Amino acid dipepetide frequency for Pea leaf distortion virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.261AlaAla: 6.261 ± 1.981
1.789AlaCys: 1.789 ± 1.458
0.894AlaAsp: 0.894 ± 0.729
0.0AlaGlu: 0.0 ± 0.0
0.0AlaPhe: 0.0 ± 0.0
1.789AlaGly: 1.789 ± 0.705
1.789AlaHis: 1.789 ± 1.038
1.789AlaIle: 1.789 ± 1.038
2.683AlaLys: 2.683 ± 0.864
7.156AlaLeu: 7.156 ± 2.518
0.0AlaMet: 0.0 ± 0.0
2.683AlaAsn: 2.683 ± 1.12
4.472AlaPro: 4.472 ± 1.462
5.367AlaGln: 5.367 ± 1.72
3.578AlaArg: 3.578 ± 1.715
3.578AlaSer: 3.578 ± 2.267
2.683AlaThr: 2.683 ± 2.187
1.789AlaVal: 1.789 ± 1.403
1.789AlaTrp: 1.789 ± 1.027
1.789AlaTyr: 1.789 ± 1.027
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
1.789CysCys: 1.789 ± 2.043
0.0CysAsp: 0.0 ± 0.0
0.894CysGlu: 0.894 ± 0.729
1.789CysPhe: 1.789 ± 1.139
1.789CysGly: 1.789 ± 0.88
0.0CysHis: 0.0 ± 0.0
0.894CysIle: 0.894 ± 0.729
0.894CysLys: 0.894 ± 0.729
0.0CysLeu: 0.0 ± 0.0
0.894CysMet: 0.894 ± 1.022
1.789CysAsn: 1.789 ± 0.88
1.789CysPro: 1.789 ± 2.043
0.894CysGln: 0.894 ± 0.629
2.683CysArg: 2.683 ± 0.943
3.578CysSer: 3.578 ± 1.739
1.789CysThr: 1.789 ± 1.226
0.894CysVal: 0.894 ± 0.729
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.683AspAla: 2.683 ± 1.888
0.0AspCys: 0.0 ± 0.0
2.683AspAsp: 2.683 ± 1.137
2.683AspGlu: 2.683 ± 0.864
1.789AspPhe: 1.789 ± 0.705
1.789AspGly: 1.789 ± 1.259
1.789AspHis: 1.789 ± 1.139
1.789AspIle: 1.789 ± 1.018
1.789AspLys: 1.789 ± 0.705
8.945AspLeu: 8.945 ± 2.848
0.0AspMet: 0.0 ± 0.0
2.683AspAsn: 2.683 ± 1.42
3.578AspPro: 3.578 ± 1.625
1.789AspGln: 1.789 ± 0.88
2.683AspArg: 2.683 ± 1.288
3.578AspSer: 3.578 ± 1.429
1.789AspThr: 1.789 ± 1.038
5.367AspVal: 5.367 ± 1.797
1.789AspTrp: 1.789 ± 0.88
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
5.367GluAla: 5.367 ± 1.389
0.894GluCys: 0.894 ± 0.807
0.894GluAsp: 0.894 ± 1.006
8.05GluGlu: 8.05 ± 3.88
3.578GluPhe: 3.578 ± 1.877
4.472GluGly: 4.472 ± 1.572
0.894GluHis: 0.894 ± 0.807
0.894GluIle: 0.894 ± 0.973
0.894GluLys: 0.894 ± 0.629
3.578GluLeu: 3.578 ± 1.715
0.0GluMet: 0.0 ± 0.0
4.472GluAsn: 4.472 ± 1.944
2.683GluPro: 2.683 ± 1.12
2.683GluGln: 2.683 ± 1.363
0.0GluArg: 0.0 ± 0.0
4.472GluSer: 4.472 ± 1.141
1.789GluThr: 1.789 ± 1.412
1.789GluVal: 1.789 ± 1.018
2.683GluTrp: 2.683 ± 1.301
0.894GluTyr: 0.894 ± 1.022
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
0.894PheCys: 0.894 ± 0.729
4.472PheAsp: 4.472 ± 1.214
1.789PheGlu: 1.789 ± 0.705
1.789PhePhe: 1.789 ± 0.705
0.894PheGly: 0.894 ± 0.729
1.789PheHis: 1.789 ± 1.259
0.894PheIle: 0.894 ± 0.629
2.683PheLys: 2.683 ± 1.9
8.05PheLeu: 8.05 ± 2.17
0.894PheMet: 0.894 ± 0.629
2.683PheAsn: 2.683 ± 1.122
0.894PhePro: 0.894 ± 1.022
2.683PheGln: 2.683 ± 1.301
1.789PheArg: 1.789 ± 1.412
1.789PheSer: 1.789 ± 0.88
1.789PheThr: 1.789 ± 1.139
2.683PheVal: 2.683 ± 1.12
0.0PheTrp: 0.0 ± 0.0
1.789PheTyr: 1.789 ± 1.134
0.0PheXaa: 0.0 ± 0.0
Gly
4.472GlyAla: 4.472 ± 1.132
2.683GlyCys: 2.683 ± 1.696
1.789GlyAsp: 1.789 ± 1.259
3.578GlyGlu: 3.578 ± 1.133
1.789GlyPhe: 1.789 ± 1.202
4.472GlyGly: 4.472 ± 1.036
1.789GlyHis: 1.789 ± 0.88
0.894GlyIle: 0.894 ± 0.629
6.261GlyLys: 6.261 ± 2.626
1.789GlyLeu: 1.789 ± 1.018
0.0GlyMet: 0.0 ± 0.0
2.683GlyAsn: 2.683 ± 3.019
4.472GlyPro: 4.472 ± 1.563
2.683GlyGln: 2.683 ± 0.96
0.894GlyArg: 0.894 ± 0.629
5.367GlySer: 5.367 ± 2.004
1.789GlyThr: 1.789 ± 1.026
1.789GlyVal: 1.789 ± 1.946
0.0GlyTrp: 0.0 ± 0.0
0.894GlyTyr: 0.894 ± 1.022
0.0GlyXaa: 0.0 ± 0.0
His
0.894HisAla: 0.894 ± 0.729
1.789HisCys: 1.789 ± 1.202
2.683HisAsp: 2.683 ± 1.122
1.789HisGlu: 1.789 ± 1.038
3.578HisPhe: 3.578 ± 1.877
2.683HisGly: 2.683 ± 1.774
1.789HisHis: 1.789 ± 1.613
1.789HisIle: 1.789 ± 1.226
2.683HisLys: 2.683 ± 1.47
3.578HisLeu: 3.578 ± 1.328
0.0HisMet: 0.0 ± 0.0
1.789HisAsn: 1.789 ± 1.259
1.789HisPro: 1.789 ± 1.027
0.894HisGln: 0.894 ± 0.807
4.472HisArg: 4.472 ± 2.572
0.894HisSer: 0.894 ± 0.729
0.894HisThr: 0.894 ± 0.729
2.683HisVal: 2.683 ± 1.344
0.0HisTrp: 0.0 ± 0.0
0.894HisTyr: 0.894 ± 0.807
0.0HisXaa: 0.0 ± 0.0
Ile
0.0IleAla: 0.0 ± 0.0
1.789IleCys: 1.789 ± 0.929
2.683IleAsp: 2.683 ± 1.888
1.789IleGlu: 1.789 ± 1.027
2.683IlePhe: 2.683 ± 1.888
1.789IleGly: 1.789 ± 1.226
0.894IleHis: 0.894 ± 0.807
1.789IleIle: 1.789 ± 1.946
6.261IleLys: 6.261 ± 1.517
1.789IleLeu: 1.789 ± 1.435
0.0IleMet: 0.0 ± 0.0
0.894IleAsn: 0.894 ± 0.973
0.894IlePro: 0.894 ± 0.629
6.261IleGln: 6.261 ± 1.872
5.367IleArg: 5.367 ± 2.443
6.261IleSer: 6.261 ± 2.999
1.789IleThr: 1.789 ± 1.027
2.683IleVal: 2.683 ± 1.288
2.683IleTrp: 2.683 ± 1.854
1.789IleTyr: 1.789 ± 0.705
0.0IleXaa: 0.0 ± 0.0
Lys
0.0LysAla: 0.0 ± 0.0
2.683LysCys: 2.683 ± 1.398
2.683LysAsp: 2.683 ± 1.301
3.578LysGlu: 3.578 ± 1.674
1.789LysPhe: 1.789 ± 1.018
0.894LysGly: 0.894 ± 0.629
0.894LysHis: 0.894 ± 0.629
6.261LysIle: 6.261 ± 2.641
2.683LysLys: 2.683 ± 1.122
0.0LysLeu: 0.0 ± 0.0
0.894LysMet: 0.894 ± 1.006
5.367LysAsn: 5.367 ± 2.239
3.578LysPro: 3.578 ± 1.327
0.0LysGln: 0.0 ± 0.0
3.578LysArg: 3.578 ± 1.334
8.05LysSer: 8.05 ± 2.592
1.789LysThr: 1.789 ± 1.027
5.367LysVal: 5.367 ± 1.706
0.894LysTrp: 0.894 ± 0.729
5.367LysTyr: 5.367 ± 1.477
0.0LysXaa: 0.0 ± 0.0
Leu
1.789LeuAla: 1.789 ± 1.038
1.789LeuCys: 1.789 ± 1.259
3.578LeuAsp: 3.578 ± 1.844
4.472LeuGlu: 4.472 ± 1.682
1.789LeuPhe: 1.789 ± 1.139
5.367LeuGly: 5.367 ± 1.723
2.683LeuHis: 2.683 ± 1.398
3.578LeuIle: 3.578 ± 2.047
6.261LeuLys: 6.261 ± 1.756
1.789LeuLeu: 1.789 ± 1.412
0.894LeuMet: 0.894 ± 0.729
6.261LeuAsn: 6.261 ± 1.401
0.894LeuPro: 0.894 ± 0.807
4.472LeuGln: 4.472 ± 1.293
6.261LeuArg: 6.261 ± 2.33
5.367LeuSer: 5.367 ± 1.349
7.156LeuThr: 7.156 ± 2.076
2.683LeuVal: 2.683 ± 1.288
0.894LeuTrp: 0.894 ± 0.973
4.472LeuTyr: 4.472 ± 1.573
0.0LeuXaa: 0.0 ± 0.0
Met
1.789MetAla: 1.789 ± 0.705
0.894MetCys: 0.894 ± 0.729
2.683MetAsp: 2.683 ± 1.854
0.894MetGlu: 0.894 ± 0.807
1.789MetPhe: 1.789 ± 1.458
1.789MetGly: 1.789 ± 0.929
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.894MetLys: 0.894 ± 1.006
1.789MetLeu: 1.789 ± 1.134
0.0MetMet: 0.0 ± 0.0
1.789MetAsn: 1.789 ± 1.018
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
0.894MetArg: 0.894 ± 0.807
0.894MetSer: 0.894 ± 0.729
0.894MetThr: 0.894 ± 0.973
0.0MetVal: 0.0 ± 0.0
2.683MetTrp: 2.683 ± 0.943
2.683MetTyr: 2.683 ± 1.48
0.0MetXaa: 0.0 ± 0.0
Asn
3.578AsnAla: 3.578 ± 1.674
0.894AsnCys: 0.894 ± 0.807
1.789AsnAsp: 1.789 ± 1.259
1.789AsnGlu: 1.789 ± 1.134
0.894AsnPhe: 0.894 ± 0.729
1.789AsnGly: 1.789 ± 0.929
2.683AsnHis: 2.683 ± 1.587
1.789AsnIle: 1.789 ± 0.705
0.0AsnLys: 0.0 ± 0.0
7.156AsnLeu: 7.156 ± 2.211
4.472AsnMet: 4.472 ± 2.205
1.789AsnAsn: 1.789 ± 1.458
4.472AsnPro: 4.472 ± 1.072
2.683AsnGln: 2.683 ± 1.12
5.367AsnArg: 5.367 ± 1.304
2.683AsnSer: 2.683 ± 1.398
1.789AsnThr: 1.789 ± 0.929
4.472AsnVal: 4.472 ± 1.314
0.894AsnTrp: 0.894 ± 0.629
4.472AsnTyr: 4.472 ± 1.132
0.0AsnXaa: 0.0 ± 0.0
Pro
3.578ProAla: 3.578 ± 1.429
1.789ProCys: 1.789 ± 1.134
1.789ProAsp: 1.789 ± 1.134
1.789ProGlu: 1.789 ± 1.038
1.789ProPhe: 1.789 ± 1.027
0.894ProGly: 0.894 ± 0.629
3.578ProHis: 3.578 ± 1.877
4.472ProIle: 4.472 ± 1.762
3.578ProLys: 3.578 ± 2.518
4.472ProLeu: 4.472 ± 1.378
1.789ProMet: 1.789 ± 1.016
4.472ProAsn: 4.472 ± 1.784
0.894ProPro: 0.894 ± 0.629
5.367ProGln: 5.367 ± 1.566
5.367ProArg: 5.367 ± 2.427
5.367ProSer: 5.367 ± 4.02
3.578ProThr: 3.578 ± 1.858
2.683ProVal: 2.683 ± 1.288
0.0ProTrp: 0.0 ± 0.0
1.789ProTyr: 1.789 ± 0.705
0.0ProXaa: 0.0 ± 0.0
Gln
4.472GlnAla: 4.472 ± 2.371
0.0GlnCys: 0.0 ± 0.0
4.472GlnAsp: 4.472 ± 2.451
3.578GlnGlu: 3.578 ± 1.065
2.683GlnPhe: 2.683 ± 1.398
1.789GlnGly: 1.789 ± 1.259
2.683GlnHis: 2.683 ± 1.564
3.578GlnIle: 3.578 ± 1.715
1.789GlnLys: 1.789 ± 1.038
1.789GlnLeu: 1.789 ± 1.202
0.0GlnMet: 0.0 ± 0.0
3.578GlnAsn: 3.578 ± 1.328
3.578GlnPro: 3.578 ± 2.481
3.578GlnGln: 3.578 ± 1.065
2.683GlnArg: 2.683 ± 1.227
3.578GlnSer: 3.578 ± 1.674
5.367GlnThr: 5.367 ± 2.476
5.367GlnVal: 5.367 ± 2.113
0.0GlnTrp: 0.0 ± 0.0
0.894GlnTyr: 0.894 ± 0.729
0.0GlnXaa: 0.0 ± 0.0
Arg
2.683ArgAla: 2.683 ± 1.854
0.894ArgCys: 0.894 ± 1.022
3.578ArgAsp: 3.578 ± 1.327
3.578ArgGlu: 3.578 ± 1.29
2.683ArgPhe: 2.683 ± 1.12
4.472ArgGly: 4.472 ± 1.489
4.472ArgHis: 4.472 ± 2.438
4.472ArgIle: 4.472 ± 1.809
1.789ArgLys: 1.789 ± 1.458
2.683ArgLeu: 2.683 ± 1.441
2.683ArgMet: 2.683 ± 2.187
1.789ArgAsn: 1.789 ± 1.202
5.367ArgPro: 5.367 ± 1.681
2.683ArgGln: 2.683 ± 1.564
4.472ArgArg: 4.472 ± 2.367
7.156ArgSer: 7.156 ± 1.554
2.683ArgThr: 2.683 ± 1.238
6.261ArgVal: 6.261 ± 2.256
0.0ArgTrp: 0.0 ± 0.0
1.789ArgTyr: 1.789 ± 1.134
0.0ArgXaa: 0.0 ± 0.0
Ser
4.472SerAla: 4.472 ± 1.682
0.894SerCys: 0.894 ± 1.022
4.472SerAsp: 4.472 ± 1.681
6.261SerGlu: 6.261 ± 1.156
3.578SerPhe: 3.578 ± 1.106
3.578SerGly: 3.578 ± 1.585
2.683SerHis: 2.683 ± 1.47
6.261SerIle: 6.261 ± 2.304
6.261SerLys: 6.261 ± 2.127
3.578SerLeu: 3.578 ± 1.29
1.789SerMet: 1.789 ± 0.919
4.472SerAsn: 4.472 ± 1.462
8.945SerPro: 8.945 ± 1.938
4.472SerGln: 4.472 ± 2.027
5.367SerArg: 5.367 ± 1.225
16.995SerSer: 16.995 ± 5.882
5.367SerThr: 5.367 ± 2.981
1.789SerVal: 1.789 ± 1.458
0.0SerTrp: 0.0 ± 0.0
2.683SerTyr: 2.683 ± 1.301
0.0SerXaa: 0.0 ± 0.0
Thr
3.578ThrAla: 3.578 ± 1.088
0.894ThrCys: 0.894 ± 1.006
0.894ThrAsp: 0.894 ± 1.006
0.894ThrGlu: 0.894 ± 1.006
0.0ThrPhe: 0.0 ± 0.0
4.472ThrGly: 4.472 ± 1.762
3.578ThrHis: 3.578 ± 2.053
0.894ThrIle: 0.894 ± 0.629
2.683ThrLys: 2.683 ± 1.12
5.367ThrLeu: 5.367 ± 1.729
2.683ThrMet: 2.683 ± 1.9
2.683ThrAsn: 2.683 ± 1.48
3.578ThrPro: 3.578 ± 1.106
2.683ThrGln: 2.683 ± 1.54
1.789ThrArg: 1.789 ± 1.226
4.472ThrSer: 4.472 ± 2.926
1.789ThrThr: 1.789 ± 1.403
3.578ThrVal: 3.578 ± 2.267
0.894ThrTrp: 0.894 ± 1.006
2.683ThrTyr: 2.683 ± 1.238
0.0ThrXaa: 0.0 ± 0.0
Val
0.0ValAla: 0.0 ± 0.0
0.0ValCys: 0.0 ± 0.0
4.472ValAsp: 4.472 ± 0.927
1.789ValGlu: 1.789 ± 2.043
2.683ValPhe: 2.683 ± 1.122
2.683ValGly: 2.683 ± 2.031
3.578ValHis: 3.578 ± 1.65
5.367ValIle: 5.367 ± 2.121
3.578ValLys: 3.578 ± 1.971
5.367ValLeu: 5.367 ± 1.69
1.789ValMet: 1.789 ± 1.458
1.789ValAsn: 1.789 ± 1.018
4.472ValPro: 4.472 ± 0.935
4.472ValGln: 4.472 ± 1.766
3.578ValArg: 3.578 ± 2.916
4.472ValSer: 4.472 ± 1.682
3.578ValThr: 3.578 ± 2.916
2.683ValVal: 2.683 ± 1.288
0.0ValTrp: 0.0 ± 0.0
3.578ValTyr: 3.578 ± 1.971
0.0ValXaa: 0.0 ± 0.0
Trp
2.683TrpAla: 2.683 ± 1.12
0.0TrpCys: 0.0 ± 0.0
0.894TrpAsp: 0.894 ± 1.022
0.894TrpGlu: 0.894 ± 0.973
0.0TrpPhe: 0.0 ± 0.0
0.894TrpGly: 0.894 ± 0.629
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.894TrpLys: 0.894 ± 0.973
0.0TrpLeu: 0.0 ± 0.0
0.894TrpMet: 0.894 ± 0.729
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.894TrpGln: 0.894 ± 0.629
0.894TrpArg: 0.894 ± 0.807
1.789TrpSer: 1.789 ± 1.139
0.894TrpThr: 0.894 ± 0.973
0.894TrpVal: 0.894 ± 0.629
0.0TrpTrp: 0.0 ± 0.0
2.683TrpTyr: 2.683 ± 0.96
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.578TyrAla: 3.578 ± 1.971
0.0TyrCys: 0.0 ± 0.0
1.789TyrAsp: 1.789 ± 1.134
0.894TyrGlu: 0.894 ± 0.729
3.578TyrPhe: 3.578 ± 0.814
1.789TyrGly: 1.789 ± 0.705
0.0TyrHis: 0.0 ± 0.0
2.683TyrIle: 2.683 ± 1.398
1.789TyrLys: 1.789 ± 1.259
3.578TyrLeu: 3.578 ± 1.278
1.789TyrMet: 1.789 ± 0.956
2.683TyrAsn: 2.683 ± 0.845
2.683TyrPro: 2.683 ± 1.218
0.894TyrGln: 0.894 ± 0.729
4.472TyrArg: 4.472 ± 1.897
3.578TyrSer: 3.578 ± 1.877
0.894TyrThr: 0.894 ± 0.807
4.472TyrVal: 4.472 ± 1.267
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1119 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski