Amino acid dipepetide frequency for Kushneria phosphatilytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.014AlaAla: 11.014 ± 0.145	1.1AlaCys: 1.1 ± 0.031	5.505AlaAsp: 5.505 ± 0.083	6.498AlaGlu: 6.498 ± 0.093	3.527AlaPhe: 3.527 ± 0.062	8.956AlaGly: 8.956 ± 0.118	2.584AlaHis: 2.584 ± 0.06	5.606AlaIle: 5.606 ± 0.101	1.806AlaLys: 1.806 ± 0.05	13.836AlaLeu: 13.836 ± 0.143	3.275AlaMet: 3.275 ± 0.058	2.443AlaAsn: 2.443 ± 0.052	4.493AlaPro: 4.493 ± 0.081	3.768AlaGln: 3.768 ± 0.067	8.684AlaArg: 8.684 ± 0.107	6.093AlaSer: 6.093 ± 0.088	5.303AlaThr: 5.303 ± 0.078	6.72AlaVal: 6.72 ± 0.105	1.771AlaTrp: 1.771 ± 0.049	2.051AlaTyr: 2.051 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.909CysAla: 0.909 ± 0.037	0.173CysCys: 0.173 ± 0.013	0.614CysAsp: 0.614 ± 0.024	0.576CysGlu: 0.576 ± 0.028	0.374CysPhe: 0.374 ± 0.021	0.941CysGly: 0.941 ± 0.035	0.375CysHis: 0.375 ± 0.021	0.446CysIle: 0.446 ± 0.021	0.173CysLys: 0.173 ± 0.012	1.042CysLeu: 1.042 ± 0.032	0.202CysMet: 0.202 ± 0.015	0.268CysAsn: 0.268 ± 0.017	0.5CysPro: 0.5 ± 0.028	0.478CysGln: 0.478 ± 0.024	0.816CysArg: 0.816 ± 0.032	0.529CysSer: 0.529 ± 0.023	0.448CysThr: 0.448 ± 0.023	0.607CysVal: 0.607 ± 0.026	0.184CysTrp: 0.184 ± 0.013	0.272CysTyr: 0.272 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.645AspAla: 5.645 ± 0.084	0.501AspCys: 0.501 ± 0.024	3.678AspAsp: 3.678 ± 0.069	4.156AspGlu: 4.156 ± 0.076	2.109AspPhe: 2.109 ± 0.051	4.32AspGly: 4.32 ± 0.076	1.743AspHis: 1.743 ± 0.042	3.181AspIle: 3.181 ± 0.064	1.253AspLys: 1.253 ± 0.04	4.943AspLeu: 4.943 ± 0.073	1.37AspMet: 1.37 ± 0.043	1.839AspAsn: 1.839 ± 0.047	2.965AspPro: 2.965 ± 0.062	2.545AspGln: 2.545 ± 0.053	4.496AspArg: 4.496 ± 0.063	3.113AspSer: 3.113 ± 0.069	3.178AspThr: 3.178 ± 0.063	3.567AspVal: 3.567 ± 0.059	1.034AspTrp: 1.034 ± 0.035	1.673AspTyr: 1.673 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.277GluAla: 7.277 ± 0.106	0.592GluCys: 0.592 ± 0.027	2.85GluAsp: 2.85 ± 0.058	3.612GluGlu: 3.612 ± 0.084	1.652GluPhe: 1.652 ± 0.044	4.512GluGly: 4.512 ± 0.074	2.078GluHis: 2.078 ± 0.045	2.952GluIle: 2.952 ± 0.064	1.698GluLys: 1.698 ± 0.051	6.622GluLeu: 6.622 ± 0.094	1.513GluMet: 1.513 ± 0.043	1.48GluAsn: 1.48 ± 0.042	2.53GluPro: 2.53 ± 0.05	4.074GluGln: 4.074 ± 0.074	6.227GluArg: 6.227 ± 0.087	3.41GluSer: 3.41 ± 0.059	3.337GluThr: 3.337 ± 0.062	3.983GluVal: 3.983 ± 0.065	0.92GluTrp: 0.92 ± 0.031	1.309GluTyr: 1.309 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.409PheAla: 3.409 ± 0.063	0.431PheCys: 0.431 ± 0.022	2.632PheAsp: 2.632 ± 0.051	2.418PheGlu: 2.418 ± 0.05	1.293PhePhe: 1.293 ± 0.043	3.163PheGly: 3.163 ± 0.068	0.869PheHis: 0.869 ± 0.03	1.789PheIle: 1.789 ± 0.048	0.686PheLys: 0.686 ± 0.031	2.838PheLeu: 2.838 ± 0.063	0.942PheMet: 0.942 ± 0.031	1.271PheAsn: 1.271 ± 0.033	1.367PhePro: 1.367 ± 0.037	1.03PheGln: 1.03 ± 0.033	2.146PheArg: 2.146 ± 0.047	2.272PheSer: 2.272 ± 0.056	1.902PheThr: 1.902 ± 0.047	2.24PheVal: 2.24 ± 0.058	0.524PheTrp: 0.524 ± 0.024	0.957PheTyr: 0.957 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	7.228GlyAla: 7.228 ± 0.098	0.981GlyCys: 0.981 ± 0.035	4.321GlyAsp: 4.321 ± 0.074	5.397GlyGlu: 5.397 ± 0.08	3.165GlyPhe: 3.165 ± 0.058	6.365GlyGly: 6.365 ± 0.1	2.374GlyHis: 2.374 ± 0.058	4.61GlyIle: 4.61 ± 0.073	2.224GlyLys: 2.224 ± 0.05	8.627GlyLeu: 8.627 ± 0.126	2.468GlyMet: 2.468 ± 0.057	2.296GlyAsn: 2.296 ± 0.052	2.736GlyPro: 2.736 ± 0.051	3.345GlyGln: 3.345 ± 0.058	5.926GlyArg: 5.926 ± 0.083	4.645GlySer: 4.645 ± 0.072	3.844GlyThr: 3.844 ± 0.066	6.294GlyVal: 6.294 ± 0.085	1.546GlyTrp: 1.546 ± 0.039	2.489GlyTyr: 2.489 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.774HisAla: 2.774 ± 0.058	0.36HisCys: 0.36 ± 0.02	1.85HisAsp: 1.85 ± 0.045	1.661HisGlu: 1.661 ± 0.043	1.18HisPhe: 1.18 ± 0.039	2.376HisGly: 2.376 ± 0.061	1.055HisHis: 1.055 ± 0.031	1.136HisIle: 1.136 ± 0.035	0.461HisLys: 0.461 ± 0.022	2.725HisLeu: 2.725 ± 0.058	0.578HisMet: 0.578 ± 0.024	0.686HisAsn: 0.686 ± 0.025	1.655HisPro: 1.655 ± 0.044	1.3HisGln: 1.3 ± 0.037	2.141HisArg: 2.141 ± 0.047	1.258HisSer: 1.258 ± 0.033	1.18HisThr: 1.18 ± 0.039	1.81HisVal: 1.81 ± 0.047	0.544HisTrp: 0.544 ± 0.026	0.94HisTyr: 0.94 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.871IleAla: 5.871 ± 0.085	0.505IleCys: 0.505 ± 0.022	3.999IleAsp: 3.999 ± 0.069	3.981IleGlu: 3.981 ± 0.066	1.556IlePhe: 1.556 ± 0.046	4.901IleGly: 4.901 ± 0.084	1.21IleHis: 1.21 ± 0.033	2.359IleIle: 2.359 ± 0.057	1.067IleLys: 1.067 ± 0.04	4.042IleLeu: 4.042 ± 0.067	1.172IleMet: 1.172 ± 0.033	1.693IleAsn: 1.693 ± 0.045	2.309IlePro: 2.309 ± 0.053	1.376IleGln: 1.376 ± 0.039	3.569IleArg: 3.569 ± 0.06	2.969IleSer: 2.969 ± 0.061	2.89IleThr: 2.89 ± 0.064	3.558IleVal: 3.558 ± 0.066	0.52IleTrp: 0.52 ± 0.022	1.088IleTyr: 1.088 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	2.495LysAla: 2.495 ± 0.054	0.147LysCys: 0.147 ± 0.014	0.965LysAsp: 0.965 ± 0.033	1.133LysGlu: 1.133 ± 0.04	0.512LysPhe: 0.512 ± 0.025	1.818LysGly: 1.818 ± 0.048	0.52LysHis: 0.52 ± 0.023	0.942LysIle: 0.942 ± 0.032	0.819LysLys: 0.819 ± 0.04	2.349LysLeu: 2.349 ± 0.059	0.545LysMet: 0.545 ± 0.025	0.62LysAsn: 0.62 ± 0.029	1.21LysPro: 1.21 ± 0.038	1.143LysGln: 1.143 ± 0.038	2.204LysArg: 2.204 ± 0.047	1.4LysSer: 1.4 ± 0.045	1.251LysThr: 1.251 ± 0.035	1.526LysVal: 1.526 ± 0.048	0.301LysTrp: 0.301 ± 0.02	0.487LysTyr: 0.487 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.133LeuAla: 13.133 ± 0.127	1.173LeuCys: 1.173 ± 0.038	6.842LeuAsp: 6.842 ± 0.09	7.15LeuGlu: 7.15 ± 0.104	3.727LeuPhe: 3.727 ± 0.085	8.986LeuGly: 8.986 ± 0.111	2.602LeuHis: 2.602 ± 0.055	6.119LeuIle: 6.119 ± 0.094	3.085LeuLys: 3.085 ± 0.064	12.16LeuLeu: 12.16 ± 0.187	3.037LeuMet: 3.037 ± 0.069	3.032LeuAsn: 3.032 ± 0.06	6.002LeuPro: 6.002 ± 0.085	3.39LeuGln: 3.39 ± 0.068	6.924LeuArg: 6.924 ± 0.087	7.075LeuSer: 7.075 ± 0.097	6.231LeuThr: 6.231 ± 0.088	7.08LeuVal: 7.08 ± 0.101	1.501LeuTrp: 1.501 ± 0.044	2.41LeuTyr: 2.41 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.455MetAla: 3.455 ± 0.059	0.177MetCys: 0.177 ± 0.015	1.082MetAsp: 1.082 ± 0.035	1.143MetGlu: 1.143 ± 0.033	0.693MetPhe: 0.693 ± 0.028	1.904MetGly: 1.904 ± 0.052	0.576MetHis: 0.576 ± 0.024	1.371MetIle: 1.371 ± 0.041	0.849MetLys: 0.849 ± 0.031	2.964MetLeu: 2.964 ± 0.057	0.721MetMet: 0.721 ± 0.028	0.814MetAsn: 0.814 ± 0.027	1.508MetPro: 1.508 ± 0.042	1.045MetGln: 1.045 ± 0.034	1.733MetArg: 1.733 ± 0.04	1.878MetSer: 1.878 ± 0.042	2.063MetThr: 2.063 ± 0.044	1.811MetVal: 1.811 ± 0.043	0.182MetTrp: 0.182 ± 0.014	0.364MetTyr: 0.364 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.073AsnAla: 3.073 ± 0.069	0.247AsnCys: 0.247 ± 0.016	1.663AsnAsp: 1.663 ± 0.041	1.635AsnGlu: 1.635 ± 0.038	0.935AsnPhe: 0.935 ± 0.031	2.353AsnGly: 2.353 ± 0.052	0.682AsnHis: 0.682 ± 0.027	1.361AsnIle: 1.361 ± 0.043	0.522AsnLys: 0.522 ± 0.026	2.577AsnLeu: 2.577 ± 0.054	0.624AsnMet: 0.624 ± 0.027	0.852AsnAsn: 0.852 ± 0.029	1.614AsnPro: 1.614 ± 0.041	0.995AsnGln: 0.995 ± 0.035	2.134AsnArg: 2.134 ± 0.047	1.339AsnSer: 1.339 ± 0.041	1.482AsnThr: 1.482 ± 0.044	1.79AsnVal: 1.79 ± 0.047	0.447AsnTrp: 0.447 ± 0.02	0.719AsnTyr: 0.719 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.007ProAla: 5.007 ± 0.072	0.423ProCys: 0.423 ± 0.023	3.377ProAsp: 3.377 ± 0.051	4.026ProGlu: 4.026 ± 0.069	1.726ProPhe: 1.726 ± 0.044	4.434ProGly: 4.434 ± 0.074	1.192ProHis: 1.192 ± 0.037	2.211ProIle: 2.211 ± 0.051	0.939ProLys: 0.939 ± 0.034	5.265ProLeu: 5.265 ± 0.076	1.228ProMet: 1.228 ± 0.035	1.169ProAsn: 1.169 ± 0.039	2.147ProPro: 2.147 ± 0.056	1.744ProGln: 1.744 ± 0.046	3.042ProArg: 3.042 ± 0.064	2.469ProSer: 2.469 ± 0.057	2.255ProThr: 2.255 ± 0.049	3.641ProVal: 3.641 ± 0.06	0.909ProTrp: 0.909 ± 0.037	1.017ProTyr: 1.017 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.027GlnAla: 5.027 ± 0.076	0.39GlnCys: 0.39 ± 0.022	1.496GlnAsp: 1.496 ± 0.049	1.856GlnGlu: 1.856 ± 0.055	1.112GlnPhe: 1.112 ± 0.036	3.198GlnGly: 3.198 ± 0.057	1.231GlnHis: 1.231 ± 0.036	1.568GlnIle: 1.568 ± 0.038	0.995GlnLys: 0.995 ± 0.036	5.163GlnLeu: 5.163 ± 0.079	0.962GlnMet: 0.962 ± 0.031	0.903GlnAsn: 0.903 ± 0.032	2.246GlnPro: 2.246 ± 0.053	3.03GlnGln: 3.03 ± 0.071	3.916GlnArg: 3.916 ± 0.079	2.3GlnSer: 2.3 ± 0.049	1.98GlnThr: 1.98 ± 0.047	2.664GlnVal: 2.664 ± 0.06	0.849GlnTrp: 0.849 ± 0.027	0.915GlnTyr: 0.915 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	7.078ArgAla: 7.078 ± 0.101	0.687ArgCys: 0.687 ± 0.029	4.398ArgAsp: 4.398 ± 0.068	5.395ArgGlu: 5.395 ± 0.078	3.14ArgPhe: 3.14 ± 0.065	4.732ArgGly: 4.732 ± 0.074	2.796ArgHis: 2.796 ± 0.058	4.087ArgIle: 4.087 ± 0.068	1.607ArgLys: 1.607 ± 0.042	9.857ArgLeu: 9.857 ± 0.13	1.968ArgMet: 1.968 ± 0.049	1.966ArgAsn: 1.966 ± 0.047	3.265ArgPro: 3.265 ± 0.057	4.077ArgGln: 4.077 ± 0.066	6.417ArgArg: 6.417 ± 0.087	3.851ArgSer: 3.851 ± 0.064	3.259ArgThr: 3.259 ± 0.057	5.189ArgVal: 5.189 ± 0.079	1.255ArgTrp: 1.255 ± 0.045	2.322ArgTyr: 2.322 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.804SerAla: 5.804 ± 0.091	0.456SerCys: 0.456 ± 0.023	3.561SerAsp: 3.561 ± 0.062	3.51SerGlu: 3.51 ± 0.061	1.956SerPhe: 1.956 ± 0.058	5.374SerGly: 5.374 ± 0.084	1.519SerHis: 1.519 ± 0.037	2.664SerIle: 2.664 ± 0.059	1.144SerLys: 1.144 ± 0.04	6.473SerLeu: 6.473 ± 0.091	1.667SerMet: 1.667 ± 0.042	1.548SerAsn: 1.548 ± 0.046	2.81SerPro: 2.81 ± 0.051	2.254SerGln: 2.254 ± 0.055	4.461SerArg: 4.461 ± 0.065	3.603SerSer: 3.603 ± 0.085	2.823SerThr: 2.823 ± 0.061	3.909SerVal: 3.909 ± 0.064	0.902SerTrp: 0.902 ± 0.034	1.252SerTyr: 1.252 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.326ThrAla: 5.326 ± 0.083	0.423ThrCys: 0.423 ± 0.022	2.726ThrAsp: 2.726 ± 0.06	2.506ThrGlu: 2.506 ± 0.057	1.796ThrPhe: 1.796 ± 0.038	4.816ThrGly: 4.816 ± 0.079	1.46ThrHis: 1.46 ± 0.045	2.377ThrIle: 2.377 ± 0.051	0.751ThrLys: 0.751 ± 0.031	7.54ThrLeu: 7.54 ± 0.115	1.164ThrMet: 1.164 ± 0.034	1.163ThrAsn: 1.163 ± 0.039	3.661ThrPro: 3.661 ± 0.067	1.672ThrGln: 1.672 ± 0.047	4.029ThrArg: 4.029 ± 0.063	2.91ThrSer: 2.91 ± 0.058	2.925ThrThr: 2.925 ± 0.064	3.602ThrVal: 3.602 ± 0.052	0.65ThrTrp: 0.65 ± 0.026	0.924ThrTyr: 0.924 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	7.22ValAla: 7.22 ± 0.103	0.659ValCys: 0.659 ± 0.026	3.97ValAsp: 3.97 ± 0.064	4.275ValGlu: 4.275 ± 0.077	2.282ValPhe: 2.282 ± 0.051	4.78ValGly: 4.78 ± 0.076	1.568ValHis: 1.568 ± 0.04	4.091ValIle: 4.091 ± 0.071	1.467ValLys: 1.467 ± 0.043	7.339ValLeu: 7.339 ± 0.104	2.003ValMet: 2.003 ± 0.046	1.957ValAsn: 1.957 ± 0.046	3.113ValPro: 3.113 ± 0.052	2.047ValGln: 2.047 ± 0.049	4.711ValArg: 4.711 ± 0.079	4.294ValSer: 4.294 ± 0.069	4.208ValThr: 4.208 ± 0.074	5.118ValVal: 5.118 ± 0.086	0.848ValTrp: 0.848 ± 0.031	1.458ValTyr: 1.458 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.1TrpAla: 1.1 ± 0.038	0.218TrpCys: 0.218 ± 0.016	0.532TrpAsp: 0.532 ± 0.024	0.626TrpGlu: 0.626 ± 0.025	0.577TrpPhe: 0.577 ± 0.026	0.952TrpGly: 0.952 ± 0.032	0.527TrpHis: 0.527 ± 0.026	0.73TrpIle: 0.73 ± 0.026	0.322TrpLys: 0.322 ± 0.02	2.599TrpLeu: 2.599 ± 0.061	0.391TrpMet: 0.391 ± 0.018	0.345TrpAsn: 0.345 ± 0.017	0.851TrpPro: 0.851 ± 0.032	1.334TrpGln: 1.334 ± 0.04	1.448TrpArg: 1.448 ± 0.048	0.872TrpSer: 0.872 ± 0.028	0.637TrpThr: 0.637 ± 0.023	0.882TrpVal: 0.882 ± 0.036	0.337TrpTrp: 0.337 ± 0.02	0.386TrpTyr: 0.386 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.188TyrAla: 2.188 ± 0.045	0.287TyrCys: 0.287 ± 0.019	1.249TyrAsp: 1.249 ± 0.039	1.074TyrGlu: 1.074 ± 0.039	0.866TyrPhe: 0.866 ± 0.03	2.002TyrGly: 2.002 ± 0.046	0.709TyrHis: 0.709 ± 0.028	1.037TyrIle: 1.037 ± 0.032	0.519TyrLys: 0.519 ± 0.024	2.699TyrLeu: 2.699 ± 0.055	0.501TyrMet: 0.501 ± 0.025	0.699TyrAsn: 0.699 ± 0.029	1.237TyrPro: 1.237 ± 0.037	1.151TyrGln: 1.151 ± 0.035	2.321TyrArg: 2.321 ± 0.045	1.409TyrSer: 1.409 ± 0.039	1.224TyrThr: 1.224 ± 0.037	1.417TyrVal: 1.417 ± 0.042	0.444TyrTrp: 0.444 ± 0.02	0.733TyrTyr: 0.733 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3055 proteins (948163 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---