Amino acid dipepetide frequency for Acinetobacter sp. ANC 4558

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.457AlaAla: 6.457 ± 0.109
0.889AlaCys: 0.889 ± 0.028
3.834AlaAsp: 3.834 ± 0.075
4.975AlaGlu: 4.975 ± 0.088
3.347AlaPhe: 3.347 ± 0.061
5.531AlaGly: 5.531 ± 0.09
1.798AlaHis: 1.798 ± 0.043
6.498AlaIle: 6.498 ± 0.102
4.902AlaLys: 4.902 ± 0.091
9.133AlaLeu: 9.133 ± 0.116
2.231AlaMet: 2.231 ± 0.049
3.315AlaAsn: 3.315 ± 0.063
2.652AlaPro: 2.652 ± 0.058
4.148AlaGln: 4.148 ± 0.073
3.274AlaArg: 3.274 ± 0.063
4.762AlaSer: 4.762 ± 0.076
4.27AlaThr: 4.27 ± 0.077
5.328AlaVal: 5.328 ± 0.092
1.063AlaTrp: 1.063 ± 0.034
2.666AlaTyr: 2.666 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.701CysAla: 0.701 ± 0.027
0.134CysCys: 0.134 ± 0.012
0.445CysAsp: 0.445 ± 0.021
0.542CysGlu: 0.542 ± 0.02
0.49CysPhe: 0.49 ± 0.022
0.754CysGly: 0.754 ± 0.029
0.248CysHis: 0.248 ± 0.017
0.808CysIle: 0.808 ± 0.029
0.401CysLys: 0.401 ± 0.022
1.013CysLeu: 1.013 ± 0.032
0.211CysMet: 0.211 ± 0.014
0.333CysAsn: 0.333 ± 0.017
0.37CysPro: 0.37 ± 0.022
0.409CysGln: 0.409 ± 0.021
0.401CysArg: 0.401 ± 0.021
0.621CysSer: 0.621 ± 0.027
0.489CysThr: 0.489 ± 0.025
0.608CysVal: 0.608 ± 0.024
0.109CysTrp: 0.109 ± 0.01
0.324CysTyr: 0.324 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.278AspAla: 4.278 ± 0.09
0.432AspCys: 0.432 ± 0.023
2.553AspAsp: 2.553 ± 0.057
3.419AspGlu: 3.419 ± 0.072
2.455AspPhe: 2.455 ± 0.059
3.121AspGly: 3.121 ± 0.066
1.427AspHis: 1.427 ± 0.04
3.967AspIle: 3.967 ± 0.062
2.455AspLys: 2.455 ± 0.06
5.491AspLeu: 5.491 ± 0.079
1.095AspMet: 1.095 ± 0.034
1.807AspAsn: 1.807 ± 0.046
1.861AspPro: 1.861 ± 0.047
2.741AspGln: 2.741 ± 0.054
2.224AspArg: 2.224 ± 0.051
2.525AspSer: 2.525 ± 0.052
2.284AspThr: 2.284 ± 0.047
3.544AspVal: 3.544 ± 0.069
0.755AspTrp: 0.755 ± 0.03
1.906AspTyr: 1.906 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
4.573GluAla: 4.573 ± 0.085
0.421GluCys: 0.421 ± 0.021
2.729GluAsp: 2.729 ± 0.058
3.231GluGlu: 3.231 ± 0.072
2.321GluPhe: 2.321 ± 0.053
3.072GluGly: 3.072 ± 0.056
1.585GluHis: 1.585 ± 0.044
4.812GluIle: 4.812 ± 0.076
4.486GluLys: 4.486 ± 0.08
6.148GluLeu: 6.148 ± 0.097
1.475GluMet: 1.475 ± 0.037
3.331GluAsn: 3.331 ± 0.058
1.62GluPro: 1.62 ± 0.044
3.735GluGln: 3.735 ± 0.072
2.805GluArg: 2.805 ± 0.057
3.167GluSer: 3.167 ± 0.062
2.989GluThr: 2.989 ± 0.062
3.626GluVal: 3.626 ± 0.069
0.801GluTrp: 0.801 ± 0.028
2.058GluTyr: 2.058 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.575PheAla: 3.575 ± 0.06
0.481PheCys: 0.481 ± 0.02
2.588PheAsp: 2.588 ± 0.049
2.642PheGlu: 2.642 ± 0.058
1.979PhePhe: 1.979 ± 0.06
3.133PheGly: 3.133 ± 0.067
0.879PheHis: 0.879 ± 0.032
3.641PheIle: 3.641 ± 0.066
2.684PheLys: 2.684 ± 0.058
4.045PheLeu: 4.045 ± 0.082
1.101PheMet: 1.101 ± 0.035
2.473PheAsn: 2.473 ± 0.058
1.493PhePro: 1.493 ± 0.037
1.598PheGln: 1.598 ± 0.044
1.424PheArg: 1.424 ± 0.038
3.34PheSer: 3.34 ± 0.077
2.349PheThr: 2.349 ± 0.053
2.443PheVal: 2.443 ± 0.052
0.566PheTrp: 0.566 ± 0.025
1.635PheTyr: 1.635 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
4.972GlyAla: 4.972 ± 0.092
0.762GlyCys: 0.762 ± 0.031
2.827GlyAsp: 2.827 ± 0.054
3.527GlyGlu: 3.527 ± 0.065
3.257GlyPhe: 3.257 ± 0.061
4.527GlyGly: 4.527 ± 0.091
1.5GlyHis: 1.5 ± 0.038
5.265GlyIle: 5.265 ± 0.093
3.643GlyLys: 3.643 ± 0.052
6.974GlyLeu: 6.974 ± 0.111
1.694GlyMet: 1.694 ± 0.044
2.546GlyAsn: 2.546 ± 0.056
1.492GlyPro: 1.492 ± 0.046
3.007GlyGln: 3.007 ± 0.053
2.77GlyArg: 2.77 ± 0.055
3.893GlySer: 3.893 ± 0.073
3.451GlyThr: 3.451 ± 0.062
4.675GlyVal: 4.675 ± 0.082
0.933GlyTrp: 0.933 ± 0.036
2.51GlyTyr: 2.51 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.851HisAla: 1.851 ± 0.045
0.245HisCys: 0.245 ± 0.016
1.18HisAsp: 1.18 ± 0.038
1.284HisGlu: 1.284 ± 0.036
1.137HisPhe: 1.137 ± 0.034
1.573HisGly: 1.573 ± 0.041
0.833HisHis: 0.833 ± 0.038
1.786HisIle: 1.786 ± 0.045
1.027HisLys: 1.027 ± 0.034
2.639HisLeu: 2.639 ± 0.057
0.495HisMet: 0.495 ± 0.022
0.888HisAsn: 0.888 ± 0.033
1.276HisPro: 1.276 ± 0.034
1.415HisGln: 1.415 ± 0.038
1.041HisArg: 1.041 ± 0.034
1.369HisSer: 1.369 ± 0.036
1.12HisThr: 1.12 ± 0.031
1.473HisVal: 1.473 ± 0.042
0.363HisTrp: 0.363 ± 0.018
0.927HisTyr: 0.927 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
6.815IleAla: 6.815 ± 0.096
0.867IleCys: 0.867 ± 0.028
4.401IleAsp: 4.401 ± 0.075
5.091IleGlu: 5.091 ± 0.077
3.391IlePhe: 3.391 ± 0.078
5.287IleGly: 5.287 ± 0.1
1.793IleHis: 1.793 ± 0.039
5.228IleIle: 5.228 ± 0.101
3.884IleLys: 3.884 ± 0.068
7.535IleLeu: 7.535 ± 0.119
1.54IleMet: 1.54 ± 0.037
3.577IleAsn: 3.577 ± 0.076
3.292IlePro: 3.292 ± 0.068
4.013IleGln: 4.013 ± 0.074
3.128IleArg: 3.128 ± 0.061
5.262IleSer: 5.262 ± 0.079
4.051IleThr: 4.051 ± 0.069
4.645IleVal: 4.645 ± 0.063
0.863IleTrp: 0.863 ± 0.031
2.454IleTyr: 2.454 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
