547AsnThr: 2.547 ± 0.068
3.424AsnVal: 3.424 ± 0.068
0.583AsnTrp: 0.583 ± 0.031
1.958AsnTyr: 1.958 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
3.582ProAla: 3.582 ± 0.077
0.415ProCys: 0.415 ± 0.023
3.207ProAsp: 3.207 ± 0.068
3.566ProGlu: 3.566 ± 0.073
1.617ProPhe: 1.617 ± 0.041
2.914ProGly: 2.914 ± 0.077
0.915ProHis: 0.915 ± 0.037
2.305ProIle: 2.305 ± 0.057
2.062ProLys: 2.062 ± 0.056
3.445ProLeu: 3.445 ± 0.075
1.149ProMet: 1.149 ± 0.037
1.698ProAsn: 1.698 ± 0.048
0.986ProPro: 0.986 ± 0.043
1.684ProGln: 1.684 ± 0.045
1.762ProArg: 1.762 ± 0.051
2.59ProSer: 2.59 ± 0.06
2.294ProThr: 2.294 ± 0.052
3.518ProVal: 3.518 ± 0.072
0.538ProTrp: 0.538 ± 0.026
1.679ProTyr: 1.679 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
2.438GlnAla: 2.438 ± 0.062
0.406GlnCys: 0.406 ± 0.022
1.275GlnAsp: 1.275 ± 0.043
1.588GlnGlu: 1.588 ± 0.047
1.279GlnPhe: 1.279 ± 0.036
2.065GlnGly: 2.065 ± 0.049
0.675GlnHis: 0.675 ± 0.026
2.152GlnIle: 2.152 ± 0.057
1.882GlnLys: 1.882 ± 0.053
3.277GlnLeu: 3.277 ± 0.064
1.061GlnMet: 1.061 ± 0.041
1.449GlnAsn: 1.449 ± 0.046
1.362GlnPro: 1.362 ± 0.042
1.504GlnGln: 1.504 ± 0.052
1.742GlnArg: 1.742 ± 0.049
2.014GlnSer: 2.014 ± 0.049
1.641GlnThr: 1.641 ± 0.047
1.84GlnVal: 1.84 ± 0.046
0.505GlnTrp: 0.505 ± 0.025
1.317GlnTyr: 1.317 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
3.451ArgAla: 3.451 ± 0.075
0.579ArgCys: 0.579 ± 0.03
2.504ArgAsp: 2.504 ± 0.059
2.988ArgGlu: 2.988 ± 0.073
2.248ArgPhe: 2.248 ± 0.052
2.909ArgGly: 2.909 ± 0.066
1.362ArgHis: 1.362 ± 0.049
3.634ArgIle: 3.634 ± 0.07
2.994ArgLys: 2.994 ± 0.079
4.602ArgLeu: 4.602 ± 0.084
1.626ArgMet: 1.626 ± 0.048
2.608ArgAsn: 2.608 ± 0.062
1.932ArgPro: 1.932 ± 0.057
1.854ArgGln: 1.854 ± 0.057
2.929ArgArg: 2.929 ± 0.061
2.81ArgSer: 2.81 ± 0.067
2.753ArgThr: 2.753 ± 0.062
3.116ArgVal: 3.116 ± 0.068
0.625ArgTrp: 0.625 ± 0.037
2.329ArgTyr: 2.329 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
5.169SerAla: 5.169 ± 0.087
0.806SerCys: 0.806 ± 0.04
3.725SerAsp: 3.725 ± 0.08
3.487SerGlu: 3.487 ± 0.069
2.84SerPhe: 2.84 ± 0.065
4.899SerGly: 4.899 ± 0.082
1.41SerHis: 1.41 ± 0.043
4.318SerIle: 4.318 ± 0.085
3.077SerLys: 3.077 ± 0.076
6.15SerLeu: 6.15 ± 0.092
1.834SerMet: 1.834 ± 0.049
2.762SerAsn: 2.762 ± 0.068
2.8SerPro: 2.8 ± 0.062
2.134SerGln: 2.134 ± 0.064
3.346SerArg: 3.346 ± 0.077
4.163SerSer: 4.163 ± 0.09
3.622SerThr: 3.622 ± 0.072
4.805SerVal: 4.805 ± 0.093
0.819SerTrp: 0.819 ± 0.035
2.499SerTyr: 2.499 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
5.021ThrAla: 5.021 ± 0.078
0.555ThrCys: 0.555 ± 0.028
3.637ThrAsp: 3.637 ± 0.085
3.175ThrGlu: 3.175 ± 0.065
2.425ThrPhe: 2.425 ± 0.061
4.328ThrGly: 4.328 ± 0.081
1.227ThrHis: 1.227 ± 0.039
3.932ThrIle: 3.932 ± 0.078
2.436ThrLys: 2.436 ± 0.057
5.644ThrLeu: 5.644 ± 0.097
1.384ThrMet: 1.384 ± 0.047
2.303ThrAsn: 2.303 ± 0.063
3.477ThrPro: 3.477 ± 0.062
1.719ThrGln: 1.719 ± 0.045
2.43ThrArg: 2.43 ± 0.055
3.614ThrSer: 3.614 ± 0.069
3.359ThrThr: 3.359 ± 0.081
4.7ThrVal: 4.7 ± 0.092
0.594ThrTrp: 0.594 ± 0.032
2.121ThrTyr: 2.121 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
6.057ValAla: 6.057 ± 0.097
1.003ValCys: 1.003 ± 0.039
4.146ValAsp: 4.146 ± 0.076
4.098ValGlu: 4.098 ± 0.08
2.695ValPhe: 2.695 ± 0.062
4.423ValGly: 4.423 ± 0.083
1.197ValHis: 1.197 ± 0.037
4.665ValIle: 4.665 ± 0.095
3.974ValLys: 3.974 ± 0.082
6.024ValLeu: 6.024 ± 0.112
1.968ValMet: 1.968 ± 0.055
3.5ValAsn: 3.5 ± 0.072
3.146ValPro: 3.146 ± 0.07
1.801ValGln: 1.801 ± 0.048
3.321ValArg: 3.321 ± 0.069
4.85ValSer: 4.85 ± 0.076
4.381ValThr: 4.381 ± 0.086
5.064ValVal: 5.064 ± 0.094
0.836ValTrp: 0.836 ± 0.034
2.459ValTyr: 2.459 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
0.823TrpAla: 0.823 ± 0.034
0.227TrpCys: 0.227 ± 0.02
0.651TrpAsp: 0.651 ± 0.035
0.598TrpGlu: 0.598 ± 0.029
0.501TrpPhe: 0.501 ± 0.027
0.896TrpGly: 0.896 ± 0.034
0.384TrpHis: 0.384 ± 0.022
0.754TrpIle: 0.754 ± 0.033
0.581TrpLys: 0.581 ± 0.028
1.273TrpLeu: 1.273 ± 0.044
0.419TrpMet: 0.419 ± 0.023
0.634TrpAsn: 0.634 ± 0.032
0.319TrpPro: 0.319 ± 0.022
0.553TrpGln: 0.553 ± 0.028
0.725TrpArg: 0.725 ± 0.033
0.756TrpSer: 0.756 ± 0.034
0.675TrpThr: 0.675 ± 0.036
0.747TrpVal: 0.747 ± 0.031
0.224TrpTrp: 0.224 ± 0.02
0.433TrpTyr: 0.433 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.062TyrAla: 3.062 ± 0.068
0.573TyrCys: 0.573 ± 0.029
2.338TyrAsp: 2.338 ± 0.059
2.124TyrGlu: 2.124 ± 0.052
1.847TyrPhe: 1.847 ± 0.049
2.902TyrGly: 2.902 ± 0.058
0.845TyrHis: 0.845 ± 0.033
2.52TyrIle: 2.52 ± 0.066
1.954TyrLys: 1.954 ± 0.054
3.487TyrLeu: 3.487 ± 0.081
1.042TyrMet: 1.042 ± 0.041
2.351TyrAsn: 2.351 ± 0.063
1.714TyrPro: 1.714 ± 0.044
1.081TyrGln: 1.081 ± 0.035
2.097TyrArg: 2.097 ± 0.058
2.747TyrSer: 2.747 ± 0.062
2.478TyrThr: 2.478 ± 0.061
2.622TyrVal: 2.622 ± 0.051
0.455TyrTrp: 0.455 ± 0.025
1.868TyrTyr: 1.868 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2231 proteins (770787 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski