Amino acid dipepetide frequency for Tenacibaculum dicentrarchi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.062AlaAla: 4.062 ± 0.161	0.544AlaCys: 0.544 ± 0.028	3.86AlaAsp: 3.86 ± 0.137	3.607AlaGlu: 3.607 ± 0.08	3.231AlaPhe: 3.231 ± 0.072	4.38AlaGly: 4.38 ± 0.142	1.057AlaHis: 1.057 ± 0.038	6.053AlaIle: 6.053 ± 0.094	5.626AlaLys: 5.626 ± 0.102	5.88AlaLeu: 5.88 ± 0.105	1.41AlaMet: 1.41 ± 0.054	3.812AlaAsn: 3.812 ± 0.1	1.958AlaPro: 1.958 ± 0.095	2.397AlaGln: 2.397 ± 0.056	1.892AlaArg: 1.892 ± 0.054	4.6AlaSer: 4.6 ± 0.084	4.516AlaThr: 4.516 ± 0.191	4.333AlaVal: 4.333 ± 0.093	0.536AlaTrp: 0.536 ± 0.026	2.227AlaTyr: 2.227 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.471CysAla: 0.471 ± 0.032	0.076CysCys: 0.076 ± 0.01	0.441CysAsp: 0.441 ± 0.033	0.53CysGlu: 0.53 ± 0.066	0.425CysPhe: 0.425 ± 0.026	0.619CysGly: 0.619 ± 0.057	0.154CysHis: 0.154 ± 0.015	0.523CysIle: 0.523 ± 0.028	0.649CysLys: 0.649 ± 0.05	0.595CysLeu: 0.595 ± 0.029	0.129CysMet: 0.129 ± 0.014	0.413CysAsn: 0.413 ± 0.026	0.272CysPro: 0.272 ± 0.029	0.195CysGln: 0.195 ± 0.014	0.172CysArg: 0.172 ± 0.015	0.615CysSer: 0.615 ± 0.067	0.437CysThr: 0.437 ± 0.045	0.418CysVal: 0.418 ± 0.028	0.059CysTrp: 0.059 ± 0.009	0.279CysTyr: 0.279 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.261AspAla: 4.261 ± 0.132	0.386AspCys: 0.386 ± 0.026	2.883AspAsp: 2.883 ± 0.134	3.356AspGlu: 3.356 ± 0.082	3.675AspPhe: 3.675 ± 0.07	3.385AspGly: 3.385 ± 0.197	0.699AspHis: 0.699 ± 0.033	4.519AspIle: 4.519 ± 0.075	5.042AspLys: 5.042 ± 0.079	4.814AspLeu: 4.814 ± 0.093	0.899AspMet: 0.899 ± 0.042	3.255AspAsn: 3.255 ± 0.129	1.237AspPro: 1.237 ± 0.059	1.367AspGln: 1.367 ± 0.064	1.432AspArg: 1.432 ± 0.042	2.726AspSer: 2.726 ± 0.066	3.067AspThr: 3.067 ± 0.111	3.696AspVal: 3.696 ± 0.116	0.629AspTrp: 0.629 ± 0.03	2.506AspTyr: 2.506 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	4.059GluAla: 4.059 ± 0.086	0.301GluCys: 0.301 ± 0.017	3.031GluAsp: 3.031 ± 0.081	4.152GluGlu: 4.152 ± 0.099	2.955GluPhe: 2.955 ± 0.075	2.989GluGly: 2.989 ± 0.083	1.067GluHis: 1.067 ± 0.038	5.828GluIle: 5.828 ± 0.104	6.374GluLys: 6.374 ± 0.135	5.989GluLeu: 5.989 ± 0.102	1.392GluMet: 1.392 ± 0.042	5.288GluAsn: 5.288 ± 0.106	1.204GluPro: 1.204 ± 0.037	2.227GluGln: 2.227 ± 0.064	2.057GluArg: 2.057 ± 0.063	2.817GluSer: 2.817 ± 0.064	3.464GluThr: 3.464 ± 0.075	4.172GluVal: 4.172 ± 0.094	0.425GluTrp: 0.425 ± 0.025	2.241GluTyr: 2.241 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	2.656PheAla: 2.656 ± 0.068	0.455PheCys: 0.455 ± 0.025	3.34PheAsp: 3.34 ± 0.081	3.243PheGlu: 3.243 ± 0.079	2.68PhePhe: 2.68 ± 0.08	3.44PheGly: 3.44 ± 0.092	0.705PheHis: 0.705 ± 0.03	4.21PheIle: 4.21 ± 0.107	4.564PheLys: 4.564 ± 0.102	4.757PheLeu: 4.757 ± 0.116	1.049PheMet: 1.049 ± 0.04	3.463PheAsn: 3.463 ± 0.076	1.456PhePro: 1.456 ± 0.049	1.41PheGln: 1.41 ± 0.046	1.38PheArg: 1.38 ± 0.043	4.039PheSer: 4.039 ± 0.078	3.412PheThr: 3.412 ± 0.117	2.806PheVal: 2.806 ± 0.064	0.49PheTrp: 0.49 ± 0.028	2.085PheTyr: 2.085 ± 0.062	0.0PheXaa: 0.0 ± 0.0
Gly	4.332GlyAla: 4.332 ± 0.107	0.602GlyCys: 0.602 ± 0.054	3.129GlyAsp: 3.129 ± 0.075	3.185GlyGlu: 3.185 ± 0.07	3.625GlyPhe: 3.625 ± 0.082	4.259GlyGly: 4.259 ± 0.112	1.017GlyHis: 1.017 ± 0.039	5.225GlyIle: 5.225 ± 0.097	5.116GlyLys: 5.116 ± 0.098	5.508GlyLeu: 5.508 ± 0.098	1.355GlyMet: 1.355 ± 0.049	3.596GlyAsn: 3.596 ± 0.096	0.948GlyPro: 0.948 ± 0.044	1.598GlyGln: 1.598 ± 0.046	1.827GlyArg: 1.827 ± 0.053	3.703GlySer: 3.703 ± 0.094	4.362GlyThr: 4.362 ± 0.247	4.366GlyVal: 4.366 ± 0.099	0.663GlyTrp: 0.663 ± 0.033	2.567GlyTyr: 2.567 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	0.949HisAla: 0.949 ± 0.034	0.144HisCys: 0.144 ± 0.012	0.748HisAsp: 0.748 ± 0.032	0.839HisGlu: 0.839 ± 0.037	1.094HisPhe: 1.094 ± 0.043	0.927HisGly: 0.927 ± 0.037	0.454HisHis: 0.454 ± 0.026	1.368HisIle: 1.368 ± 0.055	1.395HisLys: 1.395 ± 0.046	1.743HisLeu: 1.743 ± 0.054	0.272HisMet: 0.272 ± 0.018	0.902HisAsn: 0.902 ± 0.035	0.81HisPro: 0.81 ± 0.038	0.867HisGln: 0.867 ± 0.033	0.587HisArg: 0.587 ± 0.032	0.924HisSer: 0.924 ± 0.039	0.965HisThr: 0.965 ± 0.035	0.766HisVal: 0.766 ± 0.027	0.163HisTrp: 0.163 ± 0.016	0.714HisTyr: 0.714 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.148IleAla: 6.148 ± 0.105	0.666IleCys: 0.666 ± 0.054	5.172IleAsp: 5.172 ± 0.094	5.576IleGlu: 5.576 ± 0.105	3.655IlePhe: 3.655 ± 0.085	5.024IleGly: 5.024 ± 0.102	1.363IleHis: 1.363 ± 0.044	6.741IleIle: 6.741 ± 0.128	7.303IleLys: 7.303 ± 0.107	7.126IleLeu: 7.126 ± 0.133	1.257IleMet: 1.257 ± 0.045	5.422IleAsn: 5.422 ± 0.087	3.093IlePro: 3.093 ± 0.072	2.682IleGln: 2.682 ± 0.065	2.471IleArg: 2.471 ± 0.062	6.146IleSer: 6.146 ± 0.09	5.745IleThr: 5.745 ± 0.207	4.645IleVal: 4.645 ± 0.087	0.574IleTrp: 0.574 ± 0.027	2.693IleTyr: 2.693 ± 0.075	0.0IleXaa: 0.0 ± 0.0
Lys	5.751LysAla: 5.751 ± 0.118	0.371LysCys: 0.371 ± 0.021	4.729LysAsp: 4.729 ± 0.11	7.185LysGlu: 7.185 ± 0.141	3.226LysPhe: 3.226 ± 0.061	5.269LysGly: 5.269 ± 0.088	1.589LysHis: 1.589 ± 0.058	7.977LysIle: 7.977 ± 0.117	9.293LysLys: 9.293 ± 0.172	7.314LysLeu: 7.314 ± 0.117	2.22LysMet: 2.22 ± 0.056	7.327LysAsn: 7.327 ± 0.157	2.54LysPro: 2.54 ± 0.066	3.312LysGln: 3.312 ± 0.085	2.997LysArg: 2.997 ± 0.078	5.152LysSer: 5.152 ± 0.102	5.882LysThr: 5.882 ± 0.13	5.107LysVal: 5.107 ± 0.102	0.802LysTrp: 0.802 ± 0.034	3.437LysTyr: 3.437 ± 0.08	0.0LysXaa: 0.0 ± 0.0
Leu	5.989LeuAla: 5.989 ± 0.097	0.561LeuCys: 0.561 ± 0.027	4.666LeuAsp: 4.666 ± 0.091	5.771LeuGlu: 5.771 ± 0.107	4.78LeuPhe: 4.78 ± 0.119	5.598LeuGly: 5.598 ± 0.11	1.601LeuHis: 1.601 ± 0.049	7.06LeuIle: 7.06 ± 0.143	9.067LeuLys: 9.067 ± 0.172	8.259LeuLeu: 8.259 ± 0.183	1.804LeuMet: 1.804 ± 0.057	5.917LeuAsn: 5.917 ± 0.119	3.273LeuPro: 3.273 ± 0.074	3.235LeuGln: 3.235 ± 0.077	2.782LeuArg: 2.782 ± 0.07	6.467LeuSer: 6.467 ± 0.095	5.237LeuThr: 5.237 ± 0.117	5.122LeuVal: 5.122 ± 0.097	0.661LeuTrp: 0.661 ± 0.031	2.896LeuTyr: 2.896 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.446MetAla: 1.446 ± 0.046	0.154MetCys: 0.154 ± 0.013	0.908MetAsp: 0.908 ± 0.038	1.039MetGlu: 1.039 ± 0.039	0.774MetPhe: 0.774 ± 0.032	1.136MetGly: 1.136 ± 0.042	0.308MetHis: 0.308 ± 0.02	1.494MetIle: 1.494 ± 0.052	2.045MetLys: 2.045 ± 0.062	1.886MetLeu: 1.886 ± 0.058	0.523MetMet: 0.523 ± 0.022	1.289MetAsn: 1.289 ± 0.048	0.771MetPro: 0.771 ± 0.032	0.723MetGln: 0.723 ± 0.032	0.749MetArg: 0.749 ± 0.031	1.256MetSer: 1.256 ± 0.041	1.069MetThr: 1.069 ± 0.04	1.078MetVal: 1.078 ± 0.042	0.151MetTrp: 0.151 ± 0.014	0.699MetTyr: 0.699 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	4.021AsnAla: 4.021 ± 0.076	0.643AsnCys: 0.643 ± 0.103	3.428AsnAsp: 3.428 ± 0.108	3.509AsnGlu: 3.509 ± 0.075	3.374AsnPhe: 3.374 ± 0.077	3.948AsnGly: 3.948 ± 0.136	1.086AsnHis: 1.086 ± 0.04	5.582AsnIle: 5.582 ± 0.103	5.626AsnLys: 5.626 ± 0.112	5.888AsnLeu: 5.888 ± 0.095	1.135AsnMet: 1.135 ± 0.039	4.601AsnAsn: 4.601 ± 0.103	2.858AsnPro: 2.858 ± 0.106	2.404AsnGln: 2.404 ± 0.06	1.907AsnArg: 1.907 ± 0.053	4.175AsnSer: 4.175 ± 0.089	4.402AsnThr: 4.402 ± 0.116	3.369AsnVal: 3.369 ± 0.065	0.74AsnTrp: 0.74 ± 0.036	3.063AsnTyr: 3.063 ± 0.077	0.0AsnXaa: 0.0 ± 0.0
Pro	1.916ProAla: 1.916 ± 0.079	0.221ProCys: 0.221 ± 0.017	1.564ProAsp: 1.564 ± 0.053	2.254ProGlu: 2.254 ± 0.063	1.679ProPhe: 1.679 ± 0.053	1.539ProGly: 1.539 ± 0.063	0.518ProHis: 0.518 ± 0.024	2.749ProIle: 2.749 ± 0.082	2.86ProLys: 2.86 ± 0.065	2.648ProLeu: 2.648 ± 0.071	0.631ProMet: 0.631 ± 0.028	2.038ProAsn: 2.038 ± 0.046	0.629ProPro: 0.629 ± 0.033	0.938ProGln: 0.938 ± 0.04	0.818ProArg: 0.818 ± 0.035	1.975ProSer: 1.975 ± 0.065	2.273ProThr: 2.273 ± 0.121	2.044ProVal: 2.044 ± 0.058	0.288ProTrp: 0.288 ± 0.019	1.175ProTyr: 1.175 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.101GlnAla: 2.101 ± 0.067	0.17GlnCys: 0.17 ± 0.014	1.425GlnAsp: 1.425 ± 0.048	2.504GlnGlu: 2.504 ± 0.068	1.645GlnPhe: 1.645 ± 0.05	1.909GlnGly: 1.909 ± 0.05	0.598GlnHis: 0.598 ± 0.03	2.839GlnIle: 2.839 ± 0.074	3.545GlnLys: 3.545 ± 0.082	3.232GlnLeu: 3.232 ± 0.073	0.717GlnMet: 0.717 ± 0.029	2.271GlnAsn: 2.271 ± 0.059	0.905GlnPro: 0.905 ± 0.039	1.585GlnGln: 1.585 ± 0.052	1.129GlnArg: 1.129 ± 0.04	1.597GlnSer: 1.597 ± 0.048	1.886GlnThr: 1.886 ± 0.055	1.977GlnVal: 1.977 ± 0.056	0.326GlnTrp: 0.326 ± 0.021	1.341GlnTyr: 1.341 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	1.932ArgAla: 1.932 ± 0.055	0.2ArgCys: 0.2 ± 0.015	1.425ArgAsp: 1.425 ± 0.047	1.873ArgGlu: 1.873 ± 0.057	1.721ArgPhe: 1.721 ± 0.051	1.697ArgGly: 1.697 ± 0.054	0.524ArgHis: 0.524 ± 0.029	2.572ArgIle: 2.572 ± 0.07	2.977ArgLys: 2.977 ± 0.081	2.898ArgLeu: 2.898 ± 0.069	0.759ArgMet: 0.759 ± 0.033	1.897ArgAsn: 1.897 ± 0.059	0.88ArgPro: 0.88 ± 0.039	0.885ArgGln: 0.885 ± 0.031	1.115ArgArg: 1.115 ± 0.047	1.618ArgSer: 1.618 ± 0.053	1.813ArgThr: 1.813 ± 0.059	1.827ArgVal: 1.827 ± 0.047	0.313ArgTrp: 0.313 ± 0.022	1.355ArgTyr: 1.355 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.954SerAla: 3.954 ± 0.091	0.651SerCys: 0.651 ± 0.046	3.487SerAsp: 3.487 ± 0.109	4.142SerGlu: 4.142 ± 0.086	3.874SerPhe: 3.874 ± 0.091	4.202SerGly: 4.202 ± 0.084	0.926SerHis: 0.926 ± 0.035	5.145SerIle: 5.145 ± 0.108	5.681SerLys: 5.681 ± 0.108	5.857SerLeu: 5.857 ± 0.119	1.106SerMet: 1.106 ± 0.04	3.715SerAsn: 3.715 ± 0.073	1.847SerPro: 1.847 ± 0.037	1.87SerGln: 1.87 ± 0.05	1.801SerArg: 1.801 ± 0.06	4.209SerSer: 4.209 ± 0.094	3.772SerThr: 3.772 ± 0.171	4.129SerVal: 4.129 ± 0.091	0.608SerTrp: 0.608 ± 0.029	2.716SerTyr: 2.716 ± 0.069	0.0SerXaa: 0.0 ± 0.0
Thr	4.628ThrAla: 4.628 ± 0.162	0.437ThrCys: 0.437 ± 0.057	3.816ThrAsp: 3.816 ± 0.192	3.351ThrGlu: 3.351 ± 0.06	3.067ThrPhe: 3.067 ± 0.144	4.316ThrGly: 4.316 ± 0.167	1.046ThrHis: 1.046 ± 0.035	5.461ThrIle: 5.461 ± 0.141	4.895ThrLys: 4.895 ± 0.091	5.598ThrLeu: 5.598 ± 0.13	0.858ThrMet: 0.858 ± 0.043	3.633ThrAsn: 3.633 ± 0.109	2.653ThrPro: 2.653 ± 0.109	2.182ThrGln: 2.182 ± 0.073	1.647ThrArg: 1.647 ± 0.06	4.208ThrSer: 4.208 ± 0.118	4.208ThrThr: 4.208 ± 0.172	4.44ThrVal: 4.44 ± 0.205	0.558ThrTrp: 0.558 ± 0.06	2.391ThrTyr: 2.391 ± 0.091	0.0ThrXaa: 0.0 ± 0.0
Val	4.468ValAla: 4.468 ± 0.117	0.519ValCys: 0.519 ± 0.029	3.266ValAsp: 3.266 ± 0.08	3.437ValGlu: 3.437 ± 0.108	3.347ValPhe: 3.347 ± 0.087	3.516ValGly: 3.516 ± 0.08	0.971ValHis: 0.971 ± 0.039	4.783ValIle: 4.783 ± 0.095	5.109ValLys: 5.109 ± 0.116	6.2ValLeu: 6.2 ± 0.111	1.107ValMet: 1.107 ± 0.04	3.705ValAsn: 3.705 ± 0.084	1.948ValPro: 1.948 ± 0.077	1.711ValGln: 1.711 ± 0.047	1.788ValArg: 1.788 ± 0.051	4.536ValSer: 4.536 ± 0.096	3.846ValThr: 3.846 ± 0.151	4.348ValVal: 4.348 ± 0.124	0.488ValTrp: 0.488 ± 0.024	2.037ValTyr: 2.037 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.596TrpAla: 0.596 ± 0.034	0.073TrpCys: 0.073 ± 0.009	0.476TrpAsp: 0.476 ± 0.024	0.521TrpGlu: 0.521 ± 0.028	0.545TrpPhe: 0.545 ± 0.03	0.518TrpGly: 0.518 ± 0.022	0.187TrpHis: 0.187 ± 0.015	0.699TrpIle: 0.699 ± 0.04	0.762TrpLys: 0.762 ± 0.036	0.956TrpLeu: 0.956 ± 0.043	0.245TrpMet: 0.245 ± 0.019	0.6TrpAsn: 0.6 ± 0.033	0.136TrpPro: 0.136 ± 0.013	0.368TrpGln: 0.368 ± 0.022	0.319TrpArg: 0.319 ± 0.019	0.512TrpSer: 0.512 ± 0.032	0.421TrpThr: 0.421 ± 0.027	0.513TrpVal: 0.513 ± 0.028	0.114TrpTrp: 0.114 ± 0.013	0.394TrpTyr: 0.394 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.244TyrAla: 2.244 ± 0.057	0.297TyrCys: 0.297 ± 0.021	2.043TyrAsp: 2.043 ± 0.055	1.958TyrGlu: 1.958 ± 0.062	2.268TyrPhe: 2.268 ± 0.059	2.311TyrGly: 2.311 ± 0.061	0.756TyrHis: 0.756 ± 0.032	2.673TyrIle: 2.673 ± 0.064	3.553TyrLys: 3.553 ± 0.074	3.597TyrLeu: 3.597 ± 0.083	0.63TyrMet: 0.63 ± 0.029	2.617TyrAsn: 2.617 ± 0.066	1.339TyrPro: 1.339 ± 0.045	1.745TyrGln: 1.745 ± 0.05	1.41TyrArg: 1.41 ± 0.048	2.419TyrSer: 2.419 ± 0.056	2.614TyrThr: 2.614 ± 0.105	1.976TyrVal: 1.976 ± 0.05	0.367TyrTrp: 0.367 ± 0.02	1.711TyrTyr: 1.711 ± 0.061	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2382 proteins (823913 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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