4.7LysAla: 4.7 ± 0.092
0.327LysCys: 0.327 ± 0.018
3.039LysAsp: 3.039 ± 0.057
3.445LysGlu: 3.445 ± 0.068
2.206LysPhe: 2.206 ± 0.047
3.121LysGly: 3.121 ± 0.058
1.31LysHis: 1.31 ± 0.033
4.62LysIle: 4.62 ± 0.067
4.046LysLys: 4.046 ± 0.072
5.589LysLeu: 5.589 ± 0.073
1.515LysMet: 1.515 ± 0.039
3.62LysAsn: 3.62 ± 0.069
2.179LysPro: 2.179 ± 0.049
3.013LysGln: 3.013 ± 0.062
2.469LysArg: 2.469 ± 0.055
3.569LysSer: 3.569 ± 0.065
3.472LysThr: 3.472 ± 0.066
3.799LysVal: 3.799 ± 0.055
0.642LysTrp: 0.642 ± 0.025
1.911LysTyr: 1.911 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
8.927LeuAla: 8.927 ± 0.114
1.006LeuCys: 1.006 ± 0.032
5.551LeuAsp: 5.551 ± 0.085
6.106LeuGlu: 6.106 ± 0.094
4.507LeuPhe: 4.507 ± 0.09
6.939LeuGly: 6.939 ± 0.093
2.103LeuHis: 2.103 ± 0.05
7.891LeuIle: 7.891 ± 0.108
6.756LeuLys: 6.756 ± 0.099
9.738LeuLeu: 9.738 ± 0.148
2.445LeuMet: 2.445 ± 0.05
5.918LeuAsn: 5.918 ± 0.09
4.369LeuPro: 4.369 ± 0.062
4.354LeuGln: 4.354 ± 0.083
3.944LeuArg: 3.944 ± 0.075
7.698LeuSer: 7.698 ± 0.098
5.74LeuThr: 5.74 ± 0.073
6.032LeuVal: 6.032 ± 0.097
1.125LeuTrp: 1.125 ± 0.037
2.758LeuTyr: 2.758 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
1.938MetAla: 1.938 ± 0.05
0.19MetCys: 0.19 ± 0.014
0.998MetAsp: 0.998 ± 0.034
0.964MetGlu: 0.964 ± 0.029
0.853MetPhe: 0.853 ± 0.03
1.636MetGly: 1.636 ± 0.043
0.51MetHis: 0.51 ± 0.025
1.762MetIle: 1.762 ± 0.045
1.42MetLys: 1.42 ± 0.041
2.42MetLeu: 2.42 ± 0.055
0.688MetMet: 0.688 ± 0.03
1.415MetAsn: 1.415 ± 0.035
1.022MetPro: 1.022 ± 0.033
1.217MetGln: 1.217 ± 0.034
1.024MetArg: 1.024 ± 0.033
1.974MetSer: 1.974 ± 0.042
1.546MetThr: 1.546 ± 0.04
1.479MetVal: 1.479 ± 0.042
0.211MetTrp: 0.211 ± 0.016
0.573MetTyr: 0.573 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.907AsnAla: 3.907 ± 0.068
0.382AsnCys: 0.382 ± 0.021
2.379AsnAsp: 2.379 ± 0.056
2.69AsnGlu: 2.69 ± 0.056
2.121AsnPhe: 2.121 ± 0.057
2.859AsnGly: 2.859 ± 0.063
1.285AsnHis: 1.285 ± 0.045
4.003AsnIle: 4.003 ± 0.069
2.816AsnLys: 2.816 ± 0.051
4.933AsnLeu: 4.933 ± 0.074
1.082AsnMet: 1.082 ± 0.033
2.418AsnAsn: 2.418 ± 0.066
2.177AsnPro: 2.177 ± 0.044
2.629AsnGln: 2.629 ± 0.06
1.905AsnArg: 1.905 ± 0.046
2.902AsnSer: 2.902 ± 0.071
2.781AsnThr: 2.781 ± 0.064
2.9AsnVal: 2.9 ± 0.057
0.594AsnTrp: 0.594 ± 0.032
1.713AsnTyr: 1.713 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
2.7ProAla: 2.7 ± 0.06
0.267ProCys: 0.267 ± 0.016
1.918ProAsp: 1.918 ± 0.043
2.989ProGlu: 2.989 ± 0.053
1.775ProPhe: 1.775 ± 0.045
1.653ProGly: 1.653 ± 0.041
0.881ProHis: 0.881 ± 0.03
2.881ProIle: 2.881 ± 0.053
2.345ProLys: 2.345 ± 0.05
3.823ProLeu: 3.823 ± 0.071
0.86ProMet: 0.86 ± 0.029
2.063ProAsn: 2.063 ± 0.042
1.07ProPro: 1.07 ± 0.033
1.731ProGln: 1.731 ± 0.041
1.311ProArg: 1.311 ± 0.036
2.309ProSer: 2.309 ± 0.051
2.352ProThr: 2.352 ± 0.05
2.64ProVal: 2.64 ± 0.06
0.461ProTrp: 0.461 ± 0.023
1.361ProTyr: 1.361 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
4.263GlnAla: 4.263 ± 0.068
0.414GlnCys: 0.414 ± 0.021
2.292GlnAsp: 2.292 ± 0.053
2.599GlnGlu: 2.599 ± 0.047
2.045GlnPhe: 2.045 ± 0.041
2.838GlnGly: 2.838 ± 0.054
1.564GlnHis: 1.564 ± 0.046
3.642GlnIle: 3.642 ± 0.061
3.132GlnLys: 3.132 ± 0.06
5.291GlnLeu: 5.291 ± 0.084
1.124GlnMet: 1.124 ± 0.032
2.643GlnAsn: 2.643 ± 0.056
1.79GlnPro: 1.79 ± 0.048
3.307GlnGln: 3.307 ± 0.073
2.243GlnArg: 2.243 ± 0.054
2.898GlnSer: 2.898 ± 0.058
2.594GlnThr: 2.594 ± 0.059
3.186GlnVal: 3.186 ± 0.055
0.653GlnTrp: 0.653 ± 0.025
1.907GlnTyr: 1.907 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
3.05ArgAla: 3.05 ± 0.055
0.334ArgCys: 0.334 ± 0.019
2.057ArgAsp: 2.057 ± 0.054
2.541ArgGlu: 2.541 ± 0.055
1.921ArgPhe: 1.921 ± 0.038
2.37ArgGly: 2.37 ± 0.053
1.05ArgHis: 1.05 ± 0.033
3.16ArgIle: 3.16 ± 0.055
2.355ArgLys: 2.355 ± 0.045
4.559ArgLeu: 4.559 ± 0.062
1.022ArgMet: 1.022 ± 0.03
1.91ArgAsn: 1.91 ± 0.048
1.59ArgPro: 1.59 ± 0.047
2.118ArgGln: 2.118 ± 0.045
2.013ArgArg: 2.013 ± 0.053
2.281ArgSer: 2.281 ± 0.054
2.135ArgThr: 2.135 ± 0.049
2.664ArgVal: 2.664 ± 0.057
0.513ArgTrp: 0.513 ± 0.022
1.658ArgTyr: 1.658 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
4.759SerAla: 4.759 ± 0.07
0.605SerCys: 0.605 ± 0.025
3.108SerAsp: 3.108 ± 0.057
3.584SerGlu: 3.584 ± 0.062
3.093SerPhe: 3.093 ± 0.067
4.291SerGly: 4.291 ± 0.067
1.514SerHis: 1.514 ± 0.038
4.993SerIle: 4.993 ± 0.075
3.575SerLys: 3.575 ± 0.068
6.684SerLeu: 6.684 ± 0.092
1.53SerMet: 1.53 ± 0.039
2.972SerAsn: 2.972 ± 0.062
2.364SerPro: 2.364 ± 0.049
2.889SerGln: 2.889 ± 0.05
2.474SerArg: 2.474 ± 0.046
4.235SerSer: 4.235 ± 0.073
3.651SerThr: 3.651 ± 0.066
3.88SerVal: 3.88 ± 0.065
0.71SerTrp: 0.71 ± 0.026
2.167SerTyr: 2.167 ± 0.052
0.001SerXaa: 0.001 ± 0.001
Thr
4.7ThrAla: 4.7 ± 0.081
0.478ThrCys: 0.478 ± 0.02
2.705ThrAsp: 2.705 ± 0.062
3.135ThrGlu: 3.135 ± 0.062
2.222ThrPhe: 2.222 ± 0.045
4.08ThrGly: 4.08 ± 0.077
1.257ThrHis: 1.257 ± 0.037
3.851ThrIle: 3.851 ± 0.069
2.583ThrLys: 2.583 ± 0.049
6.003ThrLeu: 6.003 ± 0.071
1.049ThrMet: 1.049 ± 0.034
2.302ThrAsn: 2.302 ± 0.05
2.605ThrPro: 2.605 ± 0.05
2.776ThrGln: 2.776 ± 0.054
2.151ThrArg: 2.151 ± 0.054
3.253ThrSer: 3.253 ± 0.06
3.206ThrThr: 3.206 ± 0.071
3.594ThrVal: 3.594 ± 0.064
0.669ThrTrp: 0.669 ± 0.027
1.735ThrTyr: 1.735 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
5.317ValAla: 5.317 ± 0.085
0.679ValCys: 0.679 ± 0.026
3.429ValAsp: 3.429 ± 0.063
3.981ValGlu: 3.981 ± 0.07
2.67ValPhe: 2.67 ± 0.059
4.4ValGly: 4.4 ± 0.079
1.292ValHis: 1.292 ± 0.034
4.983ValIle: 4.983 ± 0.07
3.65ValLys: 3.65 ± 0.065
6.565ValLeu: 6.565 ± 0.094
1.655ValMet: 1.655 ± 0.04
2.97ValAsn: 2.97 ± 0.062
2.46ValPro: 2.46 ± 0.054
2.686ValGln: 2.686 ± 0.055
2.48ValArg: 2.48 ± 0.052
4.019ValSer: 4.019 ± 0.061
3.51ValThr: 3.51 ± 0.068
4.282ValVal: 4.282 ± 0.065
0.744ValTrp: 0.744 ± 0.034
1.762ValTyr: 1.762 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.828TrpAla: 0.828 ± 0.032
0.137TrpCys: 0.137 ± 0.012
0.565TrpAsp: 0.565 ± 0.024
0.485TrpGlu: 0.485 ± 0.024
0.624TrpPhe: 0.624 ± 0.023
0.806TrpGly: 0.806 ± 0.031
0.289TrpHis: 0.289 ± 0.017
0.988TrpIle: 0.988 ± 0.036
0.669TrpLys: 0.669 ± 0.029
1.58TrpLeu: 1.58 ± 0.049
0.37TrpMet: 0.37 ± 0.02
0.637TrpAsn: 0.637 ± 0.027
0.338TrpPro: 0.338 ± 0.019
0.709TrpGln: 0.709 ± 0.028
0.592TrpArg: 0.592 ± 0.025
0.824TrpSer: 0.824 ± 0.029
0.601TrpThr: 0.601 ± 0.025
0.815TrpVal: 0.815 ± 0.032
0.154TrpTrp: 0.154 ± 0.012
0.395TrpTyr: 0.395 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.762TyrAla: 2.762 ± 0.052
0.362TyrCys: 0.362 ± 0.017
1.742TyrAsp: 1.742 ± 0.045
1.756TyrGlu: 1.756 ± 0.045
1.656TyrPhe: 1.656 ± 0.047
2.232TyrGly: 2.232 ± 0.048
0.805TyrHis: 0.805 ± 0.03
2.338TyrIle: 2.338 ± 0.054
1.766TyrLys: 1.766 ± 0.046
3.744TyrLeu: 3.744 ± 0.065
0.657TyrMet: 0.657 ± 0.03
1.337TyrAsn: 1.337 ± 0.041
1.368TyrPro: 1.368 ± 0.042
1.928TyrGln: 1.928 ± 0.046
1.628TyrArg: 1.628 ± 0.041
2.179TyrSer: 2.179 ± 0.058
1.762TyrThr: 1.762 ± 0.045
1.921TyrVal: 1.921 ± 0.046
0.478TyrTrp: 0.478 ± 0.022
1.121TyrTyr: 1.121 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.001XaaMet: 0.001 ± 0.001
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3352 proteins (1026157 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski